Development Level

Tbio 706 | 11,651
Tchem 141 | 1,388
Tdark 82 | 6,593
Tclin 42 | 612

Collection

RFA-RM-18-021 6 | 328
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 49 | 979
preweaning lethality, incomple... 33 | 499
decreased vertical activity 18 | 208
embryonic lethality prior to t... 16 | 278
abnormal behavior 15 | 298
decreased bone mineral content 12 | 151
hypoactivity 12 | 132
decreased total body fat amoun... 11 | 207
abnormal seminal vesicle morph... 10 | 114
embryonic lethality prior to o... 10 | 239
abnormal embryo size 9 | 220
increased bone mineral content 9 | 108
increased circulating sodium l... 9 | 71
increased lean body mass 9 | 172
short tibia 9 | 97
abnormal retina morphology 8 | 71
decreased circulating insulin ... 8 | 76
enlarged heart 8 | 210
abnormal sleep behavior 7 | 70
cataract 7 | 92
decreased bone mineral density 7 | 126
decreased circulating serum al... 7 | 82
decreased grip strength 7 | 116
increased total body fat amoun... 7 | 134
abnormal bone structure 6 | 187
abnormal kidney morphology 6 | 65
decreased mean corpuscular hem... 6 | 50
edema 6 | 59
enlarged lymph nodes 6 | 37
hyperactivity 6 | 148
increased circulating alkaline... 6 | 122
abnormal coat-hair pigmentatio... 5 | 64
abnormal lens morphology 5 | 81
abnormal testis morphology 5 | 43
decreased body length 5 | 101
decreased caudal vertebrae num... 5 | 53
decreased circulating choleste... 5 | 93
embryonic growth retardation 5 | 106
increased bone mineral density 5 | 72
abnormal behavioral response t... 4 | 66
abnormal eye morphology 4 | 68
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
decreased circulating HDL chol... 4 | 68
decreased circulating glucose ... 4 | 126
decreased fasted circulating g... 4 | 65
decreased lean body mass 4 | 135
decreased mean corpuscular hem... 4 | 31
hemorrhage 4 | 23
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased circulating chloride... 4 | 41
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 47
increased mean corpuscular hem... 4 | 36
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
male infertility 4 | 123
prenatal lethality 4 | 28
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
small testis 4 | 58
abnormal coat appearance 3 | 31
abnormal lung morphology 3 | 26
brachydactyly 3 | 19
decreased circulating LDL chol... 3 | 38
decreased circulating amylase ... 3 | 28
decreased circulating bilirubi... 3 | 19
decreased circulating total pr... 3 | 49
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased threshold for audito... 3 | 26
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased circulating triglyce... 3 | 42
increased erythrocyte cell num... 3 | 39
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
persistence of hyaloid vascula... 3 | 33
small spleen 3 | 19
small superior vagus ganglion 3 | 74
thrombocytopenia 3 | 56
tremors 3 | 39
abnormal epididymis morphology 2 | 42
abnormal retinal vasculature m... 2 | 27
abnormal vibrissa morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased circulating calcium ... 2 | 36
decreased circulating creatini... 2 | 39
decreased hemoglobin content 2 | 68
enlarged urinary bladder 2 | 8
increased body weight 2 | 25
increased circulating aspartat... 2 | 15
increased circulating fructosa... 2 | 13
increased circulating iron lev... 2 | 30
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
prenatal lethality prior to he... 2 | 87

