Development Level

Tbio 1,452 | 11,178
Tchem 518 | 1,885
Tclin 343 | 612
Tdark 218 | 6,569

Collection

Ion Channel: IDG Consortium (T... 59 | 99
GPCR: IDG Consortium (Targets) 54 | 126
GPCR: IDG Consortium (Complete... 17 | 25
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 107 | 979
preweaning lethality, incomple... 76 | 499
abnormal behavior 54 | 298
decreased vertical activity 39 | 208
decreased total body fat amoun... 38 | 207
embryonic lethality prior to t... 38 | 278
enlarged heart 37 | 210
abnormal bone structure 32 | 187
abnormal embryo size 31 | 220
decreased body weight 28 | 161
hyperactivity 28 | 148
increased lean body mass 27 | 172
embryonic lethality prior to o... 26 | 239
abnormal heart morphology 24 | 162
abnormal seminal vesicle morph... 23 | 114
decreased bone mineral content 22 | 151
increased startle reflex 22 | 112
decreased grip strength 21 | 116
decreased lymphocyte cell numb... 21 | 83
increased total body fat amoun... 20 | 134
abnormal retina morphology 19 | 71
hypoactivity 19 | 132
impaired glucose tolerance 19 | 75
increased circulating alkaline... 19 | 122
increased mean corpuscular vol... 19 | 92
small superior vagus ganglion 19 | 74
decreased circulating choleste... 18 | 93
decreased prepulse inhibition 18 | 82
abnormal gait 17 | 69
increased bone mineral content 17 | 108
decreased circulating HDL chol... 16 | 68
improved glucose tolerance 16 | 79
decreased circulating insulin ... 15 | 76
decreased circulating triglyce... 15 | 79
embryonic growth retardation 15 | 106
increased monocyte cell number 15 | 63
decreased bone mineral density 14 | 126
decreased circulating glucose ... 14 | 126
decreased fasted circulating g... 14 | 65
increased circulating sodium l... 14 | 71
increased mean corpuscular hem... 14 | 96
increased or absent threshold ... 14 | 101
tremors 14 | 39
abnormal lens morphology 13 | 81
cataract 13 | 92
decreased lean body mass 13 | 135
decreased mean corpuscular vol... 13 | 79
increased circulating choleste... 13 | 66
increased heart weight 13 | 62
abnormal sleep behavior 12 | 70
decreased startle reflex 12 | 75
increased fasted circulating g... 12 | 76
increased neutrophil cell numb... 12 | 46
abnormal kidney morphology 11 | 65
cardiovascular system phenotyp... 11 | 36
decreased circulating LDL chol... 11 | 38
decreased leukocyte cell numbe... 11 | 73
hydrometra 11 | 53
increased circulating HDL chol... 11 | 80
limb grasping 11 | 41
abnormal epididymis morphology 10 | 42
decreased circulating alkaline... 10 | 46
decreased circulating creatini... 10 | 39
decreased hemoglobin content 10 | 68
increased circulating chloride... 10 | 41
increased circulating triglyce... 10 | 42
increased hematocrit 10 | 46
increased leukocyte cell numbe... 10 | 47
short tibia 10 | 97
abnormal behavioral response t... 9 | 66
abnormal eye morphology 9 | 68
abnormal skin morphology 9 | 50
edema 9 | 59
increased circulating creatini... 9 | 38
thrombocytopenia 9 | 56
decreased body length 8 | 101
decreased circulating serum al... 8 | 82
decreased eosinophil cell numb... 8 | 24
decreased erythrocyte cell num... 8 | 62
decreased heart weight 8 | 27
enlarged spleen 8 | 41
increased blood urea nitrogen ... 8 | 48
increased lymphocyte cell numb... 8 | 32
increased mean platelet volume 8 | 45
male infertility 8 | 123
prolonged QT interval 8 | 38
small testis 8 | 58
abnormal spleen morphology 7 | 55
abnormal vibrissa morphology 7 | 25
decreased circulating alanine ... 7 | 47
decreased circulating amylase ... 7 | 28
decreased circulating chloride... 7 | 30
decreased mean corpuscular hem... 7 | 50
enlarged epididymis 7 | 31
increased circulating calcium ... 7 | 34
increased erythrocyte cell num... 7 | 39
pale yolk sac 7 | 25
persistence of hyaloid vascula... 7 | 33
prenatal lethality prior to he... 7 | 87
prolonged ST segment 7 | 36

