Development Level

Tbio 5,572 | 10,625
Tdark 1,335 | 7,003
Tchem 989 | 1,890
Tclin 274 | 602

Collection

Eligible Kinase Proteins 48 | 134
Eligible Ion Channel Proteins 11 | 117
Eligible non-olfactory GPCR Proteins 11 | 143

IMPC Term

preweaning lethality, complete... 440 | 633
preweaning lethality, incomple... 140 | 260
embryonic lethality prior to t... 132 | 187
embryonic lethality prior to o... 116 | 148
abnormal behavior 113 | 226
decreased lean body mass 106 | 195
decreased total body fat amoun... 105 | 186
decreased body weight 103 | 174
decreased bone mineral content 90 | 157
abnormal bone structure 75 | 131
abnormal embryo size 73 | 112
decreased grip strength 68 | 123
increased circulating alkaline... 68 | 119
decreased body length 66 | 108
decreased bone mineral density 64 | 126
decreased circulating glucose ... 64 | 121
increased or absent threshold ... 64 | 128
abnormal retina morphology 61 | 100
increased lean body mass 59 | 107
increased mean corpuscular hem... 56 | 93
hyperactivity 55 | 108
decreased circulating choleste... 54 | 85
increased bone mineral content 54 | 92
increased mean corpuscular vol... 52 | 91
enlarged heart 50 | 111
decreased circulating HDL chol... 47 | 77
hypoactivity 47 | 89
abnormal lens morphology 45 | 73
increased grip strength 44 | 83
short tibia 43 | 82
decreased circulating triglyce... 42 | 83
decreased circulating serum al... 41 | 79
prenatal lethality prior to he... 41 | 64
increased circulating sodium l... 38 | 71
abnormal retinal pigmentation 37 | 61
decreased mean corpuscular vol... 37 | 50
abnormal bone mineralization 36 | 55
decreased circulating insulin ... 36 | 75
increased fasted circulating g... 35 | 68
decreased lumbar vertebrae num... 33 | 62
abnormal sleep behavior 32 | 63
decreased rib number 32 | 59
increased sacral vertebrae num... 32 | 62
decreased fasted circulating g... 31 | 49
decreased leukocyte cell numbe... 31 | 54
increased bone mineral density 31 | 52
increased circulating HDL chol... 31 | 63
increased total body fat amoun... 31 | 57
decreased hemoglobin content 30 | 53
decreased prepulse inhibition 30 | 52
abnormal coat/hair pigmentatio... 29 | 54
decreased circulating alanine ... 29 | 53
increased circulating choleste... 29 | 53
male infertility 29 | 62
abnormal gait 26 | 51
decreased caudal vertebrae num... 26 | 49
decreased circulating LDL chol... 26 | 37
increased blood urea nitrogen ... 26 | 44
decreased erythrocyte cell num... 25 | 43
decreased startle reflex 25 | 48
impaired glucose tolerance 25 | 52
increased circulating chloride... 25 | 43
embryonic growth retardation 24 | 28
increased heart weight 24 | 37
abnormal behavioral response t... 23 | 52
abnormal heart morphology 23 | 51
abnormal neural tube closure 23 | 37
decreased mean corpuscular hem... 23 | 34
improved glucose tolerance 23 | 56
abnormal eye morphology 22 | 38
decreased circulating total pr... 22 | 41
increased exploration in new e... 22 | 56
thrombocytopenia 22 | 46
tremors 22 | 34
decreased heart weight 21 | 44
increased hemoglobin content 21 | 45
limb grasping 21 | 35
decreased eosinophil cell numb... 20 | 41
increased body weight 20 | 42
abnormal seminal vesicle morph... 19 | 47
decreased circulating alkaline... 19 | 41
decreased circulating aspartat... 19 | 27
decreased circulating free fat... 19 | 39
decreased hematocrit 19 | 25
increased circulating creatini... 19 | 29
increased startle reflex 19 | 38
cardiovascular system phenotyp... 18 | 35
decreased circulating fructosa... 18 | 31
increased leukocyte cell numbe... 18 | 37
small testis 18 | 37
abnormal locomotor activation 17 | 26
decreased T cell number 17 | 31
abnormal cranium morphology 16 | 32
abnormal kidney morphology 16 | 30
abnormal testis morphology 16 | 30
cataract 16 | 26
decreased circulating calcium ... 16 | 33
increased mean corpuscular hem... 16 | 25
increased rib number 16 | 41
abnormal epididymis morphology 15 | 31

