Development Level

Tbio 675 | 11,651
Tdark 125 | 6,593
Tchem 101 | 1,388
Tclin 59 | 612

Collection

RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Target... 3 | 125
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 74 | 979
preweaning lethality, incomple... 39 | 499
embryonic lethality prior to t... 25 | 278
abnormal behavior 18 | 298
abnormal embryo size 18 | 220
decreased body weight 17 | 161
decreased total body fat amoun... 17 | 207
abnormal bone structure 15 | 187
embryonic lethality prior to o... 15 | 239
hyperactivity 13 | 148
decreased bone mineral content 12 | 151
decreased circulating glucose ... 12 | 126
decreased body length 11 | 101
decreased bone mineral density 10 | 126
decreased circulating serum al... 10 | 82
hypoactivity 10 | 132
increased startle reflex 10 | 112
increased total body fat amoun... 10 | 134
decreased circulating choleste... 9 | 93
decreased grip strength 9 | 116
decreased lean body mass 9 | 135
embryonic growth retardation 9 | 106
abnormal sleep behavior 8 | 70
decreased circulating HDL chol... 8 | 68
decreased circulating LDL chol... 8 | 38
decreased vertical activity 8 | 208
increased circulating alkaline... 8 | 122
increased heart weight 8 | 62
short tibia 8 | 97
abnormal seminal vesicle morph... 7 | 114
cataract 7 | 92
decreased mean corpuscular vol... 7 | 79
increased body length 7 | 32
increased mean corpuscular hem... 7 | 96
increased mean corpuscular vol... 7 | 92
prenatal lethality prior to he... 7 | 87
abnormal behavioral response t... 6 | 66
abnormal lens morphology 6 | 81
abnormal retina morphology 6 | 71
decreased circulating alkaline... 6 | 46
decreased circulating total pr... 6 | 49
decreased startle reflex 6 | 75
edema 6 | 59
improved glucose tolerance 6 | 79
increased bone mineral content 6 | 108
increased circulating chloride... 6 | 41
increased fasted circulating g... 6 | 76
increased lean body mass 6 | 172
increased or absent threshold ... 6 | 101
male infertility 6 | 123
abnormal gait 5 | 69
abnormal tail morphology 5 | 25
cardiovascular system phenotyp... 5 | 36
decreased caudal vertebrae num... 5 | 53
decreased circulating free fat... 5 | 31
decreased circulating insulin ... 5 | 76
decreased leukocyte cell numbe... 5 | 73
decreased lymphocyte cell numb... 5 | 83
hemorrhage 5 | 23
impaired glucose tolerance 5 | 75
increased blood urea nitrogen ... 5 | 48
increased circulating HDL chol... 5 | 80
limb grasping 5 | 41
prolonged ST segment 5 | 36
small superior vagus ganglion 5 | 74
tremors 5 | 39
abnormal bone mineralization 4 | 38
abnormal coat appearance 4 | 31
abnormal cranium morphology 4 | 36
abnormal embryo turning 4 | 31
abnormal femur morphology 4 | 14
abnormal heart morphology 4 | 162
convulsive seizures 4 | 13
cyanosis 4 | 7
decreased blood urea nitrogen ... 4 | 51
decreased circulating alanine ... 4 | 47
decreased circulating aspartat... 4 | 34
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
decreased circulating triglyce... 4 | 79
decreased fasted circulating g... 4 | 65
decreased red blood cell distr... 4 | 41
enlarged heart 4 | 210
increased bone mineral density 4 | 72
increased circulating choleste... 4 | 66
increased circulating creatini... 4 | 38
increased circulating phosphat... 4 | 26
increased circulating triglyce... 4 | 42
increased hemoglobin content 4 | 45
increased mean corpuscular hem... 4 | 36
pallor 4 | 34
prolonged QT interval 4 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal eye morphology 3 | 68
abnormal head morphology 3 | 10
abnormal lung morphology 3 | 26
abnormal skin morphology 3 | 50
increased circulating sodium l... 3 | 71
increased hematocrit 3 | 46
increased monocyte cell number 3 | 63

