Development Level

Tbio 319 | 11,445
Tchem 176 | 1,598
Tclin 172 | 613
Tdark 19 | 6,588

Collection

RFA-RM-18-021 18 | 328
Ion Channel: IDG Consortium (T... 11 | 99
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 41 | 979
preweaning lethality, incomple... 25 | 499
decreased vertical activity 17 | 208
embryonic lethality prior to t... 17 | 278
abnormal embryo size 15 | 220
abnormal behavior 13 | 298
embryonic lethality prior to o... 13 | 239
enlarged heart 11 | 210
increased total body fat amoun... 10 | 134
decreased total body fat amoun... 9 | 207
embryonic growth retardation 9 | 106
increased lean body mass 9 | 172
increased mean corpuscular vol... 9 | 92
decreased body weight 8 | 161
decreased bone mineral content 8 | 151
increased circulating HDL chol... 8 | 80
increased startle reflex 8 | 112
small superior vagus ganglion 8 | 74
abnormal bone structure 7 | 187
decreased heart weight 7 | 27
decreased lean body mass 7 | 135
decreased lymphocyte cell numb... 7 | 83
decreased mean corpuscular vol... 7 | 79
increased circulating sodium l... 7 | 71
increased neutrophil cell numb... 7 | 46
limb grasping 7 | 41
abnormal seminal vesicle morph... 6 | 114
decreased prepulse inhibition 6 | 82
improved glucose tolerance 6 | 79
increased circulating alkaline... 6 | 122
increased circulating choleste... 6 | 66
thrombocytopenia 6 | 56
abnormal gait 5 | 69
abnormal heart morphology 5 | 162
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
hyperactivity 5 | 148
increased bone mineral content 5 | 108
increased erythrocyte cell num... 5 | 39
increased lymphocyte cell numb... 5 | 32
increased monocyte cell number 5 | 63
short tibia 5 | 97
tremors 5 | 39
abnormal kidney morphology 4 | 65
abnormal retina morphology 4 | 71
decreased circulating LDL chol... 4 | 38
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
decreased circulating serum al... 4 | 82
decreased circulating sodium l... 4 | 22
decreased fasted circulating g... 4 | 65
decreased grip strength 4 | 116
decreased leukocyte cell numbe... 4 | 73
decreased neutrophil cell numb... 4 | 42
hydrometra 4 | 53
hypoactivity 4 | 132
increased circulating iron lev... 4 | 30
increased circulating total pr... 4 | 28
increased circulating triglyce... 4 | 42
increased leukocyte cell numbe... 4 | 47
increased mean corpuscular hem... 4 | 96
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
small testis 4 | 58
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal epididymis morphology 3 | 42
abnormal eye anterior chamber ... 3 | 9
abnormal lung morphology 3 | 26
abnormal pericardium morpholog... 3 | 26
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
abnormal testis morphology 3 | 43
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased circulating alkaline... 3 | 46
decreased circulating glucose ... 3 | 126
decreased hemoglobin content 3 | 68
decreased large unstained cell... 3 | 11
decreased mean corpuscular hem... 3 | 50
decreased startle reflex 3 | 75
edema 3 | 59
enlarged lymph nodes 3 | 37
enlarged uterus 3 | 11
impaired righting response 3 | 26
increased bone mineral density 3 | 72
increased circulating calcium ... 3 | 34
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased circulating phosphat... 3 | 26
increased circulating serum al... 3 | 22
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
increased mean platelet volume 3 | 45
increased spleen weight 3 | 10
male infertility 3 | 123
decreased bone mineral density 2 | 126
decreased circulating insulin ... 2 | 76
decreased hematocrit 2 | 46
impaired glucose tolerance 2 | 75

