Development Level

Tbio 2,856 | 10,625
Tchem 741 | 1,890
Tdark 472 | 7,003
Tclin 370 | 602

Collection

Eligible Ion Channel Proteins 63 | 117
Eligible Kinase Proteins 18 | 134
Eligible non-olfactory GPCR Proteins 8 | 145

IMPC Term

preweaning lethality, complete... 304 | 633
embryonic lethality prior to t... 98 | 187
embryonic lethality prior to o... 84 | 148
preweaning lethality, incomple... 80 | 260
decreased lean body mass 65 | 195
abnormal behavior 62 | 226
decreased total body fat amoun... 55 | 186
abnormal embryo size 54 | 112
decreased body weight 51 | 174
decreased bone mineral content 50 | 157
abnormal bone structure 41 | 131
decreased circulating glucose ... 40 | 121
decreased bone mineral density 38 | 126
abnormal retina morphology 37 | 100
increased circulating alkaline... 37 | 119
increased mean corpuscular vol... 37 | 91
decreased body length 36 | 108
decreased grip strength 34 | 123
increased mean corpuscular hem... 34 | 93
increased lean body mass 31 | 107
enlarged heart 30 | 111
increased grip strength 30 | 83
increased or absent threshold ... 29 | 128
hyperactivity 28 | 108
increased circulating sodium l... 27 | 71
abnormal lens morphology 26 | 73
decreased circulating triglyce... 25 | 83
increased fasted circulating g... 25 | 68
increased bone mineral content 24 | 92
decreased circulating choleste... 23 | 85
decreased circulating insulin ... 23 | 75
prenatal lethality prior to he... 23 | 64
decreased circulating HDL chol... 22 | 77
decreased lumbar vertebrae num... 22 | 62
decreased circulating alanine ... 21 | 53
hypoactivity 21 | 89
increased circulating HDL chol... 21 | 63
thrombocytopenia 21 | 46
abnormal bone mineralization 20 | 55
abnormal gait 20 | 51
decreased circulating serum al... 20 | 79
increased sacral vertebrae num... 20 | 62
short tibia 20 | 82
decreased leukocyte cell numbe... 19 | 54
decreased mean corpuscular vol... 19 | 50
increased circulating choleste... 19 | 53
increased exploration in new e... 19 | 56
male infertility 19 | 62
abnormal retinal pigmentation 17 | 61
decreased erythrocyte cell num... 17 | 43
decreased prepulse inhibition 17 | 52
increased bone mineral density 17 | 52
increased total body fat amoun... 17 | 57
abnormal neural tube closure 16 | 37
abnormal sleep behavior 16 | 63
decreased heart weight 16 | 44
impaired glucose tolerance 16 | 52
abnormal heart morphology 15 | 51
decreased fasted circulating g... 15 | 49
decreased hemoglobin content 15 | 53
decreased rib number 15 | 59
decreased startle reflex 15 | 48
increased circulating chloride... 15 | 43
increased hematocrit 15 | 36
increased hemoglobin content 15 | 45
increased leukocyte cell numbe... 15 | 37
tremors 15 | 34
abnormal behavioral response t... 14 | 52
abnormal coat/hair pigmentatio... 14 | 54
abnormal hindbrain development 14 | 24
cardiovascular system phenotyp... 14 | 35
decreased circulating free fat... 14 | 39
embryonic growth retardation 14 | 28
increased blood urea nitrogen ... 14 | 44
increased heart weight 14 | 37
abnormal midbrain development 13 | 22
cataract 13 | 26
decreased circulating alkaline... 13 | 41
increased body weight 13 | 42
vertebral fusion 13 | 23
decreased caudal vertebrae num... 12 | 49
decreased circulating aspartat... 12 | 27
decreased circulating fructosa... 12 | 31
abnormal forebrain development 11 | 18
abnormal tooth morphology 11 | 24
decreased T cell number 11 | 31
decreased circulating LDL chol... 11 | 37
decreased eosinophil cell numb... 11 | 41
improved glucose tolerance 11 | 56
increased mean corpuscular hem... 11 | 25
increased monocyte cell number 11 | 27
persistence of hyaloid vascula... 11 | 22
small testis 11 | 37
decreased NK T cell number 10 | 28
decreased blood urea nitrogen ... 10 | 31
decreased circulating total pr... 10 | 41
decreased effector memory CD8-... 10 | 24
decreased mean corpuscular hem... 10 | 34
limb grasping 10 | 35
prenatal lethality 10 | 16

