Development Level

Tbio 291 | 11,651
Tdark 32 | 6,593
Tchem 22 | 1,388
Tclin 3 | 612

Collection

RFA-RM-18-021 3 | 328
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 13 | 499
embryonic lethality prior to t... 11 | 278
abnormal bone structure 10 | 187
decreased total body fat amoun... 9 | 207
abnormal sleep behavior 7 | 70
decreased body weight 7 | 161
increased heart weight 7 | 62
embryonic lethality prior to o... 6 | 239
increased startle reflex 6 | 112
abnormal behavior 5 | 298
abnormal behavioral response t... 5 | 66
abnormal embryo size 5 | 220
decreased circulating HDL chol... 5 | 68
decreased grip strength 5 | 116
increased bone mineral content 5 | 108
increased lean body mass 5 | 172
increased mean corpuscular vol... 5 | 92
abnormal eye morphology 4 | 68
abnormal retina morphology 4 | 71
decreased circulating LDL chol... 4 | 38
decreased circulating alanine ... 4 | 47
decreased circulating choleste... 4 | 93
decreased circulating insulin ... 4 | 76
edema 4 | 59
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
increased bone mineral density 4 | 72
increased circulating alkaline... 4 | 122
limb grasping 4 | 41
male infertility 4 | 123
abnormal craniofacial morpholo... 3 | 33
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal limb bud morphology 3 | 17
abnormal limb morphology 3 | 13
abnormal seminal vesicle morph... 3 | 114
abnormal tail movements 3 | 12
anophthalmia 3 | 33
cataract 3 | 92
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased mean corpuscular hem... 3 | 50
decreased vertical activity 3 | 208
enlarged heart 3 | 210
hyperactivity 3 | 148
increased grip strength 3 | 41
increased mean corpuscular hem... 3 | 96
increased or absent threshold ... 3 | 101
polydactyly 3 | 7
abnormal body wall morphology 2 | 9
abnormal coat appearance 2 | 31
abnormal epididymis morphology 2 | 42
abnormal facial morphology 2 | 17
abnormal heart morphology 2 | 162
abnormal response to new envir... 2 | 10
abnormal snout morphology 2 | 23
cleft palate 2 | 8
decreased B cell number 2 | 5
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating creatini... 2 | 39
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
facial cleft 2 | 3
increased blood urea nitrogen ... 2 | 48
increased body weight 2 | 25
increased circulating amylase ... 2 | 25
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 36
pale yolk sac 2 | 25
pallor 2 | 34
premature death 2 | 5
tremors 2 | 39
abnormal gait 1 | 69
abnormal spleen morphology 1 | 55
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased pulmonary respirator... 1 | 5
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
microphthalmia 1 | 26

