Development Level

Tbio 3,452 | 11,445
Tdark 1,176 | 6,588
Tchem 781 | 1,598
Tclin 421 | 613

Collection

RFA-RM-18-021 209 | 328
GPCR: IDG Consortium (Targets) 119 | 126
Ion Channel: IDG Consortium (T... 88 | 99
Kinase: IDG Consortium (Target... 25 | 125
GPCR: IDG Consortium (Complete... 24 | 25
Kinase: IDG Consortium (Comple... 9 | 37

IMPC Phenotype

preweaning lethality, complete... 255 | 979
preweaning lethality, incomple... 177 | 499
abnormal behavior 105 | 298
embryonic lethality prior to t... 85 | 278
decreased vertical activity 83 | 208
enlarged heart 77 | 210
decreased total body fat amoun... 69 | 207
abnormal embryo size 67 | 220
abnormal bone structure 62 | 187
embryonic lethality prior to o... 62 | 239
hyperactivity 60 | 148
increased lean body mass 56 | 172
abnormal heart morphology 53 | 162
decreased body weight 53 | 161
decreased bone mineral content 52 | 151
increased total body fat amoun... 51 | 134
abnormal seminal vesicle morph... 46 | 114
increased circulating alkaline... 44 | 122
decreased bone mineral density 41 | 126
decreased lean body mass 40 | 135
hypoactivity 40 | 132
increased startle reflex 39 | 112
decreased circulating glucose ... 38 | 126
decreased grip strength 36 | 116
increased bone mineral content 36 | 108
increased or absent threshold ... 36 | 101
embryonic growth retardation 35 | 106
improved glucose tolerance 34 | 79
decreased lymphocyte cell numb... 32 | 83
decreased prepulse inhibition 32 | 82
short tibia 32 | 97
decreased body length 31 | 101
decreased circulating choleste... 31 | 93
decreased mean corpuscular vol... 31 | 79
abnormal gait 30 | 69
increased mean corpuscular vol... 30 | 92
abnormal retina morphology 29 | 71
impaired glucose tolerance 29 | 75
decreased fasted circulating g... 28 | 65
decreased startle reflex 28 | 75
increased mean corpuscular hem... 28 | 96
prenatal lethality prior to he... 28 | 87
small superior vagus ganglion 28 | 74
cataract 26 | 92
increased heart weight 26 | 62
increased monocyte cell number 26 | 63
abnormal sleep behavior 25 | 70
decreased circulating insulin ... 25 | 76
limb grasping 25 | 41
male infertility 25 | 123
abnormal kidney morphology 24 | 65
increased fasted circulating g... 24 | 76
increased leukocyte cell numbe... 23 | 47
decreased circulating HDL chol... 22 | 68
decreased circulating triglyce... 22 | 79
decreased leukocyte cell numbe... 22 | 73
edema 22 | 59
abnormal eye morphology 21 | 68
abnormal lens morphology 21 | 81
decreased hemoglobin content 20 | 68
increased bone mineral density 20 | 72
increased circulating HDL chol... 20 | 80
increased circulating chloride... 20 | 41
increased circulating choleste... 20 | 66
increased circulating sodium l... 20 | 71
increased neutrophil cell numb... 20 | 46
thrombocytopenia 20 | 56
tremors 20 | 39
abnormal skin morphology 19 | 50
decreased circulating creatini... 19 | 39
decreased circulating serum al... 19 | 82
abnormal coat-hair pigmentatio... 18 | 64
abnormal epididymis morphology 18 | 42
decreased erythrocyte cell num... 18 | 62
decreased mean corpuscular hem... 18 | 50
hydrometra 18 | 53
increased blood urea nitrogen ... 18 | 48
increased circulating triglyce... 18 | 42
increased hematocrit 18 | 46
abnormal behavioral response t... 17 | 66
abnormal spleen morphology 17 | 55
enlarged spleen 17 | 41
increased hemoglobin content 17 | 45
increased lymphocyte cell numb... 17 | 32
increased mean platelet volume 17 | 45
abnormal coat appearance 16 | 31
decreased neutrophil cell numb... 16 | 42
increased circulating calcium ... 16 | 34
pallor 16 | 34
prolonged QT interval 16 | 38
abnormal neural tube closure 15 | 46
cardiovascular system phenotyp... 15 | 36
decreased blood urea nitrogen ... 15 | 51
decreased circulating LDL chol... 15 | 38
enlarged lymph nodes 15 | 37
prolonged ST segment 15 | 36
small testis 15 | 58
abnormal testis morphology 14 | 43
decreased circulating alkaline... 13 | 46
decreased circulating calcium ... 13 | 36

