Development Level

Tbio 66 | 11,651
Tclin 49 | 612
Tdark 11 | 6,593
Tchem 7 | 1,388

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 24 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 7 | 278
abnormal embryo size 5 | 220
pallor 4 | 34
cataract 3 | 92
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
decreased bone mineral content 2 | 151
preweaning lethality, incomple... 2 | 499
abnormal allantois morphology 1 | 8
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal digit morphology 1 | 10
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal embryonic autopod pla... 1 | 2
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
abnormal sensory capabilities-... 1 | 8
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased circulating LDL chol... 1 | 38
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating free fat... 1 | 31
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased total retina thickne... 1 | 17
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pale yolk sac 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
vertebral fusion 1 | 23

Disease

ovarian cancer 69 | 8,520
Diabetes mellitus type 2 48 | 69
Treatment Refractory Type 2 Diabetes Mellitus 48 | 53
osteosarcoma 46 | 7,950
Cerebellar Ataxia 44 | 304
Leigh disease 44 | 100
Multiple myeloma 42 | 1,332
Carcinoma 41 | 11,493
Autosomal recessive predisposition 40 | 1,442
Acidosis, Lactic 36 | 97
Lactic acidemia 36 | 95
psoriasis 35 | 6,694
lung cancer 33 | 4,740
Blepharoptosis 32 | 231
Cognitive delay 32 | 608
Global developmental delay 32 | 608
Mental and motor retardation 32 | 608
Sensorineural Hearing Loss (disorder) 32 | 284
Mitochondrial complex I deficiency 31 | 46
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
Epilepsy 29 | 792
Increased serum lactate 29 | 60
Seizures 29 | 596
Muscle hypotonia 28 | 571
Nystagmus 28 | 317
Optic Atrophy 28 | 242
Failure to gain weight 27 | 365
Pediatric failure to thrive 27 | 365
diabetes mellitus 27 | 1,728
Highly variable clinical phenotype 26 | 150
Highly variable phenotype and severity 26 | 150
Highly variable phenotype, even within families 26 | 150
Phenotypic variability 26 | 150
Dystonia 25 | 164
astrocytic glioma 25 | 2,597
glioblastoma 25 | 5,792
medulloblastoma, large-cell 25 | 6,241
CSF lactate increased 24 | 33
Dystonic disease 24 | 106
Muscle Weakness 24 | 170
ependymoma 24 | 4,679
Hyperreflexia 23 | 209
Hypertrophic Cardiomyopathy 23 | 117
Muscle Spasticity 23 | 195
Developmental regression 22 | 95
Leigh syndrome 22 | 28
Loss of developmental milestones 22 | 95
Mental deterioration in childhood 22 | 95
Neurodevelopmental regression 22 | 95
Psychomotor regression 22 | 95
Psychomotor regression beginning in infancy 22 | 95
Psychomotor regression in infants 22 | 95
Psychomotor regression, progressive 22 | 95
Respiratory Failure 22 | 104
Strabismus 22 | 270
Mitochondrial Complex 1 Deficiency 21 | 28
atypical teratoid / rhabdoid tumor 21 | 5,112
Dull intelligence 20 | 645
Intellectual disability 20 | 1,016
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Ophthalmoplegia 20 | 106
Poor school performance 20 | 645
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Impaired exercise tolerance 19 | 42
Retinitis Pigmentosa 19 | 226
Abnormal mitochondria in muscle tissue 18 | 20
Cancer 18 | 2,499
NADH:Q(1) Oxidoreductase deficiency 18 | 24
Atrophy of cerebellum 16 | 103
Cerebellar degeneration 16 | 103
Dysarthria 16 | 192
Hypoglycemia 16 | 152
Infratentorial atrophy 16 | 103
Liver Failure 16 | 73
Obesity 16 | 678
Babinski Reflex 15 | 100
Lactic acidosis 15 | 51
Neurogenic Muscular Atrophy 15 | 139
Neurogenic muscle atrophy, especially in the lower limbs 15 | 139
Schizophrenia 15 | 1,160
Skeletal muscle atrophy 15 | 139
Waldenstrons macroglobulinemia 15 | 765
muscle degeneration 15 | 139
Comatose 14 | 56
Decreased tendon reflex 14 | 122
Feeding difficulties in infancy 14 | 175
Heart failure 14 | 162
Infantile onset 14 | 238
Mood swings 14 | 77
Myopathy 14 | 185
Vomiting 14 | 116
X-linked dominant 14 | 57
Blind Vision 13 | 111
Blindness, Legal 13 | 110
Gliosis 13 | 56
Lethargy 13 | 77
Neuropathy 13 | 261
Progressive disorder 13 | 142

Tissue

Endocrine System 131 | 18,159
Blood and immune system 130 | 16,909
Digestive Tract 130 | 17,369
Female tissues 130 | 17,400
Male tissues 130 | 17,142
Skin and soft tissues 130 | 17,230
Urinary Tract 130 | 16,678
Liver and Pancreas 129 | 16,750
Nervous System 129 | 16,725
Cardiovascular System 128 | 15,192
Respiratory system 127 | 16,393

Target Family

Enzyme 96 | 4,145
Non-IDG 30 | 12,091
Kinase 2 | 634
Transcription Factor 2 | 1,400
Transporter 2 | 473
Nuclear Receptor 1 | 48

Compartment GO Term

Respiratory chain 133 | 133
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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