Disease

Carcinoma 1,839 | 11,192
osteosarcoma 1,116 | 7,766
ovarian cancer 1,105 | 8,297
psoriasis 1,098 | 6,514
glioblastoma 968 | 5,635
medulloblastoma, large-cell 948 | 6,086
lung cancer 823 | 4,607
atypical teratoid / rhabdoid tumor 810 | 4,971
ependymoma 778 | 4,559
Cancer 718 | 2,388
adult high grade glioma 679 | 3,701
lung carcinoma 669 | 2,755
Astrocytoma, Pilocytic 635 | 3,006
Breast cancer 583 | 3,469
group 3 medulloblastoma 569 | 4,002
Kidney cancer 568 | 2,548
malignant mesothelioma 552 | 3,135
interstitial cystitis 530 | 2,237
non-small cell lung cancer 530 | 2,799
intraductal papillary-mucinous neoplasm (IPMN) 529 | 3,204
invasive ductal carcinoma 529 | 2,867
lung adenocarcinoma 518 | 2,627
intraductal papillary-mucinous adenoma (IPMA) 516 | 2,872
oligodendroglioma 511 | 2,768
intraductal papillary-mucinous carcinoma (IPMC) 502 | 2,902
pancreatic cancer 475 | 2,322
primitive neuroectodermal tumor 460 | 2,957
subependymal giant cell astrocytoma 444 | 2,230
astrocytic glioma 435 | 2,530
tuberculosis 415 | 1,963
ulcerative colitis 387 | 1,765
diabetes mellitus 381 | 1,683
pituitary cancer 380 | 1,915
Schizophrenia 373 | 1,136
Autosomal recessive predisposition 334 | 1,407
cystic fibrosis 331 | 1,629
ductal carcinoma in situ 325 | 1,686
colon cancer 302 | 1,428
cutaneous lupus erythematosus 289 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 286 | 1,911
breast carcinoma 285 | 1,589
Pick disease 282 | 1,856
group 4 medulloblastoma 270 | 1,806
Rheumatoid arthritis 267 | 1,156
adrenocortical carcinoma 225 | 1,385
Bipolar Disorder 222 | 646
Epilepsy 210 | 775
Melanoma 204 | 689
Kidney disease 199 | 411
Intellectual disability 198 | 998
primary pancreatic ductal adenocarcinoma 198 | 1,071
Multiple Sclerosis 194 | 527
Obesity 192 | 655
astrocytoma 187 | 1,113
Liver Cirrhosis, Experimental 185 | 733
Hypertension 181 | 372
pediatric high grade glioma 177 | 1,035
juvenile dermatomyositis 176 | 1,147
Alzheimer's disease 175 | 640
dermatomyositis 175 | 941
Hypersensitivity reaction type II disease 167 | 245
Liver cancer 166 | 589
active Crohn's disease 166 | 882
Arthritis 165 | 276
gastric carcinoma 162 | 781
acute quadriplegic myopathy 161 | 1,133
Depressive disorder 159 | 401
nasopharyngeal carcinoma 159 | 1,024
active ulcerative colitis 158 | 736
spina bifida 158 | 1,053
primary Sjogren syndrome 156 | 710
Skin cancer 155 | 451
Asthma 149 | 370
esophageal adenocarcinoma 148 | 696
Anemia 147 | 353
Atopic dermatitis 143 | 915
Duchenne muscular dystrophy 142 | 587
Dull intelligence 138 | 634
Low intelligence 138 | 634
Mental Retardation 138 | 634
Mental deficiency 138 | 634
Multiple myeloma 138 | 1,296
Poor school performance 138 | 634
mucosa-associated lymphoid tissue lymphoma 138 | 473
Down syndrome 137 | 480
Seizures 133 | 584
Mental Depression 128 | 325
Alcoholic Intoxication, Chronic 126 | 283
Autistic Disorder 126 | 358
Liver disease 123 | 227
Heart disease 119 | 288
Hypertensive disease 118 | 278
aldosterone-producing adenoma 116 | 646
Breast Neoplasms 115 | 423
Parkinson's disease 113 | 378
Vascular disease 113 | 294
medulloblastoma 113 | 702
Atherosclerosis 112 | 276
Mammary Neoplasms 112 | 403
Major Depressive Disorder 110 | 293

Tissue

Endocrine System 2,361 | 18,159
Digestive Tract 2,300 | 17,369
Female tissues 2,280 | 17,400
Skin and soft tissues 2,277 | 17,230
Male tissues 2,262 | 17,142
Nervous System 2,252 | 16,725
Urinary Tract 2,229 | 16,678
Liver and Pancreas 2,228 | 16,750
Blood and immune system 2,221 | 16,909
Respiratory system 2,148 | 16,393
Cardiovascular System 1,959 | 15,192

Target Family

Non-IDG 1,302 | 12,091
GPCR 272 | 408
Enzyme 269 | 4,145
Transporter 257 | 473
Ion Channel 256 | 344
Kinase 140 | 634
Transcription Factor 21 | 1,400
oGPCR 9 | 421
Epigenetic 3 | 242
Nuclear Receptor 2 | 48

Compartment GO Term

Plasma membrane part 2,531 | 2,531
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
Cannabinoid receptor 2 CNR2 Tchem GPCR -2.45761 269.7 345
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Prominin-2 PROM2 Tbio Non-IDG -1.12562 11.0 199
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103