Disease

Carcinoma 4,054 | 11,493
ovarian cancer 2,521 | 8,520
osteosarcoma 2,433 | 7,950
psoriasis 2,257 | 6,694
medulloblastoma, large-cell 2,058 | 6,241
glioblastoma 2,036 | 5,792
atypical teratoid / rhabdoid tumor 1,776 | 5,112
ependymoma 1,655 | 4,679
lung cancer 1,649 | 4,740
adult high grade glioma 1,436 | 3,801
Astrocytoma, Pilocytic 1,282 | 3,081
lung carcinoma 1,272 | 2,843
group 3 medulloblastoma 1,239 | 4,104
Breast cancer 1,209 | 3,578
Cancer 1,132 | 2,499
malignant mesothelioma 1,104 | 3,232
non-small cell lung cancer 1,104 | 2,890
invasive ductal carcinoma 1,101 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 1,088 | 3,291
Kidney cancer 1,080 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 1,075 | 2,955
lung adenocarcinoma 1,058 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 1,032 | 2,989
oligodendroglioma 1,026 | 2,850
interstitial cystitis 998 | 2,312
primitive neuroectodermal tumor 982 | 3,035
pancreatic cancer 939 | 2,398
astrocytic glioma 888 | 2,597
subependymal giant cell astrocytoma 885 | 2,287
tuberculosis 771 | 2,010
pituitary cancer 740 | 1,972
ulcerative colitis 731 | 1,819
diabetes mellitus 705 | 1,728
ductal carcinoma in situ 680 | 1,745
cystic fibrosis 664 | 1,696
group 4 medulloblastoma 639 | 1,855
Pick disease 638 | 1,894
breast carcinoma 592 | 1,638
Schizophrenia 582 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 572 | 1,962
colon cancer 547 | 1,478
Autosomal recessive predisposition 546 | 1,442
cutaneous lupus erythematosus 487 | 1,057
adrenocortical carcinoma 481 | 1,428
Rheumatoid arthritis 464 | 1,191
primary pancreatic ductal adenocarcinoma 432 | 1,109
astrocytoma 410 | 1,146
juvenile dermatomyositis 384 | 1,187
spina bifida 377 | 1,074
active Crohn's disease 365 | 922
acute quadriplegic myopathy 357 | 1,158
nasopharyngeal carcinoma 356 | 1,058
pediatric high grade glioma 348 | 1,064
Intellectual disability 347 | 1,016
Atopic dermatitis 341 | 952
Melanoma 340 | 711
Bipolar Disorder 332 | 666
gastric carcinoma 329 | 807
Epilepsy 328 | 792
dermatomyositis 328 | 966
esophageal adenocarcinoma 325 | 737
Liver Cirrhosis, Experimental 322 | 769
Alzheimer's disease 318 | 658
Multiple myeloma 318 | 1,332
active ulcerative colitis 317 | 764
Obesity 314 | 678
primary Sjogren syndrome 303 | 735
Liver cancer 298 | 604
Multiple Sclerosis 291 | 540
Duchenne muscular dystrophy 271 | 601
non primary Sjogren syndrome sicca 264 | 891
Kidney disease 262 | 430
Hypertension 255 | 396
Skin cancer 249 | 469
mucosa-associated lymphoid tissue lymphoma 243 | 484
aldosterone-producing adenoma 235 | 665
Down syndrome 230 | 499
Seizures 224 | 596
fibroadenoma 222 | 559
acute myeloid leukemia 221 | 783
Dull intelligence 217 | 645
Low intelligence 217 | 645
Mental Retardation 217 | 645
Mental deficiency 217 | 645
Poor school performance 217 | 645
Depressive disorder 215 | 409
Asthma 213 | 385
medulloblastoma 213 | 720
autosomal dominant Emery-Dreifuss muscular dystrophy 210 | 510
Arthritis 206 | 290
Autistic Disorder 202 | 364
Hypersensitivity reaction type II disease 202 | 253
Parkinson's disease 199 | 392
Prostatic Neoplasms 197 | 495
Waldenstrons macroglobulinemia 196 | 765
pancreatic carcinoma 195 | 562
progressive supranuclear palsy 194 | 676
Endometriosis 192 | 540
Anemia 189 | 365
Breast Neoplasms 188 | 445

Tissue

Endocrine System 5,288 | 18,159
Female tissues 5,095 | 17,400
Digestive Tract 5,093 | 17,369
Skin and soft tissues 5,040 | 17,230
Male tissues 4,995 | 17,142
Blood and immune system 4,952 | 16,909
Nervous System 4,935 | 16,725
Urinary Tract 4,915 | 16,678
Liver and Pancreas 4,909 | 16,750
Respiratory system 4,769 | 16,393
Cardiovascular System 4,378 | 15,192

Target Family

Non-IDG 3,094 | 12,091
Enzyme 921 | 4,145
GPCR 391 | 408
oGPCR 380 | 421
Transporter 365 | 473
Ion Channel 323 | 344
Kinase 249 | 634
Transcription Factor 78 | 1,400
Epigenetic 22 | 242
Nuclear Receptor 4 | 48
TF/Epigenetic 3 | 38

Compartment GO Term

Plasma membrane 5,830 | 5,830
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Shadow of prion protein SPRN Tbio Non-IDG -2.49698 315.1 88