1. Home
  2. Targets
Target Filters...

Development Level

Tbio 387 | 10,625
Tchem 181 | 1,890
Tclin 139 | 602
Tdark 13 | 7,003

Collection

Eligible Ion Channel Proteins 41 | 117

IMPC Term

preweaning lethality, complete... 29 | 633
abnormal behavior 13 | 226
decreased body weight 10 | 174
embryonic lethality prior to t... 10 | 187
abnormal bone mineralization 8 | 55
abnormal bone structure 7 | 131
abnormal embryo size 7 | 112
hyperactivity 7 | 108
preweaning lethality, incomple... 7 | 260
cardiovascular system phenotyp... 6 | 35
decreased circulating choleste... 6 | 85
decreased total body fat amoun... 6 | 186
increased circulating sodium l... 6 | 71
decreased circulating serum al... 5 | 79
decreased circulating triglyce... 5 | 83
enlarged heart 5 | 111
increased blood urea nitrogen ... 5 | 44
increased bone mineral content 5 | 92
increased mean corpuscular vol... 5 | 91
abnormal lens morphology 4 | 73
decreased bone mineral content 4 | 157
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
decreased fasted circulating g... 4 | 49
decreased grip strength 4 | 123
decreased lean body mass 4 | 195
decreased mean corpuscular vol... 4 | 50
embryonic lethality prior to o... 4 | 148
increased circulating HDL chol... 4 | 63
increased heart weight 4 | 37
tremors 4 | 34
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
abnormal retina morphology 3 | 100
abnormal spleen morphology 3 | 36
cataract 3 | 26
decreased B cell number 3 | 30
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating LDL chol... 3 | 37
decreased circulating bilirubi... 3 | 14
decreased circulating free fat... 3 | 39
decreased circulating insulin ... 3 | 75
decreased circulating sodium l... 3 | 18
decreased heart rate variabili... 3 | 11
decreased lumbar vertebrae num... 3 | 62
decreased mature B cell number 3 | 25
decreased prepulse inhibition 3 | 52
edema 3 | 11
impaired glucose tolerance 3 | 52
increased body weight 3 | 42
increased circulating LDL chol... 3 | 15
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased circulating free fat... 3 | 17
increased circulating phosphat... 3 | 24
increased circulating triglyce... 3 | 24
increased exploration in new e... 3 | 56
increased hemoglobin content 3 | 45
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular hem... 3 | 93
increased startle reflex 3 | 38
small superior vagus ganglion 3 | 20
thrombocytopenia 3 | 46
abnormal behavioral response t... 2 | 52
abnormal eye morphology 2 | 38
abnormal head morphology 2 | 10
abnormal neural tube closure 2 | 37
abnormal skin morphology 2 | 23
abnormal startle reflex 2 | 14
abnormal tooth morphology 2 | 24
abnormal vibrissa morphology 2 | 17
cyanosis 2 | 6
decreased CD4-positive, CD25-p... 2 | 24
decreased NK T cell number 2 | 28
decreased circulating calcium ... 2 | 33
decreased eosinophil cell numb... 2 | 41
decreased gamma-delta T cell n... 2 | 18
decreased heart weight 2 | 44
decreased neutrophil cell numb... 2 | 37
enlarged spleen 2 | 26
hemorrhage 2 | 12
hydrops fetalis 2 | 22
hypoactivity 2 | 89
impaired righting response 2 | 19
improved glucose tolerance 2 | 56
increased NK cell number 2 | 19
increased circulating chloride... 2 | 43
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 25
increased or absent threshold ... 2 | 128
increased vertical activity 2 | 18
limb grasping 2 | 35
male infertility 2 | 62
persistence of hyaloid vascula... 2 | 22
prenatal lethality 2 | 16
short tibia 2 | 82
small testis 2 | 37

