Development Level

Tbio 232 | 10,625
Tchem 46 | 1,890
Tdark 33 | 7,003
Tclin 7 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 21 | 633
decreased body weight 5 | 174
increased mean corpuscular hem... 5 | 93
increased mean corpuscular vol... 5 | 91
preweaning lethality, incomple... 5 | 260
abnormal retina morphology 4 | 100
decreased bone mineral content 4 | 157
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 195
decreased mean corpuscular vol... 4 | 50
decreased total body fat amoun... 4 | 186
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
increased fasted circulating g... 4 | 68
increased or absent threshold ... 4 | 128
abnormal coat-hair pigmentatio... 3 | 54
abnormal cranium morphology 3 | 32
decreased circulating glucose ... 3 | 121
decreased grip strength 3 | 123
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased exploration in new e... 3 | 56
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal head morphology 2 | 10
abnormal humerus morphology 2 | 11
abnormal lens morphology 2 | 73
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased erythrocyte cell num... 2 | 43
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating creatini... 2 | 29
increased leukocyte cell numbe... 2 | 37
increased mean platelet volume 2 | 19
increased red blood cell distr... 2 | 21
increased thermal nociceptive ... 2 | 9
narrow eye opening 2 | 15
thrombocytopenia 2 | 46
tremors 2 | 34
abnormal body wall morphology 1 | 7
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal kidney morphology 1 | 30
abnormal liver morphology 1 | 5
abnormal optic disc morphology 1 | 10
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased CD4-positive NK T ce... 1 | 3
increased NK T cell number 1 | 11
increased body length 1 | 20
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating glycerol... 1 | 11
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased memory-marker CD4-po... 1 | 3
increased rib number 1 | 41
limb grasping 1 | 35
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small testis 1 | 37
thrombocytosis 1 | 23
urinary bladder obstruction 1 | 2
vertebral fusion 1 | 23

Disease

ovarian cancer 192 | 8,491
psoriasis 159 | 6,685
medulloblastoma, large-cell 155 | 6,234
osteosarcoma 151 | 7,933
glioblastoma 142 | 5,572
lung cancer 133 | 4,473
primitive neuroectodermal tumor 106 | 3,031
atypical teratoid / rhabdoid tumor 105 | 4,369
Breast cancer 101 | 3,098
malignant mesothelioma 100 | 3,163
non-small cell lung cancer 96 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 95 | 3,289
pediatric high grade glioma 94 | 2,712
Cancer 92 | 2,346
group 3 medulloblastoma 91 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 91 | 2,988
lung adenocarcinoma 85 | 2,714
invasive ductal carcinoma 82 | 2,950
adrenocortical carcinoma 79 | 1,427
pancreatic cancer 75 | 2,300
oligodendroglioma 66 | 2,849
ductal carcinoma in situ 61 | 1,745
colon cancer 60 | 1,475
breast carcinoma 58 | 1,614
Carcinoma 56 | 2,147
pilocytic astrocytoma 56 | 3,086
Endometriosis 54 | 535
Atopic dermatitis 53 | 944
nasopharyngeal carcinoma 53 | 1,056
subependymal giant cell astrocytoma 51 | 2,287
ulcerative colitis 51 | 2,087
posterior fossa group A ependymoma 49 | 1,511
astrocytic glioma 47 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,956
ependymoma 44 | 2,514
Pick disease 43 | 1,893
pituitary cancer 40 | 1,972
sonic hedgehog group medulloblastoma 40 | 1,482
interstitial cystitis 38 | 2,299
IGA Glomerulonephritis 37 | 454
Multiple myeloma 37 | 1,327
posterior fossa group B ependymoma 37 | 1,530
atypical teratoid/rhabdoid tumor 36 | 1,095
lung carcinoma 36 | 2,844
diabetes mellitus 33 | 1,663
adult high grade glioma 32 | 2,148
astrocytoma 29 | 1,493
medulloblastoma 29 | 1,524
primary Sjogren syndrome 29 | 788
Waldenstrons macroglobulinemia 28 | 764
group 4 medulloblastoma 28 | 1,875
primary pancreatic ductal adenocarcinoma 28 | 1,271
acute quadriplegic myopathy 27 | 1,157
Microcephaly 26 | 149
tuberculosis 26 | 1,563
Rheumatoid Arthritis 25 | 1,170
active Crohn's disease 25 | 918
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,795
Intellectual disability 23 | 573
cystic fibrosis 22 | 1,670
dermatomyositis 22 | 966
non primary Sjogren syndrome sicca 22 | 840
Kidney disease 21 | 397
juvenile dermatomyositis 21 | 1,189
acute myeloid leukemia 19 | 785
pancreatic carcinoma 18 | 567
cutaneous lupus erythematosus 17 | 1,056
esophageal adenocarcinoma 17 | 737
hepatocellular carcinoma 17 | 550
tuberculosis and treatment for 6 months 17 | 686
Alzheimer's disease 16 | 644
gastric carcinoma 16 | 832
Mammary Neoplasms 15 | 410
Amyotrophic Lateral Sclerosis 14 | 432
Stomach Neoplasms 14 | 282
spina bifida 14 | 1,064
Prostatic Neoplasms 13 | 471
Renal Cell Carcinoma 13 | 199
Schizophrenia 13 | 503
chronic rhinosinusitis 13 | 512
progressive supranuclear palsy 13 | 674
Down syndrome 12 | 548
Vascular disease 12 | 281
aldosterone-producing adenoma 12 | 664
gastric cancer 12 | 436
non-small cell lung carcinoma 12 | 413
Adenoma 11 | 165
Duchenne muscular dystrophy 11 | 602
Hypertension 11 | 293
Lung disease 11 | 136
Neurodegenerative disease 11 | 383
hereditary spastic paraplegia 11 | 313
inflammatory breast cancer 11 | 404
Bladder Neoplasm 10 | 109
Cerebrovascular disease 10 | 231
Heart disease 10 | 279
Obesity 10 | 616
Peripheral Neuropathy 10 | 303
Polycystic Ovary Syndrome 10 | 334
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499

