Development Level

Tbio 82 | 10,625
Tclin 69 | 602
Tchem 53 | 1,890
Tdark 7 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 15 | 633
embryonic lethality prior to o... 4 | 148
abnormal lens morphology 3 | 73
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
increased bone mineral content 3 | 92
increased lean body mass 3 | 107
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal epididymis morphology 2 | 31
abnormal femur morphology 2 | 14
abnormal gait 2 | 51
abnormal tooth morphology 2 | 24
decreased NK cell number 2 | 16
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased rib number 2 | 59
decreased total retina thickne... 2 | 20
enlarged epididymis 2 | 27
increased CD4-positive, CD25-p... 2 | 18
increased T cell number 2 | 15
increased alpha-beta T cell nu... 2 | 9
increased circulating free fat... 2 | 17
increased grip strength 2 | 83
increased or absent threshold ... 2 | 128
abnormal QRS complex 1 | 25
abnormal clavicle morphology 1 | 5
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 12
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal maxilla morphology 1 | 16
abnormal placement of pupils 1 | 4
abnormal radius morphology 1 | 8
abnormal retinal inner nuclear... 1 | 5
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal thoracic cage shape 1 | 3
abnormal thoracic vertebrae mo... 1 | 16
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
abnormal visceral yolk sac mor... 1 | 2
cataract 1 | 26
decreased B cell number 1 | 30
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating serum al... 1 | 79
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
embryonic growth retardation 1 | 28
hypoactivity 1 | 89
impaired righting response 1 | 19
increased CD4-positive, alpha ... 1 | 15
increased CD8-positive, alpha-... 1 | 11
increased Ly6C high monocyte n... 1 | 12
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased memory-marker gamma-... 1 | 2
increased spleen weight 1 | 3
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small testis 1 | 37
stereotypic behavior 1 | 3
trunk curl 1 | 15

Disease

ovarian cancer 119 | 8,484
Cancer 90 | 2,346
psoriasis 87 | 6,685
osteosarcoma 85 | 7,933
diabetes mellitus 77 | 1,663
lung cancer 76 | 4,466
glioblastoma 74 | 5,572
medulloblastoma, large-cell 59 | 6,234
Multiple myeloma 58 | 1,327
Kidney disease 57 | 396
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
Atherosclerosis 49 | 275
Diabetes mellitus type 2 48 | 69
Obesity 47 | 616
Treatment Refractory Type 2 Diabetes Mellitus 47 | 53
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,289
ulcerative colitis 47 | 2,087
lung adenocarcinoma 46 | 2,713
lung carcinoma 45 | 2,844
non-small cell lung cancer 44 | 2,798
Hypertension 43 | 287
atypical teratoid / rhabdoid tumor 43 | 4,369
Heart disease 41 | 279
Cerebrovascular disease 40 | 231
invasive ductal carcinoma 40 | 2,950
malignant mesothelioma 39 | 3,162
pancreatic cancer 39 | 2,300
Alzheimer's disease 38 | 644
Arthritis 38 | 248
tuberculosis 38 | 1,557
Asthma 37 | 349
Breast cancer 37 | 3,094
interstitial cystitis 37 | 2,299
pediatric high grade glioma 37 | 2,712
Coronary artery disease 34 | 240
Hyperglycemia 34 | 120
cystic fibrosis 34 | 1,665
pilocytic astrocytoma 34 | 3,086
Hypertensive disease 33 | 193
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,988
Diabetes Mellitus, Experimental 32 | 106
Leigh disease 32 | 81
Liver disease 32 | 219
Lung disease 32 | 132
Toxic encephalopathy 32 | 131
astrocytic glioma 32 | 2,241
ependymoma 32 | 2,514
oligodendroglioma 31 | 2,849
Brain Ischemia 30 | 87
Prostatic Neoplasms 30 | 471
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
Parkinson's disease 29 | 364
Vascular disease 29 | 281
astrocytoma 29 | 1,493
adrenocortical carcinoma 28 | 1,427
Anemia 27 | 252
Heart failure 27 | 80
Rheumatoid Arthritis 27 | 1,160
acute quadriplegic myopathy 27 | 1,157
Brain disease 26 | 83
MITOCHONDRIAL COMPLEX I DEFICIENCY 26 | 37
Mammary Neoplasms 26 | 410
Neurodegenerative disease 26 | 383
Reperfusion Injury 26 | 84
primitive neuroectodermal tumor 26 | 3,031
Inflammatory bowel disease 25 | 142
Stomach Neoplasms 25 | 282
Waldenstrons macroglobulinemia 25 | 765
Inflammation 24 | 109
Liver carcinoma 23 | 217
Osteoporosis 23 | 257
posterior fossa group A ependymoma 23 | 1,511
subependymal giant cell astrocytoma 23 | 2,287
Hypersensitivity reaction type II disease 22 | 235
Metabolic syndrome X 22 | 155
Diabetes Mellitus, Non-Insulin-Dependent 21 | 157
cutaneous lupus erythematosus 21 | 1,056
medulloblastoma 21 | 1,524
Malaria 20 | 140
breast carcinoma 20 | 1,614
Endometriosis 19 | 535
Eye disease 19 | 55
Multiple Sclerosis 19 | 498
Myocardial Infarction 19 | 126
Myocardial Ischemia 19 | 169
ductal carcinoma in situ 19 | 1,745
group 4 medulloblastoma 19 | 1,875
Colonic Neoplasms 18 | 126
Drug-Induced Liver Injury 18 | 118
Lung Neoplasms 18 | 171
Pancreatitis 18 | 97
Squamous cell carcinoma 18 | 94
acute myeloid leukemia 18 | 780
Atopic dermatitis 17 | 944
Neuropathy 17 | 210
Pick disease 17 | 1,893
Schizophrenia 17 | 501
adult high grade glioma 17 | 2,148
esophageal adenocarcinoma 17 | 737
nasopharyngeal carcinoma 17 | 1,056

Tissue

Blood and immune system 209 | 17,995
Digestive Tract 209 | 18,473
Endocrine System 209 | 18,512
Liver and Pancreas 209 | 18,136
Nervous System 209 | 18,561
Female tissues 208 | 18,647
Male tissues 208 | 17,969
Skin and soft tissues 208 | 18,115
Urinary Tract 208 | 18,444
Cardiovascular System 207 | 17,958
Respiratory system 207 | 17,484

Target Family

Enzyme 128 | 4,146
Non-IDG 60 | 11,971
Kinase 9 | 634
Transcription Factor 6 | 1,400
Epigenetic 2 | 242
Transporter 2 | 473
GPCR 1 | 406
Ion Channel 1 | 341
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

Oxidoreductase complex 211 | 211
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122
Glutamate dehydrogenase 2, mitochondrial GLUD2 Tbio Enzyme -1.13407 13.6 143
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129