Disease

Cancer 376 | 2,346
psoriasis 360 | 6,685
osteosarcoma 319 | 7,933
ovarian cancer 317 | 8,484
glioblastoma 315 | 5,572
medulloblastoma, large-cell 265 | 6,234
lung cancer 243 | 4,466
lung carcinoma 237 | 2,844
pilocytic astrocytoma 211 | 3,086
diabetes mellitus 205 | 1,663
atypical teratoid / rhabdoid tumor 203 | 4,369
pediatric high grade glioma 170 | 2,712
interstitial cystitis 168 | 2,299
malignant mesothelioma 165 | 3,162
subependymal giant cell astrocytoma 165 | 2,287
invasive ductal carcinoma 160 | 2,950
Carcinoma 155 | 2,147
ulcerative colitis 150 | 2,087
lung adenocarcinoma 148 | 2,713
Rheumatoid Arthritis 144 | 1,160
oligodendroglioma 143 | 2,849
Breast cancer 141 | 3,094
non-small cell lung cancer 141 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 140 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 139 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 138 | 2,956
primitive neuroectodermal tumor 135 | 3,031
Kidney disease 134 | 396
Hypersensitivity reaction type II disease 131 | 235
Arthritis 128 | 248
pancreatic cancer 128 | 2,300
Multiple Sclerosis 124 | 498
ependymoma 124 | 2,514
tuberculosis 117 | 1,557
adult high grade glioma 111 | 2,148
pituitary cancer 109 | 1,972
posterior fossa group A ependymoma 101 | 1,511
cystic fibrosis 100 | 1,665
astrocytic glioma 99 | 2,241
astrocytoma 95 | 1,493
cutaneous lupus erythematosus 95 | 1,056
group 4 medulloblastoma 94 | 1,875
ductal carcinoma in situ 91 | 1,745
Anemia 88 | 252
colon cancer 87 | 1,475
Pick disease 86 | 1,893
Heart disease 84 | 279
Alzheimer's disease 83 | 644
Acquired immunodeficiency syndrome 81 | 164
Ankylosing spondylitis 81 | 138
Liver disease 81 | 219
breast carcinoma 80 | 1,614
Hypertension 77 | 287
pancreatic ductal adenocarcinoma liver metastasis 76 | 1,795
primary pancreatic ductal adenocarcinoma 75 | 1,271
Uveitis 74 | 103
Asthma 73 | 349
Obesity 72 | 616
Atherosclerosis 70 | 275
adrenocortical carcinoma 70 | 1,427
group 3 medulloblastoma 69 | 2,254
Juvenile rheumatoid arthritis 68 | 104
medulloblastoma 66 | 1,524
Mammary Neoplasms 65 | 410
juvenile dermatomyositis 65 | 1,189
primary Sjogren syndrome 65 | 789
Cerebrovascular disease 61 | 231
acute quadriplegic myopathy 61 | 1,157
dermatomyositis 61 | 933
Duchenne muscular dystrophy 60 | 602
Coronary artery disease 59 | 240
sonic hedgehog group medulloblastoma 59 | 1,482
Epilepsy 58 | 346
Psoriatic arthritis 58 | 83
Behcet's disease 57 | 74
Vascular disease 57 | 281
Lung disease 56 | 132
Inflammatory bowel disease 55 | 142
Multiple myeloma 55 | 1,327
Down syndrome 54 | 548
Prostatic Neoplasms 54 | 471
Schizophrenia 53 | 501
posterior fossa group B ependymoma 53 | 1,530
gastric carcinoma 52 | 832
nasopharyngeal carcinoma 49 | 1,056
Endometriosis 47 | 535
Hypertensive disease 47 | 193
Thrombocytopenia 47 | 105
atypical teratoid/rhabdoid tumor 47 | 1,095
Hepatitis B 46 | 103
Lung Neoplasms 46 | 171
Human immunodeficiency virus infectious disease 45 | 92
Stomach Neoplasms 45 | 282
non-small cell lung carcinoma 45 | 413
Parkinson's disease 44 | 364
Stevens-Johnson syndrome 44 | 78
esophageal adenocarcinoma 44 | 737
Atopic dermatitis 43 | 944
Adenoma 42 | 165
Waldenstrons macroglobulinemia 42 | 765

Tissue

Nervous System 647 | 18,561
Endocrine System 645 | 18,512
Female tissues 645 | 18,647
Urinary Tract 645 | 18,444
Blood and immune system 644 | 17,995
Digestive Tract 644 | 18,473
Liver and Pancreas 642 | 18,136
Cardiovascular System 636 | 17,958
Respiratory system 633 | 17,484
Male tissues 632 | 17,969
Skin and soft tissues 630 | 18,115

Target Family

Non-IDG 424 | 11,971
Ion Channel 127 | 341
Enzyme 70 | 4,146
Kinase 42 | 634
Transcription Factor 22 | 1,400
Transporter 22 | 473
GPCR 10 | 406
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

Compartment GO Term

Plasma membrane protein comple... 720 | 720
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Interferon lambda receptor 1 IFNLR1 Tchem Non-IDG -1.48464 33.1 128
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67