Development Level

Tbio 1,418 | 10,625
Tchem 534 | 1,890
Tclin 346 | 602
Tdark 265 | 7,003

Collection

Eligible Ion Channel Proteins 73 | 117
Eligible non-olfactory GPCR Proteins 61 | 143
Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 75 | 633
preweaning lethality, incomple... 42 | 260
abnormal behavior 35 | 226
decreased total body fat amoun... 33 | 186
decreased lean body mass 25 | 195
increased circulating alkaline... 25 | 119
decreased body weight 24 | 174
embryonic lethality prior to t... 24 | 187
abnormal bone structure 23 | 131
decreased bone mineral content 23 | 157
decreased bone mineral density 22 | 126
decreased grip strength 21 | 123
enlarged heart 20 | 111
decreased circulating choleste... 19 | 85
increased or absent threshold ... 18 | 128
hyperactivity 17 | 108
decreased circulating triglyce... 16 | 83
increased mean corpuscular vol... 16 | 91
decreased circulating HDL chol... 15 | 77
increased mean corpuscular hem... 15 | 93
hypoactivity 14 | 89
increased circulating sodium l... 14 | 71
abnormal embryo size 13 | 112
abnormal retina morphology 13 | 100
cardiovascular system phenotyp... 13 | 35
increased blood urea nitrogen ... 13 | 44
increased body weight 13 | 42
increased bone mineral content 13 | 92
increased lean body mass 13 | 107
abnormal gait 12 | 51
decreased circulating alanine ... 12 | 53
decreased fasted circulating g... 12 | 49
decreased prepulse inhibition 12 | 52
impaired glucose tolerance 12 | 52
improved glucose tolerance 12 | 56
increased circulating HDL chol... 12 | 63
increased grip strength 12 | 83
tremors 12 | 34
abnormal bone mineralization 11 | 55
decreased circulating insulin ... 11 | 75
increased circulating choleste... 11 | 53
abnormal lens morphology 10 | 73
embryonic lethality prior to o... 10 | 148
short tibia 10 | 82
abnormal seminal vesicle morph... 9 | 47
decreased body length 9 | 108
decreased circulating LDL chol... 9 | 37
decreased circulating alkaline... 9 | 41
decreased circulating glucose ... 9 | 121
increased fasted circulating g... 9 | 68
increased heart weight 9 | 37
increased hematocrit 9 | 36
thrombocytopenia 9 | 46
abnormal epididymis morphology 8 | 31
abnormal retinal pigmentation 8 | 61
abnormal sleep behavior 8 | 63
decreased circulating calcium ... 8 | 33
decreased circulating creatini... 8 | 31
decreased circulating serum al... 8 | 79
decreased heart weight 8 | 44
decreased mean corpuscular vol... 8 | 50
enlarged epididymis 8 | 27
increased circulating creatini... 8 | 29
increased circulating potassiu... 8 | 31
increased hemoglobin content 8 | 45
limb grasping 8 | 35
abnormal heart morphology 7 | 51
decreased NK T cell number 7 | 28
decreased T cell number 7 | 31
decreased circulating chloride... 7 | 32
decreased circulating free fat... 7 | 39
decreased lumbar vertebrae num... 7 | 62
increased circulating chloride... 7 | 43
increased circulating phosphat... 7 | 24
increased vertical activity 7 | 18
small superior vagus ganglion 7 | 20
abnormal QRS complex 6 | 25
abnormal skin morphology 6 | 23
decreased eosinophil cell numb... 6 | 41
decreased rib number 6 | 59
decreased startle reflex 6 | 48
enlarged spleen 6 | 26
increased bone mineral density 6 | 52
increased exploration in new e... 6 | 56
increased startle reflex 6 | 38
male infertility 6 | 62
persistence of hyaloid vascula... 6 | 22
abnormal behavioral response t... 5 | 52
abnormal kidney morphology 5 | 30
abnormal locomotor activation 5 | 26
abnormal neural tube closure 5 | 37
abnormal vibrissa morphology 5 | 17
decreased blood urea nitrogen ... 5 | 31
decreased heart rate variabili... 5 | 11
decreased hemoglobin content 5 | 53
increased circulating total pr... 5 | 20
increased circulating triglyce... 5 | 24
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
small testis 5 | 37

