Development Level

Tbio 627 | 11,445
Tdark 164 | 6,588
Tchem 55 | 1,598
Tclin 19 | 613

Collection

Kinase: IDG Consortium (Target... 7 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 88 | 979
embryonic lethality prior to o... 34 | 239
embryonic lethality prior to t... 24 | 278
preweaning lethality, incomple... 17 | 499
abnormal embryo size 15 | 220
abnormal behavior 13 | 298
abnormal bone structure 13 | 187
embryonic growth retardation 10 | 106
prenatal lethality prior to he... 9 | 87
abnormal retina morphology 7 | 71
decreased bone mineral density 7 | 126
enlarged heart 7 | 210
increased fasted circulating g... 7 | 76
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
decreased leukocyte cell numbe... 6 | 73
increased lean body mass 6 | 172
increased mean corpuscular hem... 6 | 96
increased mean corpuscular vol... 6 | 92
increased total body fat amoun... 6 | 134
abnormal coat-hair pigmentatio... 5 | 64
abnormal heart morphology 5 | 162
decreased bone mineral content 5 | 151
decreased neutrophil cell numb... 5 | 42
decreased vertical activity 5 | 208
hypoactivity 5 | 132
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
increased grip strength 5 | 41
increased mean platelet volume 5 | 45
male infertility 5 | 123
abnormal lens morphology 4 | 81
decreased circulating choleste... 4 | 93
decreased lean body mass 4 | 135
decreased total body fat amoun... 4 | 207
short tibia 4 | 97
abnormal behavioral response t... 3 | 66
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
cataract 3 | 92
decreased erythrocyte cell num... 3 | 62
decreased lymphocyte cell numb... 3 | 83
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased circulating HDL chol... 3 | 80
increased circulating chloride... 3 | 41
increased circulating choleste... 3 | 66
increased circulating total pr... 3 | 28
increased heart weight 3 | 62
increased lymphocyte cell numb... 3 | 32
increased or absent threshold ... 3 | 101
increased startle reflex 3 | 112
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal skin morphology 2 | 50
abnormal snout morphology 2 | 23
abnormal spine curvature 2 | 9
absent startle reflex 2 | 24
cardiovascular system phenotyp... 2 | 36
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating phosphat... 2 | 27
decreased circulating potassiu... 2 | 20
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
decreased startle reflex 2 | 75
edema 2 | 59
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased body length 2 | 32
increased bone mineral density 2 | 72
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased erythrocyte cell num... 2 | 39
increased spleen weight 2 | 10
pallor 2 | 34
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
thrombocytosis 2 | 27
vertebral fusion 2 | 23
vertebral transformation 2 | 12

