Development Level

Tchem 8 | 1,388
Tbio 5 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
absent vibrissae 1 | 12
decreased bone mineral content 1 | 151
decreased respiratory quotient 1 | 16
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased basophil cell number 1 | 7
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Cancer 11 | 2,499
Carcinoma 10 | 11,493
ovarian cancer 8 | 8,520
lung cancer 7 | 4,740
lung carcinoma 7 | 2,843
psoriasis 7 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
glioblastoma 5 | 5,792
interstitial cystitis 5 | 2,312
osteosarcoma 5 | 7,950
Autoimmune lymphoproliferative syndrome type 2B 4 | 9
cutaneous lupus erythematosus 4 | 1,057
ependymoma 4 | 4,679
Astrocytoma, Pilocytic 3 | 3,081
Autoimmune lymphoproliferative syndrome 3 | 11
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Leukemia 3 | 104
Splenomegaly 3 | 190
Stomach Neoplasms 3 | 300
active Crohn's disease 3 | 922
atypical teratoid / rhabdoid tumor 3 | 5,112
group 4 medulloblastoma 3 | 1,855
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Alzheimer's disease 2 | 658
Autosomal recessive predisposition 2 | 1,442
Brain Ischemia 2 | 110
Breast Neoplasms 2 | 445
Constipation 2 | 181
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Diarrhea 2 | 253
Dyschezia 2 | 135
Edema 2 | 81
Fatty Liver 2 | 70
Fever 2 | 138
HIV Infections 2 | 102
Lymphadenopathy 2 | 62
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Myocardial Reperfusion Injury 2 | 37
Pick disease 2 | 1,894
Pneumonia 2 | 174
Reperfusion Injury 2 | 86
Skin Neoplasms 2 | 69
Somatic mutation 2 | 61
Type 2 diabetes mellitus 2 | 272
Vascular disease 2 | 319
active ulcerative colitis 2 | 764
adult high grade glioma 2 | 3,801
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
hepatocellular carcinoma 2 | 547
medulloblastoma, large-cell 2 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
Amyloidosis 1 | 67
Anti-nuclear factor positive 1 | 18
Appendicitis 1 | 15
Autoimmune hemolytic anemia 1 | 31
Behcet's syndrome 1 | 50
Biliary cirrhosis 1 | 45
Biopsy shows villous atrophy 1 | 16
C-reactive protein increased 1 | 15
Chronic diarrhea 1 | 29
Decreased T cell activation 1 | 4
Duodenal villous atrophy 1 | 16
ESR raised 1 | 20
Eczema 1 | 45
Elevated C-reactive protein level 1 | 15
Elevated serum IgA 1 | 5
Exanthem 1 | 37
Gastric Cancer, Hereditary Diffuse 1 | 12
Heart Valve Diseases 1 | 25
Hyperphagia 1 | 23
Increased appetite (finding) 1 | 23
Iron deficiency anemia 1 | 12
Liver Cirrhosis, Biliary 1 | 33
Lung Injury 1 | 20
Micronodular cirrhosis 1 | 12
Muscular stiffness 1 | 12
Neoplasm of stomach 1 | 11
Platelet antibody positive 1 | 4
Pneumoconiosis 1 | 15
Red hair 1 | 6
Secondary Adrenal Insufficiency 1 | 6
Small intestine biopsy shows villous atrophy 1 | 16
Stomach Carcinoma 1 | 11
Subacute progressive viral hepatitis 1 | 9
Variable degree of villous atrophy 1 | 16
Villous atrophy 1 | 16
Villous atrophy of intestine 1 | 16
esophageal cancer 1 | 22

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 3 | 4,145
Kinase 3 | 634

Compartment GO Term

Ripoptosome 13 | 13
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.22748 161.7 603
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
Baculoviral IAP repeat-containing protein 3 BIRC3 Tchem Non-IDG -2.62553 373.2 500
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.53423 308.7 351
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
CASP8 and FADD-like apoptosis regulator CFLAR Tbio Non-IDG -2.89793 871.7 683
TIR domain-containing adapter molecule 1 TICAM1 Tbio Non-IDG -1.50467 33.0 226
Caspase-10 CASP10 Tchem Enzyme -1.97653 89.1 457
Mixed lineage kinase domain-like protein MLKL Tbio Kinase -2.75630 549.8 171
Tumor necrosis factor receptor superfamily member 1A TNFRSF1A Tchem Non-IDG -3.31515 1897.3 1051