Development Level

Tbio 5,571 | 10,625
Tdark 1,335 | 7,003
Tchem 989 | 1,890
Tclin 274 | 602

Collection

Eligible Kinase Proteins 48 | 134
Eligible non-olfactory GPCR Proteins 13 | 145
Eligible Ion Channel Proteins 11 | 117

IMPC Term

preweaning lethality, complete... 440 | 633
preweaning lethality, incomple... 140 | 260
embryonic lethality prior to t... 132 | 187
embryonic lethality prior to o... 116 | 148
abnormal behavior 113 | 226
decreased lean body mass 106 | 195
decreased total body fat amoun... 105 | 186
decreased body weight 103 | 174
decreased bone mineral content 90 | 157
abnormal bone structure 75 | 131
abnormal embryo size 73 | 112
decreased grip strength 68 | 123
increased circulating alkaline... 68 | 119
decreased body length 66 | 108
decreased bone mineral density 64 | 126
decreased circulating glucose ... 64 | 121
increased or absent threshold ... 64 | 128
abnormal retina morphology 61 | 100
increased lean body mass 59 | 107
increased mean corpuscular hem... 56 | 93
hyperactivity 55 | 108
decreased circulating choleste... 54 | 85
increased bone mineral content 54 | 92
increased mean corpuscular vol... 52 | 91
enlarged heart 50 | 111
decreased circulating HDL chol... 47 | 77
hypoactivity 47 | 89
abnormal lens morphology 45 | 73
increased grip strength 44 | 83
short tibia 43 | 82
decreased circulating triglyce... 42 | 83
decreased circulating serum al... 41 | 79
prenatal lethality prior to he... 41 | 64
increased circulating sodium l... 38 | 71
abnormal retinal pigmentation 37 | 61
decreased mean corpuscular vol... 37 | 50
abnormal bone mineralization 36 | 55
decreased circulating insulin ... 36 | 75
increased fasted circulating g... 35 | 68
decreased lumbar vertebrae num... 33 | 62
abnormal sleep behavior 32 | 63
decreased rib number 32 | 59
increased sacral vertebrae num... 32 | 62
decreased fasted circulating g... 31 | 49
decreased leukocyte cell numbe... 31 | 54
increased bone mineral density 31 | 52
increased circulating HDL chol... 31 | 63
increased total body fat amoun... 31 | 57
decreased hemoglobin content 30 | 53
decreased prepulse inhibition 30 | 52
abnormal coat/hair pigmentatio... 29 | 54
decreased circulating alanine ... 29 | 53
increased circulating choleste... 29 | 53
male infertility 29 | 62
abnormal gait 26 | 51
decreased caudal vertebrae num... 26 | 49
decreased circulating LDL chol... 26 | 37
increased blood urea nitrogen ... 26 | 44
decreased erythrocyte cell num... 25 | 43
decreased startle reflex 25 | 48
impaired glucose tolerance 25 | 52
increased circulating chloride... 25 | 43
embryonic growth retardation 24 | 28
increased heart weight 24 | 37
abnormal behavioral response t... 23 | 52
abnormal heart morphology 23 | 51
abnormal neural tube closure 23 | 37
decreased mean corpuscular hem... 23 | 34
improved glucose tolerance 23 | 56
abnormal eye morphology 22 | 38
decreased circulating total pr... 22 | 41
increased exploration in new e... 22 | 56
thrombocytopenia 22 | 46
tremors 22 | 34
decreased heart weight 21 | 44
increased hemoglobin content 21 | 45
limb grasping 21 | 35
decreased eosinophil cell numb... 20 | 41
increased body weight 20 | 42
abnormal seminal vesicle morph... 19 | 47
decreased circulating alkaline... 19 | 41
decreased circulating aspartat... 19 | 27
decreased circulating free fat... 19 | 39
decreased hematocrit 19 | 25
increased circulating creatini... 19 | 29
increased startle reflex 19 | 38
cardiovascular system phenotyp... 18 | 35
decreased circulating fructosa... 18 | 31
increased leukocyte cell numbe... 18 | 37
small testis 18 | 37
abnormal locomotor activation 17 | 26
decreased T cell number 17 | 31
abnormal cranium morphology 16 | 32
abnormal kidney morphology 16 | 30
abnormal testis morphology 16 | 30
cataract 16 | 26
decreased circulating calcium ... 16 | 33
increased mean corpuscular hem... 16 | 25
increased rib number 16 | 41
abnormal epididymis morphology 15 | 31

