Development Level

Tbio 541 | 11,445
Tchem 149 | 1,598
Tdark 122 | 6,588
Tclin 37 | 613

Collection

Kinase: IDG Consortium (Target... 7 | 125
RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 110 | 979
embryonic lethality prior to o... 39 | 239
embryonic lethality prior to t... 38 | 278
preweaning lethality, incomple... 31 | 499
abnormal embryo size 23 | 220
decreased body weight 17 | 161
abnormal behavior 14 | 298
decreased total body fat amoun... 14 | 207
decreased lean body mass 13 | 135
embryonic growth retardation 12 | 106
increased lean body mass 12 | 172
increased mean corpuscular vol... 12 | 92
increased startle reflex 12 | 112
increased total body fat amoun... 11 | 134
abnormal bone structure 10 | 187
abnormal heart morphology 10 | 162
decreased circulating glucose ... 10 | 126
decreased vertical activity 10 | 208
enlarged heart 10 | 210
increased circulating HDL chol... 10 | 80
increased mean corpuscular hem... 10 | 96
short tibia 10 | 97
male infertility 9 | 123
decreased bone mineral density 8 | 126
decreased red blood cell distr... 8 | 41
impaired glucose tolerance 8 | 75
prenatal lethality prior to he... 8 | 87
abnormal bone mineralization 7 | 38
abnormal retina morphology 7 | 71
decreased bone mineral content 7 | 151
decreased circulating choleste... 7 | 93
decreased circulating creatini... 7 | 39
decreased leukocyte cell numbe... 7 | 73
decreased startle reflex 7 | 75
increased circulating alkaline... 7 | 122
increased circulating choleste... 7 | 66
abnormal lens morphology 6 | 81
decreased circulating LDL chol... 6 | 38
decreased circulating insulin ... 6 | 76
decreased grip strength 6 | 116
enlarged spleen 6 | 41
increased bone mineral density 6 | 72
abnormal gait 5 | 69
abnormal neural tube closure 5 | 46
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased blood urea nitrogen ... 5 | 51
decreased circulating alanine ... 5 | 47
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
decreased hemoglobin content 5 | 68
female infertility 5 | 60
increased circulating creatini... 5 | 38
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 76
increased grip strength 5 | 41
increased hematocrit 5 | 46
small testis 5 | 58
thrombocytopenia 5 | 56
vertebral fusion 5 | 23
abnormal cornea morphology 4 | 31
abnormal eye morphology 4 | 68
abnormal heart left ventricle ... 4 | 16
corneal opacity 4 | 32
decreased circulating alkaline... 4 | 46
decreased circulating chloride... 4 | 30
decreased circulating iron lev... 4 | 32
decreased prepulse inhibition 4 | 82
hyperactivity 4 | 148
hypoactivity 4 | 132
increased bone mineral content 4 | 108
increased circulating glucose ... 4 | 24
increased circulating potassiu... 4 | 29
increased circulating triglyce... 4 | 42
microphthalmia 4 | 26
small adrenal glands 4 | 16
small superior vagus ganglion 4 | 74
thrombocytosis 4 | 27
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
abnormal tooth morphology 3 | 24
anophthalmia 3 | 33
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased circulating aspartat... 3 | 34
decreased circulating total pr... 3 | 49
decreased hematocrit 3 | 46
decreased neutrophil cell numb... 3 | 42
decreased total retina thickne... 3 | 17
edema 3 | 59
enlarged lymph nodes 3 | 37
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 41
increased circulating magnesiu... 3 | 10
increased hemoglobin content 3 | 45
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
limb grasping 3 | 41
small spleen 3 | 19

