Development Level

Tbio 475 | 10,625
Tdark 128 | 7,003
Tchem 118 | 1,890
Tclin 37 | 602

Collection

Kinase: IDG Consortium (Targets) 3 | 125

IMPC Phenotype

preweaning lethality, complete... 37 | 633
preweaning lethality, incomple... 21 | 260
abnormal behavior 12 | 226
decreased body weight 12 | 174
embryonic lethality prior to t... 12 | 187
decreased bone mineral content 10 | 157
increased circulating alkaline... 10 | 119
increased or absent threshold ... 10 | 128
decreased lean body mass 9 | 195
decreased total body fat amoun... 9 | 186
increased mean corpuscular hem... 9 | 93
hyperactivity 8 | 108
abnormal bone structure 7 | 131
abnormal retina morphology 7 | 100
abnormal embryo size 6 | 112
abnormal sleep behavior 6 | 63
decreased circulating glucose ... 6 | 121
decreased circulating serum al... 6 | 79
embryonic lethality prior to o... 6 | 148
increased lean body mass 6 | 107
decreased circulating LDL chol... 5 | 37
decreased circulating free fat... 5 | 39
decreased mean corpuscular vol... 5 | 50
increased mean corpuscular vol... 5 | 91
limb grasping 5 | 35
abnormal coat-hair pigmentatio... 4 | 54
abnormal lens morphology 4 | 73
decreased body length 4 | 108
decreased caudal vertebrae num... 4 | 49
decreased circulating alkaline... 4 | 41
decreased circulating calcium ... 4 | 33
decreased circulating insulin ... 4 | 75
decreased circulating triglyce... 4 | 83
increased circulating HDL chol... 4 | 63
increased circulating chloride... 4 | 43
increased circulating choleste... 4 | 53
increased fasted circulating g... 4 | 68
increased grip strength 4 | 83
increased heart weight 4 | 37
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal head morphology 3 | 10
absent pinna reflex 3 | 21
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating aspartat... 3 | 27
decreased circulating choleste... 3 | 85
decreased circulating creatini... 3 | 31
decreased circulating fructosa... 3 | 31
decreased circulating total pr... 3 | 41
decreased grip strength 3 | 123
decreased startle reflex 3 | 48
improved glucose tolerance 3 | 56
increased body length 3 | 20
increased circulating creatini... 3 | 29
increased exploration in new e... 3 | 56
increased mean corpuscular hem... 3 | 25
male infertility 3 | 62
prenatal lethality prior to he... 3 | 64
short tibia 3 | 82
thrombocytopenia 3 | 46
tremors 3 | 34
abnormal QRS complex 2 | 25
abnormal coat appearance 2 | 25
abnormal cranium morphology 2 | 32
abnormal embryo turning 2 | 15
abnormal gait 2 | 51
abnormal optic disc morphology 2 | 10
abnormal retinal pigmentation 2 | 61
abnormal tail movements 2 | 12
abnormal vertebrae morphology 2 | 14
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
convulsive seizures 2 | 11
decreased CD8-positive, alpha-... 2 | 26
decreased circulating phosphat... 2 | 15
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating glucose ... 2 | 16
increased circulating magnesiu... 2 | 10
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased sacral vertebrae num... 2 | 62
pallor 2 | 13
persistence of hyaloid vascula... 2 | 22
straub tail 2 | 26

