Development Level

Tbio 3,144 | 10,625
Tdark 1,254 | 7,003
Tchem 866 | 1,890
Tclin 409 | 602

Collection

Eligible non-olfactory GPCR Proteins 131 | 145
Eligible Ion Channel Proteins 105 | 117
Eligible Kinase Proteins 26 | 134

IMPC Term

preweaning lethality, complete... 171 | 633
preweaning lethality, incomple... 96 | 260
abnormal behavior 74 | 226
decreased lean body mass 67 | 195
decreased total body fat amoun... 60 | 186
embryonic lethality prior to t... 60 | 187
decreased bone mineral content 53 | 157
increased or absent threshold ... 49 | 128
decreased body weight 48 | 174
decreased bone mineral density 47 | 126
decreased grip strength 45 | 123
abnormal bone structure 44 | 131
increased circulating alkaline... 43 | 119
enlarged heart 38 | 111
hyperactivity 38 | 108
abnormal retina morphology 37 | 100
abnormal embryo size 35 | 112
embryonic lethality prior to o... 33 | 148
decreased circulating choleste... 31 | 85
increased lean body mass 31 | 107
decreased circulating glucose ... 30 | 121
increased mean corpuscular hem... 29 | 93
decreased body length 28 | 108
hypoactivity 28 | 89
increased mean corpuscular vol... 28 | 91
improved glucose tolerance 26 | 56
decreased circulating HDL chol... 25 | 77
decreased circulating triglyce... 25 | 83
short tibia 25 | 82
decreased circulating insulin ... 24 | 75
increased bone mineral content 24 | 92
decreased fasted circulating g... 23 | 49
increased grip strength 23 | 83
decreased prepulse inhibition 22 | 52
impaired glucose tolerance 22 | 52
increased circulating HDL chol... 22 | 63
increased total body fat amoun... 22 | 57
abnormal gait 21 | 51
abnormal lens morphology 21 | 73
abnormal retinal pigmentation 21 | 61
decreased rib number 21 | 59
decreased circulating alanine ... 19 | 53
decreased lumbar vertebrae num... 19 | 62
decreased mean corpuscular vol... 19 | 50
increased blood urea nitrogen ... 19 | 44
increased body weight 19 | 42
increased circulating sodium l... 19 | 71
increased fasted circulating g... 19 | 68
limb grasping 19 | 35
abnormal bone mineralization 18 | 55
cardiovascular system phenotyp... 18 | 35
decreased circulating serum al... 18 | 79
increased circulating choleste... 18 | 53
increased hemoglobin content 18 | 45
decreased heart weight 17 | 44
decreased leukocyte cell numbe... 17 | 54
increased circulating calcium ... 17 | 32
increased heart weight 17 | 37
male infertility 17 | 62
tremors 17 | 34
abnormal seminal vesicle morph... 16 | 47
decreased startle reflex 16 | 48
increased hematocrit 16 | 36
increased sacral vertebrae num... 16 | 62
prenatal lethality prior to he... 16 | 64
thrombocytopenia 16 | 46
abnormal sleep behavior 15 | 63
decreased circulating calcium ... 15 | 33
decreased eosinophil cell numb... 15 | 41
increased bone mineral density 15 | 52
increased circulating chloride... 15 | 43
abnormal neural tube closure 14 | 37
decreased caudal vertebrae num... 14 | 49
decreased circulating LDL chol... 14 | 37
decreased circulating alkaline... 14 | 41
decreased hemoglobin content 14 | 53
increased exploration in new e... 14 | 56
increased leukocyte cell numbe... 14 | 37
abnormal coat/hair pigmentatio... 13 | 54
abnormal heart morphology 13 | 51
abnormal kidney morphology 13 | 30
decreased circulating creatini... 13 | 31
decreased mean corpuscular hem... 13 | 34
enlarged epididymis 13 | 27
abnormal epididymis morphology 12 | 31
decreased NK T cell number 12 | 28
decreased blood urea nitrogen ... 12 | 31
increased circulating phosphat... 12 | 24
increased startle reflex 12 | 38
abnormal QRS complex 11 | 25
abnormal spleen morphology 11 | 36
decreased circulating free fat... 11 | 39
increased circulating potassiu... 11 | 31
abnormal rib morphology 10 | 28
decreased T cell number 10 | 31
decreased circulating chloride... 10 | 32
decreased vertical activity 10 | 22
enlarged spleen 10 | 26
increased circulating iron lev... 10 | 25
increased circulating total pr... 10 | 20

