Development Level

Tbio 1,735 | 10,625
Tdark 426 | 7,003
Tchem 298 | 1,890
Tclin 134 | 602

Collection

Eligible Kinase Proteins 11 | 134
Eligible Ion Channel Proteins 9 | 117
Eligible non-olfactory GPCR Proteins 8 | 143

IMPC Term

preweaning lethality, complete... 129 | 633
embryonic lethality prior to t... 46 | 187
abnormal behavior 41 | 226
embryonic lethality prior to o... 39 | 148
decreased body weight 38 | 174
decreased total body fat amoun... 36 | 186
preweaning lethality, incomple... 35 | 260
decreased bone mineral content 31 | 157
decreased lean body mass 31 | 195
decreased grip strength 28 | 123
increased mean corpuscular hem... 27 | 93
abnormal bone structure 25 | 131
hypoactivity 24 | 89
increased circulating alkaline... 22 | 119
decreased circulating choleste... 21 | 85
decreased circulating triglyce... 21 | 83
increased lean body mass 21 | 107
abnormal lens morphology 20 | 73
decreased bone mineral density 20 | 126
decreased circulating HDL chol... 20 | 77
increased mean corpuscular vol... 20 | 91
abnormal retina morphology 19 | 100
hyperactivity 19 | 108
decreased circulating glucose ... 18 | 121
abnormal embryo size 17 | 112
decreased body length 17 | 108
decreased mean corpuscular vol... 17 | 50
increased or absent threshold ... 17 | 128
increased circulating sodium l... 16 | 71
increased bone mineral content 15 | 92
enlarged heart 14 | 111
short tibia 14 | 82
abnormal bone mineralization 13 | 55
increased grip strength 13 | 83
increased heart weight 13 | 37
abnormal sleep behavior 12 | 63
decreased circulating serum al... 12 | 79
decreased mean corpuscular hem... 12 | 34
decreased prepulse inhibition 12 | 52
decreased rib number 12 | 59
increased fasted circulating g... 12 | 68
abnormal retinal pigmentation 11 | 61
cardiovascular system phenotyp... 11 | 35
decreased circulating LDL chol... 11 | 37
decreased circulating insulin ... 11 | 75
decreased heart weight 11 | 44
decreased hemoglobin content 11 | 53
decreased leukocyte cell numbe... 11 | 54
impaired glucose tolerance 11 | 52
increased blood urea nitrogen ... 11 | 44
increased bone mineral density 11 | 52
increased circulating chloride... 11 | 43
decreased circulating alanine ... 10 | 53
increased circulating potassiu... 10 | 31
increased total body fat amoun... 10 | 57
prenatal lethality prior to he... 10 | 64
abnormal QRS complex 9 | 25
abnormal eye morphology 9 | 38
decreased eosinophil cell numb... 9 | 41
decreased fasted circulating g... 9 | 49
improved glucose tolerance 9 | 56
increased body weight 9 | 42
increased leukocyte cell numbe... 9 | 37
male infertility 9 | 62
abnormal limb bud morphology 8 | 15
abnormal skin morphology 8 | 23
cataract 8 | 26
decreased caudal vertebrae num... 8 | 49
decreased erythrocyte cell num... 8 | 43
decreased hematocrit 8 | 25
decreased total retina thickne... 8 | 20
hydrops fetalis 8 | 22
increased circulating choleste... 8 | 53
increased sacral vertebrae num... 8 | 62
increased startle reflex 8 | 38
thrombocytopenia 8 | 46
abnormal behavioral response t... 7 | 52
abnormal coat appearance 7 | 25
abnormal coat/hair pigmentatio... 7 | 54
abnormal gait 7 | 51
abnormal kidney morphology 7 | 30
decreased blood urea nitrogen ... 7 | 31
decreased circulating alkaline... 7 | 41
decreased lumbar vertebrae num... 7 | 62
decreased startle reflex 7 | 48
decreased vertical activity 7 | 22
increased erythrocyte cell num... 7 | 26
increased exploration in new e... 7 | 56
persistence of hyaloid vascula... 7 | 22
tremors 7 | 34
abnormal epididymis morphology 6 | 31
decreased circulating aspartat... 6 | 27
decreased circulating calcium ... 6 | 33
decreased circulating free fat... 6 | 39
decreased circulating glycerol... 6 | 19
increased circulating aspartat... 6 | 17
increased hematocrit 6 | 36
increased hemoglobin content 6 | 45
straub tail 6 | 26
thrombocytosis 6 | 23

