Development Level

Tbio 191 | 10,625
Tchem 120 | 1,890
Tclin 27 | 602
Tdark 22 | 7,003

Collection

Eligible Kinase Proteins 9 | 134

IMPC Term

preweaning lethality, complete... 29 | 633
embryonic lethality prior to o... 13 | 148
embryonic lethality prior to t... 12 | 187
preweaning lethality, incomple... 8 | 260
abnormal embryo size 6 | 112
decreased body weight 5 | 174
increased mean corpuscular hem... 5 | 93
abnormal behavior 4 | 226
abnormal retina morphology 4 | 100
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
abnormal bone mineralization 3 | 55
abnormal epididymis morphology 3 | 31
decreased bone mineral density 3 | 126
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
decreased total body fat amoun... 3 | 186
enlarged epididymis 3 | 27
abnormal behavioral response t... 2 | 52
abnormal forebrain development 2 | 18
abnormal heart morphology 2 | 51
abnormal hindbrain development 2 | 24
abnormal neural tube closure 2 | 37
abnormal skin morphology 2 | 23
abnormal snout morphology 2 | 18
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased rib number 2 | 59
decreased startle reflex 2 | 48
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
increased circulating magnesiu... 2 | 10
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased sacral vertebrae num... 2 | 62
male infertility 2 | 62
polydactyly 2 | 22
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal head morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased mean corpuscular vol... 1 | 50
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
female infertility 1 | 34
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
microphthalmia 1 | 15
short tibia 1 | 82
small adrenal glands 1 | 15
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

ovarian cancer 215 | 8,484
osteosarcoma 186 | 7,933
Cancer 180 | 2,346
psoriasis 141 | 6,685
lung cancer 127 | 4,466
medulloblastoma, large-cell 122 | 6,234
glioblastoma 120 | 5,572
atypical teratoid / rhabdoid tumor 88 | 4,369
diabetes mellitus 87 | 1,663
malignant mesothelioma 87 | 3,162
Breast cancer 81 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,289
Carcinoma 71 | 2,147
invasive ductal carcinoma 66 | 2,950
primitive neuroectodermal tumor 66 | 3,031
oligodendroglioma 65 | 2,849
group 3 medulloblastoma 61 | 2,254
ependymoma 58 | 2,514
lung adenocarcinoma 58 | 2,713
pediatric high grade glioma 58 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,988
ulcerative colitis 57 | 2,087
non-small cell lung cancer 55 | 2,798
pilocytic astrocytoma 55 | 3,086
Obesity 54 | 616
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,956
lung carcinoma 54 | 2,844
pancreatic cancer 54 | 2,300
subependymal giant cell astrocytoma 54 | 2,287
astrocytoma 52 | 1,493
Pick disease 50 | 1,893
Mammary Neoplasms 49 | 410
astrocytic glioma 49 | 2,241
Kidney disease 46 | 396
Multiple myeloma 46 | 1,327
Prostatic Neoplasms 46 | 471
Vascular disease 46 | 281
acute quadriplegic myopathy 45 | 1,157
group 4 medulloblastoma 44 | 1,875
tuberculosis 44 | 1,557
Rheumatoid Arthritis 43 | 1,160
Stomach Neoplasms 43 | 282
interstitial cystitis 43 | 2,299
breast carcinoma 42 | 1,614
adult high grade glioma 41 | 2,148
Heart disease 40 | 279
cystic fibrosis 40 | 1,665
ductal carcinoma in situ 40 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,795
adrenocortical carcinoma 39 | 1,427
Alzheimer's disease 38 | 644
medulloblastoma 38 | 1,524
Liver carcinoma 36 | 217
Lung Neoplasms 36 | 171
Hyperglycemia 33 | 120
acute myeloid leukemia 32 | 780
colon cancer 32 | 1,475
juvenile dermatomyositis 32 | 1,189
Arthritis 31 | 248
dermatomyositis 31 | 933
posterior fossa group A ependymoma 31 | 1,511
pituitary cancer 30 | 1,972
primary pancreatic ductal adenocarcinoma 30 | 1,271
Adenoma 29 | 165
Toxic encephalopathy 29 | 131
Waldenstrons macroglobulinemia 29 | 765
Asthma 28 | 349
Cerebrovascular disease 28 | 231
Parkinson's disease 28 | 364
Diabetes Mellitus, Non-Insulin-Dependent 27 | 157
Endometriosis 27 | 535
Liver disease 27 | 219
Neoplasm Metastasis 27 | 138
Hypertension 26 | 287
Colonic Neoplasms 25 | 126
Diabetes Mellitus, Experimental 25 | 106
Myocardial Infarction 25 | 126
Neoplasm Invasiveness 25 | 127
Adenocarcinoma 24 | 115
Atherosclerosis 24 | 275
Colorectal Neoplasms 24 | 217
nasopharyngeal carcinoma 24 | 1,056
pancreatic carcinoma 24 | 567
Coronary artery disease 23 | 240
Lung disease 23 | 132
Metabolic syndrome X 23 | 155
Peripheral Neuropathy 23 | 303
Schizophrenia 23 | 501
Squamous cell carcinoma 23 | 94
ovarian neoplasm 23 | 97
sonic hedgehog group medulloblastoma 23 | 1,482
Brain Ischemia 22 | 87
Reperfusion Injury 22 | 84
spina bifida 22 | 1,064
IGA Glomerulonephritis 21 | 454
Neurodegenerative disease 21 | 383
Osteoporosis 21 | 257
Pancreatic Neoplasm 21 | 79
Inflammatory bowel disease 20 | 142
hepatocellular carcinoma 20 | 532

Tissue

Blood and immune system 356 | 17,995
Female tissues 356 | 18,647
Cardiovascular System 355 | 17,958
Male tissues 355 | 17,969
Nervous System 355 | 18,561
Digestive Tract 354 | 18,473
Endocrine System 354 | 18,512
Liver and Pancreas 354 | 18,136
Urinary Tract 354 | 18,444
Respiratory system 351 | 17,484
Skin and soft tissues 351 | 18,115

Target Family

Non-IDG 141 | 11,971
Enzyme 106 | 4,146
Kinase 85 | 634
Transcription Factor 18 | 1,400
Epigenetic 6 | 242
Nuclear Receptor 2 | 48
Transporter 2 | 473

Compartment GO Term

Transferase complex, transferr... 360 | 360
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345