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Development Level

Tbio 304 | 11,445
Tchem 68 | 1,598
Tclin 38 | 613
Tdark 11 | 6,588

Collection

Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 24 | 979
preweaning lethality, incomple... 14 | 499
increased startle reflex 11 | 112
abnormal bone structure 10 | 187
abnormal behavior 8 | 298
abnormal seminal vesicle morph... 7 | 114
embryonic lethality prior to o... 6 | 239
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
decreased lymphocyte cell numb... 5 | 83
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
enlarged heart 5 | 210
hypoactivity 5 | 132
abnormal embryo size 4 | 220
abnormal heart morphology 4 | 162
decreased circulating HDL chol... 4 | 68
embryonic growth retardation 4 | 106
increased heart weight 4 | 62
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
abnormal retina morphology 3 | 71
decreased bone mineral density 3 | 126
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating choleste... 3 | 93
decreased circulating phosphat... 3 | 27
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
decreased mean corpuscular hem... 3 | 50
enlarged uterus 3 | 11
hydrometra 3 | 53
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
short tibia 3 | 97
small superior vagus ganglion 3 | 74
thrombocytopenia 3 | 56
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal sleep behavior 2 | 70
decreased body length 2 | 101
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased exploration in new e... 2 | 11
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
enlarged kidney 2 | 14
hyperactivity 2 | 148
impaired righting response 2 | 26
increased CD4-positive, alpha ... 2 | 4
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased spleen weight 2 | 10
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal hair growth 1 | 10
abnormal lung morphology 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
persistence of hyaloid vascula... 1 | 33
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 282 | 11,493
Cancer 210 | 2,499
osteosarcoma 196 | 7,950
psoriasis 192 | 6,694
ovarian cancer 189 | 8,520
glioblastoma 150 | 5,792
medulloblastoma, large-cell 149 | 6,241
lung cancer 136 | 4,740
diabetes mellitus 125 | 1,728
atypical teratoid / rhabdoid tumor 111 | 5,112
ependymoma 110 | 4,679
lung carcinoma 108 | 2,843
Breast cancer 105 | 3,578
Astrocytoma, Pilocytic 95 | 3,081
adult high grade glioma 95 | 3,801
invasive ductal carcinoma 94 | 2,951
Rheumatoid arthritis 93 | 1,191
tuberculosis 91 | 2,010
Hypersensitivity reaction type II disease 87 | 253
interstitial cystitis 87 | 2,312
non-small cell lung cancer 84 | 2,890
malignant mesothelioma 81 | 3,232
Arthritis 80 | 290
intraductal papillary-mucinous adenoma (IPMA) 80 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,989
lung adenocarcinoma 78 | 2,716
pancreatic cancer 78 | 2,398
subependymal giant cell astrocytoma 78 | 2,287
Kidney cancer 76 | 2,613
group 3 medulloblastoma 74 | 4,104
Ankylosing spondylitis 73 | 140
intraductal papillary-mucinous neoplasm (IPMN) 73 | 3,291
Behcet's disease 72 | 89
dermatomyositis 71 | 966
oligodendroglioma 69 | 2,850
ulcerative colitis 69 | 1,819
Acquired immunodeficiency syndrome 68 | 197
Juvenile rheumatoid arthritis 68 | 111
primitive neuroectodermal tumor 64 | 3,035
Uveitis 62 | 103
Human immunodeficiency virus infectious disease 60 | 138
Herpes zoster 58 | 68
Schizophrenia 57 | 1,160
Kidney disease 56 | 430
juvenile dermatomyositis 56 | 1,187
breast carcinoma 55 | 1,638
Multiple Sclerosis 53 | 540
Psoriatic arthritis 53 | 86
pituitary cancer 53 | 1,972
Anemia 52 | 365
Autosomal recessive predisposition 52 | 1,442
astrocytic glioma 52 | 2,597
cutaneous lupus erythematosus 51 | 1,057
Pick disease 50 | 1,894
Stevens-Johnson syndrome 50 | 92
group 4 medulloblastoma 50 | 1,855
ductal carcinoma in situ 46 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,962
Dermatitis 45 | 157
Liver disease 45 | 237
Alzheimer's disease 44 | 658
cystic fibrosis 44 | 1,696
Liver Cirrhosis, Experimental 43 | 769
primary Sjogren syndrome 41 | 735
astrocytoma 40 | 1,146
acute quadriplegic myopathy 38 | 1,158
Behcet's syndrome 37 | 50
Duchenne muscular dystrophy 37 | 601
Synovitis 37 | 78
colon cancer 37 | 1,478
Nephritis 36 | 51
Retinal vasculitis 36 | 36
Takayasu's arteritis 36 | 53
drug-induced hepatitis 36 | 44
Congenital adrenal hyperplasia 35 | 73
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Obesity 34 | 678
Multiple myeloma 33 | 1,332
Hepatitis B 32 | 108
Hypertension 32 | 396
adrenocortical carcinoma 32 | 1,428
Melanoma 31 | 711
pediatric high grade glioma 31 | 1,064
primary pancreatic ductal adenocarcinoma 31 | 1,109
esophageal adenocarcinoma 30 | 737
Leprosy 29 | 73
mucosa-associated lymphoid tissue lymphoma 29 | 484
Intellectual disability 28 | 1,016
Asthma 27 | 385
Bipolar Disorder 27 | 666
Epilepsy 27 | 792
Hemochromatosis 27 | 54
Skin disease 27 | 66
spina bifida 27 | 1,074
Atherosclerosis 25 | 291
Down syndrome 25 | 499
gastric carcinoma 25 | 807
Primary immunodeficiency disease 24 | 54
Skin cancer 23 | 469
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 510

Tissue

Endocrine System 337 | 18,159
Female tissues 329 | 17,400
Skin and soft tissues 329 | 17,230
Blood and immune system 328 | 16,909
Digestive Tract 328 | 17,369
Liver and Pancreas 326 | 16,750
Male tissues 323 | 17,142
Nervous System 321 | 16,725
Urinary Tract 321 | 16,678
Respiratory system 319 | 16,393
Cardiovascular System 302 | 15,192

Target Family

Non-IDG 298 | 12,091
Enzyme 58 | 4,145
Kinase 45 | 634
Ion Channel 9 | 344
GPCR 6 | 408
Transporter 3 | 473
Transcription Factor 2 | 1,400

Compartment GO Term

Side of membrane 421 | 421
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Sorting nexin-18 SNX18 Tbio Non-IDG -0.76724 7.20 156
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178