Disease

ovarian cancer 4,491 | 8,484
osteosarcoma 3,817 | 7,933
psoriasis 3,056 | 6,685
medulloblastoma, large-cell 2,961 | 6,234
glioblastoma 2,744 | 5,572
lung cancer 2,393 | 4,466
atypical teratoid / rhabdoid tumor 2,084 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,652 | 3,289
malignant mesothelioma 1,628 | 3,162
Breast cancer 1,594 | 3,094
Cancer 1,486 | 2,346
primitive neuroectodermal tumor 1,454 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,436 | 2,988
invasive ductal carcinoma 1,402 | 2,950
pediatric high grade glioma 1,383 | 2,712
oligodendroglioma 1,363 | 2,849
pilocytic astrocytoma 1,356 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,352 | 2,956
non-small cell lung cancer 1,327 | 2,798
lung adenocarcinoma 1,253 | 2,713
ependymoma 1,210 | 2,514
group 3 medulloblastoma 1,176 | 2,254
pancreatic cancer 1,121 | 2,300
lung carcinoma 1,104 | 2,844
subependymal giant cell astrocytoma 1,041 | 2,287
astrocytic glioma 1,018 | 2,241
Pick disease 997 | 1,893
Carcinoma 995 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 977 | 1,795
Multiple myeloma 929 | 1,327
ulcerative colitis 911 | 2,087
diabetes mellitus 890 | 1,663
adult high grade glioma 879 | 2,148
group 4 medulloblastoma 874 | 1,875
interstitial cystitis 870 | 2,299
pituitary cancer 861 | 1,972
astrocytoma 842 | 1,493
ductal carcinoma in situ 823 | 1,745
breast carcinoma 771 | 1,614
colon cancer 740 | 1,475
adrenocortical carcinoma 727 | 1,427
tuberculosis 723 | 1,557
medulloblastoma 702 | 1,524
posterior fossa group A ependymoma 702 | 1,511
sonic hedgehog group medulloblastoma 695 | 1,482
cystic fibrosis 677 | 1,665
acute quadriplegic myopathy 676 | 1,157
juvenile dermatomyositis 668 | 1,189
posterior fossa group B ependymoma 642 | 1,530
primary pancreatic ductal adenocarcinoma 637 | 1,271
Rheumatoid Arthritis 635 | 1,160
dermatomyositis 580 | 933
Waldenstrons macroglobulinemia 530 | 765
atypical teratoid/rhabdoid tumor 528 | 1,095
nasopharyngeal carcinoma 513 | 1,056
spina bifida 489 | 1,064
non primary Sjogren syndrome sicca 441 | 840
cutaneous lupus erythematosus 439 | 1,056
active Crohn's disease 438 | 918
acute myeloid leukemia 438 | 780
Atopic dermatitis 395 | 944
gastric carcinoma 394 | 832
Alzheimer's disease 369 | 644
esophageal adenocarcinoma 367 | 737
tuberculosis and treatment for 6 months 364 | 686
primary Sjogren syndrome 362 | 789
Intellectual disability 358 | 573
progressive supranuclear palsy 354 | 674
aldosterone-producing adenoma 344 | 664
Obesity 329 | 616
Duchenne muscular dystrophy 306 | 602
pancreatic carcinoma 298 | 567
Down syndrome 295 | 548
Endometriosis 294 | 535
Neurodegenerative disease 281 | 383
hepatocellular carcinoma 279 | 532
Prostatic Neoplasms 275 | 471
IGA Glomerulonephritis 267 | 454
Amyotrophic Lateral Sclerosis 266 | 431
Mammary Neoplasms 265 | 410
autosomal dominant Emery-Dreifuss muscular dystrophy 261 | 499
Schizophrenia 245 | 501
Kidney disease 243 | 396
fibroadenoma 227 | 557
Multiple Sclerosis 226 | 498
gastric cancer 226 | 430
chronic rhinosinusitis 223 | 512
active ulcerative colitis 215 | 477
hereditary spastic paraplegia 206 | 313
Parkinson's disease 205 | 364
Polycystic Ovary Syndrome 200 | 332
inflammatory breast cancer 198 | 404
mucosa-associated lymphoid tissue lymphoma 195 | 480
Stomach Neoplasms 192 | 282
Heart disease 190 | 279
Vascular disease 185 | 281
non-small cell lung carcinoma 173 | 413
Anemia 172 | 252
Arthritis 171 | 248
Epilepsy 171 | 346

Tissue

Female tissues 7,993 | 18,647
Nervous System 7,989 | 18,561
Digestive Tract 7,972 | 18,473
Endocrine System 7,967 | 18,512
Urinary Tract 7,961 | 18,444
Liver and Pancreas 7,950 | 18,136
Blood and immune system 7,934 | 17,995
Male tissues 7,931 | 17,969
Cardiovascular System 7,920 | 17,958
Skin and soft tissues 7,888 | 18,115
Respiratory system 7,848 | 17,484

Target Family

Non-IDG 4,611 | 11,971
Enzyme 2,213 | 4,146
Transcription Factor 478 | 1,400
Kinase 296 | 634
Transporter 191 | 473
Epigenetic 183 | 242
Ion Channel 79 | 341
Nuclear Receptor 46 | 48
GPCR 45 | 406
TF/Epigenetic 27 | 38
oGPCR 1 | 421

Compartment GO Term

Organelle part 8,170 | 8,170
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158