Development Level

Tbio 2,054 | 11,651
Tdark 393 | 6,593
Tchem 250 | 1,388
Tclin 149 | 612

Collection

RFA-RM-18-021 31 | 328
Ion Channel: IDG Consortium (T... 12 | 99
GPCR: IDG Consortium (Targets) 11 | 126
Kinase: IDG Consortium (Target... 10 | 125
GPCR: IDG Consortium (Complete... 4 | 25
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 204 | 979
preweaning lethality, incomple... 77 | 499
embryonic lethality prior to t... 73 | 278
embryonic lethality prior to o... 61 | 239
abnormal behavior 58 | 298
abnormal embryo size 45 | 220
decreased total body fat amoun... 43 | 207
increased lean body mass 39 | 172
decreased body weight 36 | 161
abnormal bone structure 35 | 187
hyperactivity 35 | 148
decreased vertical activity 33 | 208
hypoactivity 33 | 132
decreased bone mineral content 32 | 151
enlarged heart 32 | 210
increased total body fat amoun... 30 | 134
increased startle reflex 28 | 112
abnormal heart morphology 26 | 162
cataract 26 | 92
abnormal lens morphology 25 | 81
increased mean corpuscular hem... 25 | 96
increased circulating alkaline... 24 | 122
decreased bone mineral density 22 | 126
decreased lean body mass 22 | 135
embryonic growth retardation 22 | 106
increased mean corpuscular vol... 22 | 92
decreased grip strength 21 | 116
increased bone mineral content 21 | 108
edema 20 | 59
decreased circulating choleste... 19 | 93
decreased circulating serum al... 19 | 82
decreased mean corpuscular vol... 19 | 79
short tibia 19 | 97
abnormal sleep behavior 18 | 70
increased heart weight 18 | 62
abnormal seminal vesicle morph... 17 | 114
decreased circulating HDL chol... 17 | 68
decreased circulating glucose ... 17 | 126
increased bone mineral density 17 | 72
increased circulating sodium l... 17 | 71
abnormal retina morphology 16 | 71
decreased body length 16 | 101
abnormal eye morphology 15 | 68
decreased circulating triglyce... 15 | 79
decreased lymphocyte cell numb... 15 | 83
decreased mean corpuscular hem... 15 | 50
impaired glucose tolerance 15 | 75
abnormal kidney morphology 14 | 65
decreased circulating LDL chol... 14 | 38
decreased circulating insulin ... 13 | 76
decreased hemoglobin content 13 | 68
decreased prepulse inhibition 13 | 82
improved glucose tolerance 13 | 79
increased circulating chloride... 13 | 41
increased monocyte cell number 13 | 63
increased or absent threshold ... 13 | 101
male infertility 13 | 123
abnormal gait 12 | 69
abnormal neural tube closure 12 | 46
decreased leukocyte cell numbe... 12 | 73
increased fasted circulating g... 12 | 76
pallor 12 | 34
prenatal lethality prior to he... 12 | 87
abnormal behavioral response t... 11 | 66
abnormal skin morphology 11 | 50
decreased circulating alkaline... 11 | 46
decreased hematocrit 11 | 46
small superior vagus ganglion 11 | 74
tremors 11 | 39
abnormal coat-hair pigmentatio... 10 | 64
abnormal craniofacial morpholo... 10 | 33
decreased fasted circulating g... 10 | 65
decreased heart weight 10 | 27
thrombocytopenia 10 | 56
abnormal coat appearance 9 | 31
abnormal limb bud morphology 9 | 17
cardiovascular system phenotyp... 9 | 36
increased blood urea nitrogen ... 9 | 48
increased circulating potassiu... 9 | 29
increased leukocyte cell numbe... 9 | 47
persistence of hyaloid vascula... 9 | 33
prenatal lethality 9 | 28
prolonged QT interval 9 | 38
abnormal pericardium morpholog... 8 | 26
abnormal snout morphology 8 | 23
decreased blood urea nitrogen ... 8 | 51
decreased circulating alanine ... 8 | 47
decreased circulating creatini... 8 | 39
decreased circulating total pr... 8 | 49
decreased erythrocyte cell num... 8 | 62
decreased startle reflex 8 | 75
enlarged spleen 8 | 41
increased circulating HDL chol... 8 | 80
increased circulating choleste... 8 | 66
increased circulating triglyce... 8 | 42
increased grip strength 8 | 41
increased red blood cell distr... 8 | 34
decreased circulating aspartat... 7 | 34
increased prepulse inhibition 7 | 32
small testis 7 | 58

