Development Level

Tbio 518 | 11,178
Tchem 162 | 1,885
Tdark 120 | 6,569
Tclin 37 | 612

Collection

Kinase: IDG Consortium (Target... 7 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 109 | 979
embryonic lethality prior to o... 39 | 239
embryonic lethality prior to t... 38 | 278
preweaning lethality, incomple... 31 | 499
abnormal embryo size 23 | 220
decreased body weight 15 | 161
abnormal behavior 14 | 298
decreased total body fat amoun... 12 | 207
embryonic growth retardation 12 | 106
increased lean body mass 12 | 172
increased mean corpuscular vol... 12 | 92
increased startle reflex 12 | 112
decreased lean body mass 11 | 135
increased total body fat amoun... 11 | 134
abnormal bone structure 10 | 187
abnormal heart morphology 10 | 162
decreased circulating glucose ... 10 | 126
decreased vertical activity 10 | 208
enlarged heart 10 | 210
increased circulating HDL chol... 9 | 80
increased mean corpuscular hem... 9 | 96
male infertility 9 | 123
short tibia 9 | 97
decreased bone mineral density 8 | 126
decreased red blood cell distr... 8 | 41
impaired glucose tolerance 8 | 75
abnormal bone mineralization 7 | 38
abnormal retina morphology 7 | 71
decreased circulating creatini... 7 | 39
decreased leukocyte cell numbe... 7 | 73
decreased startle reflex 7 | 75
prenatal lethality prior to he... 7 | 87
abnormal lens morphology 6 | 81
decreased bone mineral content 6 | 151
decreased circulating choleste... 6 | 93
decreased circulating insulin ... 6 | 76
decreased grip strength 6 | 116
enlarged spleen 6 | 41
increased bone mineral density 6 | 72
increased circulating alkaline... 6 | 122
increased circulating choleste... 6 | 66
abnormal neural tube closure 5 | 46
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased blood urea nitrogen ... 5 | 51
decreased circulating LDL chol... 5 | 38
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
decreased hemoglobin content 5 | 68
female infertility 5 | 60
increased circulating creatini... 5 | 38
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 76
increased grip strength 5 | 41
increased hematocrit 5 | 46
small testis 5 | 58
thrombocytopenia 5 | 56
vertebral fusion 5 | 23
abnormal cornea morphology 4 | 31
abnormal eye morphology 4 | 68
abnormal gait 4 | 69
abnormal heart left ventricle ... 4 | 16
corneal opacity 4 | 32
decreased circulating alanine ... 4 | 47
decreased circulating alkaline... 4 | 46
decreased circulating chloride... 4 | 30
decreased circulating iron lev... 4 | 32
decreased prepulse inhibition 4 | 82
hyperactivity 4 | 148
hypoactivity 4 | 132
increased bone mineral content 4 | 108
increased circulating potassiu... 4 | 29
increased circulating triglyce... 4 | 42
microphthalmia 4 | 26
small adrenal glands 4 | 16
small superior vagus ganglion 4 | 74
abnormal coat appearance 3 | 31
abnormal pericardium morpholog... 3 | 26
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
abnormal tooth morphology 3 | 24
anophthalmia 3 | 33
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased hematocrit 3 | 46
decreased lymphocyte cell numb... 3 | 83
decreased total retina thickne... 3 | 17
edema 3 | 59
enlarged lymph nodes 3 | 37
increased circulating chloride... 3 | 41
increased circulating glucose ... 3 | 24
increased circulating magnesiu... 3 | 10
increased hemoglobin content 3 | 45
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
increased or absent threshold ... 3 | 101
limb grasping 3 | 41
small spleen 3 | 19
thrombocytosis 3 | 27

