Development Level

Tbio 268 | 11,651
Tchem 38 | 1,388
Tdark 30 | 6,593
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 34 | 979
preweaning lethality, incomple... 14 | 499
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 8 | 278
abnormal bone structure 7 | 187
abnormal embryo size 6 | 220
impaired glucose tolerance 6 | 75
abnormal retina morphology 5 | 71
increased circulating alkaline... 5 | 122
increased mean corpuscular vol... 5 | 92
male infertility 5 | 123
abnormal behavior 4 | 298
cataract 4 | 92
decreased body weight 4 | 161
decreased circulating choleste... 4 | 93
decreased circulating glucose ... 4 | 126
decreased circulating serum al... 4 | 82
decreased lean body mass 4 | 135
decreased mean corpuscular vol... 4 | 79
decreased total body fat amoun... 4 | 207
increased blood urea nitrogen ... 4 | 48
increased bone mineral content 4 | 108
increased circulating HDL chol... 4 | 80
increased fasted circulating g... 4 | 76
increased mean corpuscular hem... 4 | 96
increased mean platelet volume 4 | 45
increased total body fat amoun... 4 | 134
abnormal cranium morphology 3 | 36
abnormal lens morphology 3 | 81
abnormal seminal vesicle morph... 3 | 114
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
female infertility 3 | 60
hypoactivity 3 | 132
increased circulating creatini... 3 | 38
increased lean body mass 3 | 172
short tibia 3 | 97
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo turning 2 | 31
abnormal head morphology 2 | 10
abnormal skin coloration 2 | 25
abnormal skin morphology 2 | 50
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
enlarged lymph nodes 2 | 37
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased bone mineral density 2 | 72
increased heart rate 2 | 23
increased leukocyte cell numbe... 2 | 47
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased thermal nociceptive ... 2 | 9
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
shortened RR interval 2 | 17
small testis 2 | 58
thrombocytopenia 2 | 56
thrombocytosis 2 | 27
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
convulsive seizures 1 | 13
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased exploration in new e... 1 | 8
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
limb grasping 1 | 41
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 239 | 11,493
ovarian cancer 209 | 8,520
medulloblastoma, large-cell 171 | 6,241
osteosarcoma 165 | 7,950
psoriasis 163 | 6,694
glioblastoma 155 | 5,792
group 3 medulloblastoma 154 | 4,104
atypical teratoid / rhabdoid tumor 147 | 5,112
lung cancer 145 | 4,740
Breast cancer 124 | 3,578
ependymoma 115 | 4,679
primitive neuroectodermal tumor 115 | 3,035
adult high grade glioma 111 | 3,801
malignant mesothelioma 107 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 104 | 3,291
non-small cell lung cancer 101 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 100 | 2,989
Cancer 97 | 2,499
invasive ductal carcinoma 89 | 2,951
lung adenocarcinoma 87 | 2,716
adrenocortical carcinoma 85 | 1,428
Kidney cancer 75 | 2,613
pancreatic cancer 75 | 2,398
oligodendroglioma 74 | 2,850
breast carcinoma 67 | 1,638
ductal carcinoma in situ 67 | 1,745
colon cancer 63 | 1,478
Astrocytoma, Pilocytic 60 | 3,081
Atopic dermatitis 57 | 952
Endometriosis 57 | 540
astrocytic glioma 55 | 2,597
nasopharyngeal carcinoma 54 | 1,058
subependymal giant cell astrocytoma 53 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 51 | 2,955
ulcerative colitis 51 | 1,819
Intellectual disability 49 | 1,016
Pick disease 47 | 1,894
interstitial cystitis 47 | 2,312
pituitary cancer 41 | 1,972
Multiple myeloma 40 | 1,332
Autosomal recessive predisposition 36 | 1,442
diabetes mellitus 35 | 1,728
lung carcinoma 35 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,962
tuberculosis 34 | 2,010
Waldenstrons macroglobulinemia 33 | 765
Dull intelligence 30 | 645
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Poor school performance 30 | 645
acute quadriplegic myopathy 30 | 1,158
group 4 medulloblastoma 30 | 1,855
primary Sjogren syndrome 30 | 735
Cognitive delay 29 | 608
Global developmental delay 29 | 608
Mental and motor retardation 29 | 608
Schizophrenia 27 | 1,160
Small head 27 | 374
dermatomyositis 27 | 966
Microcephaly 26 | 166
astrocytoma 26 | 1,146
cystic fibrosis 26 | 1,696
Rheumatoid arthritis 25 | 1,191
active Crohn's disease 25 | 922
juvenile dermatomyositis 25 | 1,187
Short stature 23 | 531
non primary Sjogren syndrome sicca 23 | 891
Kidney disease 21 | 430
pediatric high grade glioma 21 | 1,064
acute myeloid leukemia 20 | 783
Epilepsy 19 | 792
esophageal adenocarcinoma 19 | 737
primary pancreatic ductal adenocarcinoma 19 | 1,109
Liver cancer 18 | 604
Stomach Neoplasms 18 | 300
gastric carcinoma 18 | 807
spina bifida 18 | 1,074
Melanoma 17 | 711
chronic rhinosinusitis 17 | 512
cutaneous lupus erythematosus 17 | 1,057
pancreatic carcinoma 17 | 562
Alzheimer's disease 16 | 658
Breast Neoplasms 16 | 445
Down syndrome 16 | 499
Hypoplastic mandible condyle 16 | 275
Liver Cirrhosis, Experimental 16 | 769
Mammary Neoplasms 16 | 425
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275
progressive supranuclear palsy 16 | 676
Bipolar Disorder 15 | 666
Glaucoma 15 | 239
Seizures 15 | 596
Vascular disease 15 | 319
aldosterone-producing adenoma 15 | 665
hepatocellular carcinoma 15 | 547
medulloblastoma 15 | 720
posterior fossa group A ependymoma 15 | 468
tuberculosis and treatment for 6 months 15 | 409

Tissue

Endocrine System 337 | 18,159
Digestive Tract 334 | 17,369
Urinary Tract 334 | 16,678
Male tissues 333 | 17,142
Blood and immune system 332 | 16,909
Female tissues 332 | 17,400
Liver and Pancreas 332 | 16,750
Skin and soft tissues 332 | 17,230
Respiratory system 330 | 16,393
Nervous System 329 | 16,725
Cardiovascular System 318 | 15,192

Target Family

Non-IDG 249 | 12,091
Enzyme 51 | 4,145
Kinase 24 | 634
Transcription Factor 8 | 1,400
Epigenetic 6 | 242
Transporter 2 | 473
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
oGPCR 1 | 421

Compartment GO Term

Spindle 343 | 343
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chromosome alignment-maintaining phosphoprotein 1 CHAMP1 Tbio Non-IDG -0.61730 4.58 106
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Centrosomal protein of 44 kDa CEP44 Tdark Non-IDG 0.00000 64
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Calpain-6 CAPN6 Tbio Non-IDG -1.20335 17.9 140
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168
Microtubule-associated tumor suppressor 1 MTUS1 Tbio Non-IDG -1.78224 64.2 121