Disease

Carcinoma 1,683 | 11,493
ovarian cancer 1,517 | 8,520
osteosarcoma 1,297 | 7,950
psoriasis 1,053 | 6,694
medulloblastoma, large-cell 1,036 | 6,241
glioblastoma 1,013 | 5,792
atypical teratoid / rhabdoid tumor 852 | 5,112
lung cancer 817 | 4,740
ependymoma 758 | 4,679
adult high grade glioma 621 | 3,801
Breast cancer 566 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 561 | 3,291
group 3 medulloblastoma 559 | 4,104
Astrocytoma, Pilocytic 556 | 3,081
malignant mesothelioma 518 | 3,232
lung carcinoma 512 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 504 | 2,955
invasive ductal carcinoma 502 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 500 | 2,989
Cancer 497 | 2,499
oligodendroglioma 469 | 2,850
non-small cell lung cancer 462 | 2,890
astrocytic glioma 456 | 2,597
lung adenocarcinoma 439 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 435 | 1,962
primitive neuroectodermal tumor 433 | 3,035
pancreatic cancer 426 | 2,398
tuberculosis 402 | 2,010
subependymal giant cell astrocytoma 377 | 2,287
interstitial cystitis 364 | 2,312
diabetes mellitus 360 | 1,728
Pick disease 348 | 1,894
Autosomal recessive predisposition 345 | 1,442
Kidney cancer 344 | 2,613
Multiple myeloma 340 | 1,332
group 4 medulloblastoma 323 | 1,855
ulcerative colitis 300 | 1,819
pituitary cancer 298 | 1,972
Rheumatoid arthritis 273 | 1,191
breast carcinoma 266 | 1,638
ductal carcinoma in situ 265 | 1,745
cystic fibrosis 260 | 1,696
dermatomyositis 234 | 966
Schizophrenia 233 | 1,160
juvenile dermatomyositis 232 | 1,187
astrocytoma 219 | 1,146
acute quadriplegic myopathy 215 | 1,158
adrenocortical carcinoma 213 | 1,428
colon cancer 210 | 1,478
Epilepsy 208 | 792
pediatric high grade glioma 204 | 1,064
primary pancreatic ductal adenocarcinoma 203 | 1,109
Intellectual disability 196 | 1,016
cutaneous lupus erythematosus 190 | 1,057
non primary Sjogren syndrome sicca 178 | 891
active Crohn's disease 174 | 922
Alzheimer's disease 169 | 658
Liver Cirrhosis, Experimental 166 | 769
Waldenstrons macroglobulinemia 162 | 765
Seizures 156 | 596
Cognitive delay 154 | 608
Global developmental delay 154 | 608
Mental and motor retardation 154 | 608
esophageal adenocarcinoma 151 | 737
nasopharyngeal carcinoma 148 | 1,058
spina bifida 148 | 1,074
Muscle hypotonia 145 | 571
acute myeloid leukemia 144 | 783
gastric carcinoma 144 | 807
active ulcerative colitis 140 | 764
aldosterone-producing adenoma 139 | 665
Dull intelligence 137 | 645
Low intelligence 137 | 645
Mental Retardation 137 | 645
Mental deficiency 137 | 645
Obesity 137 | 678
Poor school performance 137 | 645
primary Sjogren syndrome 135 | 735
Neurodegenerative disease 132 | 414
Bipolar Disorder 130 | 666
Melanoma 119 | 711
Duchenne muscular dystrophy 118 | 601
mucosa-associated lymphoid tissue lymphoma 118 | 484
Atopic dermatitis 117 | 952
Kidney disease 117 | 430
Multiple Sclerosis 117 | 540
Failure to gain weight 115 | 365
Pediatric failure to thrive 115 | 365
Prostatic Neoplasms 113 | 495
Arthritis 112 | 290
pancreatic carcinoma 111 | 562
Parkinson's disease 109 | 392
Hypersensitivity reaction type II disease 107 | 253
Short stature 107 | 531
medulloblastoma 107 | 720
progressive supranuclear palsy 106 | 676
Anemia 105 | 365
Down syndrome 105 | 499
hepatocellular carcinoma 102 | 547
Cerebellar Ataxia 101 | 304

Tissue

Endocrine System 2,705 | 18,159
Digestive Tract 2,671 | 17,369
Female tissues 2,659 | 17,400
Skin and soft tissues 2,649 | 17,230
Male tissues 2,641 | 17,142
Liver and Pancreas 2,637 | 16,750
Blood and immune system 2,626 | 16,909
Urinary Tract 2,617 | 16,678
Nervous System 2,616 | 16,725
Respiratory system 2,585 | 16,393
Cardiovascular System 2,467 | 15,192

Target Family

Non-IDG 1,560 | 12,091
Enzyme 876 | 4,145
Transporter 154 | 473
Kinase 82 | 634
Ion Channel 66 | 344
GPCR 50 | 408
Transcription Factor 41 | 1,400
Epigenetic 10 | 242
oGPCR 4 | 421
Nuclear Receptor 3 | 48

Compartment GO Term

Organelle membrane 2,846 | 2,846
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184