Development Level

Tbio 534 | 11,445
Tclin 126 | 613
Tchem 120 | 1,598
Tdark 61 | 6,588

Collection

RFA-RM-18-021 25 | 328
Ion Channel: IDG Consortium (T... 20 | 99
GPCR: IDG Consortium (Targets) 7 | 126
GPCR: IDG Consortium (Complete... 3 | 25
Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 50 | 979
abnormal behavior 23 | 298
decreased total body fat amoun... 18 | 207
abnormal bone structure 17 | 187
preweaning lethality, incomple... 17 | 499
decreased body weight 16 | 161
decreased grip strength 15 | 116
embryonic lethality prior to t... 15 | 278
decreased vertical activity 12 | 208
increased lean body mass 12 | 172
increased mean corpuscular vol... 12 | 92
abnormal retina morphology 11 | 71
decreased bone mineral content 11 | 151
hyperactivity 11 | 148
impaired glucose tolerance 11 | 75
increased startle reflex 11 | 112
abnormal embryo size 10 | 220
enlarged heart 10 | 210
increased circulating alkaline... 10 | 122
increased heart weight 10 | 62
decreased circulating choleste... 9 | 93
hypoactivity 9 | 132
increased or absent threshold ... 9 | 101
increased total body fat amoun... 9 | 134
decreased circulating HDL chol... 8 | 68
decreased circulating triglyce... 8 | 79
embryonic lethality prior to o... 8 | 239
increased circulating chloride... 8 | 41
tremors 8 | 39
abnormal heart morphology 7 | 162
decreased fasted circulating g... 7 | 65
decreased startle reflex 7 | 75
embryonic growth retardation 7 | 106
increased blood urea nitrogen ... 7 | 48
abnormal lens morphology 6 | 81
abnormal locomotor behavior 6 | 24
cataract 6 | 92
decreased lean body mass 6 | 135
decreased leukocyte cell numbe... 6 | 73
decreased lymphocyte cell numb... 6 | 83
improved glucose tolerance 6 | 79
increased bone mineral content 6 | 108
increased circulating HDL chol... 6 | 80
increased circulating choleste... 6 | 66
increased fasted circulating g... 6 | 76
increased mean corpuscular hem... 6 | 96
abnormal eye morphology 5 | 68
abnormal gait 5 | 69
abnormal pericardium morpholog... 5 | 26
abnormal sleep behavior 5 | 70
cardiovascular system phenotyp... 5 | 36
decreased circulating glucose ... 5 | 126
decreased mean corpuscular vol... 5 | 79
decreased prepulse inhibition 5 | 82
increased circulating creatini... 5 | 38
increased circulating iron lev... 5 | 30
increased circulating total pr... 5 | 28
increased lymphocyte cell numb... 5 | 32
persistence of hyaloid vascula... 5 | 33
abnormal bone mineralization 4 | 38
abnormal cornea morphology 4 | 31
abnormal seminal vesicle morph... 4 | 114
abnormal vibrissa morphology 4 | 25
decreased body length 4 | 101
decreased bone mineral density 4 | 126
decreased circulating LDL chol... 4 | 38
decreased circulating alkaline... 4 | 46
decreased circulating chloride... 4 | 30
decreased circulating insulin ... 4 | 76
decreased heart weight 4 | 27
decreased hemoglobin content 4 | 68
decreased neutrophil cell numb... 4 | 42
increased bone mineral density 4 | 72
increased circulating sodium l... 4 | 71
increased hematocrit 4 | 46
increased leukocyte cell numbe... 4 | 47
increased mean platelet volume 4 | 45
increased monocyte cell number 4 | 63
prenatal lethality prior to he... 4 | 87
abnormal coat-hair pigmentatio... 3 | 64
abnormal kidney morphology 3 | 65
abnormal limb bud morphology 3 | 17
abnormal spleen morphology 3 | 55
abnormal whole-body plethysmog... 3 | 4
decreased circulating creatini... 3 | 39
decreased heart rate variabili... 3 | 13
decreased mean corpuscular hem... 3 | 31
decreased spleen weight 3 | 10
enlarged spleen 3 | 41
increased anti-nuclear antigen... 3 | 19
increased body weight 3 | 25
increased circulating amylase ... 3 | 25
increased circulating calcium ... 3 | 34
increased circulating potassiu... 3 | 29
increased circulating triglyce... 3 | 42
increased hemoglobin content 3 | 45
pale yolk sac 3 | 25
pallor 3 | 34
short tibia 3 | 97
small thymus 3 | 16

