Development Level

Tbio 214 | 10,625
Tchem 64 | 1,890
Tdark 34 | 7,003
Tclin 12 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 6 | 187
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
decreased bone mineral content 5 | 157
decreased grip strength 5 | 123
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
enlarged heart 5 | 111
decreased body length 4 | 108
hypoactivity 4 | 89
increased or absent threshold ... 4 | 128
abnormal bone structure 3 | 131
abnormal coat-hair pigmentatio... 3 | 54
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
abnormal retinal blood vessel ... 3 | 18
cataract 3 | 26
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating LDL chol... 3 | 37
decreased circulating insulin ... 3 | 75
decreased heart weight 3 | 44
decreased vertical activity 3 | 22
increased bone mineral content 3 | 92
increased total body fat amoun... 3 | 57
male infertility 3 | 62
short tibia 3 | 82
abnormal behavioral response t... 2 | 52
abnormal epididymis morphology 2 | 31
abnormal humerus morphology 2 | 11
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
abnormal tooth morphology 2 | 24
decreased circulating bilirubi... 2 | 14
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular hem... 2 | 19
decreased monocyte cell number 2 | 28
embryonic lethality prior to o... 2 | 148
hemorrhage 2 | 12
hyperactivity 2 | 108
increased blood urea nitrogen ... 2 | 44
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
thrombocytopenia 2 | 46
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal facial morphology 1 | 9
abnormal heart morphology 1 | 51
abnormal limb bud morphology 1 | 15
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
absent teeth 1 | 4
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased effector memory CD8-... 1 | 24
decreased gamma-delta T cell n... 1 | 18
decreased mean corpuscular vol... 1 | 50
decreased threshold for audito... 1 | 32
embryonic growth retardation 1 | 28
hydrops fetalis 1 | 22
impaired righting response 1 | 19
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating amylase ... 1 | 13
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased rib number 1 | 41
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
premature death 1 | 5
prenatal lethality prior to he... 1 | 64
shortened PQ interval 1 | 6
stereotypic behavior 1 | 3
trunk curl 1 | 15