Disease

ovarian cancer 369 | 8,491
psoriasis 351 | 6,685
osteosarcoma 313 | 7,933
glioblastoma 301 | 5,572
medulloblastoma, large-cell 293 | 6,234
lung cancer 261 | 4,473
Cancer 254 | 2,346
atypical teratoid / rhabdoid tumor 211 | 4,369
Breast cancer 194 | 3,098
pilocytic astrocytoma 189 | 3,086
malignant mesothelioma 182 | 3,163
pediatric high grade glioma 176 | 2,712
primitive neuroectodermal tumor 172 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 170 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 170 | 3,289
oligodendroglioma 169 | 2,849
invasive ductal carcinoma 167 | 2,950
non-small cell lung cancer 166 | 2,798
lung adenocarcinoma 153 | 2,714
pancreatic cancer 152 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 149 | 2,956
lung carcinoma 149 | 2,844
Carcinoma 140 | 2,147
ependymoma 130 | 2,514
subependymal giant cell astrocytoma 128 | 2,287
group 3 medulloblastoma 121 | 2,254
ductal carcinoma in situ 118 | 1,745
diabetes mellitus 113 | 1,663
breast carcinoma 111 | 1,614
colon cancer 111 | 1,475
interstitial cystitis 111 | 2,299
adrenocortical carcinoma 109 | 1,427
ulcerative colitis 108 | 2,087
astrocytic glioma 105 | 2,241
pituitary cancer 105 | 1,972
Pick disease 103 | 1,893
posterior fossa group A ependymoma 98 | 1,511
posterior fossa group B ependymoma 97 | 1,530
group 4 medulloblastoma 96 | 1,875
astrocytoma 92 | 1,493
adult high grade glioma 90 | 2,148
cystic fibrosis 83 | 1,670
tuberculosis 83 | 1,563
nasopharyngeal carcinoma 82 | 1,056
Alzheimer's disease 80 | 644
sonic hedgehog group medulloblastoma 80 | 1,482
atypical teratoid/rhabdoid tumor 79 | 1,095
primary pancreatic ductal adenocarcinoma 78 | 1,271
Endometriosis 75 | 535
medulloblastoma 71 | 1,524
Atopic dermatitis 69 | 944
Kidney disease 68 | 397
acute quadriplegic myopathy 68 | 1,157
Multiple myeloma 62 | 1,327
juvenile dermatomyositis 61 | 1,189
Down syndrome 60 | 548
Rheumatoid Arthritis 60 | 1,170
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,795
spina bifida 59 | 1,064
Neurodegenerative disease 55 | 383
dermatomyositis 55 | 966
Mammary Neoplasms 54 | 410
Duchenne muscular dystrophy 53 | 602
Cerebrovascular disease 52 | 231
Heart disease 52 | 279
Neuropathy 52 | 210
Amyotrophic Lateral Sclerosis 51 | 432
gastric carcinoma 51 | 832
Toxic encephalopathy 50 | 131
Vascular disease 50 | 281
cutaneous lupus erythematosus 50 | 1,056
Parkinson's disease 49 | 364
Obesity 48 | 616
Schizophrenia 48 | 503
esophageal adenocarcinoma 46 | 737
autosomal dominant Emery-Dreifuss muscular dystrophy 45 | 499
Prostatic Neoplasms 44 | 471
Hypertension 43 | 293
Liver disease 42 | 219
Stomach Neoplasms 42 | 282
Waldenstrons macroglobulinemia 42 | 764
non-small cell lung carcinoma 42 | 413
IGA Glomerulonephritis 41 | 454
Intellectual disability 41 | 573
Multiple Sclerosis 41 | 498
acute myeloid leukemia 40 | 785
Adenoma 38 | 165
Arthritis 38 | 248
progressive supranuclear palsy 38 | 674
Neoplasm Metastasis 37 | 138
Osteoporosis 37 | 259
hepatocellular carcinoma 37 | 550
Asthma 36 | 349
Epilepsy 36 | 346
Liver carcinoma 35 | 217
chronic rhinosinusitis 35 | 512
primary Sjogren syndrome 35 | 788
Neoplasm Invasiveness 34 | 127
fibroadenoma 34 | 557
Lung disease 33 | 136

Tissue

Female tissues 737 | 18,646
Nervous System 731 | 18,560
Endocrine System 730 | 18,511
Digestive Tract 728 | 18,472
Skin and soft tissues 722 | 18,114
Urinary Tract 722 | 18,443
Cardiovascular System 719 | 17,957
Liver and Pancreas 718 | 18,135
Male tissues 718 | 17,968
Blood and immune system 715 | 17,994
Respiratory system 705 | 17,483

Target Family

Non-IDG 606 | 11,969
Enzyme 75 | 4,146
Kinase 37 | 634
Transcription Factor 27 | 1,400
GPCR 5 | 408
Epigenetic 3 | 242
Transporter 3 | 473
Nuclear Receptor 2 | 48

Compartment GO Term

Supramolecular fiber 758 | 758
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HAUS augmin-like complex subunit 8 HAUS8 Tbio Non-IDG 1.00 0.07 117
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
T-complex protein 1 subunit alpha TCP1 Tbio Non-IDG -2.24310 169.4 383
Myristoylated alanine-rich C-kinase substrate MARCKS Tbio Enzyme -2.67051 512.2 639
CD40 ligand CD40LG Tchem Non-IDG -4.56976 36580.5 1095
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.66256 471.8 306
HAUS augmin-like complex subunit 7 HAUS7 Tbio Non-IDG -0.21560 1.53 128
Trichoplein keratin filament-binding protein TCHP Tbio Non-IDG -2.30520 126.7 92
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896