Development Level

Tbio 66 | 11,445
Tchem 10 | 1,598
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased circulating serum al... 2 | 82
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal vertebral arch morpho... 1 | 9
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased grip strength 1 | 116
decreased kidney weight 1 | 1
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
female infertility 1 | 60
fusion of vertebral arches 1 | 7
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate 1 | 23
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased vertical activity 1 | 24
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
prolonged QRS complex duration 1 | 8
short tibia 1 | 97
shortened RR interval 1 | 17
thrombocytopenia 1 | 56
vertebral transformation 1 | 12

Disease

Carcinoma 54 | 11,493
ovarian cancer 54 | 8,520
osteosarcoma 39 | 7,950
psoriasis 24 | 6,694
medulloblastoma, large-cell 22 | 6,241
Cancer 21 | 2,499
lung cancer 21 | 4,740
Kidney cancer 19 | 2,613
glioblastoma 19 | 5,792
Multiple myeloma 17 | 1,332
atypical teratoid / rhabdoid tumor 16 | 5,112
group 3 medulloblastoma 16 | 4,104
malignant mesothelioma 15 | 3,232
Breast cancer 14 | 3,578
adult high grade glioma 12 | 3,801
ependymoma 12 | 4,679
astrocytic glioma 11 | 2,597
Cockayne syndrome 10 | 60
Intellectual disability 10 | 1,016
astrocytoma 10 | 1,146
oligodendroglioma 10 | 2,850
pituitary cancer 10 | 1,972
primitive neuroectodermal tumor 10 | 3,035
acute myeloid leukemia 9 | 783
diabetes mellitus 9 | 1,728
acute quadriplegic myopathy 8 | 1,158
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
non-small cell lung cancer 8 | 2,890
pancreatic cancer 8 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
tuberculosis 8 | 2,010
Cryptorchidism 7 | 296
Pick disease 7 | 1,894
Waldenstrons macroglobulinemia 7 | 765
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung adenocarcinoma 7 | 2,716
Autosomal recessive predisposition 6 | 1,442
Cerebellar Ataxia 6 | 304
Rheumatoid arthritis 6 | 1,191
dermatomyositis 6 | 966
group 4 medulloblastoma 6 | 1,855
interstitial cystitis 6 | 2,312
progressive supranuclear palsy 6 | 676
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Breast Neoplasms 5 | 445
Dull intelligence 5 | 645
Hemangioma 5 | 69
Leukemia 5 | 104
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Muscle hypotonia 5 | 571
Poor school performance 5 | 645
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
non primary Sjogren syndrome sicca 5 | 891
pediatric high grade glioma 5 | 1,064
subependymal giant cell astrocytoma 5 | 2,287
Cataract 4 | 297
Cognitive delay 4 | 608
Epilepsy 4 | 792
Feeding difficulties in infancy 4 | 175
Global developmental delay 4 | 608
High forehead 4 | 102
Hypogonadism 4 | 173
Hypoplastic mandible condyle 4 | 275
Mandibular hypoplasia 4 | 275
Mental and motor retardation 4 | 608
Micrognathism 4 | 275
Nystagmus 4 | 317
Orbital separation excessive 4 | 244
Photosensitive trichothiodystrophy 4 | 30
Seizures 4 | 596
Small head 4 | 374
Tall forehead 4 | 102
colon cancer 4 | 1,478
juvenile dermatomyositis 4 | 1,187
nasopharyngeal carcinoma 4 | 1,058
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074
Acquired scoliosis 3 | 281
Anteverted nostril 3 | 191
Broad flat nasal bridge 3 | 236
Byzanthine arch palate 3 | 194
Curvature of spine 3 | 282
Decreased tendon reflex 3 | 122
Failure to gain weight 3 | 365
Liver cancer 3 | 604
Low-set, posteriorly rotated ears 3 | 110
Lung Neoplasms 3 | 232
Malaria 3 | 160
Multiple Sclerosis 3 | 540
Nasal bridge wide 3 | 236
Pediatric failure to thrive 3 | 365
adrenocortical carcinoma 3 | 1,428
cystic fibrosis 3 | 1,696
invasive ductal carcinoma 3 | 2,951
sonic hedgehog group medulloblastoma 3 | 467
tuberculosis and treatment for 6 months 3 | 409

Tissue

Blood and immune system 77 | 16,909
Endocrine System 77 | 18,159
Male tissues 77 | 17,142
Nervous System 77 | 16,725
Cardiovascular System 76 | 15,192
Digestive Tract 76 | 17,369
Female tissues 76 | 17,400
Liver and Pancreas 76 | 16,750
Respiratory system 76 | 16,393
Skin and soft tissues 76 | 17,230
Urinary Tract 76 | 16,678

Target Family

Non-IDG 49 | 12,091
Enzyme 18 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 4 | 242
Kinase 4 | 634
GPCR 1 | 408

Compartment GO Term

Transcription elongation facto... 81 | 81
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
FACT complex subunit SPT16 SUPT16H Tbio Enzyme -1.85453 70.7 324
Negative elongation factor B NELFB Tbio Non-IDG -1.16040 16.4 158
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Transcription elongation factor SPT6 SUPT6H Tbio Non-IDG -1.80696 66.9 123
Histone-lysine N-methyltransferase SETD2 SETD2 Tchem Epigenetic -2.83266 645.3 214
Transcription termination factor 2 TTF2 Tbio Non-IDG -0.36173 2.95 140
Protein IWS1 homolog IWS1 Tbio Non-IDG -0.66795 4.84 56
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157