Disease

Carcinoma 561 | 11,493
ovarian cancer 521 | 8,520
osteosarcoma 439 | 7,950
psoriasis 307 | 6,694
medulloblastoma, large-cell 305 | 6,241
glioblastoma 294 | 5,792
Cancer 277 | 2,499
lung cancer 268 | 4,740
atypical teratoid / rhabdoid tumor 248 | 5,112
group 3 medulloblastoma 217 | 4,104
Breast cancer 205 | 3,578
ependymoma 205 | 4,679
malignant mesothelioma 184 | 3,232
Kidney cancer 164 | 2,613
adult high grade glioma 162 | 3,801
primitive neuroectodermal tumor 156 | 3,035
oligodendroglioma 152 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,291
invasive ductal carcinoma 133 | 2,951
diabetes mellitus 132 | 1,728
astrocytic glioma 123 | 2,597
non-small cell lung cancer 123 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 121 | 2,989
Multiple myeloma 117 | 1,332
subependymal giant cell astrocytoma 114 | 2,287
lung adenocarcinoma 110 | 2,716
Astrocytoma, Pilocytic 109 | 3,081
pancreatic cancer 108 | 2,398
group 4 medulloblastoma 107 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 107 | 2,955
tuberculosis 99 | 2,010
Pick disease 98 | 1,894
breast carcinoma 95 | 1,638
lung carcinoma 94 | 2,843
Intellectual disability 87 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 86 | 1,962
Schizophrenia 85 | 1,160
Autosomal recessive predisposition 84 | 1,442
acute quadriplegic myopathy 82 | 1,158
ulcerative colitis 82 | 1,819
astrocytoma 81 | 1,146
Rheumatoid arthritis 80 | 1,191
adrenocortical carcinoma 80 | 1,428
ductal carcinoma in situ 76 | 1,745
dermatomyositis 70 | 966
pituitary cancer 69 | 1,972
Breast Neoplasms 68 | 445
Alzheimer's disease 66 | 658
Mammary Neoplasms 66 | 425
juvenile dermatomyositis 66 | 1,187
interstitial cystitis 65 | 2,312
Obesity 63 | 678
cystic fibrosis 63 | 1,696
Prostatic Neoplasms 61 | 495
Epilepsy 60 | 792
colon cancer 60 | 1,478
Dull intelligence 59 | 645
Low intelligence 59 | 645
Mental Retardation 59 | 645
Mental deficiency 59 | 645
Poor school performance 59 | 645
Waldenstrons macroglobulinemia 59 | 765
pediatric high grade glioma 59 | 1,064
Seizures 56 | 596
Stomach Neoplasms 56 | 300
acute myeloid leukemia 56 | 783
Short stature 54 | 531
Vascular disease 53 | 319
Cognitive delay 51 | 608
Global developmental delay 51 | 608
Kidney disease 51 | 430
Mental and motor retardation 51 | 608
spina bifida 50 | 1,074
Carcinoma, Hepatocellular 49 | 228
Liver carcinoma 49 | 240
primary pancreatic ductal adenocarcinoma 49 | 1,109
Heart disease 48 | 306
Hypertension 48 | 396
hepatocellular carcinoma 48 | 547
Parkinson's disease 46 | 392
Lung Neoplasms 45 | 232
Melanoma 44 | 711
Muscle hypotonia 44 | 571
non primary Sjogren syndrome sicca 44 | 891
Bipolar Disorder 43 | 666
Small head 42 | 374
nasopharyngeal carcinoma 42 | 1,058
Endometriosis 41 | 540
Liver Cirrhosis, Experimental 41 | 769
Hyperglycemia 40 | 137
Liver cancer 40 | 604
Hypertensive disease 39 | 292
Cerebrovascular disease 38 | 238
Squamous cell carcinoma 38 | 129
Toxic encephalopathy 38 | 141
Arthritis 36 | 290
Carcinoma, Squamous Cell 36 | 110
Neurodegenerative disease 36 | 414
Asthma 35 | 385
Depressive disorder 35 | 409

Tissue

Endocrine System 838 | 18,159
Skin and soft tissues 833 | 17,230
Male tissues 831 | 17,142
Digestive Tract 830 | 17,369
Nervous System 829 | 16,725
Blood and immune system 828 | 16,909
Female tissues 828 | 17,400
Liver and Pancreas 823 | 16,750
Urinary Tract 823 | 16,678
Respiratory system 820 | 16,393
Cardiovascular System 808 | 15,192

Target Family

Non-IDG 448 | 12,091
Enzyme 217 | 4,145
Kinase 91 | 634
Epigenetic 56 | 242
Transcription Factor 28 | 1,400
TF/Epigenetic 4 | 38
Nuclear Receptor 2 | 48
Transporter 2 | 473
GPCR 1 | 408

Compartment GO Term

Transferase complex 849 | 849
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
LIM domain only protein 7 LMO7 Tbio Non-IDG -1.24771 19.7 80
Unconventional prefoldin RPB5 interactor 1 URI1 Tbio Enzyme -2.15409 134.8 150
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148
DCN1-like protein 5 DCUN1D5 Tdark Non-IDG -0.30103 2.00 14