Development Level

Tbio 618 | 11,651
Tchem 131 | 1,388
Tdark 68 | 6,593
Tclin 35 | 612

Collection

RFA-RM-18-021 6 | 328
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 42 | 979
preweaning lethality, incomple... 30 | 499
embryonic lethality prior to t... 16 | 278
decreased vertical activity 15 | 208
abnormal behavior 10 | 298
abnormal seminal vesicle morph... 10 | 114
embryonic lethality prior to o... 10 | 239
hypoactivity 10 | 132
abnormal embryo size 8 | 220
decreased total body fat amoun... 8 | 207
enlarged heart 8 | 210
decreased bone mineral content 7 | 151
increased bone mineral content 7 | 108
increased lean body mass 7 | 172
short tibia 7 | 97
abnormal kidney morphology 6 | 65
cataract 6 | 92
decreased circulating insulin ... 6 | 76
decreased circulating serum al... 6 | 82
decreased grip strength 6 | 116
enlarged lymph nodes 6 | 37
increased circulating alkaline... 6 | 122
increased circulating sodium l... 6 | 71
increased total body fat amoun... 6 | 134
abnormal bone structure 5 | 187
abnormal retina morphology 5 | 71
decreased bone mineral density 5 | 126
decreased mean corpuscular hem... 5 | 50
edema 5 | 59
embryonic growth retardation 5 | 106
hyperactivity 5 | 148
increased bone mineral density 5 | 72
abnormal coat-hair pigmentatio... 4 | 64
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
abnormal sleep behavior 4 | 70
decreased caudal vertebrae num... 4 | 53
decreased circulating choleste... 4 | 93
decreased lean body mass 4 | 135
decreased mean corpuscular hem... 4 | 31
hemorrhage 4 | 23
impaired glucose tolerance 4 | 75
increased leukocyte cell numbe... 4 | 47
male infertility 4 | 123
abnormal coat appearance 3 | 31
abnormal eye morphology 3 | 68
abnormal lung morphology 3 | 26
abnormal testis morphology 3 | 43
brachydactyly 3 | 19
decreased body length 3 | 101
decreased circulating HDL chol... 3 | 68
decreased circulating amylase ... 3 | 28
decreased circulating bilirubi... 3 | 19
decreased circulating calcium ... 3 | 36
decreased circulating glucose ... 3 | 126
decreased circulating total pr... 3 | 49
decreased fasted circulating g... 3 | 65
decreased threshold for audito... 3 | 26
improved glucose tolerance 3 | 79
increased circulating creatini... 3 | 38
increased circulating triglyce... 3 | 42
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 96
increased mean corpuscular hem... 3 | 36
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
prenatal lethality 3 | 28
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal neural tube closure 2 | 46
abnormal retinal vasculature m... 2 | 27
abnormal snout morphology 2 | 23
abnormal vibrissa morphology 2 | 25
decreased circulating LDL chol... 2 | 38
decreased circulating phosphat... 2 | 27
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased food intake 2 | 13
decreased mean platelet volume 2 | 25
increased blood urea nitrogen ... 2 | 48
increased circulating aspartat... 2 | 15
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating fructosa... 2 | 13
increased circulating iron lev... 2 | 30
increased circulating magnesiu... 2 | 10
increased circulating potassiu... 2 | 29
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
premature death 2 | 5
prenatal lethality prior to he... 2 | 87
small spleen 2 | 19
small superior vagus ganglion 2 | 74
small testis 2 | 58
syndactyly 2 | 23

