Development Level

Tbio 264 | 10,625
Tchem 214 | 1,890
Tclin 159 | 602
Tdark 19 | 7,003

Collection

Eligible Ion Channel Proteins 21 | 117
Eligible non-olfactory GPCR Proteins 8 | 145

IMPC Term

preweaning lethality, complete... 30 | 633
preweaning lethality, incomple... 14 | 260
embryonic lethality prior to t... 10 | 187
abnormal behavior 8 | 226
abnormal embryo size 8 | 112
decreased body weight 8 | 174
decreased bone mineral content 7 | 157
decreased grip strength 7 | 123
decreased total body fat amoun... 7 | 186
embryonic lethality prior to o... 7 | 148
enlarged heart 7 | 111
decreased lean body mass 6 | 195
decreased prepulse inhibition 6 | 52
increased circulating HDL chol... 6 | 63
increased mean corpuscular vol... 6 | 91
decreased bone mineral density 5 | 126
decreased circulating choleste... 5 | 85
decreased mean corpuscular vol... 5 | 50
improved glucose tolerance 5 | 56
increased circulating alkaline... 5 | 119
increased circulating phosphat... 5 | 24
increased lean body mass 5 | 107
thrombocytopenia 5 | 46
abnormal behavioral response t... 4 | 52
abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating calcium ... 4 | 33
decreased circulating glucose ... 4 | 121
decreased circulating triglyce... 4 | 83
increased bone mineral content 4 | 92
increased circulating choleste... 4 | 53
increased hematocrit 4 | 36
increased mean corpuscular hem... 4 | 93
limb grasping 4 | 35
tremors 4 | 34
abnormal epididymis morphology 3 | 31
abnormal forebrain development 3 | 18
abnormal gait 3 | 51
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
abnormal retina morphology 3 | 100
decreased circulating LDL chol... 3 | 37
decreased circulating alkaline... 3 | 41
decreased circulating creatini... 3 | 31
decreased circulating sodium l... 3 | 18
decreased fasted circulating g... 3 | 49
decreased heart weight 3 | 44
decreased leukocyte cell numbe... 3 | 54
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
increased bone mineral density 3 | 52
increased circulating calcium ... 3 | 32
increased circulating creatini... 3 | 29
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 24
increased grip strength 3 | 83
increased hemoglobin content 3 | 45
increased or absent threshold ... 3 | 128
increased total body fat amoun... 3 | 57
abnormal coping response 2 | 12
abnormal eye morphology 2 | 38
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal lung morphology 2 | 15
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
cardiovascular system phenotyp... 2 | 35
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased T cell number 2 | 31
decreased alpha-beta T cell nu... 2 | 12
decreased blood urea nitrogen ... 2 | 31
decreased circulating bilirubi... 2 | 14
decreased circulating chloride... 2 | 32
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased monocyte cell number 2 | 28
decreased neutrophil cell numb... 2 | 37
decreased startle reflex 2 | 48
enlarged epididymis 2 | 27
hyperactivity 2 | 108
increased body weight 2 | 42
increased circulating free fat... 2 | 17
increased circulating potassiu... 2 | 31
increased circulating serum al... 2 | 25
increased circulating total pr... 2 | 20
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 25
increased prepulse inhibition 2 | 21
increased startle reflex 2 | 38
small superior vagus ganglion 2 | 20
small testis 2 | 37