Disease

Carcinoma 229 | 11,493
ovarian cancer 215 | 8,520
osteosarcoma 178 | 7,950
psoriasis 146 | 6,694
medulloblastoma, large-cell 141 | 6,241
glioblastoma 136 | 5,792
atypical teratoid / rhabdoid tumor 108 | 5,112
lung cancer 99 | 4,740
ependymoma 98 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 79 | 2,989
adult high grade glioma 76 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 76 | 3,291
Breast cancer 75 | 3,578
Astrocytoma, Pilocytic 73 | 3,081
malignant mesothelioma 70 | 3,232
pancreatic cancer 63 | 2,398
invasive ductal carcinoma 60 | 2,951
group 3 medulloblastoma 59 | 4,104
Kidney cancer 58 | 2,613
astrocytic glioma 56 | 2,597
lung adenocarcinoma 55 | 2,716
lung carcinoma 54 | 2,843
Pick disease 52 | 1,894
group 4 medulloblastoma 50 | 1,855
oligodendroglioma 50 | 2,850
subependymal giant cell astrocytoma 50 | 2,287
non-small cell lung cancer 49 | 2,890
primitive neuroectodermal tumor 48 | 3,035
Cancer 47 | 2,499
tuberculosis 46 | 2,010
diabetes mellitus 43 | 1,728
interstitial cystitis 43 | 2,312
Multiple myeloma 42 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,962
breast carcinoma 39 | 1,638
cystic fibrosis 39 | 1,696
ductal carcinoma in situ 39 | 1,745
pituitary cancer 37 | 1,972
astrocytoma 33 | 1,146
juvenile dermatomyositis 33 | 1,187
pediatric high grade glioma 32 | 1,064
primary pancreatic ductal adenocarcinoma 32 | 1,109
Autosomal recessive predisposition 31 | 1,442
Intellectual disability 31 | 1,016
acute quadriplegic myopathy 31 | 1,158
Alzheimer's disease 30 | 658
ulcerative colitis 30 | 1,819
Neurodegenerative disease 27 | 414
Rheumatoid arthritis 27 | 1,191
colon cancer 27 | 1,478
Waldenstrons macroglobulinemia 26 | 765
Duchenne muscular dystrophy 24 | 601
active Crohn's disease 24 | 922
dermatomyositis 24 | 966
Schizophrenia 23 | 1,160
non primary Sjogren syndrome sicca 22 | 891
adrenocortical carcinoma 21 | 1,428
spina bifida 21 | 1,074
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
active ulcerative colitis 20 | 764
hereditary spastic paraplegia 20 | 318
Down syndrome 19 | 499
Liver Cirrhosis, Experimental 19 | 769
Liver cancer 19 | 604
aldosterone-producing adenoma 19 | 665
progressive supranuclear palsy 19 | 676
Atopic dermatitis 18 | 952
Dull intelligence 18 | 645
Epilepsy 18 | 792
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
acute myeloid leukemia 18 | 783
cutaneous lupus erythematosus 17 | 1,057
tuberculosis and treatment for 6 months 17 | 409
Amyotrophic lateral sclerosis 16 | 451
Multiple Sclerosis 16 | 540
esophageal adenocarcinoma 16 | 737
primary Sjogren syndrome 16 | 735
Cataract 8 multiple types 15 | 33
Muscle hypotonia 15 | 571
gastric carcinoma 15 | 807
Kidney disease 14 | 430
Obesity 14 | 678
atypical teratoid/rhabdoid tumor 14 | 357
nasopharyngeal carcinoma 14 | 1,058
Bipolar Disorder 13 | 666
Gaucher disease type 1 13 | 180
Seizures 13 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
pancreatic carcinoma 13 | 562
Prostatic Neoplasms 12 | 495
Short stature 12 | 531
Small head 12 | 374
limb girdle muscular dystrophy 2A 12 | 213
mucosa-associated lymphoid tissue lymphoma 12 | 484

Tissue

Endocrine System 333 | 18,159
Female tissues 331 | 17,400
Nervous System 330 | 16,725
Digestive Tract 329 | 17,369
Liver and Pancreas 329 | 16,750
Skin and soft tissues 329 | 17,230
Blood and immune system 327 | 16,909
Male tissues 326 | 17,142
Respiratory system 326 | 16,393
Urinary Tract 325 | 16,678
Cardiovascular System 318 | 15,192

Target Family

Non-IDG 212 | 12,091
Enzyme 115 | 4,145
Transporter 8 | 473
Kinase 6 | 634
GPCR 4 | 408
Ion Channel 3 | 344

Compartment GO Term

Organelle subcompartment 348 | 348
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
Polypeptide N-acetylgalactosaminyltransferase 3 GALNT3 Tbio Enzyme -2.80894 644.1 124
Beta-1,3-galactosyltransferase 6 B3GALT6 Tbio Enzyme -1.00350 10.1 132
Alpha-(1,3)-fucosyltransferase 7 FUT7 Tchem Enzyme -1.85814 81.0 121
RNA binding protein fox-1 homolog 1 RBFOX1 Tbio Non-IDG -2.00815 99.2 207