Development Level

Tbio 30 | 11,445
Tchem 7 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

IMPC Phenotype

decreased body weight 2 | 161
preweaning lethality, incomple... 2 | 499
tremors 2 | 39
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal hair texture 1 | 4
abnormal vertebrae morphology 1 | 18
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating glycerol... 1 | 16
decreased food intake 1 | 13
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
prenatal lethality 1 | 28
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 31 | 11,493
osteosarcoma 27 | 7,950
ovarian cancer 24 | 8,520
medulloblastoma, large-cell 19 | 6,241
psoriasis 16 | 6,694
lung cancer 15 | 4,740
glioblastoma 14 | 5,792
Cancer 13 | 2,499
group 3 medulloblastoma 13 | 4,104
malignant mesothelioma 13 | 3,232
Nijmegen breakage syndrome 12 | 24
Breast cancer 11 | 3,578
atypical teratoid / rhabdoid tumor 11 | 5,112
primitive neuroectodermal tumor 11 | 3,035
Ataxia telangiectasia 10 | 34
Kidney cancer 10 | 2,613
Pick disease 10 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
adult high grade glioma 8 | 3,801
Fanconi anemia 7 | 56
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
progressive supranuclear palsy 7 | 676
Breast Neoplasms 6 | 445
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
Mammary Neoplasms 6 | 425
breast carcinoma 6 | 1,638
non-small cell lung cancer 6 | 2,890
Autosomal recessive predisposition 5 | 1,442
Chromosome Breakage 5 | 36
astrocytic glioma 5 | 2,597
Malignant neoplasm of breast 4 | 15
Microcephaly 4 | 166
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Short stature 4 | 531
Waldenstrons macroglobulinemia 4 | 765
Werner syndrome 4 | 29
Xeroderma pigmentosum 4 | 43
invasive ductal carcinoma 4 | 2,951
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Anemia 3 | 365
Aplastic Anemia 3 | 21
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Bloom syndrome 3 | 29
Decreased platelet count 3 | 111
Disease Progression 3 | 136
Dull intelligence 3 | 645
Dysarthria 3 | 192
Dystonia 3 | 164
Dystonic disease 3 | 106
Increased chromosomal breakage 3 | 27
Intellectual disability 3 | 1,016
Liver cancer 3 | 604
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Muscle Spasticity 3 | 195
Neoplasms 3 | 63
Pancreatic Neoplasm 3 | 85
Poor school performance 3 | 645
Prostate cancer 3 | 175
Prostate cancer, familial 3 | 13
Seckel syndrome 3 | 34
Small head 3 | 374
Stomach Neoplasms 3 | 300
Thrombocytopenia 3 | 197
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
nasopharyngeal carcinoma 3 | 1,058
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
primary Sjogren syndrome 3 | 735
tuberculosis 3 | 2,010
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Depressive disorder 2 | 409
Endometriosis 2 | 540
Pancreatic Neoplasms 2 | 85
Polycystic ovary syndrome 2 | 360
dermatomyositis 2 | 966
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Cardiovascular System 39 | 15,192
Nervous System 39 | 16,725
Urinary Tract 39 | 16,678

Target Family

Non-IDG 21 | 12,091
Enzyme 10 | 4,145
Epigenetic 4 | 242
Kinase 3 | 634
Transcription Factor 2 | 1,400

Compartment GO Term

Site of DNA damage 40 | 40
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
Serine/threonine-protein kinase Chk1 CHEK1 Tchem Kinase -3.04423 1089.6 1375
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Nibrin NBN Tbio Non-IDG -1.95649 97.2 1094
Serine-protein kinase ATM ATM Tchem Kinase -3.57054 3681.6 1024
Histone H2AX H2AFX Tbio Non-IDG -3.24839 1588.9 993
DNA repair protein RAD51 homolog 1 RAD51 Tchem Non-IDG -3.82649 6590.0 594
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Double-strand break repair protein MRE11 MRE11 Tbio Non-IDG -2.02762 98.5 459