Development Level

Tbio 2,811 | 10,625
Tdark 1,020 | 7,003
Tchem 823 | 1,890
Tclin 405 | 602

Collection

Eligible non-olfactory GPCR Proteins 129 | 143
Eligible Ion Channel Proteins 101 | 117
Eligible Kinase Proteins 21 | 134

IMPC Term

preweaning lethality, complete... 148 | 633
preweaning lethality, incomple... 87 | 260
abnormal behavior 67 | 226
decreased lean body mass 59 | 195
decreased total body fat amoun... 53 | 186
embryonic lethality prior to t... 52 | 187
decreased bone mineral content 50 | 157
decreased body weight 44 | 174
decreased bone mineral density 42 | 126
increased or absent threshold ... 42 | 128
abnormal bone structure 40 | 131
decreased grip strength 39 | 123
increased circulating alkaline... 39 | 119
hyperactivity 35 | 108
enlarged heart 34 | 111
abnormal retina morphology 32 | 100
embryonic lethality prior to o... 29 | 148
abnormal embryo size 28 | 112
decreased circulating choleste... 28 | 85
increased lean body mass 27 | 107
decreased circulating glucose ... 25 | 121
hypoactivity 25 | 89
decreased circulating HDL chol... 23 | 77
decreased circulating insulin ... 23 | 75
decreased circulating triglyce... 23 | 83
increased mean corpuscular hem... 23 | 93
increased mean corpuscular vol... 23 | 91
increased bone mineral content 22 | 92
decreased body length 21 | 108
decreased fasted circulating g... 21 | 49
decreased prepulse inhibition 21 | 52
increased grip strength 21 | 83
short tibia 21 | 82
abnormal retinal pigmentation 20 | 61
decreased rib number 20 | 59
improved glucose tolerance 20 | 56
increased circulating HDL chol... 20 | 63
abnormal lens morphology 19 | 73
decreased circulating alanine ... 19 | 53
increased blood urea nitrogen ... 19 | 44
increased circulating sodium l... 19 | 71
increased total body fat amoun... 19 | 57
abnormal gait 18 | 51
cardiovascular system phenotyp... 18 | 35
decreased lumbar vertebrae num... 18 | 62
impaired glucose tolerance 18 | 52
increased body weight 18 | 42
increased circulating choleste... 17 | 53
increased heart weight 17 | 37
limb grasping 17 | 35
tremors 17 | 34
abnormal bone mineralization 16 | 55
decreased mean corpuscular vol... 16 | 50
increased fasted circulating g... 16 | 68
increased hemoglobin content 16 | 45
prenatal lethality prior to he... 16 | 64
abnormal seminal vesicle morph... 15 | 47
decreased heart weight 15 | 44
decreased leukocyte cell numbe... 15 | 54
increased hematocrit 15 | 36
abnormal sleep behavior 14 | 63
decreased circulating serum al... 14 | 79
decreased startle reflex 14 | 48
increased circulating chloride... 14 | 43
increased exploration in new e... 14 | 56
increased leukocyte cell numbe... 14 | 37
thrombocytopenia 14 | 46
abnormal kidney morphology 13 | 30
decreased hemoglobin content 13 | 53
decreased mean corpuscular hem... 13 | 34
enlarged epididymis 13 | 27
increased bone mineral density 13 | 52
increased circulating calcium ... 13 | 32
male infertility 13 | 62
abnormal heart morphology 12 | 51
abnormal neural tube closure 12 | 37
decreased circulating alkaline... 12 | 41
decreased circulating creatini... 12 | 31
decreased eosinophil cell numb... 12 | 41
increased sacral vertebrae num... 12 | 62
abnormal epididymis morphology 11 | 31
abnormal spleen morphology 11 | 36
decreased NK T cell number 11 | 28
decreased blood urea nitrogen ... 11 | 31
decreased caudal vertebrae num... 11 | 49
decreased circulating LDL chol... 11 | 37
increased startle reflex 11 | 38
abnormal QRS complex 10 | 25
abnormal hindbrain development 10 | 24
abnormal midbrain development 10 | 22
decreased circulating calcium ... 10 | 33
decreased circulating chloride... 10 | 32
decreased vertical activity 10 | 22
enlarged spleen 10 | 26
increased circulating creatini... 10 | 29
increased circulating potassiu... 10 | 31
increased rib number 10 | 41
abnormal coat/hair pigmentatio... 9 | 54
decreased circulating free fat... 9 | 39
decreased circulating fructosa... 9 | 31

