Development Level

Tbio 411 | 11,445
Tchem 74 | 1,598
Tdark 38 | 6,588
Tclin 21 | 613

Collection

RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Target... 5 | 125
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 35 | 979
preweaning lethality, incomple... 24 | 499
abnormal embryo size 13 | 220
abnormal bone structure 12 | 187
abnormal behavior 10 | 298
decreased total body fat amoun... 10 | 207
embryonic lethality prior to t... 8 | 278
increased startle reflex 8 | 112
abnormal lens morphology 7 | 81
decreased body weight 7 | 161
decreased bone mineral density 7 | 126
decreased grip strength 7 | 116
decreased vertical activity 7 | 208
embryonic lethality prior to o... 7 | 239
increased heart weight 7 | 62
increased mean corpuscular hem... 7 | 96
abnormal gait 6 | 69
cataract 6 | 92
decreased bone mineral content 6 | 151
decreased lean body mass 6 | 135
hypoactivity 6 | 132
increased bone mineral density 6 | 72
increased lean body mass 6 | 172
increased total body fat amoun... 6 | 134
abnormal sleep behavior 5 | 70
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased lymphocyte cell numb... 5 | 83
edema 5 | 59
female infertility 5 | 60
hyperactivity 5 | 148
increased bone mineral content 5 | 108
increased neutrophil cell numb... 5 | 46
male infertility 5 | 123
tremors 5 | 39
abnormal retina morphology 4 | 71
abnormal seminal vesicle morph... 4 | 114
decreased circulating triglyce... 4 | 79
decreased fasted circulating g... 4 | 65
decreased leukocyte cell numbe... 4 | 73
decreased startle reflex 4 | 75
embryonic growth retardation 4 | 106
impaired glucose tolerance 4 | 75
increased circulating alkaline... 4 | 122
increased hematocrit 4 | 46
increased mean corpuscular vol... 4 | 92
abnormal body wall morphology 3 | 9
abnormal limb morphology 3 | 13
convulsive seizures 3 | 13
decreased circulating alkaline... 3 | 46
decreased circulating creatini... 3 | 39
decreased circulating insulin ... 3 | 76
decreased heart weight 3 | 27
decreased mean platelet volume 3 | 25
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased blood urea nitrogen ... 3 | 48
increased body weight 3 | 25
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
limb grasping 3 | 41
mammalian phenotype 3 | 17
pallor 3 | 34
abnormal behavioral response t... 2 | 66
abnormal craniofacial morpholo... 2 | 33
abnormal eye morphology 2 | 68
abnormal facial morphology 2 | 17
abnormal head morphology 2 | 10
abnormal limb bud morphology 2 | 17
abnormal pericardium morpholog... 2 | 26
abnormal retinal blood vessel ... 2 | 26
anophthalmia 2 | 33
cleft palate 2 | 8
decreased T cell number 2 | 15
decreased body length 2 | 101
decreased circulating aspartat... 2 | 34
decreased circulating free fat... 2 | 31
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased heart left ventricle... 2 | 28
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
facial cleft 2 | 3
hemorrhage 2 | 23
impaired righting response 2 | 26
increased circulating chloride... 2 | 41
increased circulating serum al... 2 | 22
increased heart rate 2 | 23
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
increased vertical activity 2 | 24
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small thymus 2 | 16
thrombocytosis 2 | 27

