Development Level

Tbio 45 | 11,651
Tchem 14 | 1,388
Tclin 3 | 612
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to t... 4 | 278
abnormal behavior 2 | 298
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
dilated heart left ventricle 1 | 11
enlarged adrenal glands 1 | 3
enlarged kidney 1 | 14
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased cardiac stroke volum... 1 | 1
increased circulating LDL chol... 1 | 13
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 42 | 11,493
ovarian cancer 40 | 8,520
Cancer 38 | 2,499
osteosarcoma 30 | 7,950
psoriasis 23 | 6,694
medulloblastoma, large-cell 22 | 6,241
lung cancer 19 | 4,740
Breast cancer 18 | 3,578
glioblastoma 18 | 5,792
atypical teratoid / rhabdoid tumor 17 | 5,112
Kidney cancer 16 | 2,613
diabetes mellitus 15 | 1,728
group 3 medulloblastoma 14 | 4,104
invasive ductal carcinoma 14 | 2,951
malignant mesothelioma 14 | 3,232
adult high grade glioma 13 | 3,801
ependymoma 13 | 4,679
Renal Cell Carcinoma 12 | 214
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
tuberculosis 12 | 2,010
Alzheimer's disease 11 | 658
Obesity 11 | 678
breast carcinoma 11 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
oligodendroglioma 11 | 2,850
subependymal giant cell astrocytoma 11 | 2,287
Epilepsy 10 | 792
Schizophrenia 10 | 1,160
acute quadriplegic myopathy 10 | 1,158
cystic fibrosis 10 | 1,696
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
non-small cell lung cancer 10 | 2,890
pituitary cancer 10 | 1,972
Intellectual disability 9 | 1,016
Pick disease 9 | 1,894
Vascular disease 9 | 319
astrocytic glioma 9 | 2,597
group 4 medulloblastoma 9 | 1,855
lung adenocarcinoma 9 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Carcinoma, Hepatocellular 8 | 228
Hyperglycemia 8 | 137
Hypertension 8 | 396
Liver carcinoma 8 | 240
Lung Neoplasms 8 | 232
Seizures 8 | 596
adrenocortical carcinoma 8 | 1,428
colon cancer 8 | 1,478
Breast Neoplasms 7 | 445
Hypothyroidism 7 | 122
Mammary Neoplasms 7 | 425
Prostatic Neoplasms 7 | 495
Rheumatoid arthritis 7 | 1,191
Abnormality of metabolism/homeostasis 6 | 134
Astrocytoma, Pilocytic 6 | 3,081
Attention deficit hyperactivity disorder 6 | 278
Autistic Disorder 6 | 364
Bipolar Disorder 6 | 666
Carcinoma, Renal Cell 6 | 124
Cognitive delay 6 | 608
Dull intelligence 6 | 645
Global developmental delay 6 | 608
Hyperinsulinism 6 | 133
Hypertensive disease 6 | 292
Lipid metabolism disorder 6 | 114
Low intelligence 6 | 645
Lymphangioleiomyomatosis 6 | 16
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Muscular atrophy 6 | 71
Neurodegenerative disease 6 | 414
Polycystic ovary syndrome 6 | 360
Poor school performance 6 | 645
Squamous cell carcinoma 6 | 129
astrocytoma 6 | 1,146
juvenile dermatomyositis 6 | 1,187
Adenocarcinoma 5 | 122
Adenoma 5 | 167
Adult onset 5 | 82
Autosomal recessive predisposition 5 | 1,442
Carcinoma, Squamous Cell 5 | 110
Fatty liver disease 5 | 103
Heart disease 5 | 306
Hyperthyroidism 5 | 53
Insulin Resistance 5 | 72
Kidney disease 5 | 430
Liver cancer 5 | 604
Multiple myeloma 5 | 1,332
Myopathy 5 | 185
Parkinson's disease 5 | 392
Precancerous Conditions 5 | 80
Sebaceous adenoma 5 | 26
Skin tag 5 | 14
Toxic encephalopathy 5 | 141
interstitial cystitis 5 | 2,312
lung carcinoma 5 | 2,843
pancreatic cancer 5 | 2,398
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Blood and immune system 62 | 16,909
Cardiovascular System 62 | 15,192
Digestive Tract 62 | 17,369
Endocrine System 62 | 18,159
Female tissues 62 | 17,400
Liver and Pancreas 62 | 16,750
Nervous System 62 | 16,725
Respiratory system 62 | 16,393
Skin and soft tissues 62 | 17,230
Urinary Tract 62 | 16,678
Male tissues 61 | 17,142

Target Family

Non-IDG 38 | 12,091
Kinase 12 | 634
Enzyme 6 | 4,145
Transporter 5 | 473
Transcription Factor 3 | 1,400

Compartment GO Term

TORC1 complex 64 | 64
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Target of rapamycin complex subunit LST8 MLST8 Tbio Non-IDG -2.64631 429.3 360
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.33238 204.8 739
Mitogen-activated protein kinase kinase kinase kinase 3 MAP4K3 Tchem Kinase -1.15845 15.3 254
GATOR complex protein NPRL2 NPRL2 Tbio Enzyme -1.30624 22.7 214
Eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 Tbio Non-IDG -2.83637 578.9 1455
Insulin INS Tbio Non-IDG -5.17849 146933.7 2197
Ragulator complex protein LAMTOR1 LAMTOR1 Tbio Non-IDG -1.09203 13.9 36
Ephrin-A5 EFNA5 Tbio Non-IDG -2.57120 355.6 202
Repressor of RNA polymerase III transcription MAF1 homolog MAF1 Tbio Enzyme -1.78903 66.5 127
Hamartin TSC1 Tbio Non-IDG -2.25451 173.9 1622