Development Level

Tbio 169 | 11,651
Tdark 26 | 6,593
Tchem 14 | 1,388
Tclin 4 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 11 | 499
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 9 | 278
abnormal embryo size 8 | 220
abnormal behavior 7 | 298
decreased grip strength 4 | 116
abnormal bone structure 3 | 187
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
embryonic growth retardation 3 | 106
increased fasted circulating g... 3 | 76
increased heart weight 3 | 62
small testis 3 | 58
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
absent startle reflex 2 | 24
cataract 2 | 92
decreased basophil cell number 2 | 16
decreased bone mineral content 2 | 151
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased erythrocyte cell num... 2 | 62
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
edema 2 | 59
enlarged heart 2 | 210
hypoactivity 2 | 132
increased body length 2 | 32
increased grip strength 2 | 41
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
pallor 2 | 34
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal locomotor behavior 1 | 24
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal spine curvature 1 | 9
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
abnormal vocalization 1 | 21
absent spleen 1 | 3
convulsive seizures 1 | 13
decreased IgE level 1 | 6
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged kidney 1 | 14
hyperactivity 1 | 148
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating phosphat... 1 | 26
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
male infertility 1 | 123
polycystic kidney 1 | 15
prenatal lethality 1 | 28
shortened RR interval 1 | 17
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 145 | 11,493
ovarian cancer 119 | 8,520
osteosarcoma 114 | 7,950
medulloblastoma, large-cell 81 | 6,241
atypical teratoid / rhabdoid tumor 75 | 5,112
glioblastoma 72 | 5,792
psoriasis 72 | 6,694
lung cancer 68 | 4,740
group 3 medulloblastoma 53 | 4,104
Cancer 52 | 2,499
Kidney cancer 51 | 2,613
ependymoma 51 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
Breast cancer 46 | 3,578
adult high grade glioma 46 | 3,801
primitive neuroectodermal tumor 43 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
oligodendroglioma 40 | 2,850
Multiple myeloma 39 | 1,332
astrocytic glioma 38 | 2,597
subependymal giant cell astrocytoma 37 | 2,287
invasive ductal carcinoma 33 | 2,951
lung adenocarcinoma 33 | 2,716
malignant mesothelioma 33 | 3,232
Astrocytoma, Pilocytic 32 | 3,081
group 4 medulloblastoma 30 | 1,855
juvenile dermatomyositis 30 | 1,187
Pick disease 28 | 1,894
acute quadriplegic myopathy 27 | 1,158
pancreatic cancer 27 | 2,398
Waldenstrons macroglobulinemia 25 | 765
dermatomyositis 25 | 966
lung carcinoma 24 | 2,843
Amyotrophic lateral sclerosis 23 | 451
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
non-small cell lung cancer 21 | 2,890
tuberculosis 20 | 2,010
adrenocortical carcinoma 19 | 1,428
Rheumatoid arthritis 18 | 1,191
astrocytoma 18 | 1,146
progressive supranuclear palsy 18 | 676
ulcerative colitis 18 | 1,819
breast carcinoma 17 | 1,638
colon cancer 16 | 1,478
cutaneous lupus erythematosus 16 | 1,057
cystic fibrosis 16 | 1,696
pituitary cancer 16 | 1,972
spina bifida 16 | 1,074
Schizophrenia 15 | 1,160
diabetes mellitus 15 | 1,728
ductal carcinoma in situ 15 | 1,745
Depressive disorder 14 | 409
Neurodegenerative disease 14 | 414
interstitial cystitis 14 | 2,312
primary pancreatic ductal adenocarcinoma 14 | 1,109
hepatocellular carcinoma 12 | 547
non primary Sjogren syndrome sicca 12 | 891
Alzheimer's disease 11 | 658
Bipolar Disorder 11 | 666
Intellectual disability 11 | 1,016
pediatric high grade glioma 11 | 1,064
Atopic dermatitis 10 | 952
Autosomal recessive predisposition 10 | 1,442
Infertility 10 | 188
Male infertility 10 | 206
active Crohn's disease 10 | 922
active ulcerative colitis 10 | 764
acute myeloid leukemia 10 | 783
medulloblastoma 10 | 720
nasopharyngeal carcinoma 10 | 1,058
Duchenne muscular dystrophy 9 | 601
Melanoma 9 | 711
atypical teratoid/rhabdoid tumor 9 | 357
primary Sjogren syndrome 9 | 735
Anxiety 8 | 136
Anxiety disease 8 | 113
Breast Neoplasms 8 | 445
Dysarthria 8 | 192
Frontotemporal dementia 8 | 51
Liver cancer 8 | 604
Mammary Neoplasms 8 | 425
Muscle hypotonia 8 | 571
aldosterone-producing adenoma 8 | 665
hereditary spastic paraplegia 8 | 318
Dementia 7 | 175
Down syndrome 7 | 499
Fatigue 7 | 182
Multiple Sclerosis 7 | 540
Myocardial Ischemia 7 | 169
Neurodegenerative Disorders 7 | 79
Parkinson's disease 7 | 392
Polycystic ovary syndrome 7 | 360
Skin cancer 7 | 469
gastric cancer 7 | 459
pancreatic carcinoma 7 | 562
sarcoidosis 7 | 370
Epilepsy 6 | 792
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
gastric carcinoma 6 | 807

Tissue

Endocrine System 206 | 18,159
Digestive Tract 203 | 17,369
Female tissues 203 | 17,400
Blood and immune system 202 | 16,909
Male tissues 202 | 17,142
Liver and Pancreas 200 | 16,750
Nervous System 200 | 16,725
Respiratory system 200 | 16,393
Skin and soft tissues 200 | 17,230
Urinary Tract 199 | 16,678
Cardiovascular System 193 | 15,192

Target Family

Non-IDG 140 | 12,091
Enzyme 52 | 4,145
Epigenetic 9 | 242
Transcription Factor 6 | 1,400
Kinase 5 | 634
TF/Epigenetic 1 | 38

Compartment GO Term

Ribonucleoprotein granule 213 | 213
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
Nucleolysin TIA-1 isoform p40 TIA1 Tbio Non-IDG -2.86461 714.2 314
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
Synphilin-1 SNCAIP Tbio Non-IDG -1.92755 92.1 157
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
EP300-interacting inhibitor of differentiation 1 EID1 Tbio Non-IDG -1.90769 78.8 100
Protein argonaute-1 AGO1 Tbio Non-IDG -2.22336 158.4 203
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Putative small nuclear ribonucleoprotein G-like protein 15 SNRPGP15 Tdark Non-IDG 0.12 1.33 0