Development Level

Tbio 12 | 11,445
Tchem 9 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal testis morphology 1 | 43
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased eosinophil cell numb... 1 | 24
decreased hemoglobin content 1 | 68
edema 1 | 59
enlarged lymph nodes 1 | 37
increased heart weight 1 | 62
increased prepulse inhibition 1 | 32
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Cancer 17 | 2,499
Carcinoma 17 | 11,493
osteosarcoma 17 | 7,950
ovarian cancer 17 | 8,520
glioblastoma 12 | 5,792
atypical teratoid / rhabdoid tumor 11 | 5,112
lung carcinoma 11 | 2,843
psoriasis 11 | 6,694
Astrocytoma, Pilocytic 10 | 3,081
Breast cancer 9 | 3,578
Hypertensive disease 9 | 292
adult high grade glioma 9 | 3,801
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
medulloblastoma, large-cell 9 | 6,241
malignant mesothelioma 8 | 3,232
Coronary artery disease 7 | 268
Craniofacial Abnormalities 7 | 151
Increase in blood pressure 7 | 119
Kidney cancer 7 | 2,613
Ureteral obstruction 7 | 33
cystic fibrosis 7 | 1,696
invasive ductal carcinoma 7 | 2,951
non-small cell lung cancer 7 | 2,890
Acquired scoliosis 6 | 281
Aortic Valve Insufficiency 6 | 40
Curvature of spine 6 | 282
Fibrodysplasia ossificans progressiva 6 | 17
Loeys-Dietz syndrome 6 | 23
Pulmonary Fibrosis 6 | 106
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung adenocarcinoma 6 | 2,716
lung cancer 6 | 4,740
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Abnormality of the iris 5 | 14
Acquired flat foot 5 | 72
Aortic aneurysm, familial thoracic 3 5 | 13
Arachnodactyly 5 | 49
Ascending aortic dissection 5 | 13
Byzanthine arch palate 5 | 194
Cardiomegaly 5 | 116
Chest Pain 5 | 38
Cleft Palate 5 | 271
Cutis marmorata 5 | 32
Cystic medial necrosis of aorta 5 | 13
Descending aortic dissection 5 | 13
Dyspnea on exertion 5 | 24
Dyspnea, Paroxysmal 5 | 13
Familial thoracic aortic aneurysm and aortic dissection 5 | 13
Flatfoot 5 | 73
Heart disease 5 | 306
Hereditary hemorrhagic telangiectasia 5 | 13
Hypertension 5 | 396
Impaired left ventricular function 5 | 16
Kidney disease 5 | 430
Left-Sided Heart Failure 5 | 16
Liver Cirrhosis 5 | 181
Liver Cirrhosis, Experimental 5 | 769
Loeys-Dietz Aortic Aneurysm Syndrome 5 | 13
Orbital separation excessive 5 | 244
diabetes mellitus 5 | 1,728
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
tuberculosis 5 | 2,010
Anemia 4 | 365
Aortic aneurysm 4 | 38
Arterial tortuosity 4 | 5
Colorectal Neoplasms 4 | 243
Craniosynostosis 4 | 74
Decreased joint mobility 4 | 53
Dissection of aorta 4 | 9
Epilepsy 4 | 792
Eye Abnormalities 4 | 35
Hemoglobin low 4 | 124
Hernia, Inguinal 4 | 89
Intermittent migraine headaches 4 | 68
Liver disease 4 | 237
Migraine Disorders 4 | 76
Osteoarthritis 4 | 184
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Seizures 4 | 596
Systemic scleroderma 4 | 60
Tall stature 4 | 34
Thoracic aortic aneurysm 4 | 15
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
ductal carcinoma in situ 4 | 1,745
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287
Inflammatory bowel disease 3 | 151
Lung disease 3 | 142
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
pediatric high grade glioma 3 | 1,064

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Kinase 9 | 634
Non-IDG 6 | 12,091
Transcription Factor 6 | 1,400
Enzyme 1 | 4,145

Compartment GO Term

Transforming growth factor bet... 22 | 22
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
ALK tyrosine kinase receptor ALK Tclin Kinase -3.44312 2942.9 976
Bone morphogenetic protein receptor type-1B BMPR1B Tchem Kinase -2.00303 86.8 498
Activin receptor type-1B ACVR1B Tchem Kinase -2.00550 91.2 418
Bone morphogenetic protein receptor type-1A BMPR1A Tchem Kinase -2.34984 211.0 622
Transforming growth factor beta-2 TGFB2 Tbio Non-IDG -3.14427 1378.3 384
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Serine/threonine-protein kinase receptor R3 ACVRL1 Tchem Kinase -2.98370 969.8 432