Development Level

Tbio 219 | 11,651
Tchem 103 | 1,388
Tclin 32 | 612
Tdark 21 | 6,593

Collection

Kinase: IDG Consortium (Target... 6 | 125
RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 56 | 979
embryonic lethality prior to o... 23 | 239
embryonic lethality prior to t... 19 | 278
preweaning lethality, incomple... 12 | 499
abnormal embryo size 10 | 220
abnormal retina morphology 5 | 71
decreased body weight 5 | 161
increased mean corpuscular vol... 5 | 92
increased total body fat amoun... 5 | 134
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
decreased leukocyte cell numbe... 4 | 73
decreased red blood cell distr... 4 | 41
decreased vertical activity 4 | 208
increased lean body mass 4 | 172
increased mean corpuscular hem... 4 | 96
male infertility 4 | 123
small superior vagus ganglion 4 | 74
abnormal bone mineralization 3 | 38
abnormal neural tube closure 3 | 46
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
hyperactivity 3 | 148
increased neutrophil cell numb... 3 | 46
increased startle reflex 3 | 112
short tibia 3 | 97
small testis 3 | 58
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating insulin ... 2 | 76
decreased erythrocyte cell num... 2 | 62
decreased mean platelet volume 2 | 25
decreased startle reflex 2 | 75
enlarged epididymis 2 | 31
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
female infertility 2 | 60
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating magnesiu... 2 | 10
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
increased spleen weight 2 | 10
microphthalmia 2 | 26
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased mean corpuscular hem... 1 | 31
enlarged urinary bladder 1 | 8
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean platelet volume 1 | 45
thrombocytosis 1 | 27
tremors 1 | 39
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 248 | 11,493
ovarian cancer 230 | 8,520
Cancer 196 | 2,499
osteosarcoma 196 | 7,950
psoriasis 147 | 6,694
lung cancer 145 | 4,740
glioblastoma 136 | 5,792
medulloblastoma, large-cell 128 | 6,241
atypical teratoid / rhabdoid tumor 106 | 5,112
Breast cancer 102 | 3,578
group 3 medulloblastoma 100 | 4,104
malignant mesothelioma 99 | 3,232
diabetes mellitus 96 | 1,728
ependymoma 94 | 4,679
Kidney cancer 92 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 80 | 3,291
adult high grade glioma 74 | 3,801
invasive ductal carcinoma 71 | 2,951
primitive neuroectodermal tumor 70 | 3,035
oligodendroglioma 67 | 2,850
non-small cell lung cancer 65 | 2,890
Schizophrenia 63 | 1,160
lung adenocarcinoma 63 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,989
pancreatic cancer 60 | 2,398
breast carcinoma 59 | 1,638
astrocytic glioma 58 | 2,597
Astrocytoma, Pilocytic 57 | 3,081
Breast Neoplasms 56 | 445
Mammary Neoplasms 56 | 425
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,955
subependymal giant cell astrocytoma 56 | 2,287
ulcerative colitis 55 | 1,819
Obesity 53 | 678
lung carcinoma 53 | 2,843
Autosomal recessive predisposition 52 | 1,442
Stomach Neoplasms 50 | 300
Vascular disease 50 | 319
Pick disease 49 | 1,894
Prostatic Neoplasms 49 | 495
Multiple myeloma 48 | 1,332
tuberculosis 48 | 2,010
acute quadriplegic myopathy 47 | 1,158
astrocytoma 47 | 1,146
Kidney disease 46 | 430
Heart disease 45 | 306
group 4 medulloblastoma 45 | 1,855
Alzheimer's disease 44 | 658
Intellectual disability 44 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,962
Rheumatoid arthritis 43 | 1,191
interstitial cystitis 43 | 2,312
Hypertension 42 | 396
adrenocortical carcinoma 42 | 1,428
ductal carcinoma in situ 42 | 1,745
Carcinoma, Hepatocellular 41 | 228
Liver carcinoma 41 | 240
cystic fibrosis 40 | 1,696
Hyperglycemia 37 | 137
Lung Neoplasms 37 | 232
Epilepsy 36 | 792
Short stature 36 | 531
pituitary cancer 36 | 1,972
Seizures 35 | 596
colon cancer 35 | 1,478
Bipolar Disorder 34 | 666
Liver Cirrhosis, Experimental 34 | 769
Melanoma 34 | 711
acute myeloid leukemia 34 | 783
juvenile dermatomyositis 34 | 1,187
Arthritis 33 | 290
Dull intelligence 33 | 645
Low intelligence 33 | 645
Mental Retardation 33 | 645
Mental deficiency 33 | 645
Neoplasm Metastasis 33 | 168
Poor school performance 33 | 645
Depressive disorder 32 | 409
Hypertensive disease 32 | 292
Squamous cell carcinoma 32 | 129
Toxic encephalopathy 32 | 141
Adenoma 31 | 167
Anemia 31 | 365
dermatomyositis 31 | 966
Adenocarcinoma 30 | 122
Asthma 30 | 385
Carcinoma, Squamous Cell 30 | 110
Cerebrovascular disease 30 | 238
Colorectal Neoplasms 30 | 243
Waldenstrons macroglobulinemia 30 | 765
Cognitive delay 29 | 608
Colonic Neoplasms 29 | 142
Global developmental delay 29 | 608
Mental and motor retardation 29 | 608
Neoplasm Invasiveness 29 | 161
Parkinson's disease 29 | 392
Endometriosis 28 | 540
hepatocellular carcinoma 28 | 547
nasopharyngeal carcinoma 28 | 1,058
pediatric high grade glioma 28 | 1,064

Tissue

Blood and immune system 366 | 16,909
Endocrine System 366 | 18,159
Digestive Tract 365 | 17,369
Skin and soft tissues 365 | 17,230
Female tissues 364 | 17,400
Liver and Pancreas 364 | 16,750
Nervous System 364 | 16,725
Urinary Tract 364 | 16,678
Male tissues 363 | 17,142
Respiratory system 362 | 16,393
Cardiovascular System 358 | 15,192

Target Family

Non-IDG 154 | 12,091
Enzyme 104 | 4,145
Kinase 89 | 634
Transcription Factor 18 | 1,400
Epigenetic 6 | 242
Nuclear Receptor 2 | 48
Transporter 2 | 473

Compartment GO Term

Transferase complex, transferr... 375 | 375
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Putative uncharacterized protein encoded by MIR7-3HG MIR7-3HG Tdark Non-IDG -0.12740 2.08 0
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
DNA-directed RNA polymerase III subunit RPC3 POLR3C Tbio Enzyme -0.84213 6.37 136
Mediator of RNA polymerase II transcription subunit 18 MED18 Tbio Enzyme -1.00423 10.4 161
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
DNA-directed RNA polymerase I subunit RPA43 TWISTNB Tdark Enzyme -0.05799 1.13 69