Disease

Carcinoma 552 | 11,192
ovarian cancer 513 | 8,297
osteosarcoma 435 | 7,766
psoriasis 303 | 6,514
medulloblastoma, large-cell 301 | 6,086
glioblastoma 287 | 5,635
Cancer 271 | 2,388
lung cancer 263 | 4,607
atypical teratoid / rhabdoid tumor 242 | 4,971
group 3 medulloblastoma 215 | 4,002
Breast cancer 202 | 3,469
ependymoma 202 | 4,559
malignant mesothelioma 180 | 3,135
adult high grade glioma 160 | 3,701
Kidney cancer 159 | 2,548
primitive neuroectodermal tumor 153 | 2,957
oligodendroglioma 149 | 2,768
intraductal papillary-mucinous neoplasm (IPMN) 143 | 3,204
invasive ductal carcinoma 131 | 2,867
diabetes mellitus 128 | 1,683
astrocytic glioma 121 | 2,530
non-small cell lung cancer 119 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 117 | 2,902
Multiple myeloma 115 | 1,296
subependymal giant cell astrocytoma 112 | 2,230
Astrocytoma, Pilocytic 108 | 3,006
lung adenocarcinoma 106 | 2,627
pancreatic cancer 106 | 2,322
group 4 medulloblastoma 105 | 1,806
intraductal papillary-mucinous adenoma (IPMA) 104 | 2,872
Pick disease 97 | 1,856
tuberculosis 97 | 1,963
breast carcinoma 92 | 1,589
lung carcinoma 90 | 2,755
Intellectual disability 86 | 998
pancreatic ductal adenocarcinoma liver metastasis 86 | 1,911
Autosomal recessive predisposition 82 | 1,407
Schizophrenia 82 | 1,136
acute quadriplegic myopathy 81 | 1,133
ulcerative colitis 79 | 1,765
adrenocortical carcinoma 78 | 1,385
astrocytoma 78 | 1,113
Rheumatoid arthritis 77 | 1,156
ductal carcinoma in situ 74 | 1,686
dermatomyositis 69 | 941
pituitary cancer 67 | 1,915
Alzheimer's disease 64 | 640
Breast Neoplasms 64 | 423
juvenile dermatomyositis 64 | 1,147
interstitial cystitis 63 | 2,237
Mammary Neoplasms 62 | 403
Obesity 61 | 655
cystic fibrosis 60 | 1,629
Dull intelligence 58 | 634
Epilepsy 58 | 775
Low intelligence 58 | 634
Mental Retardation 58 | 634
Mental deficiency 58 | 634
Poor school performance 58 | 634
Prostatic Neoplasms 58 | 472
Waldenstrons macroglobulinemia 58 | 742
pediatric high grade glioma 58 | 1,035
colon cancer 57 | 1,428
Stomach Neoplasms 56 | 287
Seizures 54 | 584
acute myeloid leukemia 54 | 760
Vascular disease 52 | 294
Short stature 51 | 514
Cognitive delay 50 | 596
Global developmental delay 50 | 596
Mental and motor retardation 50 | 596
spina bifida 50 | 1,053
Kidney disease 48 | 411
hepatocellular carcinoma 47 | 536
Carcinoma, Hepatocellular 46 | 217
Heart disease 46 | 288
Liver carcinoma 46 | 229
Hypertension 45 | 372
Parkinson's disease 45 | 378
primary pancreatic ductal adenocarcinoma 45 | 1,071
Melanoma 44 | 689
Lung Neoplasms 43 | 217
Muscle hypotonia 43 | 562
non primary Sjogren syndrome sicca 43 | 861
Bipolar Disorder 42 | 646
Small head 41 | 366
Hyperglycemia 40 | 134
nasopharyngeal carcinoma 40 | 1,024
Liver cancer 39 | 589
Endometriosis 38 | 521
Liver Cirrhosis, Experimental 38 | 733
Toxic encephalopathy 37 | 139
Cerebrovascular disease 36 | 223
Hypertensive disease 36 | 278
Squamous cell carcinoma 36 | 125
Adenoma 35 | 159
Neurodegenerative disease 35 | 402
Asthma 34 | 370
Carcinoma, Squamous Cell 34 | 107
Colorectal Neoplasms 34 | 235

Tissue

Endocrine System 826 | 18,159
Skin and soft tissues 821 | 17,230
Male tissues 819 | 17,142
Digestive Tract 818 | 17,369
Nervous System 817 | 16,725
Blood and immune system 816 | 16,909
Female tissues 816 | 17,400
Liver and Pancreas 811 | 16,750
Urinary Tract 811 | 16,678
Respiratory system 808 | 16,393
Cardiovascular System 796 | 15,192

Target Family

Non-IDG 444 | 12,091
Enzyme 211 | 4,145
Kinase 91 | 634
Epigenetic 56 | 242
Transcription Factor 26 | 1,400
TF/Epigenetic 4 | 38
Nuclear Receptor 2 | 48
Transporter 2 | 473
GPCR 1 | 408

Compartment GO Term

Transferase complex 837 | 837
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
DNA damage-binding protein 1 DDB1 Tchem Non-IDG -2.34719 202.5 353
S-adenosylmethionine synthase isoform type-2 MAT2A Tbio Enzyme -1.91969 84.1 242
DNA-directed RNA polymerase II subunit RPB3 POLR2C Tbio Enzyme -1.40207 26.1 119
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A STT3A Tbio Enzyme -1.76110 54.3 68