Development Level

Tbio 6,192 | 11,178
Tdark 1,246 | 6,569
Tchem 1,018 | 1,885
Tclin 299 | 612

Collection

Kinase: IDG Consortium (Target... 48 | 125
Kinase: IDG Consortium (Comple... 19 | 37
GPCR: IDG Consortium (Targets) 17 | 126
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 732 | 979
preweaning lethality, incomple... 268 | 499
embryonic lethality prior to t... 214 | 278
embryonic lethality prior to o... 190 | 239
abnormal behavior 154 | 298
abnormal embryo size 149 | 220
decreased total body fat amoun... 118 | 207
abnormal bone structure 104 | 187
decreased body weight 103 | 161
enlarged heart 98 | 210
increased lean body mass 95 | 172
decreased vertical activity 92 | 208
abnormal heart morphology 82 | 162
decreased bone mineral content 82 | 151
increased total body fat amoun... 82 | 134
decreased lean body mass 77 | 135
hypoactivity 76 | 132
increased startle reflex 76 | 112
embryonic growth retardation 75 | 106
hyperactivity 74 | 148
increased circulating alkaline... 71 | 122
decreased bone mineral density 69 | 126
decreased circulating glucose ... 67 | 126
decreased grip strength 62 | 116
decreased circulating choleste... 61 | 93
male infertility 61 | 123
cataract 59 | 92
abnormal seminal vesicle morph... 56 | 114
increased bone mineral content 55 | 108
short tibia 55 | 97
decreased body length 54 | 101
increased mean corpuscular vol... 54 | 92
prenatal lethality prior to he... 54 | 87
increased mean corpuscular hem... 53 | 96
increased or absent threshold ... 52 | 101
abnormal lens morphology 51 | 81
decreased mean corpuscular vol... 51 | 79
decreased circulating serum al... 50 | 82
decreased lymphocyte cell numb... 49 | 83
increased bone mineral density 49 | 72
impaired glucose tolerance 45 | 75
decreased circulating HDL chol... 44 | 68
decreased prepulse inhibition 43 | 82
decreased leukocyte cell numbe... 42 | 73
edema 42 | 59
increased fasted circulating g... 42 | 76
abnormal retina morphology 41 | 71
decreased hemoglobin content 41 | 68
increased circulating sodium l... 41 | 71
decreased circulating insulin ... 40 | 76
decreased circulating triglyce... 40 | 79
increased circulating HDL chol... 40 | 80
abnormal kidney morphology 39 | 65
abnormal coat-hair pigmentatio... 37 | 64
improved glucose tolerance 37 | 79
abnormal sleep behavior 36 | 70
abnormal eye morphology 35 | 68
decreased fasted circulating g... 35 | 65
abnormal behavioral response t... 34 | 66
decreased erythrocyte cell num... 34 | 62
increased circulating choleste... 34 | 66
increased heart weight 34 | 62
increased monocyte cell number 34 | 63
abnormal neural tube closure 33 | 46
decreased circulating total pr... 33 | 49
decreased mean corpuscular hem... 33 | 50
decreased startle reflex 33 | 75
small superior vagus ganglion 33 | 74
abnormal gait 32 | 69
small testis 31 | 58
decreased caudal vertebrae num... 30 | 53
decreased circulating LDL chol... 30 | 38
decreased circulating alkaline... 30 | 46
decreased hematocrit 30 | 46
decreased circulating alanine ... 28 | 47
increased circulating chloride... 28 | 41
increased circulating triglyce... 28 | 42
increased neutrophil cell numb... 28 | 46
thrombocytopenia 28 | 56
tremors 28 | 39
abnormal spleen morphology 27 | 55
increased hemoglobin content 27 | 45
increased grip strength 26 | 41
pallor 26 | 34
abnormal bone mineralization 25 | 38
female infertility 25 | 60
hydrometra 25 | 53
abnormal embryo turning 24 | 31
increased mean platelet volume 24 | 45
abnormal craniofacial morpholo... 23 | 33
abnormal skin morphology 23 | 50
abnormal testis morphology 23 | 43
corneal opacity 23 | 32
increased blood urea nitrogen ... 23 | 48
increased leukocyte cell numbe... 23 | 47
abnormal cranium morphology 22 | 36
decreased circulating creatini... 22 | 39
enlarged spleen 22 | 41
increased body length 22 | 32
limb grasping 22 | 41