Disease

ovarian cancer 4,497 | 8,492
osteosarcoma 3,817 | 7,933
psoriasis 3,056 | 6,685
medulloblastoma, large-cell 2,961 | 6,234
glioblastoma 2,743 | 5,572
lung cancer 2,399 | 4,473
atypical teratoid / rhabdoid tumor 2,083 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,652 | 3,289
malignant mesothelioma 1,629 | 3,163
Breast cancer 1,598 | 3,099
Cancer 1,485 | 2,346
primitive neuroectodermal tumor 1,454 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,436 | 2,988
invasive ductal carcinoma 1,402 | 2,950
pediatric high grade glioma 1,383 | 2,712
oligodendroglioma 1,362 | 2,849
pilocytic astrocytoma 1,356 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,352 | 2,956
non-small cell lung cancer 1,327 | 2,798
lung adenocarcinoma 1,254 | 2,714
ependymoma 1,209 | 2,514
group 3 medulloblastoma 1,175 | 2,254
pancreatic cancer 1,121 | 2,300
lung carcinoma 1,104 | 2,844
subependymal giant cell astrocytoma 1,041 | 2,287
astrocytic glioma 1,017 | 2,241
Pick disease 997 | 1,893
Carcinoma 995 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 977 | 1,795
Multiple myeloma 929 | 1,328
ulcerative colitis 911 | 2,087
diabetes mellitus 890 | 1,663
adult high grade glioma 879 | 2,148
group 4 medulloblastoma 874 | 1,875
interstitial cystitis 870 | 2,299
pituitary cancer 861 | 1,972
astrocytoma 842 | 1,493
ductal carcinoma in situ 823 | 1,745
breast carcinoma 771 | 1,614
colon cancer 740 | 1,475
adrenocortical carcinoma 727 | 1,427
tuberculosis 726 | 1,563
medulloblastoma 702 | 1,524
posterior fossa group A ependymoma 702 | 1,511
sonic hedgehog group medulloblastoma 695 | 1,482
cystic fibrosis 678 | 1,670
acute quadriplegic myopathy 676 | 1,157
juvenile dermatomyositis 668 | 1,189
posterior fossa group B ependymoma 642 | 1,530
primary pancreatic ductal adenocarcinoma 637 | 1,271
Rheumatoid Arthritis 635 | 1,171
dermatomyositis 614 | 967
Waldenstrons macroglobulinemia 530 | 765
atypical teratoid/rhabdoid tumor 528 | 1,095
nasopharyngeal carcinoma 513 | 1,056
spina bifida 489 | 1,064
acute myeloid leukemia 442 | 785
non primary Sjogren syndrome sicca 441 | 840
cutaneous lupus erythematosus 439 | 1,056
active Crohn's disease 438 | 918
Atopic dermatitis 395 | 944
gastric carcinoma 394 | 832
Alzheimer's disease 369 | 644
esophageal adenocarcinoma 367 | 737
tuberculosis and treatment for 6 months 364 | 686
primary Sjogren syndrome 362 | 789
Intellectual disability 358 | 573
progressive supranuclear palsy 354 | 674
aldosterone-producing adenoma 344 | 664
Obesity 329 | 616
Duchenne muscular dystrophy 306 | 602
pancreatic carcinoma 298 | 567
Down syndrome 295 | 548
Endometriosis 294 | 535
hepatocellular carcinoma 292 | 550
Neurodegenerative disease 281 | 383
Prostatic Neoplasms 275 | 471
Amyotrophic Lateral Sclerosis 267 | 432
IGA Glomerulonephritis 267 | 454
Mammary Neoplasms 265 | 410
autosomal dominant Emery-Dreifuss muscular dystrophy 261 | 499
Schizophrenia 247 | 503
Kidney disease 243 | 397
gastric cancer 230 | 436
fibroadenoma 227 | 557
Multiple Sclerosis 226 | 498
chronic rhinosinusitis 223 | 512
active ulcerative colitis 215 | 477
hereditary spastic paraplegia 206 | 313
Parkinson's disease 205 | 364
Polycystic Ovary Syndrome 203 | 335
inflammatory breast cancer 198 | 404
mucosa-associated lymphoid tissue lymphoma 195 | 480
Stomach Neoplasms 192 | 282
Heart disease 190 | 279
Vascular disease 185 | 281
non-small cell lung carcinoma 173 | 413
Anemia 172 | 252
Arthritis 171 | 248
Epilepsy 171 | 346

Tissue

Female tissues 7,992 | 18,647
Nervous System 7,988 | 18,561
Digestive Tract 7,971 | 18,473
Endocrine System 7,966 | 18,512
Urinary Tract 7,960 | 18,444
Liver and Pancreas 7,949 | 18,136
Blood and immune system 7,933 | 17,995
Male tissues 7,930 | 17,969
Cardiovascular System 7,919 | 17,958
Skin and soft tissues 7,887 | 18,115
Respiratory system 7,847 | 17,484

Target Family

Non-IDG 4,609 | 11,969
Enzyme 2,213 | 4,146
Transcription Factor 477 | 1,400
Kinase 296 | 634
Transporter 191 | 473
Epigenetic 183 | 242
Ion Channel 79 | 341
GPCR 47 | 408
Nuclear Receptor 46 | 48
TF/Epigenetic 27 | 38
oGPCR 1 | 421

Compartment GO Term

Organelle part 8,169 | 8,169
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57