Development Level

Tbio 47 | 10,625
Tchem 31 | 1,890
Tclin 6 | 602
Tdark 4 | 7,003

IMPC Term

preweaning lethality, complete... 4 | 633
decreased blood urea nitrogen ... 3 | 31
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
increased fasted circulating g... 2 | 68
increased mean corpuscular hem... 2 | 93
abnormal QRS complex 1 | 25
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 20
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
cardiovascular system phenotyp... 1 | 35
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased erythrocyte cell num... 1 | 43
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased memory-marker CD4-ne... 1 | 4
decreased threshold for audito... 1 | 32
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased CD4-negative NK T ce... 1 | 4
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased exploration in new e... 1 | 56
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased vertical activity 1 | 18
long tibia 1 | 13
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
premature death 1 | 5
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26
thrombocytopenia 1 | 46

Disease

ovarian cancer 58 | 8,484
medulloblastoma, large-cell 43 | 6,234
osteosarcoma 41 | 7,933
lung cancer 38 | 4,466
psoriasis 37 | 6,685
glioblastoma 35 | 5,572
Cancer 34 | 2,346
atypical teratoid / rhabdoid tumor 32 | 4,369
Carcinoma 25 | 2,147
Breast cancer 24 | 3,094
non-small cell lung cancer 24 | 2,798
oligodendroglioma 22 | 2,849
diabetes mellitus 21 | 1,663
ependymoma 21 | 2,514
Pick disease 20 | 1,893
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
adult high grade glioma 19 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
lung adenocarcinoma 19 | 2,713
lung carcinoma 19 | 2,844
malignant mesothelioma 19 | 3,162
invasive ductal carcinoma 18 | 2,950
pilocytic astrocytoma 18 | 3,086
primitive neuroectodermal tumor 18 | 3,031
subependymal giant cell astrocytoma 18 | 2,287
ulcerative colitis 18 | 2,087
interstitial cystitis 17 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
medulloblastoma 16 | 1,524
Multiple myeloma 15 | 1,327
astrocytic glioma 15 | 2,241
group 4 medulloblastoma 15 | 1,875
pediatric high grade glioma 15 | 2,712
astrocytoma 14 | 1,493
pancreatic cancer 14 | 2,300
Prostatic Neoplasms 12 | 471
colon cancer 12 | 1,475
ductal carcinoma in situ 12 | 1,745
group 3 medulloblastoma 12 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Rheumatoid Arthritis 11 | 1,160
breast carcinoma 11 | 1,614
Alzheimer's disease 10 | 644
Kidney disease 10 | 396
Obesity 10 | 616
pituitary cancer 10 | 1,972
Adenoma 9 | 165
Vascular disease 9 | 281
Waldenstrons macroglobulinemia 9 | 765
acute quadriplegic myopathy 9 | 1,157
adrenocortical carcinoma 9 | 1,427
cystic fibrosis 9 | 1,665
gastric carcinoma 9 | 832
spina bifida 9 | 1,064
Mammary Neoplasms 8 | 410
Stomach Neoplasms 8 | 282
aldosterone-producing adenoma 8 | 664
nasopharyngeal carcinoma 8 | 1,056
ovarian neoplasm 8 | 97
posterior fossa group A ependymoma 8 | 1,511
tuberculosis 8 | 1,557
Adenocarcinoma 7 | 115
Disease Progression 7 | 125
Heart disease 7 | 279
Liver carcinoma 7 | 217
Lung Neoplasms 7 | 171
cutaneous lupus erythematosus 7 | 1,056
dermatomyositis 7 | 933
juvenile dermatomyositis 7 | 1,189
posterior fossa group B ependymoma 7 | 1,530
sonic hedgehog group medulloblastoma 7 | 1,482
Colorectal Neoplasms 6 | 217
Diarrhea 6 | 155
Liver disease 6 | 219
Melanoma 6 | 261
Renal Cell Carcinoma 6 | 199
Schizophrenia 6 | 501
atypical teratoid/rhabdoid tumor 6 | 1,095
primary pancreatic ductal adenocarcinoma 6 | 1,271
tuberculosis and treatment for 6 months 6 | 686
Anemia 5 | 252
Arthritis 5 | 248
Asthma 5 | 349
Chronic Lymphocytic Leukemia 5 | 242
Colonic Neoplasms 5 | 126
Exanthem 5 | 39
IGA Glomerulonephritis 5 | 454
Intellectual disability 5 | 573
Lung disease 5 | 132
Neutropenia 5 | 78
Osteoporosis 5 | 257
Parkinson's disease 5 | 364
Peripheral Neuropathy 5 | 303
Toxic encephalopathy 5 | 131
active Crohn's disease 5 | 918
acute myeloid leukemia 5 | 780
fibroadenoma 5 | 557
glioblastoma multiforme 5 | 347
hereditary spastic paraplegia 5 | 313
primary Sjogren syndrome 5 | 789

Tissue

Blood and immune system 87 | 17,995
Cardiovascular System 87 | 17,958
Digestive Tract 87 | 18,473
Endocrine System 87 | 18,512
Female tissues 87 | 18,647
Liver and Pancreas 87 | 18,136
Male tissues 87 | 17,969
Nervous System 87 | 18,561
Skin and soft tissues 87 | 18,115
Urinary Tract 87 | 18,444
Respiratory system 86 | 17,484

Target Family

Enzyme 67 | 4,146
Non-IDG 12 | 11,971
Kinase 6 | 634
Transcription Factor 2 | 1,400
Nuclear Receptor 1 | 48

Compartment GO Term

Phosphatase complex 88 | 88
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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