Disease

ovarian cancer 1,394 | 8,484
osteosarcoma 1,157 | 7,933
medulloblastoma, large-cell 950 | 6,234
psoriasis 944 | 6,685
glioblastoma 891 | 5,572
lung cancer 697 | 4,466
atypical teratoid / rhabdoid tumor 691 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 516 | 3,289
pilocytic astrocytoma 494 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 450 | 2,956
pediatric high grade glioma 447 | 2,712
Breast cancer 445 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 445 | 2,988
invasive ductal carcinoma 445 | 2,950
oligodendroglioma 440 | 2,849
lung carcinoma 438 | 2,844
malignant mesothelioma 433 | 3,162
Cancer 426 | 2,346
primitive neuroectodermal tumor 408 | 3,031
ependymoma 386 | 2,514
pancreatic cancer 385 | 2,300
lung adenocarcinoma 383 | 2,713
non-small cell lung cancer 381 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 372 | 1,795
astrocytic glioma 350 | 2,241
subependymal giant cell astrocytoma 337 | 2,287
Pick disease 330 | 1,893
diabetes mellitus 313 | 1,663
Multiple myeloma 312 | 1,327
adult high grade glioma 303 | 2,148
interstitial cystitis 301 | 2,299
ulcerative colitis 288 | 2,087
group 4 medulloblastoma 283 | 1,875
astrocytoma 281 | 1,493
pituitary cancer 279 | 1,972
group 3 medulloblastoma 270 | 2,254
tuberculosis 253 | 1,557
Carcinoma 250 | 2,147
posterior fossa group A ependymoma 250 | 1,511
Rheumatoid Arthritis 242 | 1,160
ductal carcinoma in situ 237 | 1,745
breast carcinoma 234 | 1,614
medulloblastoma 229 | 1,524
cystic fibrosis 225 | 1,665
primary pancreatic ductal adenocarcinoma 214 | 1,271
juvenile dermatomyositis 206 | 1,189
sonic hedgehog group medulloblastoma 195 | 1,482
posterior fossa group B ependymoma 193 | 1,530
adrenocortical carcinoma 192 | 1,427
acute quadriplegic myopathy 187 | 1,157
colon cancer 186 | 1,475
dermatomyositis 174 | 933
active Crohn's disease 155 | 918
cutaneous lupus erythematosus 154 | 1,056
atypical teratoid/rhabdoid tumor 153 | 1,095
non primary Sjogren syndrome sicca 148 | 840
Alzheimer's disease 144 | 644
spina bifida 138 | 1,064
Waldenstrons macroglobulinemia 135 | 765
aldosterone-producing adenoma 132 | 664
gastric carcinoma 130 | 832
esophageal adenocarcinoma 129 | 737
acute myeloid leukemia 127 | 780
Neurodegenerative disease 124 | 383
nasopharyngeal carcinoma 124 | 1,056
primary Sjogren syndrome 124 | 789
Obesity 113 | 616
pancreatic carcinoma 105 | 567
progressive supranuclear palsy 105 | 674
tuberculosis and treatment for 6 months 103 | 686
Atopic dermatitis 102 | 944
Schizophrenia 101 | 501
Down syndrome 100 | 548
Kidney disease 100 | 396
Arthritis 96 | 248
Duchenne muscular dystrophy 95 | 602
Hypersensitivity reaction type II disease 95 | 235
Multiple Sclerosis 95 | 498
Parkinson's disease 95 | 364
IGA Glomerulonephritis 93 | 454
Intellectual disability 93 | 573
Prostatic Neoplasms 93 | 471
hereditary spastic paraplegia 93 | 313
mucosa-associated lymphoid tissue lymphoma 88 | 480
hepatocellular carcinoma 86 | 532
fibroadenoma 84 | 557
Ankylosing spondylitis 82 | 138
Amyotrophic Lateral Sclerosis 81 | 431
active ulcerative colitis 79 | 477
Mammary Neoplasms 78 | 410
Epilepsy 77 | 346
Liver disease 77 | 219
autosomal dominant Emery-Dreifuss muscular dystrophy 74 | 499
Acquired immunodeficiency syndrome 70 | 164
Vascular disease 69 | 281
Anemia 68 | 252
Heart disease 68 | 279
Juvenile rheumatoid arthritis 67 | 104
gastric cancer 67 | 430
Uveitis 64 | 103

Tissue

Nervous System 2,490 | 18,561
Digestive Tract 2,484 | 18,473
Endocrine System 2,483 | 18,512
Female tissues 2,482 | 18,647
Liver and Pancreas 2,479 | 18,136
Urinary Tract 2,479 | 18,444
Blood and immune system 2,471 | 17,995
Male tissues 2,471 | 17,969
Cardiovascular System 2,469 | 17,958
Skin and soft tissues 2,456 | 18,115
Respiratory system 2,449 | 17,484

Target Family

Non-IDG 1,401 | 11,971
Enzyme 826 | 4,146
Transporter 150 | 473
Kinase 80 | 634
Ion Channel 59 | 341
Transcription Factor 35 | 1,400
GPCR 31 | 406
Epigenetic 8 | 242
Nuclear Receptor 3 | 48

Compartment GO Term

Organelle membrane 2,593 | 2,593
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166