Development Level

Tbio 6,499 | 11,445
Tdark 1,266 | 6,588
Tchem 902 | 1,598
Tclin 308 | 613

Collection

RFA-RM-18-021 80 | 328
Kinase: IDG Consortium (Target... 50 | 125
Kinase: IDG Consortium (Comple... 19 | 37
GPCR: IDG Consortium (Targets) 17 | 126
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 745 | 979
preweaning lethality, incomple... 275 | 499
embryonic lethality prior to t... 217 | 278
embryonic lethality prior to o... 191 | 239
abnormal behavior 161 | 298
abnormal embryo size 154 | 220
decreased total body fat amoun... 121 | 207
decreased body weight 107 | 161
abnormal bone structure 106 | 187
enlarged heart 100 | 210
increased lean body mass 97 | 172
decreased vertical activity 93 | 208
decreased bone mineral content 85 | 151
increased total body fat amoun... 85 | 134
abnormal heart morphology 84 | 162
decreased lean body mass 83 | 135
hypoactivity 82 | 132
embryonic growth retardation 78 | 106
hyperactivity 78 | 148
increased startle reflex 77 | 112
increased circulating alkaline... 74 | 122
decreased bone mineral density 71 | 126
decreased circulating glucose ... 69 | 126
decreased circulating choleste... 64 | 93
decreased grip strength 63 | 116
male infertility 62 | 123
cataract 59 | 92
decreased body length 59 | 101
short tibia 58 | 97
abnormal seminal vesicle morph... 57 | 114
increased bone mineral content 56 | 108
increased mean corpuscular hem... 56 | 96
increased mean corpuscular vol... 56 | 92
prenatal lethality prior to he... 56 | 87
increased or absent threshold ... 53 | 101
decreased mean corpuscular vol... 52 | 79
abnormal lens morphology 51 | 81
decreased circulating serum al... 50 | 82
increased bone mineral density 50 | 72
decreased lymphocyte cell numb... 49 | 83
decreased circulating HDL chol... 47 | 68
decreased prepulse inhibition 45 | 82
impaired glucose tolerance 45 | 75
abnormal retina morphology 44 | 71
decreased circulating triglyce... 44 | 79
edema 43 | 59
increased circulating sodium l... 43 | 71
increased fasted circulating g... 43 | 76
decreased leukocyte cell numbe... 42 | 73
increased circulating HDL chol... 42 | 80
decreased circulating insulin ... 41 | 76
decreased hemoglobin content 41 | 68
abnormal kidney morphology 40 | 65
abnormal coat-hair pigmentatio... 39 | 64
abnormal sleep behavior 37 | 70
decreased fasted circulating g... 37 | 65
improved glucose tolerance 37 | 79
abnormal eye morphology 36 | 68
increased circulating choleste... 36 | 66
abnormal gait 35 | 69
increased heart weight 35 | 62
abnormal behavioral response t... 34 | 66
abnormal neural tube closure 34 | 46
decreased erythrocyte cell num... 34 | 62
decreased mean corpuscular hem... 34 | 50
decreased startle reflex 34 | 75
increased monocyte cell number 34 | 63
decreased circulating total pr... 33 | 49
small superior vagus ganglion 33 | 74
decreased circulating alkaline... 31 | 46
small testis 31 | 58
decreased caudal vertebrae num... 30 | 53
decreased circulating LDL chol... 30 | 38
decreased hematocrit 30 | 46
thrombocytopenia 30 | 56
increased circulating chloride... 29 | 41
tremors 29 | 39
decreased circulating alanine ... 28 | 47
increased circulating triglyce... 28 | 42
increased neutrophil cell numb... 28 | 46
abnormal spleen morphology 27 | 55
increased hemoglobin content 27 | 45
abnormal bone mineralization 26 | 38
female infertility 26 | 60
increased grip strength 26 | 41
pallor 26 | 34
decreased blood urea nitrogen ... 25 | 51
hydrometra 25 | 53
increased blood urea nitrogen ... 25 | 48
abnormal craniofacial morpholo... 24 | 33
abnormal embryo turning 24 | 31
abnormal skin morphology 24 | 50
decreased circulating creatini... 24 | 39
increased leukocyte cell numbe... 24 | 47
increased mean platelet volume 24 | 45
abnormal testis morphology 23 | 43
corneal opacity 23 | 32
limb grasping 23 | 41
decreased neutrophil cell numb... 22 | 42
enlarged spleen 22 | 41