Disease

ovarian cancer 504 | 8,520
Carcinoma 497 | 11,493
osteosarcoma 367 | 7,950
lung cancer 278 | 4,740
medulloblastoma, large-cell 275 | 6,241
psoriasis 250 | 6,694
group 3 medulloblastoma 220 | 4,104
glioblastoma 219 | 5,792
atypical teratoid / rhabdoid tumor 197 | 5,112
Multiple myeloma 182 | 1,332
ependymoma 158 | 4,679
Breast cancer 145 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 134 | 3,291
Cancer 132 | 2,499
oligodendroglioma 129 | 2,850
malignant mesothelioma 123 | 3,232
primitive neuroectodermal tumor 121 | 3,035
Kidney cancer 120 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 120 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 118 | 2,989
adult high grade glioma 114 | 3,801
acute quadriplegic myopathy 113 | 1,158
diabetes mellitus 109 | 1,728
Waldenstrons macroglobulinemia 102 | 765
astrocytic glioma 100 | 2,597
non-small cell lung cancer 99 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 95 | 1,962
lung adenocarcinoma 92 | 2,716
invasive ductal carcinoma 86 | 2,951
subependymal giant cell astrocytoma 83 | 2,287
dermatomyositis 81 | 966
Pick disease 80 | 1,894
astrocytoma 80 | 1,146
Astrocytoma, Pilocytic 73 | 3,081
colon cancer 70 | 1,478
juvenile dermatomyositis 67 | 1,187
pancreatic cancer 66 | 2,398
group 4 medulloblastoma 61 | 1,855
non primary Sjogren syndrome sicca 56 | 891
Intellectual disability 55 | 1,016
acute myeloid leukemia 54 | 783
breast carcinoma 51 | 1,638
pediatric high grade glioma 51 | 1,064
cystic fibrosis 50 | 1,696
progressive supranuclear palsy 49 | 676
lung carcinoma 45 | 2,843
tuberculosis 44 | 2,010
Amyotrophic lateral sclerosis 43 | 451
Rheumatoid arthritis 43 | 1,191
adrenocortical carcinoma 40 | 1,428
Autosomal recessive predisposition 38 | 1,442
pituitary cancer 38 | 1,972
primary pancreatic ductal adenocarcinoma 37 | 1,109
Breast Neoplasms 36 | 445
ulcerative colitis 36 | 1,819
Mammary Neoplasms 35 | 425
Neurodegenerative disease 35 | 414
Schizophrenia 35 | 1,160
Anemia 34 | 365
Short stature 33 | 531
spina bifida 33 | 1,074
nasopharyngeal carcinoma 32 | 1,058
hepatocellular carcinoma 31 | 547
Dull intelligence 30 | 645
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Poor school performance 30 | 645
Stomach Neoplasms 30 | 300
cutaneous lupus erythematosus 30 | 1,057
Disease Models, Animal 29 | 155
Fatigue 29 | 182
ductal carcinoma in situ 29 | 1,745
Adenocarcinoma of lung 28 | 142
Epilepsy 28 | 792
sonic hedgehog group medulloblastoma 28 | 467
tuberculosis and treatment for 6 months 28 | 409
Alzheimer's disease 27 | 658
Cognitive delay 27 | 608
Diamond-Blackfan anemia 27 | 31
Disease Progression 27 | 136
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
Melanoma 26 | 711
Prostatic Neoplasms 26 | 495
Bipolar Disorder 25 | 666
Depressive disorder 25 | 409
interstitial cystitis 25 | 2,312
Cleft Palate 24 | 271
Obesity 24 | 678
medulloblastoma 24 | 720
Cardiac Arrhythmia 23 | 103
Cardiac conduction abnormalities 23 | 78
Conduction disorder of the heart 23 | 79
EKG abnormalities 23 | 78
Electrocardiogram abnormal 23 | 81
Electrocardiogram change 23 | 78
Osteoporosis 23 | 363
Small head 23 | 374
active Crohn's disease 23 | 922

Tissue

Endocrine System 843 | 18,159
Female tissues 835 | 17,400
Digestive Tract 834 | 17,369
Blood and immune system 832 | 16,909
Male tissues 831 | 17,142
Skin and soft tissues 831 | 17,230
Nervous System 829 | 16,725
Liver and Pancreas 828 | 16,750
Respiratory system 826 | 16,393
Urinary Tract 826 | 16,678
Cardiovascular System 813 | 15,192

Target Family

Non-IDG 648 | 12,091
Enzyme 160 | 4,145
Kinase 24 | 634
Epigenetic 14 | 242
Transcription Factor 14 | 1,400
Transporter 2 | 473
GPCR 1 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

Ribonucleoprotein complex 865 | 865
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
NACHT domain- and WD repeat-containing protein 1 NWD1 Tdark Non-IDG 0.08 1.22 3
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Poly [ADP-ribose] polymerase 4 PARP4 Tchem Enzyme -1.45503 26.0 123
RNA-binding protein Raly RALY Tbio Non-IDG -1.12263 14.4 176
Putative postmeiotic segregation increased 2-like protein 1 PMS2P1 Tdark Enzyme -2.19299 339.5 0
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18