Development Level

Tbio 490 | 10,625
Tchem 163 | 1,890
Tdark 131 | 7,003
Tclin 32 | 602

Collection

Eligible Kinase Proteins 10 | 134

IMPC Term

preweaning lethality, complete... 69 | 633
embryonic lethality prior to o... 24 | 148
embryonic lethality prior to t... 24 | 187
preweaning lethality, incomple... 18 | 260
decreased body weight 13 | 174
abnormal behavior 12 | 226
decreased total body fat amoun... 12 | 186
increased mean corpuscular vol... 12 | 91
abnormal embryo size 11 | 112
decreased bone mineral density 11 | 126
decreased grip strength 11 | 123
decreased lean body mass 11 | 195
increased mean corpuscular hem... 10 | 93
decreased leukocyte cell numbe... 9 | 54
increased grip strength 9 | 83
abnormal bone mineralization 8 | 55
decreased circulating insulin ... 8 | 75
increased lean body mass 8 | 107
decreased circulating glucose ... 7 | 121
abnormal retina morphology 6 | 100
decreased circulating triglyce... 6 | 83
decreased lumbar vertebrae num... 6 | 62
decreased rib number 6 | 59
enlarged spleen 6 | 26
increased or absent threshold ... 6 | 128
increased sacral vertebrae num... 6 | 62
abnormal gait 5 | 51
decreased body length 5 | 108
decreased bone mineral content 5 | 157
decreased circulating alanine ... 5 | 53
decreased circulating choleste... 5 | 85
decreased startle reflex 5 | 48
enlarged heart 5 | 111
hypoactivity 5 | 89
increased bone mineral density 5 | 52
increased circulating HDL chol... 5 | 63
increased circulating choleste... 5 | 53
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 68
male infertility 5 | 62
prenatal lethality prior to he... 5 | 64
short tibia 5 | 82
vertebral fusion 5 | 23
abnormal bone structure 4 | 131
abnormal lens morphology 4 | 73
abnormal neural tube closure 4 | 37
decreased T cell number 4 | 31
decreased blood urea nitrogen ... 4 | 31
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased circulating alkaline... 4 | 41
decreased circulating creatini... 4 | 31
decreased erythrocyte cell num... 4 | 43
decreased prepulse inhibition 4 | 52
increased bone mineral content 4 | 92
increased circulating triglyce... 4 | 24
increased exploration in new e... 4 | 56
increased hematocrit 4 | 36
increased monocyte cell number 4 | 27
small adrenal glands 4 | 15
abnormal epididymis morphology 3 | 31
abnormal forebrain development 3 | 18
abnormal heart left ventricle ... 3 | 20
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal rib morphology 3 | 28
abnormal spleen morphology 3 | 36
abnormal tooth morphology 3 | 24
decreased B cell number 3 | 30
decreased CD4-positive, alpha ... 3 | 19
decreased circulating aspartat... 3 | 27
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased lymphocyte cell numb... 3 | 9
decreased total retina thickne... 3 | 20
embryonic growth retardation 3 | 28
enlarged epididymis 3 | 27
enlarged lymph nodes 3 | 27
increased circulating LDL chol... 3 | 15
increased circulating alkaline... 3 | 119
increased circulating glucose ... 3 | 16
increased circulating serum al... 3 | 25
increased effector memory CD4-... 3 | 15
increased hemoglobin content 3 | 45
increased neutrophil cell numb... 3 | 15
increased total body fat amoun... 3 | 57
limb grasping 3 | 35
small testis 3 | 37
thrombocytopenia 3 | 46
thrombocytosis 3 | 23
vertebral transformation 3 | 12
abnormal coat appearance 2 | 25
abnormal cornea morphology 2 | 24
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased neutrophil cell numb... 2 | 37
increased cardiac muscle contr... 2 | 5
increased circulating bilirubi... 2 | 16
increased circulating potassiu... 2 | 31