Disease

ovarian cancer 2,435 | 8,492
osteosarcoma 2,362 | 7,933
psoriasis 2,199 | 6,685
medulloblastoma, large-cell 2,007 | 6,234
glioblastoma 1,906 | 5,572
lung cancer 1,483 | 4,473
atypical teratoid / rhabdoid tumor 1,459 | 4,369
pilocytic astrocytoma 1,257 | 3,086
lung carcinoma 1,250 | 2,844
invasive ductal carcinoma 1,076 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 1,062 | 3,289
Cancer 1,059 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 1,047 | 2,956
malignant mesothelioma 1,044 | 3,163
non-small cell lung cancer 1,039 | 2,798
lung adenocarcinoma 1,033 | 2,714
oligodendroglioma 1,005 | 2,849
Breast cancer 1,003 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 1,002 | 2,988
pediatric high grade glioma 984 | 2,712
interstitial cystitis 979 | 2,299
primitive neuroectodermal tumor 970 | 3,031
Carcinoma 929 | 2,147
pancreatic cancer 868 | 2,300
subependymal giant cell astrocytoma 867 | 2,287
ependymoma 846 | 2,514
ulcerative colitis 838 | 2,087
adult high grade glioma 757 | 2,148
pituitary cancer 720 | 1,972
astrocytic glioma 715 | 2,241
ductal carcinoma in situ 674 | 1,745
diabetes mellitus 668 | 1,663
group 4 medulloblastoma 645 | 1,875
cystic fibrosis 640 | 1,670
Pick disease 631 | 1,893
tuberculosis 590 | 1,563
group 3 medulloblastoma 586 | 2,254
posterior fossa group A ependymoma 567 | 1,511
breast carcinoma 564 | 1,614
astrocytoma 549 | 1,493
colon cancer 537 | 1,475
medulloblastoma 510 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 489 | 1,795
primary pancreatic ductal adenocarcinoma 483 | 1,271
adrenocortical carcinoma 472 | 1,427
cutaneous lupus erythematosus 472 | 1,056
sonic hedgehog group medulloblastoma 465 | 1,482
posterior fossa group B ependymoma 460 | 1,530
Rheumatoid Arthritis 456 | 1,171
atypical teratoid/rhabdoid tumor 394 | 1,095
juvenile dermatomyositis 380 | 1,189
spina bifida 365 | 1,064
active Crohn's disease 361 | 918
nasopharyngeal carcinoma 351 | 1,056
acute quadriplegic myopathy 349 | 1,157
dermatomyositis 329 | 967
Atopic dermatitis 325 | 944
gastric carcinoma 325 | 832
Multiple myeloma 322 | 1,328
esophageal adenocarcinoma 315 | 737
primary Sjogren syndrome 312 | 789
Alzheimer's disease 305 | 644
Obesity 286 | 616
Multiple Sclerosis 272 | 498
Schizophrenia 271 | 503
Duchenne muscular dystrophy 261 | 602
Down syndrome 248 | 548
Kidney disease 244 | 397
mucosa-associated lymphoid tissue lymphoma 234 | 480
non primary Sjogren syndrome sicca 229 | 840
aldosterone-producing adenoma 225 | 664
fibroadenoma 219 | 557
acute myeloid leukemia 218 | 785
Epilepsy 205 | 346
autosomal dominant Emery-Dreifuss muscular dystrophy 202 | 499
Intellectual disability 201 | 573
Waldenstrons macroglobulinemia 199 | 765
Asthma 195 | 349
Hypertension 192 | 293
non-small cell lung carcinoma 190 | 413
pancreatic carcinoma 188 | 567
progressive supranuclear palsy 188 | 674
Prostatic Neoplasms 187 | 471
active ulcerative colitis 186 | 477
Autistic Disorder 185 | 320
Hypersensitivity reaction type II disease 184 | 235
Endometriosis 182 | 535
Arthritis 180 | 248
Parkinson's disease 179 | 364
tuberculosis and treatment for 6 months 172 | 686
IGA Glomerulonephritis 171 | 454
Mammary Neoplasms 171 | 410
Atherosclerosis 157 | 275
Vascular disease 157 | 281
Heart disease 154 | 279
Amyotrophic Lateral Sclerosis 152 | 432
Cerebrovascular disease 151 | 231
hepatocellular carcinoma 151 | 550
Neurodegenerative disease 149 | 383
sarcoidosis 148 | 368

Tissue

Female tissues 5,451 | 18,647
Urinary Tract 5,401 | 18,444
Nervous System 5,372 | 18,561
Endocrine System 5,361 | 18,512
Digestive Tract 5,337 | 18,473
Skin and soft tissues 5,237 | 18,115
Liver and Pancreas 5,197 | 18,136
Blood and immune system 5,151 | 17,995
Cardiovascular System 5,140 | 17,958
Male tissues 5,100 | 17,969
Respiratory system 5,017 | 17,484

Target Family

Non-IDG 2,964 | 11,969
Enzyme 892 | 4,146
GPCR 392 | 408
oGPCR 380 | 421
Transporter 366 | 473
Ion Channel 317 | 341
Kinase 252 | 634
Transcription Factor 80 | 1,400
Epigenetic 22 | 242
Nuclear Receptor 4 | 48
TF/Epigenetic 4 | 38

Compartment GO Term

Plasma membrane 5,673 | 5,673
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..