Development Level

Tbio 380 | 10,625
Tchem 79 | 1,890
Tdark 41 | 7,003
Tclin 19 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 25 | 633
preweaning lethality, incomple... 14 | 260
abnormal behavior 8 | 226
decreased total body fat amoun... 8 | 186
abnormal bone mineralization 7 | 55
abnormal bone structure 7 | 131
decreased body weight 7 | 174
decreased bone mineral content 7 | 157
decreased bone mineral density 7 | 126
decreased grip strength 7 | 123
increased mean corpuscular hem... 7 | 93
increased or absent threshold ... 7 | 128
decreased lean body mass 6 | 195
decreased rib number 6 | 59
increased heart weight 6 | 37
increased lean body mass 6 | 107
abnormal embryo size 5 | 112
abnormal lens morphology 5 | 73
abnormal retina morphology 5 | 100
increased hematocrit 5 | 36
abnormal retinal pigmentation 4 | 61
abnormal sleep behavior 4 | 63
decreased lumbar vertebrae num... 4 | 62
decreased startle reflex 4 | 48
embryonic lethality prior to t... 4 | 187
hyperactivity 4 | 108
increased bone mineral density 4 | 52
increased circulating alkaline... 4 | 119
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular vol... 4 | 91
increased sacral vertebrae num... 4 | 62
increased total body fat amoun... 4 | 57
abnormal body wall morphology 3 | 7
decreased T cell number 3 | 31
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased circulating choleste... 3 | 85
decreased circulating free fat... 3 | 39
decreased circulating triglyce... 3 | 83
decreased fasted circulating g... 3 | 49
hypoactivity 3 | 89
impaired glucose tolerance 3 | 52
improved glucose tolerance 3 | 56
increased bone mineral content 3 | 92
increased circulating calcium ... 3 | 32
increased hemoglobin content 3 | 45
limb grasping 3 | 35
polydactyly 3 | 22
abnormal behavioral response t... 2 | 52
abnormal coping response 2 | 12
abnormal craniofacial morpholo... 2 | 12
abnormal facial morphology 2 | 9
abnormal forebrain development 2 | 18
abnormal gait 2 | 51
abnormal head morphology 2 | 10
abnormal heart morphology 2 | 51
abnormal hindbrain development 2 | 24
abnormal limb bud morphology 2 | 15
abnormal limb morphology 2 | 7
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal retinal blood vessel ... 2 | 18
abnormal seminal vesicle morph... 2 | 47
abnormal skin morphology 2 | 23
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
cleft palate 2 | 6
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating bilirubi... 2 | 14
decreased circulating fructosa... 2 | 31
decreased circulating insulin ... 2 | 75
decreased circulating potassiu... 2 | 17
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased threshold for audito... 2 | 32
decreased vertical activity 2 | 22
edema 2 | 11
enlarged spleen 2 | 26
facial cleft 2 | 3
hydrometra 2 | 13
increased blood urea nitrogen ... 2 | 44
increased body weight 2 | 42
increased circulating serum al... 2 | 25
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased respiratory quotient 2 | 12
increased startle reflex 2 | 38
increased vertical activity 2 | 18
pallor 2 | 13
short tibia 2 | 82
thrombocytosis 2 | 23
decreased heart weight 1 | 44
persistence of hyaloid vascula... 1 | 22