Disease

Carcinoma 668 | 11,493
ovarian cancer 470 | 8,520
psoriasis 452 | 6,694
glioblastoma 396 | 5,792
osteosarcoma 390 | 7,950
medulloblastoma, large-cell 373 | 6,241
lung cancer 354 | 4,740
ependymoma 345 | 4,679
atypical teratoid / rhabdoid tumor 342 | 5,112
Breast cancer 310 | 3,578
Cancer 302 | 2,499
group 3 medulloblastoma 271 | 4,104
adult high grade glioma 262 | 3,801
malignant mesothelioma 254 | 3,232
Astrocytoma, Pilocytic 236 | 3,081
non-small cell lung cancer 225 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 223 | 2,989
pancreatic cancer 223 | 2,398
invasive ductal carcinoma 220 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 218 | 3,291
primitive neuroectodermal tumor 214 | 3,035
Kidney cancer 213 | 2,613
lung adenocarcinoma 208 | 2,716
oligodendroglioma 204 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 203 | 2,955
lung carcinoma 199 | 2,843
astrocytic glioma 168 | 2,597
subependymal giant cell astrocytoma 160 | 2,287
diabetes mellitus 157 | 1,728
breast carcinoma 152 | 1,638
colon cancer 152 | 1,478
ductal carcinoma in situ 152 | 1,745
interstitial cystitis 144 | 2,312
pituitary cancer 141 | 1,972
Schizophrenia 139 | 1,160
Autosomal recessive predisposition 135 | 1,442
adrenocortical carcinoma 133 | 1,428
ulcerative colitis 129 | 1,819
Pick disease 127 | 1,894
cystic fibrosis 121 | 1,696
tuberculosis 116 | 2,010
group 4 medulloblastoma 115 | 1,855
acute quadriplegic myopathy 111 | 1,158
Alzheimer's disease 109 | 658
nasopharyngeal carcinoma 107 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 99 | 1,962
Heart disease 96 | 306
Atopic dermatitis 95 | 952
primary pancreatic ductal adenocarcinoma 95 | 1,109
Liver Cirrhosis, Experimental 94 | 769
juvenile dermatomyositis 94 | 1,187
Kidney disease 91 | 430
Intellectual disability 90 | 1,016
Duchenne muscular dystrophy 88 | 601
Liver cancer 86 | 604
Epilepsy 84 | 792
Melanoma 80 | 711
Bipolar Disorder 79 | 666
Endometriosis 79 | 540
Rheumatoid arthritis 78 | 1,191
astrocytoma 78 | 1,146
Down syndrome 76 | 499
Hypertension 76 | 396
Multiple myeloma 75 | 1,332
Cerebrovascular disease 74 | 238
Obesity 74 | 678
dermatomyositis 73 | 966
spina bifida 73 | 1,074
Neurodegenerative disease 72 | 414
esophageal adenocarcinoma 72 | 737
pediatric high grade glioma 72 | 1,064
Breast Neoplasms 71 | 445
Skin cancer 71 | 469
autosomal dominant Emery-Dreifuss muscular dystrophy 71 | 510
cutaneous lupus erythematosus 71 | 1,057
Mammary Neoplasms 70 | 425
Amyotrophic lateral sclerosis 69 | 451
Seizures 69 | 596
gastric carcinoma 69 | 807
Depressive disorder 68 | 409
Neuropathy 68 | 261
Short stature 62 | 531
Toxic encephalopathy 62 | 141
Dull intelligence 61 | 645
Low intelligence 61 | 645
Mental Retardation 61 | 645
Mental deficiency 61 | 645
Poor school performance 61 | 645
Vascular disease 60 | 319
Cognitive delay 59 | 608
Global developmental delay 59 | 608
Mental and motor retardation 59 | 608
Myopathy 59 | 185
Prostatic Neoplasms 58 | 495
Muscle hypotonia 56 | 571
Waldenstrons macroglobulinemia 55 | 765
Endometrial cancer 54 | 311
Osteoporosis 54 | 363
Parkinson's disease 54 | 392
Stomach Neoplasms 54 | 300

Tissue

Endocrine System 907 | 18,159
Female tissues 891 | 17,400
Skin and soft tissues 891 | 17,230
Digestive Tract 885 | 17,369
Male tissues 870 | 17,142
Blood and immune system 865 | 16,909
Nervous System 851 | 16,725
Urinary Tract 851 | 16,678
Liver and Pancreas 850 | 16,750
Respiratory system 834 | 16,393
Cardiovascular System 789 | 15,192

Target Family

Non-IDG 752 | 12,091
Enzyme 104 | 4,145
Kinase 41 | 634
Transcription Factor 32 | 1,400
Ion Channel 11 | 344
Transporter 7 | 473
GPCR 6 | 408
Epigenetic 4 | 242
Nuclear Receptor 3 | 48

Compartment GO Term

Supramolecular fiber 960 | 960
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Dynein heavy chain 6, axonemal DNAH6 Tbio Non-IDG -0.53057 4.17 18