Disease

Carcinoma 5,559 | 11,192
ovarian cancer 4,744 | 8,297
osteosarcoma 4,112 | 7,766
psoriasis 3,263 | 6,514
medulloblastoma, large-cell 3,147 | 6,086
glioblastoma 3,013 | 5,635
lung cancer 2,651 | 4,607
atypical teratoid / rhabdoid tumor 2,572 | 4,971
ependymoma 2,276 | 4,559
group 3 medulloblastoma 2,145 | 4,002
Breast cancer 1,918 | 3,469
adult high grade glioma 1,804 | 3,701
malignant mesothelioma 1,790 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 1,729 | 3,204
Cancer 1,609 | 2,388
intraductal papillary-mucinous carcinoma (IPMC) 1,520 | 2,902
primitive neuroectodermal tumor 1,517 | 2,957
invasive ductal carcinoma 1,494 | 2,867
non-small cell lung cancer 1,478 | 2,799
Astrocytoma, Pilocytic 1,449 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 1,444 | 2,872
oligodendroglioma 1,406 | 2,768
lung adenocarcinoma 1,361 | 2,627
Kidney cancer 1,318 | 2,548
astrocytic glioma 1,262 | 2,530
lung carcinoma 1,241 | 2,755
pancreatic cancer 1,234 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 1,121 | 1,911
subependymal giant cell astrocytoma 1,117 | 2,230
Pick disease 1,050 | 1,856
tuberculosis 1,041 | 1,963
interstitial cystitis 989 | 2,237
diabetes mellitus 971 | 1,683
Multiple myeloma 943 | 1,296
group 4 medulloblastoma 940 | 1,806
Autosomal recessive predisposition 934 | 1,407
pituitary cancer 919 | 1,915
ulcerative colitis 866 | 1,765
ductal carcinoma in situ 861 | 1,686
breast carcinoma 843 | 1,589
colon cancer 779 | 1,428
adrenocortical carcinoma 763 | 1,385
cystic fibrosis 751 | 1,629
acute quadriplegic myopathy 720 | 1,133
Rheumatoid arthritis 692 | 1,156
juvenile dermatomyositis 691 | 1,147
Intellectual disability 689 | 998
astrocytoma 684 | 1,113
dermatomyositis 645 | 941
Schizophrenia 622 | 1,136
pediatric high grade glioma 597 | 1,035
primary pancreatic ductal adenocarcinoma 591 | 1,071
Waldenstrons macroglobulinemia 550 | 742
nasopharyngeal carcinoma 550 | 1,024
spina bifida 523 | 1,053
Epilepsy 513 | 775
cutaneous lupus erythematosus 511 | 1,016
non primary Sjogren syndrome sicca 495 | 861
acute myeloid leukemia 464 | 760
Dull intelligence 458 | 634
Low intelligence 458 | 634
Mental Retardation 458 | 634
Mental deficiency 458 | 634
Poor school performance 458 | 634
Cognitive delay 455 | 596
Global developmental delay 455 | 596
Mental and motor retardation 455 | 596
active Crohn's disease 452 | 882
Atopic dermatitis 443 | 915
Liver Cirrhosis, Experimental 441 | 733
Seizures 417 | 584
Muscle hypotonia 414 | 562
gastric carcinoma 409 | 781
Alzheimer's disease 394 | 640
Obesity 393 | 655
esophageal adenocarcinoma 390 | 696
Short stature 386 | 514
primary Sjogren syndrome 376 | 710
aldosterone-producing adenoma 372 | 646
active ulcerative colitis 366 | 736
progressive supranuclear palsy 364 | 656
medulloblastoma 348 | 702
Melanoma 345 | 689
Bipolar Disorder 341 | 646
Duchenne muscular dystrophy 336 | 587
Liver cancer 309 | 589
pancreatic carcinoma 308 | 555
hepatocellular carcinoma 305 | 536
Neurodegenerative disease 304 | 402
Prostatic Neoplasms 301 | 472
Endometriosis 298 | 521
Breast Neoplasms 289 | 423
autosomal dominant Emery-Dreifuss muscular dystrophy 289 | 492
Down syndrome 286 | 480
Small head 285 | 366
Amyotrophic lateral sclerosis 284 | 437
Mammary Neoplasms 275 | 403
Kidney disease 270 | 411
Failure to gain weight 267 | 359
Pediatric failure to thrive 267 | 359

Tissue

Endocrine System 8,479 | 18,159
Digestive Tract 8,380 | 17,369
Female tissues 8,363 | 17,400
Skin and soft tissues 8,342 | 17,230
Male tissues 8,297 | 17,142
Blood and immune system 8,247 | 16,909
Liver and Pancreas 8,233 | 16,750
Urinary Tract 8,206 | 16,678
Nervous System 8,161 | 16,725
Respiratory system 8,109 | 16,393
Cardiovascular System 7,789 | 15,192

Target Family

Non-IDG 5,007 | 12,091
Enzyme 2,267 | 4,145
Transcription Factor 517 | 1,400
Kinase 324 | 634
Transporter 199 | 473
Epigenetic 193 | 242
Ion Channel 92 | 344
GPCR 78 | 408
Nuclear Receptor 45 | 48
TF/Epigenetic 28 | 38
oGPCR 5 | 421

Compartment GO Term

Organelle part 8,755 | 8,755
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83