Development Level

Tbio 171 | 11,651
Tclin 132 | 612
Tchem 48 | 1,388
Tdark 29 | 6,593

Collection

Ion Channel: IDG Consortium (T... 53 | 99
RFA-RM-18-021 52 | 328

IMPC Phenotype

preweaning lethality, complete... 26 | 979
abnormal behavior 11 | 298
hyperactivity 8 | 148
preweaning lethality, incomple... 8 | 499
impaired glucose tolerance 7 | 75
abnormal embryo size 6 | 220
decreased body weight 6 | 161
decreased total body fat amoun... 6 | 207
increased lean body mass 6 | 172
increased startle reflex 6 | 112
embryonic lethality prior to t... 5 | 278
abnormal behavioral response t... 4 | 66
decreased circulating alkaline... 4 | 46
decreased mean platelet volume 4 | 25
decreased vertical activity 4 | 208
increased bone mineral content 4 | 108
increased circulating chloride... 4 | 41
increased fasted circulating g... 4 | 76
increased mean corpuscular vol... 4 | 92
abnormal bone structure 3 | 187
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
decreased circulating LDL chol... 3 | 38
decreased circulating glucose ... 3 | 126
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
decreased prepulse inhibition 3 | 82
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 42
increased total body fat amoun... 3 | 134
limb grasping 3 | 41
prolonged ST segment 3 | 36
abnormal bone mineralization 2 | 38
abnormal response to new envir... 2 | 10
abnormal response to tactile s... 2 | 17
abnormal seminal vesicle morph... 2 | 114
abnormal sensory capabilities-... 2 | 8
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased cardiac stroke volum... 2 | 6
decreased circulating HDL chol... 2 | 68
decreased circulating glycerol... 2 | 16
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
enlarged spleen 2 | 41
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
tremors 2 | 39
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
brachydactyly 1 | 19
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating magnesiu... 1 | 10
long tibia 1 | 25
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 295 | 11,493
medulloblastoma, large-cell 169 | 6,241
glioblastoma 158 | 5,792
psoriasis 151 | 6,694
atypical teratoid / rhabdoid tumor 150 | 5,112
ependymoma 148 | 4,679
adult high grade glioma 139 | 3,801
osteosarcoma 135 | 7,950
ovarian cancer 125 | 8,520
Kidney cancer 118 | 2,613
oligodendroglioma 111 | 2,850
Astrocytoma, Pilocytic 110 | 3,081
group 3 medulloblastoma 109 | 4,104
Epilepsy 106 | 792
primitive neuroectodermal tumor 106 | 3,035
lung cancer 99 | 4,740
lung carcinoma 92 | 2,843
astrocytic glioma 91 | 2,597
Schizophrenia 80 | 1,160
Breast cancer 79 | 3,578
subependymal giant cell astrocytoma 74 | 2,287
Pick disease 71 | 1,894
malignant mesothelioma 71 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 69 | 2,955
Bipolar Disorder 67 | 666
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,291
Autosomal recessive predisposition 62 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,989
pituitary cancer 62 | 1,972
lung adenocarcinoma 59 | 2,716
Intellectual disability 49 | 1,016
cystic fibrosis 49 | 1,696
Seizures 48 | 596
Cancer 47 | 2,499
interstitial cystitis 45 | 2,312
non-small cell lung cancer 45 | 2,890
invasive ductal carcinoma 44 | 2,951
Hypertension 43 | 396
Atrial Fibrillation 41 | 124
Depressive disorder 41 | 409
colon cancer 41 | 1,478
General anesthesia 40 | 53
pancreatic cancer 40 | 2,398
Alcoholic Intoxication, Chronic 39 | 289
Autistic Disorder 39 | 364
Heart disease 38 | 306
Muscle hypotonia 38 | 571
Melanoma 37 | 711
Mental Depression 37 | 333
Dull intelligence 35 | 645
Low intelligence 35 | 645
Mental Retardation 35 | 645
Mental deficiency 35 | 645
Poor school performance 35 | 645
diabetes mellitus 34 | 1,728
ductal carcinoma in situ 34 | 1,745
Skin cancer 33 | 469
group 4 medulloblastoma 33 | 1,855
Alzheimer's disease 32 | 658
Cognitive delay 32 | 608
Global developmental delay 32 | 608
Mental and motor retardation 32 | 608
Tonic-clonic epilepsy 32 | 47
Hypertensive disease 31 | 292
Liver cancer 31 | 604
Local anesthesia 30 | 40
Neuropathy 30 | 261
Multiple Sclerosis 28 | 540
Cerebellar Ataxia 27 | 304
non primary Sjogren syndrome sicca 27 | 891
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
tuberculosis 27 | 2,010
Alcohol dependence 26 | 107
Mood Disorders 26 | 184
Neurodegenerative disease 26 | 414
Parkinson's disease 26 | 392
adrenocortical carcinoma 26 | 1,428
breast carcinoma 26 | 1,638
Infantile onset 25 | 238
Major Depressive Disorder 25 | 301
ulcerative colitis 25 | 1,819
Diarrhea 23 | 253
Eaton-Lambert syndrome 23 | 40
Kidney disease 23 | 430
Migraine 23 | 83
Obesity 23 | 678
Status Epilepticus 23 | 98
Endometrial cancer 22 | 311
Lennox-Gastaut syndrome 22 | 34
Long QT syndrome 21 | 39
Toxic encephalopathy 21 | 141
active Crohn's disease 21 | 922
Rheumatoid arthritis 20 | 1,191
Simple partial seizure 20 | 26
astrocytoma 20 | 1,146
Brugada syndrome 19 | 29
Failure to gain weight 19 | 365
Pain agnosia 19 | 104
Pediatric failure to thrive 19 | 365
Vascular disease 19 | 319

Tissue

Endocrine System 373 | 18,159
Nervous System 359 | 16,725
Digestive Tract 354 | 17,369
Female tissues 351 | 17,400
Skin and soft tissues 346 | 17,230
Male tissues 343 | 17,142
Blood and immune system 331 | 16,909
Liver and Pancreas 326 | 16,750
Urinary Tract 326 | 16,678
Respiratory system 309 | 16,393
Cardiovascular System 266 | 15,192

Target Family

Ion Channel 233 | 344
Non-IDG 78 | 12,091
Enzyme 28 | 4,145
Transporter 28 | 473
GPCR 10 | 408
Kinase 3 | 634

Compartment GO Term

Transmembrane transporter comp... 380 | 380
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Cation channel sperm-associated protein subunit epsilon CATSPERE Tdark Non-IDG 0.00000 21
Cytochrome b-c1 complex subunit 6-like, mitochondrial UQCRHL Tdark Non-IDG -0.84371 11.5 0
Cation channel sperm-associated protein 3 CATSPER3 Tchem Ion Channel -1.09150 13.5 31
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193
Cation channel sperm-associated protein subunit delta CATSPERD Tdark Non-IDG -0.06695 1.07 41