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Target Filters...

Development Level

Tbio 387 | 10,625
Tchem 182 | 1,890
Tclin 139 | 602
Tdark 13 | 7,003

Collection

Eligible Ion Channel Proteins 41 | 117

IMPC Term

preweaning lethality, complete... 29 | 633
abnormal behavior 13 | 226
decreased body weight 10 | 174
embryonic lethality prior to t... 10 | 187
abnormal bone mineralization 8 | 55
abnormal bone structure 7 | 131
abnormal embryo size 7 | 112
hyperactivity 7 | 108
preweaning lethality, incomple... 7 | 260
cardiovascular system phenotyp... 6 | 35
decreased circulating choleste... 6 | 85
decreased total body fat amoun... 6 | 186
increased circulating sodium l... 6 | 71
decreased circulating serum al... 5 | 79
decreased circulating triglyce... 5 | 83
enlarged heart 5 | 111
increased blood urea nitrogen ... 5 | 44
increased bone mineral content 5 | 92
increased mean corpuscular vol... 5 | 91
abnormal lens morphology 4 | 73
decreased bone mineral content 4 | 157
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
decreased fasted circulating g... 4 | 49
decreased grip strength 4 | 123
decreased lean body mass 4 | 195
decreased mean corpuscular vol... 4 | 50
embryonic lethality prior to o... 4 | 148
increased circulating HDL chol... 4 | 63
increased heart weight 4 | 37
tremors 4 | 34
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
abnormal retina morphology 3 | 100
abnormal spleen morphology 3 | 36
cataract 3 | 26
decreased B cell number 3 | 30
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating LDL chol... 3 | 37
decreased circulating bilirubi... 3 | 14
decreased circulating free fat... 3 | 39
decreased circulating insulin ... 3 | 75
decreased circulating sodium l... 3 | 18
decreased heart rate variabili... 3 | 11
decreased lumbar vertebrae num... 3 | 62
decreased mature B cell number 3 | 25
decreased prepulse inhibition 3 | 52
edema 3 | 11
impaired glucose tolerance 3 | 52
increased body weight 3 | 42
increased circulating LDL chol... 3 | 15
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased circulating free fat... 3 | 17
increased circulating phosphat... 3 | 24
increased circulating triglyce... 3 | 24
increased exploration in new e... 3 | 56
increased hemoglobin content 3 | 45
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular hem... 3 | 93
increased startle reflex 3 | 38
small superior vagus ganglion 3 | 20
thrombocytopenia 3 | 46
abnormal behavioral response t... 2 | 52
abnormal eye morphology 2 | 38
abnormal head morphology 2 | 10
abnormal neural tube closure 2 | 37
abnormal skin morphology 2 | 23
abnormal startle reflex 2 | 14
abnormal tooth morphology 2 | 24
abnormal vibrissa morphology 2 | 17
cyanosis 2 | 6
decreased CD4-positive, CD25-p... 2 | 24
decreased NK T cell number 2 | 28
decreased circulating calcium ... 2 | 33
decreased eosinophil cell numb... 2 | 41
decreased gamma-delta T cell n... 2 | 18
decreased heart weight 2 | 44
decreased neutrophil cell numb... 2 | 37
enlarged spleen 2 | 26
hemorrhage 2 | 12
hydrops fetalis 2 | 22
hypoactivity 2 | 89
impaired righting response 2 | 19
improved glucose tolerance 2 | 56
increased NK cell number 2 | 19
increased circulating chloride... 2 | 43
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 25
increased or absent threshold ... 2 | 128
increased vertical activity 2 | 18
limb grasping 2 | 35
male infertility 2 | 62
persistence of hyaloid vascula... 2 | 22
prenatal lethality 2 | 16
short tibia 2 | 82
small testis 2 | 37