Disease

ovarian cancer 2,408 | 8,492
osteosarcoma 2,068 | 7,933
psoriasis 1,842 | 6,685
medulloblastoma, large-cell 1,598 | 6,234
glioblastoma 1,558 | 5,572
lung cancer 1,478 | 4,473
Cancer 1,431 | 2,346
atypical teratoid / rhabdoid tumor 1,113 | 4,369
malignant mesothelioma 960 | 3,163
Breast cancer 949 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 907 | 3,289
invasive ductal carcinoma 848 | 2,950
non-small cell lung cancer 827 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 825 | 2,988
pediatric high grade glioma 810 | 2,712
primitive neuroectodermal tumor 810 | 3,031
pilocytic astrocytoma 797 | 3,086
lung adenocarcinoma 791 | 2,714
oligodendroglioma 787 | 2,849
lung carcinoma 785 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 756 | 2,956
Carcinoma 714 | 2,147
diabetes mellitus 681 | 1,663
pancreatic cancer 675 | 2,300
ependymoma 648 | 2,514
ulcerative colitis 640 | 2,087
subependymal giant cell astrocytoma 636 | 2,287
group 3 medulloblastoma 620 | 2,254
interstitial cystitis 607 | 2,299
Multiple myeloma 550 | 1,328
astrocytic glioma 538 | 2,241
Pick disease 514 | 1,893
pituitary cancer 514 | 1,972
tuberculosis 508 | 1,563
astrocytoma 495 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 495 | 1,795
ductal carcinoma in situ 490 | 1,745
breast carcinoma 479 | 1,614
group 4 medulloblastoma 478 | 1,875
colon cancer 474 | 1,475
adult high grade glioma 471 | 2,148
posterior fossa group A ependymoma 450 | 1,511
adrenocortical carcinoma 446 | 1,427
Rheumatoid Arthritis 445 | 1,171
cystic fibrosis 443 | 1,670
acute quadriplegic myopathy 395 | 1,157
medulloblastoma 385 | 1,524
sonic hedgehog group medulloblastoma 383 | 1,482
primary pancreatic ductal adenocarcinoma 382 | 1,271
juvenile dermatomyositis 378 | 1,189
dermatomyositis 373 | 967
cutaneous lupus erythematosus 339 | 1,056
Waldenstrons macroglobulinemia 317 | 765
nasopharyngeal carcinoma 307 | 1,056
posterior fossa group B ependymoma 305 | 1,530
Alzheimer's disease 280 | 644
Kidney disease 278 | 397
Obesity 277 | 616
atypical teratoid/rhabdoid tumor 276 | 1,095
gastric carcinoma 272 | 832
Atopic dermatitis 262 | 944
primary Sjogren syndrome 258 | 789
acute myeloid leukemia 244 | 785
Multiple Sclerosis 234 | 498
Mammary Neoplasms 230 | 410
spina bifida 229 | 1,064
Arthritis 222 | 248
Endometriosis 222 | 535
Duchenne muscular dystrophy 220 | 602
active Crohn's disease 218 | 918
Prostatic Neoplasms 217 | 471
Intellectual disability 215 | 573
Vascular disease 212 | 281
non primary Sjogren syndrome sicca 212 | 840
esophageal adenocarcinoma 205 | 737
Hypersensitivity reaction type II disease 203 | 235
Hypertension 203 | 293
Asthma 194 | 349
Down syndrome 193 | 548
Heart disease 189 | 279
Schizophrenia 189 | 503
Anemia 187 | 252
Atherosclerosis 185 | 275
aldosterone-producing adenoma 184 | 664
IGA Glomerulonephritis 181 | 454
hepatocellular carcinoma 181 | 550
Cerebrovascular disease 179 | 231
pancreatic carcinoma 179 | 567
progressive supranuclear palsy 179 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 173 | 499
Parkinson's disease 171 | 364
Epilepsy 169 | 346
tuberculosis and treatment for 6 months 169 | 686
Neurodegenerative disease 165 | 383
Liver disease 158 | 219
mucosa-associated lymphoid tissue lymphoma 158 | 480
Coronary artery disease 154 | 240
non-small cell lung carcinoma 151 | 413
Stomach Neoplasms 148 | 282
fibroadenoma 143 | 557

Tissue

Female tissues 4,315 | 18,647
Nervous System 4,311 | 18,561
Endocrine System 4,301 | 18,512
Digestive Tract 4,300 | 18,473
Urinary Tract 4,298 | 18,444
Liver and Pancreas 4,290 | 18,136
Blood and immune system 4,281 | 17,995
Cardiovascular System 4,279 | 17,958
Male tissues 4,265 | 17,969
Skin and soft tissues 4,249 | 18,115
Respiratory system 4,242 | 17,484

Target Family

Non-IDG 2,664 | 11,969
Enzyme 890 | 4,146
Transcription Factor 227 | 1,400
Ion Channel 199 | 341
Kinase 198 | 634
Epigenetic 105 | 242
GPCR 68 | 408
Transporter 55 | 473
Nuclear Receptor 21 | 48
TF/Epigenetic 12 | 38

Compartment GO Term

Protein complex 4,439 | 4,439
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.67656 3.42 165