Development Level

Tbio 91 | 11,178
Tclin 70 | 612
Tchem 57 | 1,885
Tdark 4 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 26 | 979
embryonic lethality prior to o... 10 | 239
embryonic lethality prior to t... 7 | 278
cataract 5 | 92
decreased erythrocyte cell num... 5 | 62
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
increased lean body mass 5 | 172
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal lens morphology 3 | 81
decreased bone mineral content 3 | 151
decreased circulating amylase ... 3 | 28
decreased heart weight 3 | 27
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
increased bone mineral content 3 | 108
increased circulating calcium ... 3 | 34
increased total body fat amoun... 3 | 134
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased lactate dehydrogenas... 2 | 16
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
decreased total retina thickne... 2 | 17
hypoactivity 2 | 132
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased neutrophil cell numb... 2 | 46
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
thrombocytopenia 2 | 56
abnormal allantois morphology 1 | 8
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal sensory capabilities-... 1 | 8
abnormal snout morphology 1 | 23
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vitelline vasculature... 1 | 6
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
enlarged epididymis 1 | 31
enlarged uterus 1 | 11
hemorrhage 1 | 23
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
small superior vagus ganglion 1 | 74
small testis 1 | 58
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

ovarian cancer 125 | 8,297
Carcinoma 108 | 11,192
Cancer 95 | 2,388
psoriasis 93 | 6,514
osteosarcoma 91 | 7,766
diabetes mellitus 84 | 1,683
lung cancer 84 | 4,607
glioblastoma 78 | 5,635
Autosomal recessive predisposition 66 | 1,407
medulloblastoma, large-cell 65 | 6,086
Multiple myeloma 62 | 1,296
Kidney disease 55 | 411
ependymoma 55 | 4,559
atypical teratoid / rhabdoid tumor 54 | 4,971
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,911
Hypertension 51 | 372
Obesity 50 | 655
Diabetes mellitus type 2 49 | 69
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,204
Treatment Refractory Type 2 Diabetes Mellitus 48 | 53
lung adenocarcinoma 48 | 2,627
non-small cell lung cancer 48 | 2,799
Atherosclerosis 46 | 276
Schizophrenia 45 | 1,136
malignant mesothelioma 45 | 3,135
Breast cancer 44 | 3,469
Seizures 44 | 584
lung carcinoma 44 | 2,755
tuberculosis 43 | 1,963
adult high grade glioma 42 | 3,701
invasive ductal carcinoma 42 | 2,867
ulcerative colitis 42 | 1,765
Epilepsy 41 | 775
Heart disease 41 | 288
Heart failure 41 | 157
Cerebellar Ataxia 40 | 302
Hypertensive disease 40 | 278
Alzheimer's disease 38 | 640
Toxic encephalopathy 38 | 139
pancreatic cancer 38 | 2,322
group 3 medulloblastoma 37 | 4,002
interstitial cystitis 37 | 2,237
Leigh disease 36 | 100
astrocytic glioma 36 | 2,530
Acidosis, Lactic 35 | 97
Arthritis 35 | 276
Asthma 35 | 370
Cerebrovascular disease 35 | 223
Muscle hypotonia 35 | 562
cystic fibrosis 35 | 1,629
Astrocytoma, Pilocytic 34 | 3,006
Hyperglycemia 34 | 134
Lactic acidemia 34 | 95
Mitochondrial complex I deficiency 34 | 46
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,902
oligodendroglioma 34 | 2,768
Brain Ischemia 32 | 107
Cognitive delay 32 | 596
Global developmental delay 32 | 596
Mental and motor retardation 32 | 596
Vascular disease 32 | 294
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,872
Coronary artery disease 31 | 253
Anemia 30 | 353
Bipolar Disorder 30 | 646
Depressive disorder 30 | 401
Diabetes Mellitus, Experimental 30 | 101
Intellectual disability 30 | 998
Liver disease 30 | 227
Prostatic Neoplasms 30 | 472
Stomach Neoplasms 30 | 287
Blepharoptosis 29 | 229
Hypoglycemia 29 | 146
Lung disease 29 | 135
Parkinson's disease 29 | 378
acute quadriplegic myopathy 29 | 1,133
adrenocortical carcinoma 29 | 1,385
primitive neuroectodermal tumor 29 | 2,957
Brain disease 28 | 95
Neurodegenerative disease 28 | 402
Rheumatoid arthritis 28 | 1,156
Dull intelligence 27 | 634
Low intelligence 27 | 634
Mental Retardation 27 | 634
Mental deficiency 27 | 634
Poor school performance 27 | 634
Waldenstrons macroglobulinemia 27 | 742
Diabetes Mellitus, Non-Insulin-Dependent 26 | 140
Hyperreflexia 26 | 208
breast carcinoma 26 | 1,589
Carcinoma, Hepatocellular 25 | 217
Dystonia 25 | 163
Liver carcinoma 25 | 229
Reperfusion Injury 25 | 84
astrocytoma 25 | 1,113
Breast Neoplasms 24 | 423
Liver Cirrhosis, Experimental 24 | 733
Mammary Neoplasms 24 | 403
Muscle Weakness 24 | 168
Failure to gain weight 23 | 359

Tissue

Endocrine System 220 | 18,159
Digestive Tract 219 | 17,369
Urinary Tract 219 | 16,678
Blood and immune system 218 | 16,909
Female tissues 218 | 17,400
Liver and Pancreas 218 | 16,750
Skin and soft tissues 218 | 17,230
Male tissues 217 | 17,142
Nervous System 214 | 16,725
Respiratory system 214 | 16,393
Cardiovascular System 203 | 15,192

Target Family

Enzyme 134 | 4,145
Non-IDG 62 | 12,091
Kinase 10 | 634
Transcription Factor 7 | 1,400
Transporter 3 | 473
Epigenetic 2 | 242
Nuclear Receptor 2 | 48
GPCR 1 | 408
Ion Channel 1 | 344

Compartment GO Term

Oxidoreductase complex 222 | 222
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1P1 Tdark Non-IDG -2.12377 231.9 0
Tyrosine-protein kinase Fes/Fps FES Tchem Kinase -3.05038 1109.2 314
Heat shock 70 kDa protein 4 HSPA4 Tbio Non-IDG -3.92672 8635.1 432
2,4-dienoyl-CoA reductase, mitochondrial DECR1 Tbio Enzyme -4.22091 15887.9 151
Frataxin, mitochondrial FXN Tbio Non-IDG -3.02739 1114.8 403
SH3 domain and tetratricopeptide repeat-containing protein 2 SH3TC2 Tbio Non-IDG -2.27646 182.7 36
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 Tclin Enzyme -1.48141 29.4 191
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial DHTKD1 Tbio Enzyme -0.96606 9.64 87
Kelch-like ECH-associated protein 1 KEAP1 Tclin Non-IDG -2.99364 962.4 463
NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 Tclin Enzyme -1.18678 15.3 139