Development Level

Tbio 183 | 11,651
Tclin 136 | 612
Tchem 63 | 1,388
Tdark 30 | 6,593

Collection

Ion Channel: IDG Consortium (T... 53 | 99
RFA-RM-18-021 52 | 328

IMPC Phenotype

preweaning lethality, complete... 29 | 979
abnormal behavior 12 | 298
hyperactivity 8 | 148
preweaning lethality, incomple... 8 | 499
decreased body weight 7 | 161
abnormal embryo size 6 | 220
decreased total body fat amoun... 6 | 207
embryonic lethality prior to t... 6 | 278
impaired glucose tolerance 6 | 75
increased lean body mass 6 | 172
increased startle reflex 6 | 112
decreased circulating LDL chol... 5 | 38
decreased circulating alkaline... 5 | 46
decreased vertical activity 5 | 208
increased mean corpuscular vol... 5 | 92
abnormal behavioral response t... 4 | 66
abnormal gait 4 | 69
decreased mean platelet volume 4 | 25
increased bone mineral content 4 | 108
increased circulating chloride... 4 | 41
increased total body fat amoun... 4 | 134
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
abnormal epididymis morphology 3 | 42
cardiovascular system phenotyp... 3 | 36
decreased circulating HDL chol... 3 | 68
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
prolonged ST segment 3 | 36
abnormal lens morphology 2 | 81
abnormal response to new envir... 2 | 10
abnormal response to tactile s... 2 | 17
abnormal seminal vesicle morph... 2 | 114
abnormal sensory capabilities-... 2 | 8
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased cardiac stroke volum... 2 | 6
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased fasted circulating g... 2 | 65
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
enlarged uterus 2 | 11
hypoactivity 2 | 132
increased circulating LDL chol... 2 | 13
increased circulating triglyce... 2 | 42
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating magnesiu... 1 | 10
increased eosinophil cell numb... 1 | 11
long tibia 1 | 25
thrombocytosis 1 | 27

Disease

Carcinoma 316 | 11,493
psoriasis 174 | 6,694
medulloblastoma, large-cell 169 | 6,241
glioblastoma 167 | 5,792
atypical teratoid / rhabdoid tumor 152 | 5,112
ependymoma 151 | 4,679
osteosarcoma 145 | 7,950
adult high grade glioma 142 | 3,801
ovarian cancer 142 | 8,520
Kidney cancer 119 | 2,613
lung cancer 118 | 4,740
group 3 medulloblastoma 113 | 4,104
Astrocytoma, Pilocytic 111 | 3,081
primitive neuroectodermal tumor 111 | 3,035
oligodendroglioma 108 | 2,850
Epilepsy 107 | 792
lung carcinoma 101 | 2,843
Breast cancer 91 | 3,578
astrocytic glioma 90 | 2,597
Schizophrenia 86 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 77 | 2,955
malignant mesothelioma 77 | 3,232
subependymal giant cell astrocytoma 77 | 2,287
Autosomal recessive predisposition 74 | 1,442
Bipolar Disorder 74 | 666
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 71 | 2,989
lung adenocarcinoma 68 | 2,716
Pick disease 66 | 1,894
Cancer 65 | 2,499
diabetes mellitus 62 | 1,728
pituitary cancer 61 | 1,972
invasive ductal carcinoma 58 | 2,951
Seizures 57 | 596
Hypertension 56 | 396
interstitial cystitis 55 | 2,312
Intellectual disability 54 | 1,016
non-small cell lung cancer 50 | 2,890
pancreatic cancer 49 | 2,398
Obesity 48 | 678
colon cancer 48 | 1,478
cystic fibrosis 47 | 1,696
Depressive disorder 46 | 409
Heart disease 46 | 306
Mental Depression 45 | 333
ductal carcinoma in situ 45 | 1,745
Autistic Disorder 42 | 364
Hypertensive disease 42 | 292
Alcoholic Intoxication, Chronic 41 | 289
Alzheimer's disease 40 | 658
Cognitive delay 40 | 608
Global developmental delay 40 | 608
Mental and motor retardation 40 | 608
Atrial Fibrillation 39 | 124
Dull intelligence 39 | 645
General anesthesia 39 | 53
Low intelligence 39 | 645
Melanoma 39 | 711
Mental Retardation 39 | 645
Mental deficiency 39 | 645
Muscle hypotonia 39 | 571
Poor school performance 39 | 645
group 4 medulloblastoma 38 | 1,855
breast carcinoma 37 | 1,638
Hyperglycemia 35 | 137
Kidney disease 35 | 430
tuberculosis 35 | 2,010
Neuropathy 34 | 261
Skin cancer 34 | 469
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
ulcerative colitis 34 | 1,819
Liver cancer 32 | 604
Multiple Sclerosis 32 | 540
Parkinson's disease 32 | 392
Cerebellar Ataxia 31 | 304
Major Depressive Disorder 31 | 301
Tonic-clonic epilepsy 31 | 47
adrenocortical carcinoma 31 | 1,428
Local anesthesia 30 | 40
Mood Disorders 30 | 184
Liver Cirrhosis, Experimental 29 | 769
Rheumatoid arthritis 29 | 1,191
Cerebrovascular disease 28 | 238
Diarrhea 27 | 253
Failure to gain weight 26 | 365
Hyperinsulinism 26 | 133
Infantile onset 26 | 238
Pediatric failure to thrive 26 | 365
active Crohn's disease 26 | 922
non primary Sjogren syndrome sicca 26 | 891
Alcohol dependence 25 | 107
Hypoglycemia 25 | 152
Status Epilepticus 25 | 98
astrocytoma 25 | 1,146
Unipolar Depression 24 | 250
Coronary artery disease 23 | 268
Diabetes Mellitus, Non-Insulin-Dependent 23 | 145
Endometrial cancer 23 | 311
Neurodegenerative disease 23 | 414
Osteoporosis 23 | 363

Tissue

Endocrine System 404 | 18,159
Nervous System 389 | 16,725
Digestive Tract 386 | 17,369
Female tissues 381 | 17,400
Skin and soft tissues 377 | 17,230
Male tissues 373 | 17,142
Blood and immune system 361 | 16,909
Liver and Pancreas 358 | 16,750
Urinary Tract 357 | 16,678
Respiratory system 339 | 16,393
Cardiovascular System 297 | 15,192

Target Family

Ion Channel 222 | 344
Non-IDG 90 | 12,091
Transporter 45 | 473
Enzyme 33 | 4,145
GPCR 9 | 408
Kinase 8 | 634
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Transporter complex 412 | 412
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Cation channel sperm-associated protein subunit epsilon CATSPERE Tdark Non-IDG 0.00000 21
Cytochrome b-c1 complex subunit 6-like, mitochondrial UQCRHL Tdark Non-IDG -0.84371 11.5 0
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Cation channel sperm-associated protein 3 CATSPER3 Tchem Ion Channel -1.09150 13.5 31
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193