Disease

Cancer 376 | 2,346
psoriasis 360 | 6,685
osteosarcoma 319 | 7,933
ovarian cancer 318 | 8,492
glioblastoma 315 | 5,572
medulloblastoma, large-cell 265 | 6,234
lung cancer 243 | 4,473
lung carcinoma 237 | 2,844
pilocytic astrocytoma 211 | 3,086
diabetes mellitus 205 | 1,663
atypical teratoid / rhabdoid tumor 203 | 4,369
pediatric high grade glioma 170 | 2,712
interstitial cystitis 168 | 2,299
malignant mesothelioma 165 | 3,163
subependymal giant cell astrocytoma 165 | 2,287
invasive ductal carcinoma 160 | 2,950
Carcinoma 155 | 2,147
ulcerative colitis 150 | 2,087
lung adenocarcinoma 148 | 2,714
Rheumatoid Arthritis 145 | 1,171
oligodendroglioma 143 | 2,849
Breast cancer 142 | 3,099
non-small cell lung cancer 141 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 140 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 139 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 138 | 2,956
primitive neuroectodermal tumor 135 | 3,031
Kidney disease 134 | 397
Hypersensitivity reaction type II disease 131 | 235
Arthritis 128 | 248
pancreatic cancer 128 | 2,300
Multiple Sclerosis 124 | 498
ependymoma 124 | 2,514
tuberculosis 117 | 1,563
adult high grade glioma 111 | 2,148
pituitary cancer 109 | 1,972
cystic fibrosis 102 | 1,670
posterior fossa group A ependymoma 101 | 1,511
astrocytic glioma 99 | 2,241
astrocytoma 95 | 1,493
cutaneous lupus erythematosus 95 | 1,056
dermatomyositis 95 | 967
group 4 medulloblastoma 94 | 1,875
ductal carcinoma in situ 91 | 1,745
Anemia 88 | 252
colon cancer 87 | 1,475
Pick disease 86 | 1,893
Heart disease 85 | 279
Alzheimer's disease 83 | 644
Acquired immunodeficiency syndrome 81 | 164
Ankylosing spondylitis 81 | 138
Human immunodeficiency virus infectious disease 81 | 129
Liver disease 81 | 219
breast carcinoma 80 | 1,614
Hypertension 79 | 293
pancreatic ductal adenocarcinoma liver metastasis 76 | 1,795
primary pancreatic ductal adenocarcinoma 75 | 1,271
Uveitis 74 | 103
Asthma 73 | 349
Obesity 72 | 616
Atherosclerosis 70 | 275
adrenocortical carcinoma 70 | 1,427
Dermatitis 69 | 141
group 3 medulloblastoma 69 | 2,254
Juvenile rheumatoid arthritis 68 | 105
medulloblastoma 66 | 1,524
Mammary Neoplasms 65 | 410
juvenile dermatomyositis 65 | 1,189
primary Sjogren syndrome 65 | 789
Cerebrovascular disease 61 | 231
acute quadriplegic myopathy 61 | 1,157
Duchenne muscular dystrophy 60 | 602
Coronary artery disease 59 | 240
sonic hedgehog group medulloblastoma 59 | 1,482
Epilepsy 58 | 346
Psoriatic arthritis 58 | 85
Behcet's disease 57 | 74
Stevens-Johnson syndrome 57 | 91
Vascular disease 57 | 281
Lung disease 56 | 136
Inflammatory bowel disease 55 | 142
Multiple myeloma 55 | 1,328
Down syndrome 54 | 548
Prostatic Neoplasms 54 | 471
Schizophrenia 53 | 503
posterior fossa group B ependymoma 53 | 1,530
gastric carcinoma 52 | 832
nasopharyngeal carcinoma 49 | 1,056
Endometriosis 47 | 535
Hypertensive disease 47 | 193
Thrombocytopenia 47 | 105
atypical teratoid/rhabdoid tumor 47 | 1,095
Hepatitis B 46 | 103
Lung Neoplasms 46 | 171
Stomach Neoplasms 45 | 282
non-small cell lung carcinoma 45 | 413
Atopic dermatitis 44 | 944
Parkinson's disease 44 | 364
Synovitis 44 | 72
esophageal adenocarcinoma 44 | 737

Tissue

Nervous System 648 | 18,561
Endocrine System 646 | 18,512
Female tissues 646 | 18,647
Urinary Tract 646 | 18,444
Blood and immune system 645 | 17,995
Digestive Tract 645 | 18,473
Liver and Pancreas 643 | 18,136
Cardiovascular System 637 | 17,958
Respiratory system 634 | 17,484
Male tissues 633 | 17,969
Skin and soft tissues 631 | 18,115

Target Family

Non-IDG 424 | 11,969
Ion Channel 127 | 341
Enzyme 71 | 4,146
Kinase 42 | 634
Transcription Factor 22 | 1,400
Transporter 22 | 473
GPCR 10 | 408
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

Compartment GO Term

Plasma membrane protein comple... 721 | 721
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Fermitin family homolog 3 FERMT3 Tbio Non-IDG -1.81454 71.6 125
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.59865 595.2 0
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.59865 595.2 386
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561
Calcium-activated potassium channel subunit beta-4 KCNMB4 Tbio Ion Channel -0.88088 6.57 115
Dystrobrevin alpha DTNA Tbio Non-IDG -2.24566 173.6 138
Guanine nucleotide-binding protein subunit alpha-15 GNA15 Tbio Non-IDG -2.74618 475.0 155
Dipeptidyl aminopeptidase-like protein 6 DPP6 Tbio Enzyme -2.02374 108.0 115