Disease

Carcinoma 571 | 11,493
ovarian cancer 464 | 8,520
osteosarcoma 457 | 7,950
psoriasis 434 | 6,694
glioblastoma 358 | 5,792
medulloblastoma, large-cell 323 | 6,241
lung cancer 315 | 4,740
Cancer 307 | 2,499
atypical teratoid / rhabdoid tumor 273 | 5,112
ependymoma 268 | 4,679
lung carcinoma 252 | 2,843
Astrocytoma, Pilocytic 248 | 3,081
adult high grade glioma 232 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 224 | 3,291
malignant mesothelioma 218 | 3,232
diabetes mellitus 213 | 1,728
group 3 medulloblastoma 209 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 208 | 2,955
Breast cancer 206 | 3,578
non-small cell lung cancer 206 | 2,890
pancreatic cancer 195 | 2,398
lung adenocarcinoma 194 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 193 | 2,989
invasive ductal carcinoma 193 | 2,951
subependymal giant cell astrocytoma 180 | 2,287
oligodendroglioma 179 | 2,850
tuberculosis 179 | 2,010
interstitial cystitis 177 | 2,312
primitive neuroectodermal tumor 150 | 3,035
astrocytic glioma 147 | 2,597
ulcerative colitis 146 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 134 | 1,962
Kidney cancer 129 | 2,613
Pick disease 126 | 1,894
Autosomal recessive predisposition 124 | 1,442
Rheumatoid arthritis 119 | 1,191
Multiple myeloma 116 | 1,332
cystic fibrosis 115 | 1,696
dermatomyositis 115 | 966
Schizophrenia 114 | 1,160
astrocytoma 104 | 1,146
pituitary cancer 104 | 1,972
Alzheimer's disease 101 | 658
cutaneous lupus erythematosus 101 | 1,057
mucosa-associated lymphoid tissue lymphoma 101 | 484
ductal carcinoma in situ 98 | 1,745
primary pancreatic ductal adenocarcinoma 98 | 1,109
colon cancer 97 | 1,478
Liver Cirrhosis, Experimental 95 | 769
breast carcinoma 95 | 1,638
Arthritis 93 | 290
juvenile dermatomyositis 93 | 1,187
Waldenstrons macroglobulinemia 92 | 765
group 4 medulloblastoma 90 | 1,855
acute quadriplegic myopathy 85 | 1,158
adrenocortical carcinoma 80 | 1,428
Duchenne muscular dystrophy 76 | 601
Kidney disease 75 | 430
esophageal adenocarcinoma 75 | 737
Atopic dermatitis 73 | 952
Epilepsy 73 | 792
Hypertension 72 | 396
gastric carcinoma 71 | 807
Hypersensitivity reaction type II disease 68 | 253
Obesity 68 | 678
nasopharyngeal carcinoma 68 | 1,058
Intellectual disability 63 | 1,016
pediatric high grade glioma 63 | 1,064
Bipolar Disorder 62 | 666
Seizures 62 | 596
Depressive disorder 58 | 409
Human immunodeficiency virus infectious disease 58 | 138
Asthma 57 | 385
non primary Sjogren syndrome sicca 57 | 891
Ankylosing spondylitis 56 | 140
Atherosclerosis 56 | 291
Dermatitis 56 | 157
Neurodegenerative disease 56 | 414
active Crohn's disease 56 | 922
active ulcerative colitis 55 | 764
spina bifida 55 | 1,074
primary Sjogren syndrome 54 | 735
Stevens-Johnson syndrome 53 | 92
Vascular disease 53 | 319
Cerebrovascular disease 52 | 238
Parkinson's disease 51 | 392
Psoriatic arthritis 51 | 86
pancreatic carcinoma 51 | 562
Behcet's disease 50 | 89
Dementia 48 | 175
Melanoma 48 | 711
Prostatic Neoplasms 48 | 495
Acquired immunodeficiency syndrome 45 | 197
Anemia 45 | 365
Down syndrome 45 | 499
Heart disease 45 | 306
Coronary artery disease 44 | 268
Diarrhea 44 | 253
Hypertensive disease 43 | 292
autosomal dominant Emery-Dreifuss muscular dystrophy 43 | 510

Tissue

Endocrine System 892 | 18,159
Digestive Tract 878 | 17,369
Female tissues 878 | 17,400
Skin and soft tissues 872 | 17,230
Liver and Pancreas 858 | 16,750
Male tissues 857 | 17,142
Blood and immune system 854 | 16,909
Urinary Tract 845 | 16,678
Respiratory system 837 | 16,393
Nervous System 834 | 16,725
Cardiovascular System 767 | 15,192

Target Family

Non-IDG 607 | 12,091
Enzyme 272 | 4,145
Transporter 34 | 473
Kinase 20 | 634
GPCR 15 | 408
Ion Channel 13 | 344
Transcription Factor 4 | 1,400
oGPCR 4 | 421
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

Secretory vesicle 971 | 971
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Mitogen-activated protein kinase 14 MAPK14 Tchem Kinase -3.36007 2240.8 1574
Amyloid-beta A4 protein APP Tchem Non-IDG -3.99225 9853.3 2781
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.75840 565.6 230
Heat shock protein HSP 90-alpha HSP90AA1 Tchem Non-IDG -3.31859 4681.5 1057
Vascular endothelial growth factor A VEGFA Tclin Non-IDG -4.27197 19076.6 1809
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677