Development Level

Tbio 524 | 11,651
Tdark 112 | 6,593
Tchem 84 | 1,388
Tclin 45 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328

IMPC Phenotype

preweaning lethality, complete... 54 | 979
preweaning lethality, incomple... 34 | 499
embryonic lethality prior to t... 18 | 278
abnormal behavior 14 | 298
decreased body weight 13 | 161
decreased total body fat amoun... 13 | 207
abnormal embryo size 12 | 220
embryonic lethality prior to o... 12 | 239
abnormal bone structure 11 | 187
hyperactivity 9 | 148
hypoactivity 8 | 132
increased startle reflex 8 | 112
increased total body fat amoun... 8 | 134
decreased bone mineral content 7 | 151
decreased bone mineral density 7 | 126
decreased circulating serum al... 7 | 82
embryonic growth retardation 7 | 106
increased circulating alkaline... 7 | 122
increased mean corpuscular hem... 7 | 96
prenatal lethality prior to he... 7 | 87
abnormal sleep behavior 6 | 70
decreased body length 6 | 101
decreased circulating LDL chol... 6 | 38
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
decreased lean body mass 6 | 135
decreased mean corpuscular vol... 6 | 79
increased fasted circulating g... 6 | 76
increased lean body mass 6 | 172
increased mean corpuscular vol... 6 | 92
short tibia 6 | 97
abnormal embryo turning 5 | 31
abnormal retina morphology 5 | 71
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased circulating HDL chol... 5 | 68
decreased circulating alkaline... 5 | 46
decreased circulating choleste... 5 | 93
increased body length 5 | 32
increased bone mineral content 5 | 108
increased circulating chloride... 5 | 41
increased or absent threshold ... 5 | 101
limb grasping 5 | 41
abnormal coat appearance 4 | 31
abnormal gait 4 | 69
abnormal lens morphology 4 | 81
cardiovascular system phenotyp... 4 | 36
decreased caudal vertebrae num... 4 | 53
decreased circulating calcium ... 4 | 36
decreased circulating free fat... 4 | 31
decreased circulating insulin ... 4 | 76
decreased circulating triglyce... 4 | 79
decreased fasted circulating g... 4 | 65
decreased lymphocyte cell numb... 4 | 83
improved glucose tolerance 4 | 79
increased circulating HDL chol... 4 | 80
increased circulating creatini... 4 | 38
male infertility 4 | 123
pallor 4 | 34
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
tremors 4 | 39
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal cranium morphology 3 | 36
abnormal head morphology 3 | 10
abnormal lung morphology 3 | 26
abnormal retinal inner nuclear... 3 | 8
abnormal vertebrae morphology 3 | 18
absent pinna reflex 3 | 23
convulsive seizures 3 | 13
decreased blood urea nitrogen ... 3 | 51
decreased circulating aspartat... 3 | 34
decreased circulating creatini... 3 | 39
decreased circulating total pr... 3 | 49
decreased coping response 3 | 8
decreased leukocyte cell numbe... 3 | 73
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
decreased vertical activity 3 | 208
edema 3 | 59
enlarged heart 3 | 210
impaired glucose tolerance 3 | 75
increased blood urea nitrogen ... 3 | 48
increased circulating choleste... 3 | 66
increased circulating phosphat... 3 | 26
increased circulating sodium l... 3 | 71
increased grip strength 3 | 41
increased heart weight 3 | 62
increased neutrophil cell numb... 3 | 46
small superior vagus ganglion 3 | 74
thrombocytopenia 3 | 56
abnormal coat-hair pigmentatio... 2 | 64
abnormal eye morphology 2 | 68
decreased circulating amylase ... 2 | 28
decreased prepulse inhibition 2 | 82
increased bone mineral density 2 | 72
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63