Disease

osteosarcoma 1,119 | 7,933
psoriasis 1,106 | 6,685
ovarian cancer 1,092 | 8,484
medulloblastoma, large-cell 946 | 6,234
glioblastoma 935 | 5,572
lung cancer 755 | 4,466
Cancer 699 | 2,346
atypical teratoid / rhabdoid tumor 693 | 4,369
lung carcinoma 680 | 2,844
pilocytic astrocytoma 636 | 3,086
invasive ductal carcinoma 537 | 2,950
Carcinoma 535 | 2,147
malignant mesothelioma 533 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 530 | 3,289
lung adenocarcinoma 527 | 2,713
interstitial cystitis 526 | 2,299
non-small cell lung cancer 517 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 511 | 2,956
oligodendroglioma 506 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 501 | 2,988
pediatric high grade glioma 499 | 2,712
Breast cancer 491 | 3,094
primitive neuroectodermal tumor 457 | 3,031
pancreatic cancer 456 | 2,300
ulcerative colitis 446 | 2,087
subependymal giant cell astrocytoma 440 | 2,287
ependymoma 395 | 2,514
pituitary cancer 382 | 1,972
diabetes mellitus 376 | 1,663
adult high grade glioma 358 | 2,148
astrocytic glioma 354 | 2,241
ductal carcinoma in situ 337 | 1,745
cystic fibrosis 335 | 1,665
tuberculosis 329 | 1,557
group 4 medulloblastoma 316 | 1,875
colon cancer 303 | 1,475
posterior fossa group A ependymoma 289 | 1,511
cutaneous lupus erythematosus 287 | 1,056
Pick disease 284 | 1,893
breast carcinoma 279 | 1,614
Rheumatoid Arthritis 267 | 1,160
astrocytoma 263 | 1,493
group 3 medulloblastoma 260 | 2,254
medulloblastoma 260 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 258 | 1,795
primary pancreatic ductal adenocarcinoma 234 | 1,271
adrenocortical carcinoma 227 | 1,427
posterior fossa group B ependymoma 223 | 1,530
Kidney disease 202 | 396
sonic hedgehog group medulloblastoma 201 | 1,482
Multiple Sclerosis 192 | 498
Obesity 183 | 616
Schizophrenia 182 | 501
juvenile dermatomyositis 182 | 1,189
active Crohn's disease 173 | 918
primary Sjogren syndrome 173 | 789
Alzheimer's disease 172 | 644
atypical teratoid/rhabdoid tumor 171 | 1,095
gastric carcinoma 171 | 832
nasopharyngeal carcinoma 165 | 1,056
acute quadriplegic myopathy 164 | 1,157
Hypersensitivity reaction type II disease 163 | 235
Arthritis 150 | 248
spina bifida 150 | 1,064
Hypertension 149 | 287
Down syndrome 147 | 548
dermatomyositis 147 | 933
esophageal adenocarcinoma 147 | 737
Asthma 146 | 349
Epilepsy 146 | 346
Atopic dermatitis 142 | 944
Duchenne muscular dystrophy 142 | 602
mucosa-associated lymphoid tissue lymphoma 140 | 480
Multiple myeloma 138 | 1,327
Anemia 122 | 252
Atherosclerosis 122 | 275
Liver disease 122 | 219
Mammary Neoplasms 117 | 410
Prostatic Neoplasms 116 | 471
Heart disease 114 | 279
Endometriosis 113 | 535
Autistic Disorder 112 | 320
aldosterone-producing adenoma 112 | 664
Intellectual disability 109 | 573
Parkinson's disease 108 | 364
fibroadenoma 106 | 557
Cerebrovascular disease 104 | 231
autosomal dominant Emery-Dreifuss muscular dystrophy 103 | 499
nephrosclerosis 102 | 329
Vascular disease 101 | 281
non-small cell lung carcinoma 99 | 413
IGA Glomerulonephritis 98 | 454
Coronary artery disease 97 | 240
active ulcerative colitis 97 | 477
Acquired immunodeficiency syndrome 96 | 164
Hypertensive disease 95 | 193
acute myeloid leukemia 95 | 780
non primary Sjogren syndrome sicca 95 | 840
Ankylosing spondylitis 94 | 138
pancreatic carcinoma 91 | 567

Tissue

Nervous System 2,446 | 18,561
Female tissues 2,445 | 18,647
Urinary Tract 2,439 | 18,444
Endocrine System 2,437 | 18,512
Digestive Tract 2,435 | 18,473
Liver and Pancreas 2,408 | 18,136
Skin and soft tissues 2,396 | 18,115
Cardiovascular System 2,387 | 17,958
Blood and immune system 2,378 | 17,995
Male tissues 2,360 | 17,969
Respiratory system 2,342 | 17,484

Target Family

Non-IDG 1,266 | 11,971
Enzyme 303 | 4,146
GPCR 276 | 406
Transporter 269 | 473
Ion Channel 255 | 341
Kinase 139 | 634
oGPCR 30 | 421
Transcription Factor 21 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Plasma membrane part 2,563 | 2,563
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.40437 1.87 71