Development Level

Tbio 78 | 11,445
Tchem 55 | 1,598
Tclin 12 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 979
embryonic lethality prior to t... 10 | 278
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to o... 8 | 239
abnormal embryo size 6 | 220
abnormal bone structure 3 | 187
decreased vertical activity 3 | 208
increased lean body mass 3 | 172
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal testis morphology 2 | 43
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased leukocyte cell numbe... 2 | 73
decreased mean platelet volume 2 | 25
decreased red blood cell distr... 2 | 41
decreased total body fat amoun... 2 | 207
edema 2 | 59
enlarged epididymis 2 | 31
enlarged heart 2 | 210
enlarged spleen 2 | 41
female infertility 2 | 60
increased circulating LDL chol... 2 | 13
increased circulating choleste... 2 | 66
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
male infertility 2 | 123
microphthalmia 2 | 26
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
absent vibrissae 1 | 12
anophthalmia 1 | 33
decreased IgG1 level 1 | 8
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased monocyte cell number 1 | 8
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased vertical activity 1 | 24
pale yolk sac 1 | 25
pallor 1 | 34
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
thrombocytosis 1 | 27
tremors 1 | 39
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

ovarian cancer 101 | 8,520
Carcinoma 98 | 11,493
Cancer 94 | 2,499
osteosarcoma 81 | 7,950
psoriasis 64 | 6,694
lung cancer 61 | 4,740
glioblastoma 57 | 5,792
medulloblastoma, large-cell 54 | 6,241
diabetes mellitus 50 | 1,728
Breast cancer 49 | 3,578
group 3 medulloblastoma 45 | 4,104
atypical teratoid / rhabdoid tumor 44 | 5,112
ependymoma 44 | 4,679
malignant mesothelioma 40 | 3,232
Kidney cancer 34 | 2,613
adult high grade glioma 34 | 3,801
primitive neuroectodermal tumor 34 | 3,035
oligodendroglioma 33 | 2,850
Obesity 32 | 678
Schizophrenia 32 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
astrocytic glioma 29 | 2,597
invasive ductal carcinoma 29 | 2,951
pancreatic cancer 28 | 2,398
Pick disease 27 | 1,894
non-small cell lung cancer 27 | 2,890
lung adenocarcinoma 26 | 2,716
breast carcinoma 25 | 1,638
ulcerative colitis 25 | 1,819
Astrocytoma, Pilocytic 24 | 3,081
acute quadriplegic myopathy 24 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
Alzheimer's disease 23 | 658
Autosomal recessive predisposition 23 | 1,442
Hyperglycemia 23 | 137
subependymal giant cell astrocytoma 23 | 2,287
Breast Neoplasms 22 | 445
Hypertension 22 | 396
Mammary Neoplasms 22 | 425
adrenocortical carcinoma 22 | 1,428
astrocytoma 22 | 1,146
Epilepsy 21 | 792
Intellectual disability 21 | 1,016
Liver Cirrhosis, Experimental 21 | 769
lung carcinoma 21 | 2,843
Hypertensive disease 20 | 292
Kidney disease 20 | 430
Vascular disease 20 | 319
colon cancer 20 | 1,478
ductal carcinoma in situ 20 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Heart disease 19 | 306
Prostatic Neoplasms 19 | 495
group 4 medulloblastoma 19 | 1,855
Carcinoma, Hepatocellular 18 | 228
Diabetes Mellitus, Non-Insulin-Dependent 18 | 145
Liver carcinoma 18 | 240
Polycystic ovary syndrome 18 | 360
interstitial cystitis 18 | 2,312
tuberculosis 18 | 2,010
Diabetes Mellitus, Type 2 17 | 142
Insulin Resistance 17 | 72
Rheumatoid arthritis 17 | 1,191
Seizures 17 | 596
Stomach Neoplasms 17 | 300
Short stature 16 | 531
acute myeloid leukemia 16 | 783
cystic fibrosis 16 | 1,696
Diabetes Mellitus, Experimental 15 | 108
Dull intelligence 15 | 645
Hyperinsulinism 15 | 133
Low intelligence 15 | 645
Lung Neoplasms 15 | 232
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
Toxic encephalopathy 15 | 141
Atopic dermatitis 14 | 952
Colonic Neoplasms 14 | 142
Coronary artery disease 14 | 268
Liver disease 14 | 237
Multiple myeloma 14 | 1,332
Waldenstrons macroglobulinemia 14 | 765
juvenile dermatomyositis 14 | 1,187
nasopharyngeal carcinoma 14 | 1,058
primary pancreatic ductal adenocarcinoma 14 | 1,109
Anemia 13 | 365
Arthritis 13 | 290
Atherosclerosis 13 | 291
Cerebrovascular disease 13 | 238
Colorectal Neoplasms 13 | 243
Fatty liver disease 13 | 103
Osteoporosis 13 | 363
dermatomyositis 13 | 966
pediatric high grade glioma 13 | 1,064
Asthma 12 | 385
Depressive disorder 12 | 409
Small head 12 | 374
pituitary cancer 12 | 1,972

Tissue

Blood and immune system 147 | 16,909
Female tissues 147 | 17,400
Nervous System 147 | 16,725
Skin and soft tissues 147 | 17,230
Digestive Tract 146 | 17,369
Endocrine System 146 | 18,159
Liver and Pancreas 146 | 16,750
Respiratory system 146 | 16,393
Urinary Tract 146 | 16,678
Cardiovascular System 145 | 15,192
Male tissues 145 | 17,142

Target Family

Non-IDG 66 | 12,091
Kinase 47 | 634
Enzyme 16 | 4,145
Transcription Factor 13 | 1,400
Epigenetic 3 | 242
Transporter 2 | 473
Nuclear Receptor 1 | 48

Compartment GO Term

Protein kinase complex 148 | 148
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Tchem Kinase -2.19064 152.6 547
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Cyclin-Y CCNY Tbio Non-IDG -1.48139 30.1 120
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157