Development Level

Tbio 1,612 | 11,651
Tchem 408 | 1,388
Tclin 347 | 612
Tdark 226 | 6,593

Collection

RFA-RM-18-021 112 | 328
Ion Channel: IDG Consortium (T... 59 | 99
GPCR: IDG Consortium (Targets) 54 | 126
GPCR: IDG Consortium (Complete... 17 | 25
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 111 | 979
preweaning lethality, incomple... 78 | 499
abnormal behavior 57 | 298
decreased vertical activity 40 | 208
embryonic lethality prior to t... 39 | 278
decreased total body fat amoun... 38 | 207
enlarged heart 37 | 210
abnormal bone structure 33 | 187
abnormal embryo size 33 | 220
hyperactivity 30 | 148
decreased body weight 29 | 161
increased lean body mass 27 | 172
embryonic lethality prior to o... 26 | 239
abnormal heart morphology 24 | 162
abnormal seminal vesicle morph... 24 | 114
increased startle reflex 23 | 112
decreased bone mineral content 22 | 151
decreased grip strength 21 | 116
decreased lymphocyte cell numb... 21 | 83
increased circulating alkaline... 21 | 122
increased total body fat amoun... 21 | 134
hypoactivity 20 | 132
abnormal retina morphology 19 | 71
decreased circulating choleste... 19 | 93
impaired glucose tolerance 19 | 75
increased mean corpuscular vol... 19 | 92
small superior vagus ganglion 19 | 74
abnormal gait 18 | 69
decreased prepulse inhibition 18 | 82
decreased circulating HDL chol... 17 | 68
embryonic growth retardation 17 | 106
increased bone mineral content 17 | 108
decreased circulating triglyce... 16 | 79
improved glucose tolerance 16 | 79
decreased circulating insulin ... 15 | 76
increased mean corpuscular hem... 15 | 96
increased monocyte cell number 15 | 63
decreased bone mineral density 14 | 126
decreased circulating glucose ... 14 | 126
decreased fasted circulating g... 14 | 65
increased circulating sodium l... 14 | 71
increased heart weight 14 | 62
increased or absent threshold ... 14 | 101
tremors 14 | 39
abnormal lens morphology 13 | 81
cataract 13 | 92
decreased lean body mass 13 | 135
decreased mean corpuscular vol... 13 | 79
increased circulating choleste... 13 | 66
abnormal sleep behavior 12 | 70
decreased startle reflex 12 | 75
increased fasted circulating g... 12 | 76
increased neutrophil cell numb... 12 | 46
limb grasping 12 | 41
abnormal eye morphology 11 | 68
abnormal kidney morphology 11 | 65
cardiovascular system phenotyp... 11 | 36
decreased circulating LDL chol... 11 | 38
decreased circulating creatini... 11 | 39
decreased leukocyte cell numbe... 11 | 73
hydrometra 11 | 53
increased circulating HDL chol... 11 | 80
increased circulating chloride... 11 | 41
short tibia 11 | 97
abnormal epididymis morphology 10 | 42
decreased circulating alkaline... 10 | 46
decreased hemoglobin content 10 | 68
increased blood urea nitrogen ... 10 | 48
increased circulating creatini... 10 | 38
increased circulating triglyce... 10 | 42
increased hematocrit 10 | 46
increased leukocyte cell numbe... 10 | 47
abnormal behavioral response t... 9 | 66
abnormal skin morphology 9 | 50
decreased body length 9 | 101
decreased erythrocyte cell num... 9 | 62
edema 9 | 59
enlarged spleen 9 | 41
prolonged QT interval 9 | 38
prolonged ST segment 9 | 36
thrombocytopenia 9 | 56
decreased circulating amylase ... 8 | 28
decreased circulating chloride... 8 | 30
decreased circulating serum al... 8 | 82
decreased eosinophil cell numb... 8 | 24
decreased heart weight 8 | 27
increased lymphocyte cell numb... 8 | 32
increased mean platelet volume 8 | 45
male infertility 8 | 123
pale yolk sac 8 | 25
prenatal lethality prior to he... 8 | 87
small testis 8 | 58
abnormal spleen morphology 7 | 55
abnormal vibrissa morphology 7 | 25
decreased circulating alanine ... 7 | 47
decreased circulating calcium ... 7 | 36
decreased mean corpuscular hem... 7 | 50
increased circulating calcium ... 7 | 34
increased erythrocyte cell num... 7 | 39
pallor 7 | 34

