Development Level

Tbio 153 | 11,651
Tchem 30 | 1,388
Tdark 14 | 6,593
Tclin 10 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 14 | 979
decreased vertical activity 8 | 208
hyperactivity 8 | 148
abnormal behavior 7 | 298
decreased body weight 6 | 161
decreased bone mineral content 6 | 151
abnormal bone structure 5 | 187
decreased lean body mass 5 | 135
hypoactivity 5 | 132
increased mean corpuscular hem... 5 | 96
preweaning lethality, incomple... 5 | 499
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased body length 4 | 101
decreased bone mineral density 4 | 126
decreased total body fat amoun... 4 | 207
increased lean body mass 4 | 172
abnormal sleep behavior 3 | 70
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased heart weight 3 | 27
decreased mean corpuscular vol... 3 | 79
decreased startle reflex 3 | 75
enlarged heart 3 | 210
increased circulating bilirubi... 3 | 16
increased total body fat amoun... 3 | 134
thrombocytopenia 3 | 56
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal skin morphology 2 | 50
abnormal tibia morphology 2 | 14
decreased circulating aspartat... 2 | 34
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
edema 2 | 59
embryonic lethality prior to t... 2 | 278
enlarged epididymis 2 | 31
increased heart rate 2 | 23
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 36
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal thymus morphology 1 | 7
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
brachydactyly 1 | 19
corneal opacity 1 | 32
cyanosis 1 | 7
decreased blood urea nitrogen ... 1 | 51
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
hemorrhage 1 | 23
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating glycerol... 1 | 9
increased circulating lipase l... 1 | 3
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
respiratory system phenotype 1 | 2
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small kidney 1 | 16
small spleen 1 | 19
small thymus 1 | 16
syndactyly 1 | 23

Disease

ovarian cancer 115 | 8,520
Carcinoma 113 | 11,493
osteosarcoma 89 | 7,950
medulloblastoma, large-cell 82 | 6,241
lung cancer 81 | 4,740
psoriasis 75 | 6,694
glioblastoma 69 | 5,792
atypical teratoid / rhabdoid tumor 65 | 5,112
ependymoma 58 | 4,679
malignant mesothelioma 51 | 3,232
invasive ductal carcinoma 47 | 2,951
Cancer 43 | 2,499
adult high grade glioma 43 | 3,801
group 3 medulloblastoma 39 | 4,104
Astrocytoma, Pilocytic 38 | 3,081
non-small cell lung cancer 38 | 2,890
Breast cancer 37 | 3,578
astrocytic glioma 37 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
oligodendroglioma 36 | 2,850
lung adenocarcinoma 34 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
ductal carcinoma in situ 32 | 1,745
pancreatic cancer 32 | 2,398
tuberculosis 32 | 2,010
Pick disease 31 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
lung carcinoma 28 | 2,843
Multiple myeloma 27 | 1,332
primitive neuroectodermal tumor 27 | 3,035
ulcerative colitis 27 | 1,819
Autosomal recessive predisposition 26 | 1,442
Alzheimer's disease 24 | 658
breast carcinoma 24 | 1,638
diabetes mellitus 24 | 1,728
group 4 medulloblastoma 24 | 1,855
colon cancer 23 | 1,478
pituitary cancer 23 | 1,972
subependymal giant cell astrocytoma 22 | 2,287
Kidney cancer 21 | 2,613
Neurodegenerative disease 21 | 414
dermatomyositis 20 | 966
interstitial cystitis 20 | 2,312
Schizophrenia 19 | 1,160
Obesity 18 | 678
Rheumatoid arthritis 17 | 1,191
aldosterone-producing adenoma 16 | 665
cystic fibrosis 15 | 1,696
juvenile dermatomyositis 15 | 1,187
pediatric high grade glioma 15 | 1,064
Muscle hypotonia 14 | 571
Parkinson's disease 14 | 392
Waldenstrons macroglobulinemia 14 | 765
acute quadriplegic myopathy 14 | 1,158
astrocytoma 14 | 1,146
progressive supranuclear palsy 14 | 676
Toxic encephalopathy 13 | 141
active Crohn's disease 13 | 922
adrenocortical carcinoma 13 | 1,428
medulloblastoma 13 | 720
Atopic dermatitis 12 | 952
Multiple Sclerosis 12 | 540
acute myeloid leukemia 12 | 783
esophageal adenocarcinoma 12 | 737
primary Sjogren syndrome 12 | 735
Bipolar Disorder 11 | 666
Breast Neoplasms 11 | 445
Epilepsy 11 | 792
Intellectual disability 11 | 1,016
Mammary Neoplasms 11 | 425
Optic Atrophy 11 | 242
cutaneous lupus erythematosus 11 | 1,057
hereditary spastic paraplegia 11 | 318
primary pancreatic ductal adenocarcinoma 11 | 1,109
Liver Cirrhosis, Experimental 10 | 769
Melanoma 10 | 711
Seizures 10 | 596
Vascular disease 10 | 319
active ulcerative colitis 10 | 764
nasopharyngeal carcinoma 10 | 1,058
non primary Sjogren syndrome sicca 10 | 891
Chronic Lymphocytic Leukemia 9 | 262
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Amyotrophic lateral sclerosis 8 | 451
Cerebrovascular disease 8 | 238
Cognitive delay 8 | 608
Endometriosis 8 | 540
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Neuropathy 8 | 261
Polycystic ovary syndrome 8 | 360
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
gastric cancer 8 | 459
gastric carcinoma 8 | 807
spina bifida 8 | 1,074

Tissue

Endocrine System 203 | 18,159
Female tissues 200 | 17,400
Blood and immune system 199 | 16,909
Digestive Tract 199 | 17,369
Male tissues 199 | 17,142
Liver and Pancreas 198 | 16,750
Skin and soft tissues 198 | 17,230
Urinary Tract 198 | 16,678
Respiratory system 196 | 16,393
Nervous System 195 | 16,725
Cardiovascular System 193 | 15,192

Target Family

Non-IDG 123 | 12,091
Enzyme 53 | 4,145
Kinase 17 | 634
Transporter 6 | 473
Epigenetic 2 | 242
GPCR 2 | 408
Transcription Factor 2 | 1,400
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

Compartment GO Term

Organelle outer membrane 207 | 207
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Apoptosis regulator Bcl-2 BCL2 Tclin Non-IDG -2.20455 130.6 2273
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.11577 1210.8 2254
Progesterone receptor PGR Tclin Nuclear Receptor -3.94412 7951.2 2098
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Apoptosis regulator BAX BAX Tchem Non-IDG -2.57834 248.4 1395
Bcl-2-like protein 1 BCL2L1 Tchem Non-IDG -3.64676 4028.0 1282
Serine/threonine-protein kinase mTOR MTOR Tclin Kinase -3.89596 7790.5 1195
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045