Development Level

Tbio 129 | 10,625
Tclin 128 | 602
Tchem 82 | 1,890
Tdark 21 | 7,003

Collection

Eligible Ion Channel Proteins 65 | 117

IMPC Term

preweaning lethality, complete... 17 | 633
abnormal behavior 8 | 226
decreased body weight 7 | 174
decreased lean body mass 6 | 195
hyperactivity 5 | 108
decreased circulating choleste... 4 | 85
embryonic lethality prior to t... 4 | 187
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased eosinophil cell numb... 3 | 41
decreased grip strength 3 | 123
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
increased bone mineral content 3 | 92
increased startle reflex 3 | 38
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal response to new envir... 2 | 8
abnormal response to tactile s... 2 | 16
absent vibrissae 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating glycerol... 2 | 19
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased rib number 2 | 59
enlarged epididymis 2 | 27
impaired glucose tolerance 2 | 52
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
prenatal lethality 2 | 16
preweaning lethality, incomple... 2 | 260
tremors 2 | 34
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal facial morphology 1 | 9
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal retina morphology 1 | 100
abnormal sensory capabilities/... 1 | 3
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
cyanosis 1 | 6
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating iron lev... 1 | 25
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased gamma-delta T cell n... 1 | 18
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart rate variabili... 1 | 4
increased vertical activity 1 | 18
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46

Disease

medulloblastoma, large-cell 163 | 6,234
glioblastoma 151 | 5,572
psoriasis 142 | 6,685
osteosarcoma 127 | 7,933
atypical teratoid / rhabdoid tumor 119 | 4,369
ovarian cancer 115 | 8,484
Carcinoma 109 | 2,147
pilocytic astrocytoma 109 | 3,086
oligodendroglioma 108 | 2,849
primitive neuroectodermal tumor 103 | 3,031
Epilepsy 93 | 346
lung carcinoma 90 | 2,844
lung cancer 87 | 4,466
pediatric high grade glioma 87 | 2,712
ependymoma 81 | 2,514
astrocytic glioma 75 | 2,241
subependymal giant cell astrocytoma 74 | 2,287
Pick disease 71 | 1,893
malignant mesothelioma 68 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 67 | 2,956
adult high grade glioma 64 | 2,148
pituitary cancer 61 | 1,972
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,988
medulloblastoma 59 | 1,524
lung adenocarcinoma 56 | 2,713
Breast cancer 51 | 3,094
Schizophrenia 48 | 501
Cancer 44 | 2,346
cystic fibrosis 43 | 1,665
posterior fossa group A ependymoma 43 | 1,511
invasive ductal carcinoma 42 | 2,950
colon cancer 41 | 1,475
interstitial cystitis 41 | 2,299
non-small cell lung cancer 41 | 2,798
sonic hedgehog group medulloblastoma 40 | 1,482
General anesthesia 39 | 53
atypical teratoid/rhabdoid tumor 39 | 1,095
Atrial Fibrillation 38 | 110
group 4 medulloblastoma 38 | 1,875
astrocytoma 33 | 1,493
group 3 medulloblastoma 33 | 2,254
pancreatic cancer 33 | 2,300
ulcerative colitis 33 | 2,087
Autistic Disorder 32 | 320
Hypertension 32 | 287
Tonic-clonic epilepsy 32 | 47
ductal carcinoma in situ 32 | 1,745
posterior fossa group B ependymoma 32 | 1,530
Alzheimer's disease 31 | 644
Heart disease 31 | 279
Local anesthesia 30 | 40
Long QT syndrome 30 | 52
Bipolar Disorder 29 | 266
Intellectual disability 29 | 573
diabetes mellitus 29 | 1,663
Neurodegenerative disease 28 | 383
Multiple Sclerosis 27 | 498
non primary Sjogren syndrome sicca 27 | 840
Alcohol dependence 26 | 107
breast carcinoma 26 | 1,614
Parkinson's disease 25 | 364
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
Hypertensive disease 24 | 193
Migraine 24 | 79
adrenocortical carcinoma 24 | 1,427
Eaton-Lambert syndrome 23 | 40
Obesity 23 | 616
Kidney disease 22 | 396
Lennox-Gastaut syndrome 22 | 34
Neuropathy 22 | 210
Rheumatoid Arthritis 22 | 1,160
Status Epilepticus 22 | 85
Pain agnosia 21 | 99
Simple partial seizure 20 | 26
Toxic encephalopathy 20 | 131
active Crohn's disease 20 | 918
Brugada syndrome 19 | 26
Epilepsy characterized by intractable complex partial seizures 19 | 28
Hypertensive disorder 19 | 58
primary pancreatic ductal adenocarcinoma 19 | 1,271
tuberculosis 19 | 1,557
Amyotrophic Lateral Sclerosis 18 | 431
Cerebrovascular disease 18 | 231
Down syndrome 18 | 548
Vascular disease 18 | 281
Irritable bowel syndrome 17 | 59
Spasticity 17 | 26
gastric carcinoma 17 | 832
nasopharyngeal carcinoma 17 | 1,056
Anxiety 16 | 24
Insomnia 16 | 20
Major Depressive Disorder 16 | 106
Myopathy 16 | 128
Nicotine dependence 16 | 53
Panic disorder 16 | 55
progressive supranuclear palsy 16 | 674
Multiple myeloma 15 | 1,327
acute quadriplegic myopathy 15 | 1,157
cutaneous lupus erythematosus 15 | 1,056

Tissue

Nervous System 357 | 18,561
Endocrine System 355 | 18,512
Female tissues 354 | 18,647
Urinary Tract 354 | 18,444
Digestive Tract 353 | 18,473
Liver and Pancreas 352 | 18,136
Skin and soft tissues 352 | 18,115
Cardiovascular System 351 | 17,958
Blood and immune system 347 | 17,995
Male tissues 344 | 17,969
Respiratory system 341 | 17,484

Target Family

Ion Channel 230 | 341
Non-IDG 65 | 11,971
Transporter 28 | 473
Enzyme 24 | 4,146
GPCR 10 | 406
Kinase 3 | 634

Compartment GO Term

Transmembrane transporter comp... 360 | 360
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Cation channel sperm-associated protein 4 CATSPER4 Tchem Ion Channel 0.06 0.89 32
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.91579 94.4 137