Development Level

Tbio 39 | 10,625
Tchem 29 | 1,890

IMPC Term

preweaning lethality, complete... 4 | 633
preweaning lethality, incomple... 3 | 260
abnormal embryo size 2 | 112
abnormal femur morphology 2 | 14
decreased lean body mass 2 | 195
decreased rib number 2 | 59
increased bone mineral density 2 | 52
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/ hair morphology 1 | 18
abnormal eye morphology 1 | 38
abnormal eyelid morphology 1 | 6
abnormal head morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal startle reflex 1 | 14
anophthalmia 1 | 20
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased hemoglobin content 1 | 53
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
hydrometra 1 | 13
hydrops fetalis 1 | 22
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating phosphat... 1 | 24
increased erythrocyte cell num... 1 | 26
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased prepulse inhibition 1 | 21
increased rib number 1 | 41
limb grasping 1 | 35
microcephaly 1 | 3
microphthalmia 1 | 15
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
small adrenal glands 1 | 15
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 45 | 8,492
osteosarcoma 42 | 7,933
Cancer 41 | 2,346
glioblastoma 36 | 5,572
atypical teratoid / rhabdoid tumor 32 | 4,369
psoriasis 31 | 6,685
medulloblastoma, large-cell 26 | 6,234
lung cancer 25 | 4,473
pilocytic astrocytoma 25 | 3,086
Breast cancer 23 | 3,099
lung carcinoma 22 | 2,844
malignant mesothelioma 22 | 3,163
lung adenocarcinoma 21 | 2,714
non-small cell lung cancer 21 | 2,798
Kidney disease 20 | 397
interstitial cystitis 20 | 2,299
ulcerative colitis 20 | 2,087
diabetes mellitus 19 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
invasive ductal carcinoma 19 | 2,950
pancreatic cancer 19 | 2,300
cystic fibrosis 18 | 1,670
pediatric high grade glioma 18 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
Carcinoma 16 | 2,147
adult high grade glioma 16 | 2,148
group 4 medulloblastoma 16 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
pituitary cancer 15 | 1,972
primitive neuroectodermal tumor 15 | 3,031
subependymal giant cell astrocytoma 15 | 2,287
tuberculosis 15 | 1,563
Mammary Neoplasms 14 | 410
oligodendroglioma 14 | 2,849
primary pancreatic ductal adenocarcinoma 14 | 1,271
Obesity 13 | 616
ductal carcinoma in situ 13 | 1,745
Heart disease 12 | 279
Liver disease 12 | 219
Osteoporosis 12 | 259
Ureteral disease 12 | 23
acute quadriplegic myopathy 12 | 1,157
posterior fossa group A ependymoma 12 | 1,511
Prostatic Neoplasms 11 | 471
Pulmonary Fibrosis 11 | 66
astrocytoma 11 | 1,493
breast carcinoma 11 | 1,614
Arthritis 10 | 248
Colorectal Neoplasms 10 | 217
Craniofacial Abnormalities 10 | 147
Fibrodysplasia ossificans progressiva 10 | 17
Lung disease 10 | 136
Osteoarthritis 10 | 96
Pick disease 10 | 1,893
Rheumatoid Arthritis 10 | 1,171
Stomach Neoplasms 10 | 282
Vascular disease 10 | 281
active Crohn's disease 10 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
colon cancer 10 | 1,475
Duchenne muscular dystrophy 9 | 602
Lung Neoplasms 9 | 171
juvenile dermatomyositis 9 | 1,189
sonic hedgehog group medulloblastoma 9 | 1,482
Adenoma 8 | 165
Alzheimer's disease 8 | 644
Ankylosis 8 | 25
Cleft palate 8 | 125
Hereditary hemorrhagic telangiectasia 8 | 14
Neoplasm Invasiveness 8 | 127
astrocytic glioma 8 | 2,241
ependymoma 8 | 2,514
gastric carcinoma 8 | 832
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Amyotrophic Lateral Sclerosis 7 | 432
Asthma 7 | 349
Atopic dermatitis 7 | 944
Colorectal Cancer 7 | 62
Endometriosis 7 | 535
Hypertension 7 | 293
Liver Cirrhosis, Experimental 7 | 108
acute myeloid leukemia 7 | 785
adrenocortical carcinoma 7 | 1,427
group 3 medulloblastoma 7 | 2,254
medulloblastoma 7 | 1,524
nasopharyngeal carcinoma 7 | 1,056
posterior fossa group B ependymoma 7 | 1,530
Craniosynostosis 6 | 47
Degenerative polyarthritis 6 | 93
Inflammatory bowel disease 6 | 142
Liver carcinoma 6 | 217
Multiple synostoses syndrome 6 | 8
Myopathy 6 | 128
Neoplasm Metastasis 6 | 138
Waldenstrons macroglobulinemia 6 | 765
active ulcerative colitis 6 | 477
chronic lymphosyte leukemia 6 | 232
cutaneous lupus erythematosus 6 | 1,056
esophageal adenocarcinoma 6 | 737
spina bifida 6 | 1,064

Tissue

Cardiovascular System 67 | 17,958
Digestive Tract 67 | 18,473
Endocrine System 67 | 18,512
Female tissues 67 | 18,647
Liver and Pancreas 67 | 18,136
Male tissues 67 | 17,969
Nervous System 67 | 18,561
Respiratory system 67 | 17,484
Skin and soft tissues 67 | 18,115
Urinary Tract 67 | 18,444
Blood and immune system 66 | 17,995

Target Family

Non-IDG 27 | 11,969
Transcription Factor 18 | 1,400
Kinase 14 | 634
Enzyme 8 | 4,146
Epigenetic 1 | 242

Compartment GO Term

SMAD protein complex 68 | 68
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Activin receptor type-2A ACVR2A Tchem Kinase -2.04309 96.6 269
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.90072 75.1 274
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.12904 1149.7 572
Cyclin-dependent kinase 4 inhibitor B CDKN2B Tbio Enzyme -2.59215 404.9 350
Serine/threonine-protein kinase receptor R3 ACVRL1 Tchem Kinase -2.94687 878.8 381
Zinc finger protein SNAI1 SNAI1 Tbio Transcription Factor -3.23809 1522.6 484
Mothers against decapentaplegic homolog 5 SMAD5 Tbio Transcription Factor -2.13357 104.4 325
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.81736 519.3 441
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.62805 3186.8 1232
Endoglin ENG Tbio Non-IDG -3.07363 1147.6 1239