Disease

psoriasis 147 | 6,685
osteosarcoma 140 | 7,933
ovarian cancer 137 | 8,491
glioblastoma 114 | 5,572
lung cancer 110 | 4,473
Cancer 109 | 2,346
medulloblastoma, large-cell 109 | 6,234
intraductal papillary-mucinous adenoma (IPMA) 94 | 2,956
lung carcinoma 87 | 2,844
pilocytic astrocytoma 87 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 86 | 3,289
pancreatic cancer 86 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 85 | 2,988
invasive ductal carcinoma 82 | 2,950
atypical teratoid / rhabdoid tumor 81 | 4,369
malignant mesothelioma 78 | 3,163
diabetes mellitus 74 | 1,663
lung adenocarcinoma 74 | 2,714
pediatric high grade glioma 71 | 2,712
oligodendroglioma 67 | 2,849
non-small cell lung cancer 66 | 2,798
Breast cancer 59 | 3,098
ulcerative colitis 58 | 2,087
primitive neuroectodermal tumor 57 | 3,031
interstitial cystitis 52 | 2,299
ductal carcinoma in situ 50 | 1,745
Carcinoma 49 | 2,147
subependymal giant cell astrocytoma 49 | 2,287
cystic fibrosis 47 | 1,670
ependymoma 47 | 2,514
tuberculosis 46 | 1,563
Pick disease 44 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,795
posterior fossa group A ependymoma 43 | 1,511
Kidney disease 42 | 397
Obesity 42 | 616
pituitary cancer 42 | 1,972
astrocytic glioma 41 | 2,241
colon cancer 40 | 1,475
Alzheimer's disease 39 | 644
astrocytoma 39 | 1,493
primary pancreatic ductal adenocarcinoma 38 | 1,271
adrenocortical carcinoma 37 | 1,427
breast carcinoma 37 | 1,614
group 4 medulloblastoma 37 | 1,875
Atherosclerosis 36 | 275
Atopic dermatitis 35 | 944
Hypertension 34 | 293
group 3 medulloblastoma 34 | 2,254
Cerebrovascular disease 33 | 231
adult high grade glioma 33 | 2,148
gastric carcinoma 33 | 832
Duchenne muscular dystrophy 31 | 602
Heart disease 31 | 279
esophageal adenocarcinoma 31 | 737
Coronary artery disease 30 | 240
sonic hedgehog group medulloblastoma 30 | 1,482
mucosa-associated lymphoid tissue lymphoma 28 | 480
pancreatic carcinoma 28 | 567
posterior fossa group B ependymoma 28 | 1,530
Lung disease 27 | 136
Rheumatoid Arthritis 27 | 1,170
cutaneous lupus erythematosus 27 | 1,056
Asthma 26 | 349
Multiple myeloma 26 | 1,327
Pancreatitis 26 | 97
juvenile dermatomyositis 26 | 1,189
Endometriosis 25 | 535
Adenoma 24 | 165
Hypertensive disease 24 | 193
Prostatic Neoplasms 24 | 471
Arthritis 23 | 248
Liver disease 23 | 219
Waldenstrons macroglobulinemia 23 | 764
active Crohn's disease 23 | 918
dermatomyositis 22 | 966
medulloblastoma 22 | 1,524
Diarrhea 21 | 155
Hypoglycemia 21 | 81
Schizophrenia 21 | 503
nasopharyngeal carcinoma 21 | 1,056
Polycystic Ovary Syndrome 20 | 334
Vascular disease 20 | 281
Down syndrome 19 | 548
Hyperglycemia 19 | 120
acute quadriplegic myopathy 19 | 1,157
atypical teratoid/rhabdoid tumor 19 | 1,095
non primary Sjogren syndrome sicca 19 | 840
spina bifida 19 | 1,064
Infertility 18 | 163
fibroadenoma 18 | 557
gastric cancer 18 | 436
hepatocellular carcinoma 18 | 550
Anemia 17 | 252
Dementia 17 | 129
Hypersensitivity reaction type II disease 17 | 235
Osteoporosis 17 | 259
Thrombophilia 17 | 37
aldosterone-producing adenoma 17 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 499

Tissue

Endocrine System 320 | 18,511
Female tissues 319 | 18,646
Nervous System 319 | 18,560
Digestive Tract 318 | 18,472
Skin and soft tissues 317 | 18,114
Urinary Tract 317 | 18,443
Liver and Pancreas 314 | 18,135
Blood and immune system 310 | 17,994
Cardiovascular System 309 | 17,957
Male tissues 309 | 17,968
Respiratory system 302 | 17,483

Target Family

Non-IDG 217 | 11,969
Enzyme 82 | 4,146
Transporter 11 | 473
Ion Channel 4 | 341
Transcription Factor 4 | 1,400
Kinase 3 | 634
Epigenetic 1 | 242
GPCR 1 | 408
TF/Epigenetic 1 | 38

Compartment GO Term

Secretory granule 324 | 324
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-1-antichymotrypsin SERPINA3 Tchem Non-IDG -2.94207 803.8 261
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809
Alpha-2-macroglobulin A2M Tbio Non-IDG -2.95602 802.7 553
Metalloproteinase inhibitor 1 TIMP1 Tbio Enzyme -3.55219 3513.4 673
Centrosomal protein of 131 kDa CEP131 Tbio Non-IDG -1.75708 61.0 81
Testis-specific serine/threonine-protein kinase 1 TSSK1B Tchem Kinase -1.41882 23.1 26
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Hepatocyte growth factor HGF Tchem Enzyme -3.29371 2317.3 573
Carboxypeptidase E CPE Tbio Enzyme -2.99888 983.1 216
Tektin-3 TEKT3 Tdark Non-IDG -0.65321 4.84 85