Development Level

Tbio 92 | 11,445
Tdark 16 | 6,588
Tchem 6 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
decreased leukocyte cell numbe... 3 | 73
embryonic lethality prior to o... 3 | 239
increased fasted circulating g... 3 | 76
abnormal behavior 2 | 298
decreased bone mineral density 2 | 126
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal neural tube morpholog... 1 | 12
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
thrombocytosis 1 | 27

Disease

ovarian cancer 77 | 8,520
Carcinoma 70 | 11,493
osteosarcoma 50 | 7,950
medulloblastoma, large-cell 43 | 6,241
group 3 medulloblastoma 42 | 4,104
lung cancer 42 | 4,740
psoriasis 42 | 6,694
glioblastoma 38 | 5,792
atypical teratoid / rhabdoid tumor 28 | 5,112
ependymoma 26 | 4,679
malignant mesothelioma 26 | 3,232
Multiple myeloma 25 | 1,332
oligodendroglioma 25 | 2,850
primitive neuroectodermal tumor 22 | 3,035
dermatomyositis 21 | 966
diabetes mellitus 19 | 1,728
Kidney cancer 18 | 2,613
Waldenstrons macroglobulinemia 17 | 765
astrocytoma 17 | 1,146
Pick disease 15 | 1,894
acute quadriplegic myopathy 15 | 1,158
astrocytic glioma 15 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Muscular atrophy 14 | 71
adult high grade glioma 14 | 3,801
Intellectual disability 13 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
progressive supranuclear palsy 13 | 676
lung adenocarcinoma 12 | 2,716
Breast cancer 11 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
juvenile dermatomyositis 11 | 1,187
Cancer 10 | 2,499
Conductive hearing loss 10 | 123
acute myeloid leukemia 10 | 783
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Spinal muscular atrophy 9 | 34
subependymal giant cell astrocytoma 9 | 2,287
Glaucoma 8 | 239
Retinitis Pigmentosa 8 | 226
Anteverted nostril 7 | 191
non-small cell lung cancer 7 | 2,890
pituitary cancer 7 | 1,972
Abnormality of retinal pigmentation 6 | 111
Abnormality of the retinal vasculature 6 | 59
Atypical scarring of skin 6 | 62
Blind Vision 6 | 111
Blindness, Legal 6 | 110
Broad flat nasal bridge 6 | 236
Cataract 6 | 297
Congenital anomaly of testis 6 | 52
Congenital hypoplasia of penis 6 | 176
Electroretinogram abnormal 6 | 95
Gaucher disease type 1 6 | 180
Hyperinsulinism 6 | 133
Hypogonadism 6 | 173
Keratoconus 6 | 113
Lens Opacities 6 | 231
Nasal bridge wide 6 | 236
Night blindness, progressive 6 | 51
Nystagmus 6 | 317
Obesity 6 | 678
Ophthalmoplegia 6 | 106
Optic Atrophy 6 | 242
Photodysphoria 6 | 121
Photophobia 6 | 121
Retinal pigment epithelial abnormality 6 | 111
Sensorineural Hearing Loss (disorder) 6 | 284
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
group 4 medulloblastoma 6 | 1,855
non primary Sjogren syndrome sicca 6 | 891
pancreatic cancer 6 | 2,398
pediatric high grade glioma 6 | 1,064
spina bifida 6 | 1,074
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Difficulties with night vision 5 | 87
HIV Infections 5 | 102
Lupus erythematosus 5 | 57
Night Blindness 5 | 101
Rheumatoid arthritis 5 | 1,191
adrenocortical carcinoma 5 | 1,428
invasive ductal carcinoma 5 | 2,951
relapsing-remitting multiple sclerosis 5 | 18
sonic hedgehog group medulloblastoma 5 | 467
Curvature of spine 4 | 282
Hypoplastic mandible condyle 4 | 275
Immune system cancer 4 | 140
Mandibular hypoplasia 4 | 275
Small head 4 | 374
Uranostaphyloschisis 4 | 167
aldosterone-producing adenoma 4 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
cutaneous lupus erythematosus 4 | 1,057

Tissue

Digestive Tract 113 | 17,369
Endocrine System 113 | 18,159
Female tissues 113 | 17,400
Liver and Pancreas 113 | 16,750
Male tissues 113 | 17,142
Nervous System 113 | 16,725
Respiratory system 113 | 16,393
Urinary Tract 113 | 16,678
Blood and immune system 112 | 16,909
Cardiovascular System 112 | 15,192
Skin and soft tissues 112 | 17,230

Target Family

Non-IDG 93 | 12,091
Enzyme 15 | 4,145
Epigenetic 4 | 242
Kinase 1 | 634
Transcription Factor 1 | 1,400

Compartment GO Term

Small nuclear ribonucleoprotei... 114 | 114
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NACHT domain- and WD repeat-containing protein 1 NWD1 Tdark Non-IDG 0.08 1.22 3
Telomerase protein component 1 TEP1 Tbio Enzyme -1.74492 50.6 71
U6 snRNA-associated Sm-like protein LSm4 LSM4 Tbio Non-IDG -2.13782 132.0 149
Cleavage and polyadenylation specificity factor subunit 3 CPSF3 Tbio Non-IDG -1.47182 27.3 190
Serine/threonine-protein kinase PRP4 homolog PRPF4B Tchem Kinase -1.17233 14.7 144
Splicing factor 3B subunit 2 SF3B2 Tbio Non-IDG -1.32229 20.7 163
Splicing factor 3B subunit 6 SF3B6 Tbio Non-IDG -0.65964 4.59 100
U6 snRNA-associated Sm-like protein LSm2 LSM2 Tbio Non-IDG -1.40226 23.0 121
Pre-mRNA-splicing factor 18 PRPF18 Tbio Non-IDG -1.36183 19.8 84
Zinc finger protein 473 ZNF473 Tbio Transcription Factor -1.11630 12.6 101