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Development Level

Tbio 340 | 11,445
Tchem 74 | 1,598
Tclin 51 | 613
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 28 | 979
preweaning lethality, incomple... 12 | 499
embryonic lethality prior to t... 11 | 278
abnormal embryo size 10 | 220
abnormal bone structure 8 | 187
embryonic lethality prior to o... 8 | 239
abnormal behavior 7 | 298
decreased vertical activity 7 | 208
small superior vagus ganglion 7 | 74
increased startle reflex 6 | 112
cardiovascular system phenotyp... 5 | 36
decreased body weight 5 | 161
decreased prepulse inhibition 5 | 82
enlarged heart 5 | 210
hydrometra 5 | 53
abnormal seminal vesicle morph... 4 | 114
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
increased heart weight 4 | 62
increased leukocyte cell numbe... 4 | 47
increased lymphocyte cell numb... 4 | 32
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
increased total body fat amoun... 4 | 134
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased circulating glucose ... 3 | 126
decreased fasted circulating g... 3 | 65
decreased heart rate variabili... 3 | 13
decreased hemoglobin content 3 | 68
edema 3 | 59
embryonic growth retardation 3 | 106
hemorrhage 3 | 23
hyperactivity 3 | 148
increased blood urea nitrogen ... 3 | 48
increased hematocrit 3 | 46
increased lean body mass 3 | 172
increased spleen weight 3 | 10
short tibia 3 | 97
thrombocytopenia 3 | 56
abnormal bone mineralization 2 | 38
abnormal kidney morphology 2 | 65
abnormal lung morphology 2 | 26
abnormal pericardium morpholog... 2 | 26
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
abnormal vibrissa morphology 2 | 25
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating bilirubi... 2 | 19
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased large unstained cell... 2 | 11
decreased mean corpuscular vol... 2 | 79
decreased monocyte cell number 2 | 8
decreased neutrophil cell numb... 2 | 42
enlarged kidney 2 | 14
enlarged seminal vesicle 2 | 10
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
small testis 2 | 58
tremors 2 | 39
unresponsive to tactile stimul... 2 | 8
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating iron lev... 1 | 30
increased exploration in new e... 1 | 8
increased mean corpuscular vol... 1 | 92
limb grasping 1 | 41
microphthalmia 1 | 26
prenatal lethality 1 | 28
vertebral fusion 1 | 23

Disease

Carcinoma 315 | 11,493
Cancer 304 | 2,499
psoriasis 228 | 6,694
ovarian cancer 221 | 8,520
osteosarcoma 215 | 7,950
glioblastoma 192 | 5,792
lung cancer 173 | 4,740
diabetes mellitus 162 | 1,728
lung carcinoma 148 | 2,843
medulloblastoma, large-cell 147 | 6,241
atypical teratoid / rhabdoid tumor 134 | 5,112
ependymoma 132 | 4,679
Breast cancer 123 | 3,578
Astrocytoma, Pilocytic 122 | 3,081
interstitial cystitis 122 | 2,312
malignant mesothelioma 121 | 3,232
tuberculosis 121 | 2,010
Hypersensitivity reaction type II disease 120 | 253
Arthritis 117 | 290
invasive ductal carcinoma 116 | 2,951
non-small cell lung cancer 115 | 2,890
Rheumatoid arthritis 113 | 1,191
adult high grade glioma 112 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 107 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 107 | 3,291
Kidney disease 98 | 430
intraductal papillary-mucinous adenoma (IPMA) 98 | 2,955
pancreatic cancer 98 | 2,398
lung adenocarcinoma 97 | 2,716
subependymal giant cell astrocytoma 97 | 2,287
ulcerative colitis 95 | 1,819
Kidney cancer 94 | 2,613
Multiple Sclerosis 86 | 540
Anemia 82 | 365
dermatomyositis 81 | 966
group 3 medulloblastoma 81 | 4,104
Acquired immunodeficiency syndrome 78 | 197
Ankylosing spondylitis 77 | 140
Autosomal recessive predisposition 77 | 1,442
Schizophrenia 77 | 1,160
oligodendroglioma 76 | 2,850
Human immunodeficiency virus infectious disease 74 | 138
Behcet's disease 70 | 89
Uveitis 70 | 103
cystic fibrosis 69 | 1,696
cutaneous lupus erythematosus 68 | 1,057
primitive neuroectodermal tumor 68 | 3,035
Liver Cirrhosis, Experimental 67 | 769
Liver disease 67 | 237
astrocytic glioma 66 | 2,597
Juvenile rheumatoid arthritis 65 | 111
Dermatitis 64 | 157
ductal carcinoma in situ 64 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 64 | 1,962
pituitary cancer 64 | 1,972
breast carcinoma 63 | 1,638
colon cancer 61 | 1,478
Herpes zoster 60 | 68
Alzheimer's disease 58 | 658
Stevens-Johnson syndrome 58 | 92
group 4 medulloblastoma 57 | 1,855
Breast Neoplasms 55 | 445
Psoriatic arthritis 55 | 86
primary pancreatic ductal adenocarcinoma 55 | 1,109
Mammary Neoplasms 54 | 425
adrenocortical carcinoma 54 | 1,428
Thrombocytopenia 53 | 197
Heart disease 52 | 306
juvenile dermatomyositis 52 | 1,187
astrocytoma 51 | 1,146
Asthma 50 | 385
Vascular disease 47 | 319
Duchenne muscular dystrophy 46 | 601
Hypertension 46 | 396
Obesity 46 | 678
Atherosclerosis 45 | 291
Synovitis 44 | 78
primary Sjogren syndrome 44 | 735
Lung disease 43 | 142
Melanoma 43 | 711
Cerebrovascular disease 42 | 238
Coronary artery disease 42 | 268
Hepatitis B 42 | 108
Down syndrome 41 | 499
Inflammatory bowel disease 41 | 151
Multiple myeloma 41 | 1,332
pediatric high grade glioma 41 | 1,064
Nephritis 40 | 51
Pick disease 40 | 1,894
Prostatic Neoplasms 40 | 495
acute quadriplegic myopathy 40 | 1,158
Diarrhea 39 | 253
Intellectual disability 38 | 1,016
Behcet's syndrome 37 | 50
Congenital adrenal hyperplasia 37 | 73
Takayasu's arteritis 37 | 53
gastric carcinoma 37 | 807
periodontitis 37 | 293
Liver cancer 36 | 604
Lung Neoplasms 36 | 232

Tissue

Endocrine System 382 | 18,159
Digestive Tract 379 | 17,369
Skin and soft tissues 379 | 17,230
Female tissues 376 | 17,400
Liver and Pancreas 376 | 16,750
Male tissues 375 | 17,142
Urinary Tract 374 | 16,678
Blood and immune system 372 | 16,909
Respiratory system 369 | 16,393
Nervous System 364 | 16,725
Cardiovascular System 353 | 15,192

Target Family

Non-IDG 359 | 12,091
Enzyme 42 | 4,145
Kinase 29 | 634
Transcription Factor 18 | 1,400
Transporter 13 | 473
Ion Channel 6 | 344
GPCR 1 | 408
Nuclear Receptor 1 | 48

Compartment GO Term

Plasma membrane protein comple... 469 | 469
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Protein O-mannosyl-transferase 1 POMT1 Tbio Enzyme -1.57372 38.3 123
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
Gap junction delta-2 protein GJD2 Tbio Non-IDG -2.48933 326.9 192
Gap junction alpha-3 protein GJA3 Tbio Non-IDG -2.14059 135.1 171
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0