Disease

Carcinoma 541 | 11,493
ovarian cancer 384 | 8,520
psoriasis 353 | 6,694
osteosarcoma 320 | 7,950
glioblastoma 318 | 5,792
medulloblastoma, large-cell 299 | 6,241
ependymoma 285 | 4,679
atypical teratoid / rhabdoid tumor 279 | 5,112
lung cancer 279 | 4,740
Cancer 262 | 2,499
Breast cancer 251 | 3,578
group 3 medulloblastoma 227 | 4,104
adult high grade glioma 210 | 3,801
malignant mesothelioma 197 | 3,232
Astrocytoma, Pilocytic 191 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 178 | 3,291
non-small cell lung cancer 177 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 176 | 2,989
invasive ductal carcinoma 172 | 2,951
primitive neuroectodermal tumor 172 | 3,035
pancreatic cancer 169 | 2,398
oligodendroglioma 168 | 2,850
lung adenocarcinoma 156 | 2,716
Kidney cancer 155 | 2,613
lung carcinoma 154 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 150 | 2,955
astrocytic glioma 135 | 2,597
subependymal giant cell astrocytoma 128 | 2,287
breast carcinoma 122 | 1,638
ductal carcinoma in situ 121 | 1,745
Schizophrenia 119 | 1,160
diabetes mellitus 117 | 1,728
adrenocortical carcinoma 116 | 1,428
interstitial cystitis 115 | 2,312
colon cancer 113 | 1,478
pituitary cancer 106 | 1,972
Pick disease 105 | 1,894
ulcerative colitis 101 | 1,819
Alzheimer's disease 92 | 658
Autosomal recessive predisposition 90 | 1,442
group 4 medulloblastoma 89 | 1,855
tuberculosis 89 | 2,010
nasopharyngeal carcinoma 88 | 1,058
cystic fibrosis 87 | 1,696
Intellectual disability 80 | 1,016
Endometriosis 76 | 540
pancreatic ductal adenocarcinoma liver metastasis 74 | 1,962
Kidney disease 73 | 430
Atopic dermatitis 72 | 952
Epilepsy 70 | 792
primary pancreatic ductal adenocarcinoma 70 | 1,109
Bipolar Disorder 68 | 666
acute quadriplegic myopathy 68 | 1,158
Liver Cirrhosis, Experimental 67 | 769
Multiple myeloma 65 | 1,332
astrocytoma 65 | 1,146
Breast Neoplasms 64 | 445
Mammary Neoplasms 64 | 425
Neurodegenerative disease 64 | 414
Rheumatoid arthritis 64 | 1,191
juvenile dermatomyositis 63 | 1,187
Down syndrome 61 | 499
Obesity 61 | 678
pediatric high grade glioma 60 | 1,064
spina bifida 60 | 1,074
Cerebrovascular disease 59 | 238
Depressive disorder 59 | 409
Heart disease 59 | 306
Liver cancer 59 | 604
Neuropathy 57 | 261
Toxic encephalopathy 57 | 141
dermatomyositis 57 | 966
Hypertension 55 | 396
Seizures 55 | 596
Amyotrophic lateral sclerosis 53 | 451
Vascular disease 53 | 319
Dull intelligence 52 | 645
Low intelligence 52 | 645
Mental Retardation 52 | 645
Mental deficiency 52 | 645
Poor school performance 52 | 645
Duchenne muscular dystrophy 51 | 601
Melanoma 51 | 711
cutaneous lupus erythematosus 51 | 1,057
Parkinson's disease 50 | 392
Prostatic Neoplasms 50 | 495
esophageal adenocarcinoma 50 | 737
Stomach Neoplasms 49 | 300
Cognitive delay 48 | 608
Global developmental delay 48 | 608
Mental and motor retardation 48 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 48 | 510
gastric carcinoma 48 | 807
Mental Depression 47 | 333
Waldenstrons macroglobulinemia 46 | 765
Multiple Sclerosis 44 | 540
Neoplasm Invasiveness 44 | 161
Liver disease 43 | 237
Neoplasm Metastasis 43 | 168
Small head 43 | 374

Tissue

Endocrine System 717 | 18,159
Female tissues 705 | 17,400
Skin and soft tissues 704 | 17,230
Digestive Tract 695 | 17,369
Male tissues 685 | 17,142
Blood and immune system 682 | 16,909
Nervous System 671 | 16,725
Liver and Pancreas 667 | 16,750
Urinary Tract 667 | 16,678
Respiratory system 664 | 16,393
Cardiovascular System 612 | 15,192

Target Family

Non-IDG 604 | 12,091
Enzyme 79 | 4,145
Kinase 38 | 634
Transcription Factor 29 | 1,400
GPCR 6 | 408
Epigenetic 3 | 242
Transporter 3 | 473
Nuclear Receptor 2 | 48
Ion Channel 1 | 344

Compartment GO Term

Polymeric cytoskeletal fiber 765 | 765
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Dynein heavy chain 6, axonemal DNAH6 Tbio Non-IDG -0.53057 4.17 18
Fidgetin FIGN Tbio Enzyme -1.34015 21.2 103
Oxygen-regulated protein 1 RP1 Tbio Non-IDG 0.30 0.88 40
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895