Disease

Carcinoma 490 | 11,493
ovarian cancer 417 | 8,520
osteosarcoma 413 | 7,950
psoriasis 394 | 6,694
glioblastoma 300 | 5,792
lung cancer 300 | 4,740
Cancer 295 | 2,499
medulloblastoma, large-cell 266 | 6,241
atypical teratoid / rhabdoid tumor 217 | 5,112
lung carcinoma 217 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 211 | 3,291
ependymoma 209 | 4,679
malignant mesothelioma 203 | 3,232
Astrocytoma, Pilocytic 198 | 3,081
non-small cell lung cancer 198 | 2,890
diabetes mellitus 197 | 1,728
Breast cancer 193 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 191 | 2,955
pancreatic cancer 187 | 2,398
adult high grade glioma 185 | 3,801
lung adenocarcinoma 184 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 183 | 2,989
invasive ductal carcinoma 183 | 2,951
tuberculosis 167 | 2,010
interstitial cystitis 165 | 2,312
group 3 medulloblastoma 163 | 4,104
subependymal giant cell astrocytoma 155 | 2,287
ulcerative colitis 138 | 1,819
oligodendroglioma 131 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 130 | 1,962
Rheumatoid arthritis 116 | 1,191
primitive neuroectodermal tumor 115 | 3,035
Autosomal recessive predisposition 114 | 1,442
dermatomyositis 112 | 966
astrocytic glioma 110 | 2,597
Multiple myeloma 106 | 1,332
cystic fibrosis 106 | 1,696
Kidney cancer 105 | 2,613
mucosa-associated lymphoid tissue lymphoma 98 | 484
cutaneous lupus erythematosus 97 | 1,057
Pick disease 95 | 1,894
breast carcinoma 95 | 1,638
ductal carcinoma in situ 94 | 1,745
Liver Cirrhosis, Experimental 93 | 769
primary pancreatic ductal adenocarcinoma 93 | 1,109
Arthritis 91 | 290
astrocytoma 90 | 1,146
colon cancer 90 | 1,478
Waldenstrons macroglobulinemia 87 | 765
Schizophrenia 86 | 1,160
juvenile dermatomyositis 86 | 1,187
pituitary cancer 86 | 1,972
Alzheimer's disease 80 | 658
acute quadriplegic myopathy 80 | 1,158
adrenocortical carcinoma 77 | 1,428
group 4 medulloblastoma 77 | 1,855
esophageal adenocarcinoma 75 | 737
Kidney disease 74 | 430
Atopic dermatitis 73 | 952
Duchenne muscular dystrophy 73 | 601
gastric carcinoma 71 | 807
Hypersensitivity reaction type II disease 67 | 253
Hypertension 67 | 396
nasopharyngeal carcinoma 66 | 1,058
Obesity 62 | 678
Atherosclerosis 58 | 291
Human immunodeficiency virus infectious disease 58 | 138
pediatric high grade glioma 58 | 1,064
Ankylosing spondylitis 56 | 140
Epilepsy 56 | 792
Dermatitis 54 | 157
non primary Sjogren syndrome sicca 54 | 891
active Crohn's disease 53 | 922
primary Sjogren syndrome 53 | 735
Stevens-Johnson syndrome 52 | 92
Psoriatic arthritis 51 | 86
Behcet's disease 50 | 89
Intellectual disability 50 | 1,016
Asthma 49 | 385
Seizures 49 | 596
Vascular disease 49 | 319
spina bifida 49 | 1,074
active ulcerative colitis 48 | 764
pancreatic carcinoma 48 | 562
Cerebrovascular disease 47 | 238
Prostatic Neoplasms 47 | 495
Coronary artery disease 46 | 268
Heart disease 46 | 306
Acquired immunodeficiency syndrome 45 | 197
Bipolar Disorder 45 | 666
Neurodegenerative disease 44 | 414
Anemia 43 | 365
Hypertensive disease 42 | 292
autosomal dominant Emery-Dreifuss muscular dystrophy 42 | 510
Lung disease 41 | 142
Melanoma 41 | 711
acute myeloid leukemia 41 | 783
Synovitis 40 | 78
Uveitis 40 | 103
hepatocellular carcinoma 40 | 547

Tissue

Endocrine System 780 | 18,159
Female tissues 769 | 17,400
Digestive Tract 767 | 17,369
Skin and soft tissues 765 | 17,230
Blood and immune system 753 | 16,909
Liver and Pancreas 753 | 16,750
Male tissues 751 | 17,142
Urinary Tract 741 | 16,678
Respiratory system 739 | 16,393
Nervous System 723 | 16,725
Cardiovascular System 677 | 15,192

Target Family

Non-IDG 521 | 12,091
Enzyme 261 | 4,145
Transporter 21 | 473
Kinase 18 | 634
GPCR 12 | 408
Ion Channel 11 | 344
Transcription Factor 6 | 1,400
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

Secretory granule 852 | 852
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Equatorin EQTN Tdark Non-IDG -1.22168 17.0 17
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Lysozyme-like protein 4 LYZL4 Tbio Enzyme -0.89841 6.89 78