Disease

Cancer 371 | 2,346
psoriasis 334 | 6,685
osteosarcoma 332 | 7,933
ovarian cancer 320 | 8,492
glioblastoma 299 | 5,572
medulloblastoma, large-cell 261 | 6,234
lung cancer 260 | 4,473
lung carcinoma 226 | 2,844
pilocytic astrocytoma 206 | 3,086
atypical teratoid / rhabdoid tumor 193 | 4,369
interstitial cystitis 189 | 2,299
invasive ductal carcinoma 176 | 2,950
ulcerative colitis 175 | 2,087
diabetes mellitus 170 | 1,663
malignant mesothelioma 166 | 3,163
pediatric high grade glioma 159 | 2,712
Carcinoma 155 | 2,147
non-small cell lung cancer 152 | 2,798
lung adenocarcinoma 151 | 2,714
Breast cancer 149 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 148 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 141 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 140 | 2,988
subependymal giant cell astrocytoma 140 | 2,287
pancreatic cancer 139 | 2,300
tuberculosis 139 | 1,563
oligodendroglioma 130 | 2,849
primitive neuroectodermal tumor 129 | 3,031
cystic fibrosis 117 | 1,670
ependymoma 116 | 2,514
Rheumatoid Arthritis 113 | 1,171
Kidney disease 112 | 397
cutaneous lupus erythematosus 109 | 1,056
Obesity 105 | 616
pituitary cancer 105 | 1,972
adult high grade glioma 102 | 2,148
ductal carcinoma in situ 102 | 1,745
Asthma 99 | 349
astrocytoma 99 | 1,493
group 4 medulloblastoma 98 | 1,875
posterior fossa group A ependymoma 97 | 1,511
Arthritis 94 | 248
Alzheimer's disease 93 | 644
colon cancer 93 | 1,475
Hypersensitivity reaction type II disease 92 | 235
Multiple Sclerosis 91 | 498
Schizophrenia 90 | 503
Hypertension 89 | 293
astrocytic glioma 84 | 2,241
breast carcinoma 84 | 1,614
Heart disease 83 | 279
primary Sjogren syndrome 83 | 789
Atherosclerosis 81 | 275
pancreatic ductal adenocarcinoma liver metastasis 79 | 1,795
Pick disease 78 | 1,893
primary pancreatic ductal adenocarcinoma 77 | 1,271
adrenocortical carcinoma 76 | 1,427
Mammary Neoplasms 74 | 410
Prostatic Neoplasms 74 | 471
Cerebrovascular disease 72 | 231
Inflammatory bowel disease 71 | 142
Liver disease 71 | 219
Vascular disease 71 | 281
Coronary artery disease 69 | 240
Lung disease 69 | 136
gastric carcinoma 66 | 832
juvenile dermatomyositis 65 | 1,189
Anemia 64 | 252
Epilepsy 64 | 346
Autistic Disorder 62 | 320
group 3 medulloblastoma 62 | 2,254
sonic hedgehog group medulloblastoma 60 | 1,482
medulloblastoma 59 | 1,524
mucosa-associated lymphoid tissue lymphoma 59 | 480
Endometriosis 57 | 535
Parkinson's disease 54 | 364
nasopharyngeal carcinoma 52 | 1,056
Metabolic syndrome X 51 | 155
Multiple myeloma 50 | 1,328
Thrombocytopenia 50 | 105
acute quadriplegic myopathy 50 | 1,157
dermatomyositis 50 | 967
esophageal adenocarcinoma 50 | 737
Allergic hypersensitivity disease 49 | 123
Atopic dermatitis 49 | 944
Dermatitis 49 | 141
Down syndrome 49 | 548
Duchenne muscular dystrophy 49 | 602
Hypertensive disease 48 | 193
non-small cell lung carcinoma 48 | 413
posterior fossa group B ependymoma 48 | 1,530
Diarrhea 47 | 155
Osteoporosis 47 | 259
Stomach Neoplasms 47 | 282
Lung Neoplasms 46 | 171
Adenoma 45 | 165
Inflammation 45 | 109
Neoplasm Metastasis 45 | 138
periodontitis 45 | 269
sarcoidosis 45 | 368

Tissue

Female tissues 646 | 18,647
Nervous System 646 | 18,561
Urinary Tract 645 | 18,444
Digestive Tract 644 | 18,473
Endocrine System 644 | 18,512
Liver and Pancreas 638 | 18,136
Skin and soft tissues 636 | 18,115
Blood and immune system 634 | 17,995
Cardiovascular System 633 | 17,958
Respiratory system 630 | 17,484
Male tissues 622 | 17,969

Target Family

Non-IDG 363 | 11,969
Ion Channel 73 | 341
GPCR 70 | 408
Kinase 57 | 634
Enzyme 52 | 4,146
Transcription Factor 22 | 1,400
Nuclear Receptor 12 | 48
Transporter 6 | 473
Epigenetic 1 | 242

Compartment GO Term

Receptor complex 656 | 656
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
5'-nucleotidase domain-containing protein 3 NT5DC3 Tdark Enzyme -1.72530 52.1 19
Fermitin family homolog 3 FERMT3 Tbio Non-IDG -1.81454 71.6 125
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.59865 595.2 0
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.59865 595.2 386
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561
Guanine nucleotide-binding protein subunit alpha-15 GNA15 Tbio Non-IDG -2.74618 475.0 155
Plexin-A4 PLXNA4 Tbio Non-IDG -1.39542 24.7 96
Activin receptor type-2A ACVR2A Tchem Kinase -2.04309 96.6 269
Metabotropic glutamate receptor 7 GRM7 Tbio GPCR -2.23649 186.6 266