Development Level

Tbio 52 | 11,651
Tchem 29 | 1,388
Tclin 9 | 612
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased leukocyte cell numbe... 2 | 73
edema 2 | 59
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 96
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal pericardium morpholog... 1 | 26
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
brachydactyly 1 | 19
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating LDL chol... 1 | 13
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
male infertility 1 | 123
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
prolonged QT interval 1 | 38
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 64 | 11,493
ovarian cancer 63 | 8,520
medulloblastoma, large-cell 46 | 6,241
osteosarcoma 44 | 7,950
glioblastoma 43 | 5,792
lung cancer 43 | 4,740
Cancer 40 | 2,499
psoriasis 40 | 6,694
atypical teratoid / rhabdoid tumor 37 | 5,112
ependymoma 34 | 4,679
adult high grade glioma 31 | 3,801
Breast cancer 28 | 3,578
Kidney cancer 28 | 2,613
diabetes mellitus 25 | 1,728
group 3 medulloblastoma 25 | 4,104
malignant mesothelioma 24 | 3,232
non-small cell lung cancer 24 | 2,890
oligodendroglioma 23 | 2,850
Pick disease 21 | 1,894
subependymal giant cell astrocytoma 21 | 2,287
astrocytic glioma 20 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
lung adenocarcinoma 20 | 2,716
Astrocytoma, Pilocytic 19 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
lung carcinoma 19 | 2,843
primitive neuroectodermal tumor 19 | 3,035
group 4 medulloblastoma 18 | 1,855
interstitial cystitis 18 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
invasive ductal carcinoma 18 | 2,951
Schizophrenia 17 | 1,160
breast carcinoma 16 | 1,638
ulcerative colitis 16 | 1,819
Multiple myeloma 15 | 1,332
pancreatic cancer 15 | 2,398
Autosomal recessive predisposition 14 | 1,442
Melanoma 14 | 711
colon cancer 14 | 1,478
Alzheimer's disease 13 | 658
Epilepsy 13 | 792
Rheumatoid arthritis 13 | 1,191
Skin cancer 13 | 469
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
tuberculosis 13 | 2,010
Prostatic Neoplasms 12 | 495
ductal carcinoma in situ 12 | 1,745
Obesity 11 | 678
Stomach Neoplasms 11 | 300
pituitary cancer 11 | 1,972
Endometrial cancer 10 | 311
Heart disease 10 | 306
Hypertension 10 | 396
Kidney disease 10 | 430
Adenoma 9 | 167
Breast Neoplasms 9 | 445
Disease Progression 9 | 136
Mammary Neoplasms 9 | 425
Renal Cell Carcinoma 9 | 214
Vascular disease 9 | 319
Waldenstrons macroglobulinemia 9 | 765
acute quadriplegic myopathy 9 | 1,158
adrenocortical carcinoma 9 | 1,428
astrocytoma 9 | 1,146
cystic fibrosis 9 | 1,696
gastric carcinoma 9 | 807
spina bifida 9 | 1,074
Adenocarcinoma 8 | 122
Carcinoma, Hepatocellular 8 | 228
Colorectal Neoplasms 8 | 243
Intellectual disability 8 | 1,016
Liver Cirrhosis, Experimental 8 | 769
Liver cancer 8 | 604
Liver carcinoma 8 | 240
Muscle hypotonia 8 | 571
Ovarian Neoplasms 8 | 102
Seizures 8 | 596
Toxic encephalopathy 8 | 141
aldosterone-producing adenoma 8 | 665
medulloblastoma 8 | 720
nasopharyngeal carcinoma 8 | 1,058
Carcinoma of colon 7 | 32
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Lung Neoplasms 7 | 232
Lung disease 7 | 142
Lymphoid leukemia 7 | 160
Mental and motor retardation 7 | 608
Orbital separation excessive 7 | 244
Papilloma 7 | 44
cutaneous lupus erythematosus 7 | 1,057
dermatomyositis 7 | 966
juvenile dermatomyositis 7 | 1,187
ovarian neoplasm 7 | 99
Arthritis 6 | 290
Bipolar Disorder 6 | 666
Chronic Lymphocytic Leukemia 6 | 262
Hypersensitivity reaction type II disease 6 | 253
acute myeloid leukemia 6 | 783
hepatocellular carcinoma 6 | 547

Tissue

Blood and immune system 90 | 16,909
Digestive Tract 90 | 17,369
Endocrine System 90 | 18,159
Female tissues 90 | 17,400
Liver and Pancreas 90 | 16,750
Respiratory system 90 | 16,393
Skin and soft tissues 90 | 17,230
Urinary Tract 90 | 16,678
Nervous System 89 | 16,725
Male tissues 88 | 17,142
Cardiovascular System 87 | 15,192

Target Family

Enzyme 69 | 4,145
Non-IDG 14 | 12,091
Kinase 6 | 634
Transcription Factor 2 | 1,400
Nuclear Receptor 1 | 48

Compartment GO Term

Phosphatase complex 92 | 92
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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