Development Level

Tbio 127 | 11,651
Tchem 15 | 1,388
Tdark 9 | 6,593
Tclin 7 | 612

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal bone structure 7 | 187
preweaning lethality, incomple... 6 | 499
decreased body weight 5 | 161
increased heart weight 5 | 62
increased startle reflex 5 | 112
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
abnormal retina morphology 4 | 71
decreased circulating triglyce... 4 | 79
edema 4 | 59
abnormal coat-hair pigmentatio... 3 | 64
decreased bone mineral content 3 | 151
decreased caudal vertebrae num... 3 | 53
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating choleste... 3 | 93
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
increased lean body mass 3 | 172
abnormal eye morphology 2 | 68
abnormal sleep behavior 2 | 70
cardiovascular system phenotyp... 2 | 36
decreased circulating HDL chol... 2 | 68
decreased circulating serum al... 2 | 82
decreased mean corpuscular hem... 2 | 50
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
impaired pupillary reflex 2 | 26
increased circulating calcium ... 2 | 34
increased fasted circulating g... 2 | 76
increased total body fat amoun... 2 | 134
increased vertical activity 2 | 24
persistence of hyaloid vascula... 2 | 33
short tibia 2 | 97
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 12
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased prepulse inhibition 1 | 32
microphthalmia 1 | 26
small superior vagus ganglion 1 | 74
small testis 1 | 58
small thymus 1 | 16
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 121 | 11,493
ovarian cancer 98 | 8,520
osteosarcoma 93 | 7,950
glioblastoma 73 | 5,792
medulloblastoma, large-cell 71 | 6,241
psoriasis 70 | 6,694
Cancer 57 | 2,499
atypical teratoid / rhabdoid tumor 55 | 5,112
Breast cancer 54 | 3,578
lung cancer 54 | 4,740
ependymoma 52 | 4,679
pancreatic cancer 47 | 2,398
Astrocytoma, Pilocytic 46 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
malignant mesothelioma 43 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
Kidney cancer 41 | 2,613
adult high grade glioma 41 | 3,801
group 3 medulloblastoma 41 | 4,104
invasive ductal carcinoma 39 | 2,951
lung adenocarcinoma 38 | 2,716
interstitial cystitis 36 | 2,312
non-small cell lung cancer 34 | 2,890
subependymal giant cell astrocytoma 34 | 2,287
lung carcinoma 31 | 2,843
oligodendroglioma 31 | 2,850
astrocytic glioma 29 | 2,597
ulcerative colitis 29 | 1,819
colon cancer 27 | 1,478
tuberculosis 27 | 2,010
primitive neuroectodermal tumor 26 | 3,035
pituitary cancer 25 | 1,972
breast carcinoma 24 | 1,638
diabetes mellitus 23 | 1,728
adrenocortical carcinoma 22 | 1,428
cystic fibrosis 22 | 1,696
group 4 medulloblastoma 22 | 1,855
primary pancreatic ductal adenocarcinoma 22 | 1,109
Pick disease 21 | 1,894
ductal carcinoma in situ 21 | 1,745
spina bifida 21 | 1,074
acute quadriplegic myopathy 20 | 1,158
juvenile dermatomyositis 20 | 1,187
gastric carcinoma 18 | 807
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Liver Cirrhosis, Experimental 17 | 769
cutaneous lupus erythematosus 17 | 1,057
astrocytoma 16 | 1,146
Autosomal recessive predisposition 14 | 1,442
Duchenne muscular dystrophy 14 | 601
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 510
pediatric high grade glioma 14 | 1,064
Atopic dermatitis 13 | 952
Intellectual disability 13 | 1,016
Kidney disease 13 | 430
Rheumatoid arthritis 13 | 1,191
Schizophrenia 13 | 1,160
aldosterone-producing adenoma 13 | 665
Alzheimer's disease 12 | 658
Bipolar Disorder 12 | 666
Neoplasm Invasiveness 12 | 161
Liver cancer 11 | 604
esophageal adenocarcinoma 11 | 737
mucosa-associated lymphoid tissue lymphoma 11 | 484
nasopharyngeal carcinoma 11 | 1,058
pancreatic carcinoma 11 | 562
primary Sjogren syndrome 11 | 735
sonic hedgehog group medulloblastoma 11 | 467
Down syndrome 10 | 499
dermatomyositis 10 | 966
Aarskog syndrome 9 | 12
Mental Depression 9 | 333
Multiple Sclerosis 9 | 540
Multiple myeloma 9 | 1,332
Obesity 9 | 678
Stomach Neoplasms 9 | 300
Waldenstrons macroglobulinemia 9 | 765
Breast Neoplasms 8 | 445
Melanoma 8 | 711
active Crohn's disease 8 | 922
hepatocellular carcinoma 8 | 547
medulloblastoma 8 | 720
progressive supranuclear palsy 8 | 676
sarcoidosis 8 | 370
Amyotrophic lateral sclerosis 7 | 451
Epilepsy 7 | 792
Mammary Neoplasms 7 | 425
Osteoporosis 7 | 363
Polycystic ovary syndrome 7 | 360
Prostatic Neoplasms 7 | 495
Seizures 7 | 596
atypical teratoid/rhabdoid tumor 7 | 357
gastric cancer 7 | 459
Adenoma 6 | 167
Asthma 6 | 385
Depressive disorder 6 | 409
Liver carcinoma 6 | 240
active ulcerative colitis 6 | 764
fibroadenoma 6 | 559

Tissue

Blood and immune system 152 | 16,909
Endocrine System 152 | 18,159
Liver and Pancreas 152 | 16,750
Male tissues 152 | 17,142
Skin and soft tissues 152 | 17,230
Female tissues 151 | 17,400
Respiratory system 151 | 16,393
Urinary Tract 151 | 16,678
Digestive Tract 150 | 17,369
Nervous System 149 | 16,725
Cardiovascular System 148 | 15,192

Target Family

Non-IDG 110 | 12,091
Enzyme 28 | 4,145
Kinase 16 | 634
Transporter 2 | 473
GPCR 1 | 408
Ion Channel 1 | 344

Compartment GO Term

Ruffle 158 | 158
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.87182 73.3 126
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Alsin ALS2 Tbio Non-IDG -2.20492 161.9 180
Rho GTPase-activating protein 7 DLC1 Tbio Enzyme -1.93185 106.7 137