Development Level

Tbio 136 | 10,625
Tclin 132 | 602
Tchem 96 | 1,890
Tdark 22 | 7,003

Collection

Eligible Ion Channel Proteins 64 | 117

IMPC Term

preweaning lethality, complete... 18 | 633
decreased body weight 8 | 174
decreased lean body mass 8 | 195
abnormal behavior 7 | 226
decreased circulating choleste... 5 | 85
decreased grip strength 5 | 123
embryonic lethality prior to t... 5 | 187
hyperactivity 5 | 108
abnormal gait 4 | 51
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased total body fat amoun... 4 | 186
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
abnormal epididymis morphology 3 | 31
cardiovascular system phenotyp... 3 | 35
decreased circulating alkaline... 3 | 41
decreased circulating triglyce... 3 | 83
decreased eosinophil cell numb... 3 | 41
enlarged heart 3 | 111
increased bone mineral content 3 | 92
increased mean corpuscular vol... 3 | 91
abnormal behavioral response t... 2 | 52
abnormal lens morphology 2 | 73
abnormal response to new envir... 2 | 8
abnormal response to tactile s... 2 | 16
abnormal retina morphology 2 | 100
absent vibrissae 2 | 14
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral content 2 | 157
decreased circulating alanine ... 2 | 53
decreased circulating serum al... 2 | 79
decreased fasted circulating g... 2 | 49
enlarged epididymis 2 | 27
impaired glucose tolerance 2 | 52
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
prenatal lethality 2 | 16
preweaning lethality, incomple... 2 | 260
tremors 2 | 34
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal sensory capabilities/... 1 | 3
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased gamma-delta T cell n... 1 | 18
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased threshold for audito... 1 | 32
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased hematocrit 1 | 36
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

psoriasis 164 | 6,685
medulloblastoma, large-cell 163 | 6,234
glioblastoma 156 | 5,572
osteosarcoma 138 | 7,933
ovarian cancer 132 | 8,484
atypical teratoid / rhabdoid tumor 120 | 4,369
Carcinoma 110 | 2,147
pilocytic astrocytoma 106 | 3,086
oligodendroglioma 104 | 2,849
primitive neuroectodermal tumor 104 | 3,031
lung cancer 102 | 4,466
lung carcinoma 98 | 2,844
pediatric high grade glioma 95 | 2,712
Epilepsy 87 | 346
ependymoma 77 | 2,514
subependymal giant cell astrocytoma 77 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 76 | 2,956
astrocytic glioma 73 | 2,241
malignant mesothelioma 72 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 70 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 69 | 2,988
lung adenocarcinoma 66 | 2,713
Pick disease 64 | 1,893
adult high grade glioma 64 | 2,148
Breast cancer 63 | 3,094
Cancer 62 | 2,346
pituitary cancer 60 | 1,972
diabetes mellitus 55 | 1,663
invasive ductal carcinoma 55 | 2,950
medulloblastoma 53 | 1,524
interstitial cystitis 50 | 2,299
posterior fossa group A ependymoma 50 | 1,511
Schizophrenia 49 | 501
colon cancer 48 | 1,475
cystic fibrosis 44 | 1,665
non-small cell lung cancer 44 | 2,798
Obesity 43 | 616
ductal carcinoma in situ 43 | 1,745
pancreatic cancer 42 | 2,300
group 3 medulloblastoma 41 | 2,254
group 4 medulloblastoma 41 | 1,875
Alzheimer's disease 40 | 644
atypical teratoid/rhabdoid tumor 40 | 1,095
sonic hedgehog group medulloblastoma 40 | 1,482
ulcerative colitis 40 | 2,087
Heart disease 39 | 279
Hypertension 39 | 287
General anesthesia 38 | 53
astrocytoma 38 | 1,493
Atrial Fibrillation 35 | 110
breast carcinoma 35 | 1,614
Autistic Disorder 34 | 320
posterior fossa group B ependymoma 34 | 1,530
Hyperglycemia 33 | 120
Hypertensive disease 31 | 193
Intellectual disability 31 | 573
Kidney disease 31 | 396
Parkinson's disease 31 | 364
Tonic-clonic epilepsy 31 | 47
Multiple Sclerosis 30 | 498
Bipolar Disorder 29 | 266
Local anesthesia 29 | 40
Rheumatoid Arthritis 29 | 1,160
adrenocortical carcinoma 29 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,795
Cerebrovascular disease 26 | 231
Long QT syndrome 26 | 52
non primary Sjogren syndrome sicca 26 | 840
Neuropathy 25 | 210
primary pancreatic ductal adenocarcinoma 25 | 1,271
Alcohol dependence 24 | 107
Hyperinsulinism 24 | 63
Neurodegenerative disease 24 | 383
Status Epilepticus 24 | 85
active Crohn's disease 24 | 918
Eaton-Lambert syndrome 23 | 40
Migraine 23 | 79
acute quadriplegic myopathy 23 | 1,157
Hypoglycemia 22 | 81
Metabolic syndrome X 22 | 155
tuberculosis 22 | 1,557
Amyotrophic Lateral Sclerosis 21 | 431
Coronary artery disease 21 | 240
Diabetes Mellitus, Non-Insulin-Dependent 21 | 157
Lennox-Gastaut syndrome 21 | 34
Endometriosis 20 | 535
Myopathy 20 | 128
Pain agnosia 20 | 99
Polycystic Ovary Syndrome 20 | 332
Toxic encephalopathy 20 | 131
gastric carcinoma 20 | 832
nasopharyngeal carcinoma 20 | 1,056
Atherosclerosis 19 | 275
Atopic dermatitis 19 | 944
Simple partial seizure 19 | 26
cutaneous lupus erythematosus 19 | 1,056
Epilepsy characterized by intractable complex partial seizures 18 | 28
Osteoporosis 18 | 257
Vascular disease 18 | 281
dermatomyositis 18 | 933

Tissue

Nervous System 383 | 18,561
Female tissues 382 | 18,647
Endocrine System 381 | 18,512
Urinary Tract 380 | 18,444
Cardiovascular System 379 | 17,958
Digestive Tract 379 | 18,473
Liver and Pancreas 378 | 18,136
Skin and soft tissues 378 | 18,115
Blood and immune system 375 | 17,995
Male tissues 371 | 17,969
Respiratory system 367 | 17,484

Target Family

Ion Channel 218 | 341
Non-IDG 73 | 11,971
Transporter 44 | 473
Enzyme 31 | 4,146
GPCR 8 | 406
Kinase 8 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Transporter complex 386 | 386
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Cation channel sperm-associated protein 4 CATSPER4 Tchem Ion Channel 0.06 0.89 32
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128