Disease

ovarian cancer 2,122 | 8,484
osteosarcoma 2,087 | 7,933
psoriasis 1,975 | 6,685
medulloblastoma, large-cell 1,797 | 6,234
glioblastoma 1,723 | 5,572
lung cancer 1,327 | 4,466
atypical teratoid / rhabdoid tumor 1,298 | 4,369
lung carcinoma 1,160 | 2,844
pilocytic astrocytoma 1,153 | 3,086
Cancer 1,005 | 2,346
invasive ductal carcinoma 961 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 958 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 938 | 2,956
lung adenocarcinoma 938 | 2,713
non-small cell lung cancer 936 | 2,798
malignant mesothelioma 930 | 3,162
oligodendroglioma 915 | 2,849
pediatric high grade glioma 902 | 2,712
interstitial cystitis 899 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 889 | 2,988
Breast cancer 880 | 3,094
primitive neuroectodermal tumor 880 | 3,031
Carcinoma 845 | 2,147
subependymal giant cell astrocytoma 786 | 2,287
pancreatic cancer 777 | 2,300
ulcerative colitis 772 | 2,087
ependymoma 761 | 2,514
adult high grade glioma 677 | 2,148
pituitary cancer 653 | 1,972
astrocytic glioma 637 | 2,241
diabetes mellitus 628 | 1,663
ductal carcinoma in situ 595 | 1,745
group 4 medulloblastoma 577 | 1,875
cystic fibrosis 575 | 1,665
Pick disease 552 | 1,893
tuberculosis 539 | 1,557
posterior fossa group A ependymoma 519 | 1,511
breast carcinoma 508 | 1,614
group 3 medulloblastoma 507 | 2,254
astrocytoma 498 | 1,493
colon cancer 485 | 1,475
medulloblastoma 458 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 437 | 1,795
cutaneous lupus erythematosus 434 | 1,056
primary pancreatic ductal adenocarcinoma 434 | 1,271
Rheumatoid Arthritis 423 | 1,160
adrenocortical carcinoma 422 | 1,427
sonic hedgehog group medulloblastoma 412 | 1,482
posterior fossa group B ependymoma 396 | 1,530
atypical teratoid/rhabdoid tumor 358 | 1,095
juvenile dermatomyositis 333 | 1,189
active Crohn's disease 327 | 918
spina bifida 311 | 1,064
acute quadriplegic myopathy 303 | 1,157
nasopharyngeal carcinoma 300 | 1,056
primary Sjogren syndrome 290 | 789
gastric carcinoma 288 | 832
Multiple myeloma 286 | 1,327
Alzheimer's disease 282 | 644
Atopic dermatitis 278 | 944
esophageal adenocarcinoma 277 | 737
Obesity 276 | 616
dermatomyositis 264 | 933
Multiple Sclerosis 262 | 498
Schizophrenia 258 | 501
Kidney disease 242 | 396
Down syndrome 235 | 548
Duchenne muscular dystrophy 233 | 602
mucosa-associated lymphoid tissue lymphoma 222 | 480
non primary Sjogren syndrome sicca 205 | 840
aldosterone-producing adenoma 198 | 664
Epilepsy 197 | 346
Asthma 191 | 349
fibroadenoma 191 | 557
acute myeloid leukemia 187 | 780
Hypersensitivity reaction type II disease 184 | 235
Hypertension 184 | 287
autosomal dominant Emery-Dreifuss muscular dystrophy 180 | 499
Arthritis 179 | 248
Autistic Disorder 179 | 320
active ulcerative colitis 179 | 477
Waldenstrons macroglobulinemia 178 | 765
Intellectual disability 177 | 573
non-small cell lung carcinoma 175 | 413
Prostatic Neoplasms 174 | 471
pancreatic carcinoma 169 | 567
Parkinson's disease 168 | 364
Endometriosis 165 | 535
progressive supranuclear palsy 164 | 674
Mammary Neoplasms 162 | 410
IGA Glomerulonephritis 161 | 454
Atherosclerosis 154 | 275
Heart disease 150 | 279
Cerebrovascular disease 148 | 231
Vascular disease 146 | 281
Anemia 141 | 252
Liver disease 140 | 219
Neurodegenerative disease 140 | 383
tuberculosis and treatment for 6 months 136 | 686
Amyotrophic Lateral Sclerosis 133 | 431

Tissue

Female tissues 4,839 | 18,647
Urinary Tract 4,793 | 18,444
Nervous System 4,761 | 18,561
Endocrine System 4,754 | 18,512
Digestive Tract 4,727 | 18,473
Skin and soft tissues 4,635 | 18,115
Liver and Pancreas 4,586 | 18,136
Blood and immune system 4,543 | 17,995
Cardiovascular System 4,531 | 17,958
Male tissues 4,490 | 17,969
Respiratory system 4,413 | 17,484

Target Family

Non-IDG 2,554 | 11,971
Enzyme 759 | 4,146
GPCR 390 | 406
oGPCR 380 | 421
Transporter 363 | 473
Ion Channel 313 | 341
Kinase 234 | 634
Transcription Factor 44 | 1,400
Epigenetic 15 | 242
Nuclear Receptor 4 | 48
TF/Epigenetic 3 | 38

Compartment GO Term

Plasma membrane 5,059 | 5,059
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5