Disease

Carcinoma 352 | 11,493
ovarian cancer 311 | 8,520
osteosarcoma 266 | 7,950
medulloblastoma, large-cell 244 | 6,241
glioblastoma 242 | 5,792
psoriasis 231 | 6,694
atypical teratoid / rhabdoid tumor 225 | 5,112
lung cancer 208 | 4,740
ependymoma 178 | 4,679
group 3 medulloblastoma 158 | 4,104
adult high grade glioma 156 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 141 | 3,291
Astrocytoma, Pilocytic 134 | 3,081
Breast cancer 130 | 3,578
primitive neuroectodermal tumor 126 | 3,035
Cancer 123 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 123 | 2,989
oligodendroglioma 123 | 2,850
invasive ductal carcinoma 118 | 2,951
malignant mesothelioma 118 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 112 | 2,955
astrocytic glioma 110 | 2,597
lung adenocarcinoma 110 | 2,716
non-small cell lung cancer 108 | 2,890
pancreatic cancer 106 | 2,398
Kidney cancer 105 | 2,613
subependymal giant cell astrocytoma 104 | 2,287
lung carcinoma 100 | 2,843
Pick disease 80 | 1,894
breast carcinoma 80 | 1,638
ulcerative colitis 79 | 1,819
interstitial cystitis 76 | 2,312
Multiple myeloma 74 | 1,332
ductal carcinoma in situ 74 | 1,745
tuberculosis 74 | 2,010
cystic fibrosis 73 | 1,696
colon cancer 72 | 1,478
pituitary cancer 72 | 1,972
group 4 medulloblastoma 71 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 69 | 1,962
diabetes mellitus 67 | 1,728
adrenocortical carcinoma 64 | 1,428
acute quadriplegic myopathy 63 | 1,158
astrocytoma 61 | 1,146
juvenile dermatomyositis 60 | 1,187
Schizophrenia 59 | 1,160
Alzheimer's disease 58 | 658
dermatomyositis 52 | 966
pediatric high grade glioma 48 | 1,064
Intellectual disability 47 | 1,016
cutaneous lupus erythematosus 47 | 1,057
Autosomal recessive predisposition 44 | 1,442
Neurodegenerative disease 40 | 414
spina bifida 40 | 1,074
Down syndrome 39 | 499
Waldenstrons macroglobulinemia 39 | 765
Atopic dermatitis 38 | 952
primary pancreatic ductal adenocarcinoma 38 | 1,109
Obesity 37 | 678
Prostatic Neoplasms 35 | 495
nasopharyngeal carcinoma 35 | 1,058
active Crohn's disease 34 | 922
gastric carcinoma 34 | 807
Duchenne muscular dystrophy 33 | 601
Rheumatoid arthritis 33 | 1,191
Seizures 33 | 596
Amyotrophic lateral sclerosis 32 | 451
Dull intelligence 32 | 645
Low intelligence 32 | 645
Mental Retardation 32 | 645
Mental deficiency 32 | 645
Poor school performance 32 | 645
esophageal adenocarcinoma 32 | 737
Bipolar Disorder 31 | 666
Epilepsy 31 | 792
primary Sjogren syndrome 31 | 735
Breast Neoplasms 30 | 445
Liver Cirrhosis, Experimental 30 | 769
Parkinson's disease 30 | 392
Endometriosis 29 | 540
Liver cancer 29 | 604
Mammary Neoplasms 29 | 425
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 510
fibroadenoma 29 | 559
medulloblastoma 29 | 720
progressive supranuclear palsy 29 | 676
Depressive disorder 28 | 409
Melanoma 27 | 711
Short stature 27 | 531
acute myeloid leukemia 27 | 783
Cognitive delay 26 | 608
Global developmental delay 26 | 608
Kidney disease 26 | 430
Mental and motor retardation 26 | 608
Osteoporosis 26 | 363
Multiple Sclerosis 25 | 540
non primary Sjogren syndrome sicca 24 | 891
pancreatic carcinoma 24 | 562
Muscle hypotonia 22 | 571
aldosterone-producing adenoma 22 | 665

Tissue

Endocrine System 532 | 18,159
Digestive Tract 519 | 17,369
Skin and soft tissues 517 | 17,230
Female tissues 516 | 17,400
Liver and Pancreas 515 | 16,750
Male tissues 515 | 17,142
Nervous System 514 | 16,725
Blood and immune system 513 | 16,909
Urinary Tract 511 | 16,678
Respiratory system 510 | 16,393
Cardiovascular System 484 | 15,192

Target Family

Non-IDG 346 | 12,091
Enzyme 124 | 4,145
Kinase 36 | 634
Transporter 13 | 473
Ion Channel 10 | 344
Transcription Factor 7 | 1,400
Epigenetic 4 | 242
GPCR 4 | 408

Compartment GO Term

Perinuclear region of cytoplas... 544 | 544
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Gasdermin-A GSDMA Tbio Non-IDG -1.44401 26.7 77
Cullin-7 CUL7 Tbio Non-IDG -1.49747 38.0 139
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.48671 270.6 121
Protein spire homolog 2 SPIRE2 Tbio Non-IDG -0.76971 5.22 91
Selenoprotein M SELENOM Tdark Non-IDG -1.51502 30.3 0
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 ARFGEF1 Tbio Non-IDG -0.85174 8.71 57