1. Home
  2. Targets
Target Filters...

Development Level

Tbio 265 | 10,625
Tchem 76 | 1,890
Tclin 34 | 602
Tdark 19 | 7,003

Collection

Eligible Ion Channel Proteins 4 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 16 | 633
preweaning lethality, incomple... 7 | 260
abnormal behavior 6 | 226
abnormal bone structure 6 | 131
decreased total body fat amoun... 6 | 186
abnormal bone mineralization 5 | 55
decreased bone mineral content 5 | 157
decreased body weight 4 | 174
enlarged heart 4 | 111
increased heart weight 4 | 37
decreased NK T cell number 3 | 28
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased fasted circulating g... 3 | 49
decreased grip strength 3 | 123
hypoactivity 3 | 89
increased CD4-positive, alpha ... 3 | 15
increased bone mineral content 3 | 92
increased circulating phosphat... 3 | 24
increased fasted circulating g... 3 | 68
increased lean body mass 3 | 107
abnormal QRS complex 2 | 25
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
corneal opacity 2 | 25
decreased T cell number 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating insulin ... 2 | 75
decreased circulating phosphat... 2 | 15
decreased lean body mass 2 | 195
decreased prepulse inhibition 2 | 52
enlarged spleen 2 | 26
impaired righting response 2 | 19
increased body weight 2 | 42
increased circulating potassiu... 2 | 31
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
male infertility 2 | 62
thrombocytopenia 2 | 46
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal rib morphology 1 | 28
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
embryonic lethality prior to t... 1 | 187
enlarged heart atrium 1 | 2
female infertility 1 | 34
hydrometra 1 | 13
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased erythrocyte cell num... 1 | 26
increased hemoglobin content 1 | 45
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
polycystic kidney 1 | 9
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
small testis 1 | 37
sparse hair 1 | 6
straub tail 1 | 26
tremors 1 | 34
vertebral fusion 1 | 23

Disease

Cancer 198 | 2,346
psoriasis 178 | 6,685
osteosarcoma 177 | 7,933
ovarian cancer 168 | 8,484
medulloblastoma, large-cell 134 | 6,234
glioblastoma 127 | 5,572
diabetes mellitus 119 | 1,663
lung cancer 110 | 4,466
lung carcinoma 101 | 2,844
pilocytic astrocytoma 92 | 3,086
Rheumatoid Arthritis 89 | 1,160
atypical teratoid / rhabdoid tumor 87 | 4,369
Breast cancer 85 | 3,094
Hypersensitivity reaction type II disease 84 | 235
invasive ductal carcinoma 83 | 2,950
interstitial cystitis 77 | 2,299
non-small cell lung cancer 77 | 2,798
lung adenocarcinoma 74 | 2,713
Ankylosing spondylitis 73 | 138
subependymal giant cell astrocytoma 73 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 72 | 2,988
pancreatic cancer 70 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 69 | 2,956
Arthritis 68 | 248
malignant mesothelioma 68 | 3,162
Acquired immunodeficiency syndrome 67 | 164
ulcerative colitis 66 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 65 | 3,289
oligodendroglioma 65 | 2,849
Juvenile rheumatoid arthritis 64 | 104
Uveitis 62 | 103
pediatric high grade glioma 61 | 2,712
primitive neuroectodermal tumor 61 | 3,031
Behcet's disease 58 | 74
Kidney disease 57 | 396
Carcinoma 55 | 2,147
juvenile dermatomyositis 54 | 1,189
Psoriatic arthritis 53 | 83
Multiple Sclerosis 52 | 498
tuberculosis 52 | 1,557
adult high grade glioma 51 | 2,148
group 4 medulloblastoma 50 | 1,875
Pick disease 47 | 1,893
breast carcinoma 47 | 1,614
pituitary cancer 47 | 1,972
cutaneous lupus erythematosus 46 | 1,056
ependymoma 46 | 2,514
Liver disease 45 | 219
astrocytoma 45 | 1,493
ductal carcinoma in situ 44 | 1,745
Anemia 42 | 252
cystic fibrosis 41 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,795
posterior fossa group A ependymoma 40 | 1,511
Alzheimer's disease 39 | 644
astrocytic glioma 39 | 2,241
primary Sjogren syndrome 39 | 789
Stevens-Johnson syndrome 37 | 78
Retinal vasculitis 36 | 36
Takayasu's arteritis 36 | 52
Congenital adrenal hyperplasia 35 | 74
acute quadriplegic myopathy 35 | 1,157
dermatomyositis 35 | 933
Duchenne muscular dystrophy 33 | 602
medulloblastoma 33 | 1,524
Hepatitis B 31 | 103
colon cancer 31 | 1,475
Multiple myeloma 30 | 1,327
group 3 medulloblastoma 30 | 2,254
primary pancreatic ductal adenocarcinoma 30 | 1,271
Obesity 29 | 616
adrenocortical carcinoma 29 | 1,427
posterior fossa group B ependymoma 29 | 1,530
Leprosy 28 | 77
esophageal adenocarcinoma 28 | 737
Atherosclerosis 27 | 275
Hemochromatosis 27 | 55
Hypertension 27 | 287
Asthma 26 | 349
Skin disease 26 | 65
mucosa-associated lymphoid tissue lymphoma 26 | 480
gastric carcinoma 25 | 832
Down syndrome 23 | 548
IGA Glomerulonephritis 23 | 454
Primary immunodeficiency disease 23 | 52
spina bifida 23 | 1,064
Human immunodeficiency virus infectious disease 22 | 92
Schizophrenia 22 | 501
active Crohn's disease 22 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 22 | 499
Coronary artery disease 21 | 240
sarcoidosis 21 | 358
Prostatic Neoplasms 20 | 471
Blastic phase chronic myeloid leukemia 19 | 58
Cerebrovascular disease 19 | 231
Chronic Myelocytic Leukemia Accelerated Phase 19 | 59
pre-eclampsia 19 | 67
Atopic dermatitis 18 | 944
Intellectual disability 18 | 573
Waldenstrons macroglobulinemia 18 | 765

Tissue

Endocrine System 320 | 18,512
Nervous System 320 | 18,561
Urinary Tract 320 | 18,444
Digestive Tract 319 | 18,473
Female tissues 319 | 18,647
Cardiovascular System 318 | 17,958
Liver and Pancreas 318 | 18,136
Blood and immune system 317 | 17,995
Male tissues 316 | 17,969
Respiratory system 315 | 17,484
Skin and soft tissues 309 | 18,115

Target Family

Non-IDG 270 | 11,971
Enzyme 64 | 4,146
Kinase 44 | 634
Ion Channel 8 | 341
GPCR 5 | 406
Transporter 3 | 473

Compartment GO Term

Side of membrane 394 | 394
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0
HLA class I histocompatibility antigen, B-38 alpha chain HLA-B Tbio Non-IDG 1568.8 0
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457