Disease

ovarian cancer 496 | 8,484
osteosarcoma 423 | 7,933
psoriasis 296 | 6,685
medulloblastoma, large-cell 289 | 6,234
glioblastoma 270 | 5,572
Cancer 253 | 2,346
lung cancer 234 | 4,466
atypical teratoid / rhabdoid tumor 214 | 4,369
Breast cancer 177 | 3,094
malignant mesothelioma 167 | 3,162
primitive neuroectodermal tumor 153 | 3,031
oligodendroglioma 149 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 148 | 3,289
ependymoma 135 | 2,514
pediatric high grade glioma 130 | 2,712
group 3 medulloblastoma 129 | 2,254
invasive ductal carcinoma 129 | 2,950
Carcinoma 124 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 119 | 2,988
non-small cell lung cancer 114 | 2,798
diabetes mellitus 113 | 1,663
pilocytic astrocytoma 112 | 3,086
subependymal giant cell astrocytoma 112 | 2,287
Multiple myeloma 110 | 1,327
lung adenocarcinoma 110 | 2,713
astrocytic glioma 108 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 107 | 2,956
pancreatic cancer 101 | 2,300
Pick disease 99 | 1,893
group 4 medulloblastoma 92 | 1,875
lung carcinoma 90 | 2,844
astrocytoma 89 | 1,493
adult high grade glioma 88 | 2,148
ulcerative colitis 88 | 2,087
medulloblastoma 87 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 84 | 1,795
tuberculosis 81 | 1,557
acute quadriplegic myopathy 78 | 1,157
adrenocortical carcinoma 78 | 1,427
Rheumatoid Arthritis 76 | 1,160
breast carcinoma 76 | 1,614
ductal carcinoma in situ 74 | 1,745
dermatomyositis 65 | 933
interstitial cystitis 65 | 2,299
juvenile dermatomyositis 64 | 1,189
pituitary cancer 64 | 1,972
cystic fibrosis 61 | 1,665
Mammary Neoplasms 60 | 410
posterior fossa group A ependymoma 60 | 1,511
colon cancer 59 | 1,475
Alzheimer's disease 57 | 644
Obesity 57 | 616
Prostatic Neoplasms 56 | 471
Waldenstrons macroglobulinemia 55 | 765
acute myeloid leukemia 54 | 780
spina bifida 54 | 1,064
sonic hedgehog group medulloblastoma 53 | 1,482
primary pancreatic ductal adenocarcinoma 52 | 1,271
Vascular disease 51 | 281
Kidney disease 48 | 396
Stomach Neoplasms 48 | 282
Intellectual disability 46 | 573
Parkinson's disease 44 | 364
tuberculosis and treatment for 6 months 44 | 686
Liver carcinoma 43 | 217
posterior fossa group B ependymoma 43 | 1,530
Heart disease 42 | 279
Lung Neoplasms 41 | 171
hepatocellular carcinoma 41 | 532
nasopharyngeal carcinoma 41 | 1,056
Endometriosis 40 | 535
atypical teratoid/rhabdoid tumor 39 | 1,095
non primary Sjogren syndrome sicca 38 | 840
Adenoma 36 | 165
Asthma 36 | 349
aldosterone-producing adenoma 35 | 664
pancreatic carcinoma 35 | 567
Hyperglycemia 34 | 120
IGA Glomerulonephritis 34 | 454
Arthritis 32 | 248
Atopic dermatitis 32 | 944
Cerebrovascular disease 32 | 231
Neurodegenerative disease 32 | 383
Peripheral Neuropathy 32 | 303
Toxic encephalopathy 32 | 131
Hypertension 31 | 287
Schizophrenia 30 | 501
Liver disease 29 | 219
gastric cancer 29 | 430
progressive supranuclear palsy 29 | 674
Multiple Sclerosis 28 | 498
primary Sjogren syndrome 28 | 789
Adenocarcinoma 27 | 115
Neoplasm Metastasis 27 | 138
active Crohn's disease 27 | 918
ovarian neoplasm 27 | 97
Amyotrophic Lateral Sclerosis 26 | 431
Atherosclerosis 26 | 275
Diabetes Mellitus, Non-Insulin-Dependent 26 | 157
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 499

Tissue

Female tissues 809 | 18,647
Nervous System 807 | 18,561
Digestive Tract 806 | 18,473
Liver and Pancreas 806 | 18,136
Blood and immune system 805 | 17,995
Cardiovascular System 805 | 17,958
Endocrine System 805 | 18,512
Male tissues 805 | 17,969
Urinary Tract 804 | 18,444
Skin and soft tissues 801 | 18,115
Respiratory system 796 | 17,484

Target Family

Non-IDG 415 | 11,971
Enzyme 228 | 4,146
Kinase 86 | 634
Epigenetic 54 | 242
Transcription Factor 25 | 1,400
TF/Epigenetic 3 | 38
Nuclear Receptor 2 | 48
Transporter 2 | 473
GPCR 1 | 406

Compartment GO Term

Transferase complex 816 | 816
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Putative GRINL1B complex locus protein 2 GCOM2 Tdark Non-IDG -1.14190 15.0 0
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641