Disease

ovarian cancer 292 | 8,484
osteosarcoma 255 | 7,933
medulloblastoma, large-cell 235 | 6,234
glioblastoma 225 | 5,572
psoriasis 218 | 6,685
lung cancer 189 | 4,466
atypical teratoid / rhabdoid tumor 175 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 133 | 3,289
pilocytic astrocytoma 133 | 3,086
pediatric high grade glioma 130 | 2,712
primitive neuroectodermal tumor 122 | 3,031
oligodendroglioma 120 | 2,849
invasive ductal carcinoma 117 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 114 | 2,988
Cancer 113 | 2,346
malignant mesothelioma 111 | 3,162
Breast cancer 108 | 3,094
lung adenocarcinoma 108 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 107 | 2,956
non-small cell lung cancer 102 | 2,798
pancreatic cancer 100 | 2,300
subependymal giant cell astrocytoma 98 | 2,287
lung carcinoma 97 | 2,844
ependymoma 93 | 2,514
astrocytic glioma 85 | 2,241
ulcerative colitis 84 | 2,087
Carcinoma 81 | 2,147
group 3 medulloblastoma 78 | 2,254
astrocytoma 77 | 1,493
Pick disease 76 | 1,893
interstitial cystitis 75 | 2,299
breast carcinoma 74 | 1,614
group 4 medulloblastoma 74 | 1,875
ductal carcinoma in situ 73 | 1,745
Multiple myeloma 72 | 1,327
pituitary cancer 72 | 1,972
colon cancer 69 | 1,475
cystic fibrosis 68 | 1,665
adult high grade glioma 67 | 2,148
adrenocortical carcinoma 62 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,795
acute quadriplegic myopathy 61 | 1,157
tuberculosis 59 | 1,557
sonic hedgehog group medulloblastoma 58 | 1,482
diabetes mellitus 57 | 1,663
juvenile dermatomyositis 57 | 1,189
posterior fossa group A ependymoma 57 | 1,511
Alzheimer's disease 56 | 644
atypical teratoid/rhabdoid tumor 56 | 1,095
medulloblastoma 54 | 1,524
dermatomyositis 52 | 933
cutaneous lupus erythematosus 45 | 1,056
posterior fossa group B ependymoma 41 | 1,530
primary pancreatic ductal adenocarcinoma 41 | 1,271
Waldenstrons macroglobulinemia 38 | 765
spina bifida 37 | 1,064
Down syndrome 36 | 548
Atopic dermatitis 35 | 944
Neurodegenerative disease 35 | 383
active Crohn's disease 35 | 918
Prostatic Neoplasms 34 | 471
gastric carcinoma 34 | 832
primary Sjogren syndrome 34 | 789
Duchenne muscular dystrophy 33 | 602
Rheumatoid Arthritis 33 | 1,160
Obesity 32 | 616
nasopharyngeal carcinoma 31 | 1,056
Endometriosis 29 | 535
esophageal adenocarcinoma 29 | 737
Parkinson's disease 28 | 364
IGA Glomerulonephritis 27 | 454
Intellectual disability 27 | 573
Kidney disease 27 | 396
Mammary Neoplasms 27 | 410
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 499
fibroadenoma 27 | 557
progressive supranuclear palsy 27 | 674
Amyotrophic Lateral Sclerosis 26 | 431
acute myeloid leukemia 26 | 780
Multiple Sclerosis 25 | 498
pancreatic carcinoma 25 | 567
Schizophrenia 24 | 501
non primary Sjogren syndrome sicca 22 | 840
tuberculosis and treatment for 6 months 22 | 686
aldosterone-producing adenoma 21 | 664
Liver carcinoma 19 | 217
Colorectal Neoplasms 16 | 217
Melanoma 16 | 261
Peripheral Neuropathy 16 | 303
Stomach Neoplasms 16 | 282
chronic rhinosinusitis 16 | 512
hereditary spastic paraplegia 16 | 313
inflammatory breast cancer 16 | 404
sarcoidosis 16 | 358
Atherosclerosis 15 | 275
Autistic Disorder 15 | 320
Heart disease 15 | 279
glioblastoma multiforme 15 | 347
Asthma 14 | 349
mucosa-associated lymphoid tissue lymphoma 14 | 480

Tissue

Endocrine System 513 | 18,512
Female tissues 513 | 18,647
Digestive Tract 512 | 18,473
Nervous System 512 | 18,561
Urinary Tract 512 | 18,444
Cardiovascular System 509 | 17,958
Male tissues 508 | 17,969
Liver and Pancreas 507 | 18,136
Blood and immune system 505 | 17,995
Skin and soft tissues 505 | 18,115
Respiratory system 501 | 17,484

Target Family

Non-IDG 337 | 11,971
Enzyme 115 | 4,146
Kinase 32 | 634
Transporter 13 | 473
Ion Channel 9 | 341
Transcription Factor 6 | 1,400
Epigenetic 4 | 242
GPCR 3 | 406

Compartment GO Term

Perinuclear region of cytoplas... 519 | 519
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Protein KIBRA WWC1 Tbio Non-IDG -1.88892 84.4 96
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91