Development Level

Tbio 3 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal retina morphology 1 | 71
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased bone mineral density 1 | 72
increased lymphocyte cell numb... 1 | 32
thrombocytopenia 1 | 56

Disease

Carcinoma 4 | 11,493
Multiple myeloma 3 | 1,332
Progeria 3 | 25
ovarian cancer 3 | 8,520
Abnormal trabecular bone morphology 2 | 6
Abnormal urinary amino-acid findings 2 | 38
Absence of pubertal development 2 | 17
Absent eyelashes 2 | 16
Acanthosis Nigricans 2 | 27
Acro-Osteolysis 2 | 12
Acro-osteolysis of distal phalanges 2 | 4
Acroosteolysis of distal phalanges (feet) 2 | 2
Aminoaciduria 2 | 38
Aplasia of eyelashes 2 | 16
Aplasia/Hypoplasia of the clavicles 2 | 2
Aplasia/Hypoplasia of the earlobes 2 | 10
Aplastic clavicles 2 | 6
Arteriosclerosis of small cerebral arteries 2 | 3
Atrophic condition of skin 2 | 25
Auricular malformation 2 | 41
Bilateral coxa valga 2 | 3
Bipartite clavicle 2 | 5
Bird-like facies 2 | 4
Brachyonychia 2 | 6
Bullet vertebral body 2 | 17
Calcinosis 2 | 70
Choanal Atresia 2 | 42
Congenital hypoplasia of clavicle 2 | 18
Convex nasal ridge 2 | 37
Coronary artery disease, premature 2 | 6
Craniofacial disproportion 2 | 3
Decreased testosterone in males 2 | 28
Double ureter 2 | 6
Dry Eye Syndromes 2 | 8
Epidermal hyperkeratosis 2 | 3
Failure of development of eyelashes 2 | 16
Familial generalized lipodystrophy 2 | 5
Familial partial lipodystrophy 2 | 12
Fetal Membranes, Premature Rupture 2 | 5
HIV-Associated Lipodystrophy Syndrome 2 | 2
Hardened artery wall in small cerebral arteries 2 | 3
High pitched voice 2 | 23
Hydrops of placenta 2 | 2
Hyperglycemia 2 | 137
Hyperkyphosis 2 | 111
Hyperlipidemia 2 | 43
Hypernasal voice 2 | 39
Hyperphosphatemia (disorder) 2 | 17
Hypoplasia of nipple 2 | 16
Hypoplastic facial bones 2 | 4
Hypotrophic facial bones 2 | 4
Increased anterioposterior diameter of chest 2 | 2
Insulin resistant diabetes 2 | 13
Intermittent claudication 2 | 20
Keratitis sicca 2 | 6
Keratoconjunctivitis sicca 2 | 25
Kyphoscoliosis deformity of spine 2 | 60
Kyphosis deformity of spine 2 | 114
Lack of skin elasticity 2 | 10
Lethal restrictive dermopathy 2 | 5
Lethal tight skin contracture syndrome (disorder) 2 | 2
Lipoatrophy 2 | 19
Lipodystrophy 2 | 40
Loss of subcutaneous adipose tissue in limbs 2 | 6
Loss of truncal adipose tissue 2 | 2
Low serum estradiol levels 2 | 22
Metaphyseal widening 2 | 22
Mottled pigmentation 2 | 4
Nasal voice 2 | 39
Overtubulated long bones 2 | 2
Ovoid vertebral bodies 2 | 17
Pinched nasal tip 2 | 2
Premature canities 2 | 24
Progressive acroosteolysis of the clavicle 2 | 3
Prominent scalp veins 2 | 3
Prothrombin time increased 2 | 7
Pseudoarthrosis of clavicle 2 | 5
Reticular pigmentation pattern 2 | 7
Reticulate skin pigmentation 2 | 7
SERUM PHOSPHATE ELEVATED 2 | 14
Short distal phalanges 2 | 50
Simple ear 2 | 41
Skin Erosion 2 | 12
Small facial bones 2 | 4
Soft calvaria 2 | 8
Sparse eyebrow 2 | 42
Sparse eyelashes 2 | 31
Steatohepatitis 2 | 44
Stillbirth 2 | 17
Stippled pigmentation 2 | 4
Stretched skin 2 | 10
Submucous cleft of hard palate 2 | 11
Submucous clefting 2 | 9
Tapering pointed ends of distal finger phalanges 2 | 3
Thin clavicle 2 | 4
Thin nails 2 | 5
Underdevelopment of facial bones 2 | 4
Widely patent fontanels and sutures 2 | 12
Wizened face 2 | 9
Xerophthalmia 2 | 16

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 4 | 4,145
Non-IDG 1 | 12,091

Compartment GO Term

Protein farnesyltransferase co... 5 | 5
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CAAX prenyl protease 1 homolog ZMPSTE24 Tbio Enzyme -2.10187 125.8 321
CAAX prenyl protease 2 RCE1 Tchem Enzyme -1.85529 71.8 98
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA Tbio Enzyme -1.32569 19.4 232
Protein farnesyltransferase subunit beta FNTB Tchem Enzyme -0.83872 7.27 198
Prelamin-A/C LMNA Tbio Non-IDG -3.03952 1089.9 1005