Development Level

Tbio 129 | 10,625
Tclin 128 | 602
Tchem 82 | 1,890
Tdark 21 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 54 | 102

IMPC Phenotype

preweaning lethality, complete... 17 | 633
abnormal behavior 8 | 226
decreased body weight 7 | 174
decreased lean body mass 6 | 195
hyperactivity 5 | 108
decreased circulating choleste... 4 | 85
embryonic lethality prior to t... 4 | 187
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased eosinophil cell numb... 3 | 41
decreased grip strength 3 | 123
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
increased bone mineral content 3 | 92
increased startle reflex 3 | 38
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal response to new envir... 2 | 8
abnormal response to tactile s... 2 | 16
absent vibrissae 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating glycerol... 2 | 19
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased rib number 2 | 59
enlarged epididymis 2 | 27
impaired glucose tolerance 2 | 52
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
prenatal lethality 2 | 16
preweaning lethality, incomple... 2 | 260
tremors 2 | 34
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal facial morphology 1 | 9
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal retina morphology 1 | 100
abnormal sensory capabilities-... 1 | 3
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
cyanosis 1 | 6
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating iron lev... 1 | 25
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased gamma-delta T cell n... 1 | 18
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart rate variabili... 1 | 4
increased vertical activity 1 | 18
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46

Disease

medulloblastoma, large-cell 163 | 6,234
glioblastoma 151 | 5,572
psoriasis 142 | 6,685
osteosarcoma 127 | 7,933
atypical teratoid / rhabdoid tumor 119 | 4,369
ovarian cancer 116 | 8,491
Carcinoma 109 | 2,147
pilocytic astrocytoma 109 | 3,086
oligodendroglioma 108 | 2,849
primitive neuroectodermal tumor 103 | 3,031
Epilepsy 93 | 346
lung carcinoma 90 | 2,844
lung cancer 87 | 4,473
pediatric high grade glioma 87 | 2,712
ependymoma 81 | 2,514
astrocytic glioma 75 | 2,241
subependymal giant cell astrocytoma 74 | 2,287
Pick disease 71 | 1,893
malignant mesothelioma 68 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 67 | 2,956
adult high grade glioma 64 | 2,148
pituitary cancer 61 | 1,972
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,988
medulloblastoma 59 | 1,524
lung adenocarcinoma 56 | 2,714
Breast cancer 51 | 3,098
Schizophrenia 48 | 503
Cancer 44 | 2,346
cystic fibrosis 43 | 1,670
posterior fossa group A ependymoma 43 | 1,511
invasive ductal carcinoma 42 | 2,950
colon cancer 41 | 1,475
interstitial cystitis 41 | 2,299
non-small cell lung cancer 41 | 2,798
sonic hedgehog group medulloblastoma 40 | 1,482
General anesthesia 39 | 53
atypical teratoid/rhabdoid tumor 39 | 1,095
Atrial Fibrillation 38 | 110
group 4 medulloblastoma 38 | 1,875
Hypertension 35 | 293
astrocytoma 33 | 1,493
group 3 medulloblastoma 33 | 2,254
pancreatic cancer 33 | 2,300
ulcerative colitis 33 | 2,087
Autistic Disorder 32 | 320
Tonic-clonic epilepsy 32 | 47
ductal carcinoma in situ 32 | 1,745
posterior fossa group B ependymoma 32 | 1,530
Alzheimer's disease 31 | 644
Heart disease 31 | 279
Local anesthesia 30 | 40
Long QT syndrome 30 | 53
Bipolar Disorder 29 | 266
Intellectual disability 29 | 573
diabetes mellitus 29 | 1,663
Neurodegenerative disease 28 | 383
Multiple Sclerosis 27 | 498
non primary Sjogren syndrome sicca 27 | 840
Alcohol dependence 26 | 107
breast carcinoma 26 | 1,614
Parkinson's disease 25 | 364
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
Hypertensive disease 24 | 193
Migraine 24 | 79
adrenocortical carcinoma 24 | 1,427
Eaton-Lambert syndrome 23 | 40
Obesity 23 | 616
Kidney disease 22 | 397
Lennox-Gastaut syndrome 22 | 34
Neuropathy 22 | 210
Rheumatoid Arthritis 22 | 1,170
Status Epilepticus 22 | 85
Pain agnosia 21 | 99
Simple partial seizure 20 | 26
Toxic encephalopathy 20 | 131
active Crohn's disease 20 | 918
Brugada syndrome 19 | 26
Epilepsy characterized by intractable complex partial seizures 19 | 28
Hypertensive disorder 19 | 58
primary pancreatic ductal adenocarcinoma 19 | 1,271
tuberculosis 19 | 1,563
Amyotrophic Lateral Sclerosis 18 | 432
Cerebrovascular disease 18 | 231
Down syndrome 18 | 548
Vascular disease 18 | 281
Irritable bowel syndrome 17 | 59
Spasticity 17 | 26
gastric carcinoma 17 | 832
nasopharyngeal carcinoma 17 | 1,056
Anxiety 16 | 24
Insomnia 16 | 20
Major Depressive Disorder 16 | 106
Myopathy 16 | 128
Nicotine dependence 16 | 53
Panic disorder 16 | 55
progressive supranuclear palsy 16 | 674
Multiple myeloma 15 | 1,327
acute quadriplegic myopathy 15 | 1,157
cutaneous lupus erythematosus 15 | 1,056

Tissue

Nervous System 357 | 18,560
Endocrine System 355 | 18,511
Female tissues 354 | 18,646
Urinary Tract 354 | 18,443
Digestive Tract 353 | 18,472
Liver and Pancreas 352 | 18,135
Skin and soft tissues 352 | 18,114
Cardiovascular System 351 | 17,957
Blood and immune system 347 | 17,994
Male tissues 344 | 17,968
Respiratory system 341 | 17,483

Target Family

Ion Channel 230 | 341
Non-IDG 65 | 11,969
Transporter 28 | 473
Enzyme 24 | 4,146
GPCR 10 | 408
Kinase 3 | 634

Compartment GO Term

Transmembrane transporter comp... 360 | 360
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Short transient receptor potential channel 5 TRPC5 Tchem Ion Channel -2.22055 159.7 209
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Tclin Ion Channel -1.54794 32.2 109
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.53667 324.2 196
Chloride intracellular channel protein 6 CLIC6 Tbio Ion Channel -1.03083 11.5 146
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 Tclin Transporter -1.08214 10.9 189
Maltase-glucoamylase, intestinal MGAM Tclin Enzyme -4.50018 27956.4 30
Potassium voltage-gated channel subfamily H member 2 KCNH2 Tclin Ion Channel -3.19173 1625.2 221
Cerebellar degeneration-related protein 2 CDR2 Tbio Non-IDG -2.65822 431.3 237
ATP-binding cassette sub-family G member 2 ABCG2 Tchem Transporter -3.38300 2531.5 239