Disease

Carcinoma 510 | 11,493
Cancer 410 | 2,499
osteosarcoma 350 | 7,950
psoriasis 349 | 6,694
ovarian cancer 335 | 8,520
glioblastoma 317 | 5,792
lung cancer 286 | 4,740
medulloblastoma, large-cell 266 | 6,241
lung carcinoma 234 | 2,843
atypical teratoid / rhabdoid tumor 231 | 5,112
ependymoma 229 | 4,679
adult high grade glioma 216 | 3,801
Astrocytoma, Pilocytic 213 | 3,081
Schizophrenia 195 | 1,160
interstitial cystitis 195 | 2,312
malignant mesothelioma 193 | 3,232
Breast cancer 190 | 3,578
diabetes mellitus 185 | 1,728
invasive ductal carcinoma 182 | 2,951
non-small cell lung cancer 173 | 2,890
tuberculosis 164 | 2,010
ulcerative colitis 161 | 1,819
Kidney cancer 160 | 2,613
lung adenocarcinoma 159 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 157 | 3,291
pancreatic cancer 152 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 147 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 146 | 2,955
group 3 medulloblastoma 144 | 4,104
subependymal giant cell astrocytoma 144 | 2,287
oligodendroglioma 133 | 2,850
primitive neuroectodermal tumor 131 | 3,035
Autosomal recessive predisposition 125 | 1,442
Kidney disease 121 | 430
Obesity 121 | 678
Rheumatoid arthritis 121 | 1,191
cystic fibrosis 121 | 1,696
cutaneous lupus erythematosus 115 | 1,057
Hypertension 112 | 396
Arthritis 111 | 290
astrocytic glioma 111 | 2,597
pituitary cancer 111 | 1,972
Bipolar Disorder 110 | 666
ductal carcinoma in situ 107 | 1,745
Asthma 103 | 385
Hypersensitivity reaction type II disease 103 | 253
Alzheimer's disease 98 | 658
Liver Cirrhosis, Experimental 98 | 769
Multiple Sclerosis 97 | 540
colon cancer 95 | 1,478
breast carcinoma 94 | 1,638
Heart disease 93 | 306
group 4 medulloblastoma 92 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 92 | 1,962
Depressive disorder 91 | 409
Vascular disease 89 | 319
Atherosclerosis 88 | 291
Epilepsy 88 | 792
Breast Neoplasms 82 | 445
Major Depressive Disorder 81 | 301
Pick disease 81 | 1,894
adrenocortical carcinoma 81 | 1,428
Anemia 80 | 365
Mammary Neoplasms 80 | 425
Coronary artery disease 79 | 268
Cerebrovascular disease 78 | 238
Liver disease 77 | 237
Alcoholic Intoxication, Chronic 76 | 289
Hypertensive disease 76 | 292
Prostatic Neoplasms 76 | 495
primary Sjogren syndrome 76 | 735
Inflammatory bowel disease 75 | 151
Mental Depression 75 | 333
Melanoma 74 | 711
Lung disease 73 | 142
astrocytoma 73 | 1,146
primary pancreatic ductal adenocarcinoma 70 | 1,109
Autistic Disorder 68 | 364
Diarrhea 67 | 253
Unipolar Depression 66 | 250
juvenile dermatomyositis 65 | 1,187
gastric carcinoma 64 | 807
Seizures 61 | 596
Thrombocytopenia 61 | 197
mucosa-associated lymphoid tissue lymphoma 61 | 484
Parkinson's disease 57 | 392
Dermatitis 56 | 157
Osteoporosis 56 | 363
Allergic hypersensitivity disease 55 | 126
Endometriosis 55 | 540
Stomach Neoplasms 55 | 300
Pneumonia 54 | 174
pediatric high grade glioma 54 | 1,064
Atopic dermatitis 53 | 952
Intellectual disability 53 | 1,016
nasopharyngeal carcinoma 53 | 1,058
periodontitis 53 | 293
Multiple myeloma 52 | 1,332
dermatomyositis 51 | 966
esophageal adenocarcinoma 51 | 737

Tissue

Endocrine System 661 | 18,159
Digestive Tract 650 | 17,369
Female tissues 640 | 17,400
Skin and soft tissues 638 | 17,230
Male tissues 637 | 17,142
Blood and immune system 634 | 16,909
Nervous System 633 | 16,725
Liver and Pancreas 629 | 16,750
Urinary Tract 626 | 16,678
Respiratory system 614 | 16,393
Cardiovascular System 563 | 15,192

Target Family

Non-IDG 373 | 12,091
GPCR 76 | 408
Ion Channel 72 | 344
Kinase 60 | 634
Enzyme 56 | 4,145
Transcription Factor 25 | 1,400
Nuclear Receptor 15 | 48
Transporter 7 | 473
Epigenetic 2 | 242

Compartment GO Term

Receptor complex 686 | 686
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154