Disease

Carcinoma 1,895 | 11,493
osteosarcoma 1,141 | 7,950
ovarian cancer 1,128 | 8,520
psoriasis 1,126 | 6,694
glioblastoma 986 | 5,792
medulloblastoma, large-cell 966 | 6,241
lung cancer 846 | 4,740
atypical teratoid / rhabdoid tumor 828 | 5,112
ependymoma 791 | 4,679
Cancer 741 | 2,499
adult high grade glioma 689 | 3,801
lung carcinoma 686 | 2,843
Astrocytoma, Pilocytic 645 | 3,081
Breast cancer 603 | 3,578
Kidney cancer 585 | 2,613
group 3 medulloblastoma 577 | 4,104
malignant mesothelioma 566 | 3,232
non-small cell lung cancer 551 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 545 | 3,291
invasive ductal carcinoma 544 | 2,951
interstitial cystitis 539 | 2,312
lung adenocarcinoma 537 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 529 | 2,955
oligodendroglioma 518 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 517 | 2,989
pancreatic cancer 490 | 2,398
primitive neuroectodermal tumor 466 | 3,035
subependymal giant cell astrocytoma 448 | 2,287
astrocytic glioma 442 | 2,597
tuberculosis 420 | 2,010
ulcerative colitis 399 | 1,819
diabetes mellitus 392 | 1,728
pituitary cancer 388 | 1,972
Schizophrenia 380 | 1,160
cystic fibrosis 344 | 1,696
Autosomal recessive predisposition 343 | 1,442
ductal carcinoma in situ 338 | 1,745
colon cancer 311 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 295 | 1,962
cutaneous lupus erythematosus 294 | 1,057
breast carcinoma 293 | 1,638
Pick disease 288 | 1,894
group 4 medulloblastoma 279 | 1,855
Rheumatoid arthritis 276 | 1,191
adrenocortical carcinoma 234 | 1,428
Bipolar Disorder 227 | 666
Epilepsy 213 | 792
Melanoma 209 | 711
Kidney disease 208 | 430
primary pancreatic ductal adenocarcinoma 207 | 1,109
Intellectual disability 201 | 1,016
Obesity 200 | 678
Liver Cirrhosis, Experimental 198 | 769
Multiple Sclerosis 197 | 540
astrocytoma 193 | 1,146
Hypertension 191 | 396
Alzheimer's disease 183 | 658
pediatric high grade glioma 181 | 1,064
juvenile dermatomyositis 180 | 1,187
dermatomyositis 179 | 966
active Crohn's disease 175 | 922
Hypersensitivity reaction type II disease 172 | 253
Arthritis 170 | 290
Liver cancer 168 | 604
gastric carcinoma 167 | 807
acute quadriplegic myopathy 166 | 1,158
nasopharyngeal carcinoma 165 | 1,058
Depressive disorder 163 | 409
active ulcerative colitis 162 | 764
spina bifida 161 | 1,074
Skin cancer 160 | 469
primary Sjogren syndrome 159 | 735
Asthma 154 | 385
esophageal adenocarcinoma 154 | 737
Anemia 153 | 365
Atopic dermatitis 149 | 952
Duchenne muscular dystrophy 145 | 601
Down syndrome 141 | 499
Dull intelligence 140 | 645
Low intelligence 140 | 645
Mental Retardation 140 | 645
Mental deficiency 140 | 645
Multiple myeloma 140 | 1,332
Poor school performance 140 | 645
mucosa-associated lymphoid tissue lymphoma 140 | 484
Seizures 135 | 596
Mental Depression 131 | 333
Alcoholic Intoxication, Chronic 130 | 289
Autistic Disorder 128 | 364
Liver disease 128 | 237
Hypertensive disease 126 | 292
Heart disease 125 | 306
Breast Neoplasms 122 | 445
Atherosclerosis 120 | 291
Mammary Neoplasms 119 | 425
aldosterone-producing adenoma 119 | 665
Vascular disease 117 | 319
Parkinson's disease 116 | 392
Prostatic Neoplasms 116 | 495
medulloblastoma 115 | 720

Tissue

Endocrine System 2,422 | 18,159
Digestive Tract 2,356 | 17,369
Female tissues 2,339 | 17,400
Skin and soft tissues 2,330 | 17,230
Male tissues 2,315 | 17,142
Nervous System 2,305 | 16,725
Urinary Tract 2,283 | 16,678
Liver and Pancreas 2,280 | 16,750
Blood and immune system 2,278 | 16,909
Respiratory system 2,197 | 16,393
Cardiovascular System 2,004 | 15,192

Target Family

Non-IDG 1,319 | 12,091
Enzyme 308 | 4,145
GPCR 272 | 408
Transporter 261 | 473
Ion Channel 256 | 344
Kinase 140 | 634
Transcription Factor 23 | 1,400
oGPCR 9 | 421
Epigenetic 3 | 242
Nuclear Receptor 2 | 48

Compartment GO Term

Plasma membrane part 2,593 | 2,593
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Tetraspanin-16 TSPAN16 Tdark Non-IDG -1.99505 87.0 42
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255