Development Level

Tbio 45 | 11,651
Tchem 24 | 1,388

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
preweaning lethality, incomple... 3 | 499
abnormal femur morphology 2 | 14
abnormal testis morphology 2 | 43
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral density 2 | 72
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
small testis 2 | 58
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal head morphology 1 | 10
abnormal head size 1 | 6
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydrometra 1 | 53
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
mammalian phenotype 1 | 17
microphthalmia 1 | 26
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
short tibia 1 | 97
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 52 | 11,493
Cancer 48 | 2,499
ovarian cancer 46 | 8,520
osteosarcoma 44 | 7,950
glioblastoma 38 | 5,792
atypical teratoid / rhabdoid tumor 35 | 5,112
psoriasis 33 | 6,694
lung cancer 29 | 4,740
medulloblastoma, large-cell 27 | 6,241
adult high grade glioma 26 | 3,801
Astrocytoma, Pilocytic 25 | 3,081
Breast cancer 25 | 3,578
ependymoma 25 | 4,679
malignant mesothelioma 24 | 3,232
non-small cell lung cancer 23 | 2,890
diabetes mellitus 21 | 1,728
lung adenocarcinoma 21 | 2,716
lung carcinoma 21 | 2,843
pancreatic cancer 21 | 2,398
Kidney disease 20 | 430
interstitial cystitis 20 | 2,312
invasive ductal carcinoma 20 | 2,951
cystic fibrosis 19 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
tuberculosis 18 | 2,010
group 4 medulloblastoma 17 | 1,855
ulcerative colitis 17 | 1,819
Kidney cancer 16 | 2,613
pituitary cancer 16 | 1,972
subependymal giant cell astrocytoma 16 | 2,287
Breast Neoplasms 15 | 445
Hypertensive disease 15 | 292
Mammary Neoplasms 15 | 425
breast carcinoma 15 | 1,638
ductal carcinoma in situ 15 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
oligodendroglioma 15 | 2,850
primitive neuroectodermal tumor 15 | 3,035
Liver Cirrhosis, Experimental 14 | 769
Liver disease 14 | 237
Osteoporosis 14 | 363
Stomach Neoplasms 14 | 300
Ureteral obstruction 14 | 33
Heart disease 13 | 306
Obesity 13 | 678
Prostatic Neoplasms 13 | 495
Pulmonary Fibrosis 13 | 106
Short stature 13 | 531
acute quadriplegic myopathy 13 | 1,158
primary pancreatic ductal adenocarcinoma 13 | 1,109
Hypertension 12 | 396
Osteoarthritis 12 | 184
Schizophrenia 12 | 1,160
Vascular disease 12 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
group 3 medulloblastoma 12 | 4,104
Acquired scoliosis 11 | 281
Arthritis 11 | 290
Craniofacial Abnormalities 11 | 151
Curvature of spine 11 | 282
Orbital separation excessive 11 | 244
astrocytoma 11 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Colorectal Neoplasms 10 | 243
Duchenne muscular dystrophy 10 | 601
Lung Neoplasms 10 | 232
Lung disease 10 | 142
Neoplasm Invasiveness 10 | 161
Pick disease 10 | 1,894
Rheumatoid arthritis 10 | 1,191
active Crohn's disease 10 | 922
active ulcerative colitis 10 | 764
astrocytic glioma 10 | 2,597
colon cancer 10 | 1,478
juvenile dermatomyositis 10 | 1,187
Acquired flat foot 9 | 72
Anemia 9 | 365
Aortic Valve Insufficiency 9 | 40
Asthma 9 | 385
Cleft Palate 9 | 271
Coronary artery disease 9 | 268
Fibrodysplasia ossificans progressiva 9 | 17
Flatfoot 9 | 73
Inflammatory bowel disease 9 | 151
Liver Cirrhosis 9 | 181
Adenoma 8 | 167
Alzheimer's disease 8 | 658
Ankylosis 8 | 28
Brachydactyly 8 | 156
Byzanthine arch palate 8 | 194
Cholestasis, Extrahepatic 8 | 25
Hypoplastic mandible condyle 8 | 275
Increase in blood pressure 8 | 119
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Neoplasm Metastasis 8 | 168
acute myeloid leukemia 7 | 783
cutaneous lupus erythematosus 7 | 1,057
gastric carcinoma 7 | 807

Tissue

Endocrine System 68 | 18,159
Liver and Pancreas 67 | 16,750
Nervous System 67 | 16,725
Digestive Tract 66 | 17,369
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Skin and soft tissues 66 | 17,230
Urinary Tract 65 | 16,678
Respiratory system 64 | 16,393
Blood and immune system 63 | 16,909
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 26 | 12,091
Transcription Factor 18 | 1,400
Kinase 14 | 634
Enzyme 10 | 4,145
Epigenetic 1 | 242

Compartment GO Term

SMAD protein complex 69 | 69
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.95365 89.3 331
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.96102 8811.6 1442
E3 ubiquitin-protein ligase Arkadia RNF111 Tbio Enzyme -1.40857 30.7 98
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Metalloproteinase inhibitor 1 TIMP1 Tbio Enzyme -3.57247 3714.8 810
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Zinc finger protein SNAI1 SNAI1 Tbio Transcription Factor -3.28636 1782.9 566