Disease

Carcinoma 657 | 11,493
ovarian cancer 381 | 8,520
osteosarcoma 377 | 7,950
medulloblastoma, large-cell 365 | 6,241
psoriasis 352 | 6,694
glioblastoma 344 | 5,792
atypical teratoid / rhabdoid tumor 314 | 5,112
ependymoma 305 | 4,679
lung cancer 274 | 4,740
adult high grade glioma 244 | 3,801
Astrocytoma, Pilocytic 232 | 3,081
group 3 medulloblastoma 228 | 4,104
Kidney cancer 221 | 2,613
lung carcinoma 211 | 2,843
Breast cancer 208 | 3,578
oligodendroglioma 206 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 194 | 3,291
malignant mesothelioma 191 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 188 | 2,955
astrocytic glioma 181 | 2,597
non-small cell lung cancer 179 | 2,890
lung adenocarcinoma 177 | 2,716
primitive neuroectodermal tumor 176 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 172 | 2,989
Cancer 169 | 2,499
invasive ductal carcinoma 166 | 2,951
pancreatic cancer 164 | 2,398
subependymal giant cell astrocytoma 158 | 2,287
Schizophrenia 157 | 1,160
interstitial cystitis 156 | 2,312
Autosomal recessive predisposition 145 | 1,442
pituitary cancer 144 | 1,972
ulcerative colitis 120 | 1,819
cystic fibrosis 119 | 1,696
Pick disease 116 | 1,894
ductal carcinoma in situ 115 | 1,745
colon cancer 112 | 1,478
Intellectual disability 106 | 1,016
tuberculosis 105 | 2,010
breast carcinoma 103 | 1,638
Epilepsy 100 | 792
pancreatic ductal adenocarcinoma liver metastasis 99 | 1,962
diabetes mellitus 95 | 1,728
group 4 medulloblastoma 95 | 1,855
Bipolar Disorder 94 | 666
Obesity 73 | 678
Alzheimer's disease 72 | 658
Dull intelligence 71 | 645
Kidney disease 71 | 430
Liver cancer 71 | 604
Low intelligence 71 | 645
Mental Retardation 71 | 645
Mental deficiency 71 | 645
Poor school performance 71 | 645
adrenocortical carcinoma 71 | 1,428
gastric carcinoma 68 | 807
primary pancreatic ductal adenocarcinoma 68 | 1,109
spina bifida 68 | 1,074
Depressive disorder 67 | 409
Autistic Disorder 66 | 364
Melanoma 66 | 711
active Crohn's disease 66 | 922
acute quadriplegic myopathy 66 | 1,158
pediatric high grade glioma 66 | 1,064
cutaneous lupus erythematosus 65 | 1,057
active ulcerative colitis 63 | 764
Alcoholic Intoxication, Chronic 59 | 289
astrocytoma 59 | 1,146
nasopharyngeal carcinoma 59 | 1,058
Liver Cirrhosis, Experimental 57 | 769
Skin cancer 57 | 469
juvenile dermatomyositis 57 | 1,187
Hypertension 56 | 396
Rheumatoid arthritis 56 | 1,191
Seizures 56 | 596
esophageal adenocarcinoma 56 | 737
Mental Depression 55 | 333
Parkinson's disease 53 | 392
Down syndrome 49 | 499
dermatomyositis 47 | 966
nephrosclerosis 46 | 333
Muscle hypotonia 45 | 571
fibroadenoma 45 | 559
Cognitive delay 44 | 608
Global developmental delay 44 | 608
Mental and motor retardation 44 | 608
Major Depressive Disorder 43 | 301
General anesthesia 42 | 53
Prostatic Neoplasms 42 | 495
medulloblastoma 42 | 720
Duchenne muscular dystrophy 41 | 601
Hypertensive disease 41 | 292
aldosterone-producing adenoma 41 | 665
Atopic dermatitis 40 | 952
Breast Neoplasms 40 | 445
Osteoporosis 40 | 363
Mammary Neoplasms 39 | 425
progressive supranuclear palsy 39 | 676
Cerebrovascular disease 38 | 238
primary Sjogren syndrome 38 | 735

Tissue

Endocrine System 812 | 18,159
Digestive Tract 790 | 17,369
Nervous System 778 | 16,725
Skin and soft tissues 778 | 17,230
Female tissues 775 | 17,400
Male tissues 770 | 17,142
Urinary Tract 767 | 16,678
Liver and Pancreas 762 | 16,750
Blood and immune system 750 | 16,909
Respiratory system 719 | 16,393
Cardiovascular System 649 | 15,192

Target Family

Non-IDG 433 | 12,091
Enzyme 113 | 4,145
Transporter 101 | 473
Ion Channel 100 | 344
GPCR 46 | 408
Kinase 45 | 634
Epigenetic 3 | 242

Compartment GO Term

Plasma membrane region 841 | 841
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597
Adherens junction-associated protein 1 AJAP1 Tbio Non-IDG -1.20907 21.2 25
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
Organic solute transporter subunit beta SLC51B Tbio Transporter -1.41741 22.6 42
Roundabout homolog 2 ROBO2 Tbio Non-IDG -1.89275 74.1 161
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150