Disease

Carcinoma 5,700 | 11,493
ovarian cancer 4,883 | 8,520
osteosarcoma 4,205 | 7,950
psoriasis 3,357 | 6,694
medulloblastoma, large-cell 3,219 | 6,241
glioblastoma 3,095 | 5,792
lung cancer 2,724 | 4,740
atypical teratoid / rhabdoid tumor 2,643 | 5,112
ependymoma 2,330 | 4,679
group 3 medulloblastoma 2,194 | 4,104
Breast cancer 1,972 | 3,578
adult high grade glioma 1,849 | 3,801
malignant mesothelioma 1,849 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,778 | 3,291
Cancer 1,686 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 1,568 | 2,989
primitive neuroectodermal tumor 1,559 | 3,035
invasive ductal carcinoma 1,536 | 2,951
non-small cell lung cancer 1,518 | 2,890
Astrocytoma, Pilocytic 1,492 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 1,488 | 2,955
oligodendroglioma 1,451 | 2,850
lung adenocarcinoma 1,405 | 2,716
Kidney cancer 1,349 | 2,613
astrocytic glioma 1,293 | 2,597
lung carcinoma 1,283 | 2,843
pancreatic cancer 1,275 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1,154 | 1,962
subependymal giant cell astrocytoma 1,146 | 2,287
Pick disease 1,068 | 1,894
tuberculosis 1,067 | 2,010
interstitial cystitis 1,021 | 2,312
diabetes mellitus 1,002 | 1,728
Multiple myeloma 975 | 1,332
group 4 medulloblastoma 967 | 1,855
Autosomal recessive predisposition 956 | 1,442
pituitary cancer 945 | 1,972
ulcerative colitis 896 | 1,819
ductal carcinoma in situ 890 | 1,745
breast carcinoma 873 | 1,638
colon cancer 807 | 1,478
adrenocortical carcinoma 792 | 1,428
cystic fibrosis 785 | 1,696
acute quadriplegic myopathy 741 | 1,158
juvenile dermatomyositis 719 | 1,187
Rheumatoid arthritis 711 | 1,191
astrocytoma 705 | 1,146
Intellectual disability 702 | 1,016
dermatomyositis 666 | 966
Schizophrenia 635 | 1,160
pediatric high grade glioma 614 | 1,064
primary pancreatic ductal adenocarcinoma 613 | 1,109
Waldenstrons macroglobulinemia 570 | 765
nasopharyngeal carcinoma 566 | 1,058
spina bifida 533 | 1,074
cutaneous lupus erythematosus 526 | 1,057
Epilepsy 525 | 792
non primary Sjogren syndrome sicca 515 | 891
acute myeloid leukemia 481 | 783
active Crohn's disease 472 | 922
Dull intelligence 466 | 645
Low intelligence 466 | 645
Mental Retardation 466 | 645
Mental deficiency 466 | 645
Poor school performance 466 | 645
Liver Cirrhosis, Experimental 465 | 769
Cognitive delay 464 | 608
Global developmental delay 464 | 608
Mental and motor retardation 464 | 608
Atopic dermatitis 458 | 952
Seizures 426 | 596
gastric carcinoma 423 | 807
Muscle hypotonia 419 | 571
esophageal adenocarcinoma 410 | 737
Obesity 409 | 678
Alzheimer's disease 406 | 658
Short stature 398 | 531
primary Sjogren syndrome 389 | 735
aldosterone-producing adenoma 383 | 665
active ulcerative colitis 381 | 764
progressive supranuclear palsy 371 | 676
medulloblastoma 359 | 720
Melanoma 352 | 711
Bipolar Disorder 351 | 666
Duchenne muscular dystrophy 347 | 601
Liver cancer 317 | 604
Neurodegenerative disease 314 | 414
Prostatic Neoplasms 314 | 495
hepatocellular carcinoma 314 | 547
Endometriosis 311 | 540
pancreatic carcinoma 310 | 562
Breast Neoplasms 307 | 445
autosomal dominant Emery-Dreifuss muscular dystrophy 303 | 510
Down syndrome 300 | 499
Amyotrophic lateral sclerosis 296 | 451
Mammary Neoplasms 293 | 425
Small head 292 | 374
Kidney disease 286 | 430
Anemia 275 | 365
Failure to gain weight 272 | 365

Tissue

Endocrine System 8,687 | 18,159
Digestive Tract 8,583 | 17,369
Female tissues 8,569 | 17,400
Skin and soft tissues 8,550 | 17,230
Male tissues 8,496 | 17,142
Blood and immune system 8,448 | 16,909
Liver and Pancreas 8,436 | 16,750
Urinary Tract 8,404 | 16,678
Nervous System 8,363 | 16,725
Respiratory system 8,306 | 16,393
Cardiovascular System 7,972 | 15,192

Target Family

Non-IDG 5,043 | 12,091
Enzyme 2,398 | 4,145
Transcription Factor 563 | 1,400
Kinase 326 | 634
Transporter 201 | 473
Epigenetic 194 | 242
Ion Channel 92 | 344
GPCR 78 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 28 | 38
oGPCR 5 | 421

Compartment GO Term

Organelle part 8,975 | 8,975
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190