Tissue

Blood and immune system 315 | 17,994
Digestive Tract 315 | 18,472
Endocrine System 315 | 18,511
Female tissues 314 | 18,646
Liver and Pancreas 314 | 18,135
Male tissues 314 | 17,968
Nervous System 314 | 18,560
Urinary Tract 314 | 18,443
Cardiovascular System 313 | 17,957
Respiratory system 312 | 17,483
Skin and soft tissues 312 | 18,114

Target Family

Non-IDG 235 | 11,969
Enzyme 43 | 4,146
Kinase 22 | 634
Transcription Factor 7 | 1,400
Epigenetic 6 | 242
Transporter 2 | 473
Ion Channel 1 | 341
Nuclear Receptor 1 | 48
oGPCR 1 | 421

Compartment GO Term

Spindle 318 | 318
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HAUS augmin-like complex subunit 8 HAUS8 Tbio Non-IDG 1.00 0.07 117
HAUS augmin-like complex subunit 7 HAUS7 Tbio Non-IDG -0.21560 1.53 128
Centrosomal protein of 89 kDa CEP89 Tbio Non-IDG -0.37964 2.98 65
WD repeat-containing protein 62 WDR62 Tbio Non-IDG -1.39132 28.4 25
Glial fibrillary acidic protein GFAP Tbio Non-IDG -3.47927 2665.9 1710
Centrosomal protein of 162 kDa CEP162 Tdark Non-IDG -0.94201 8.33 18
Kinesin-like protein KIF11 KIF11 Tchem Non-IDG -2.57588 377.6 296
BUB3-interacting and GLEBS motif-containing protein ZNF207 ZNF207 Tbio Non-IDG -0.70005 4.45 248
Mitotic checkpoint serine/threonine-protein kinase BUB1 BUB1 Tchem Kinase -2.28810 192.8 356
Centrin-1 CETN1 Tbio Non-IDG -1.79066 54.8 106