Development Level

Tbio 3,779 | 11,651
Tdark 619 | 6,593
Tchem 538 | 1,388
Tclin 154 | 612

Collection

Kinase: IDG Consortium (Target... 31 | 125
Kinase: IDG Consortium (Comple... 15 | 37
GPCR: IDG Consortium (Targets) 6 | 126
Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

preweaning lethality, complete... 498 | 979
preweaning lethality, incomple... 157 | 499
embryonic lethality prior to t... 132 | 278
embryonic lethality prior to o... 127 | 239
abnormal behavior 95 | 298
abnormal embryo size 92 | 220
decreased total body fat amoun... 68 | 207
enlarged heart 65 | 210
decreased body weight 63 | 161
abnormal bone structure 57 | 187
abnormal heart morphology 57 | 162
increased lean body mass 56 | 172
decreased vertical activity 54 | 208
decreased lean body mass 47 | 135
embryonic growth retardation 46 | 106
increased startle reflex 46 | 112
hypoactivity 44 | 132
decreased circulating choleste... 43 | 93
increased circulating alkaline... 43 | 122
decreased bone mineral content 41 | 151
decreased circulating glucose ... 41 | 126
increased total body fat amoun... 41 | 134
hyperactivity 40 | 148
cataract 36 | 92
decreased grip strength 36 | 116
male infertility 36 | 123
decreased bone mineral density 35 | 126
increased bone mineral density 35 | 72
short tibia 35 | 97
increased bone mineral content 34 | 108
increased or absent threshold ... 34 | 101
abnormal seminal vesicle morph... 33 | 114
decreased body length 33 | 101
prenatal lethality prior to he... 33 | 87
decreased prepulse inhibition 31 | 82
increased mean corpuscular hem... 31 | 96
increased mean corpuscular vol... 31 | 92
abnormal lens morphology 30 | 81
decreased circulating HDL chol... 30 | 68
decreased mean corpuscular vol... 30 | 79
abnormal coat-hair pigmentatio... 28 | 64
abnormal kidney morphology 28 | 65
decreased circulating serum al... 28 | 82
decreased circulating triglyce... 27 | 79
decreased hemoglobin content 27 | 68
impaired glucose tolerance 27 | 75
decreased leukocyte cell numbe... 26 | 73
decreased lymphocyte cell numb... 26 | 83
abnormal retina morphology 25 | 71
edema 25 | 59
increased circulating HDL chol... 24 | 80
increased circulating choleste... 24 | 66
decreased erythrocyte cell num... 23 | 62
decreased fasted circulating g... 23 | 65
increased fasted circulating g... 23 | 76
decreased circulating insulin ... 22 | 76
decreased circulating total pr... 21 | 49
abnormal gait 20 | 69
increased heart weight 20 | 62
abnormal eye morphology 19 | 68
abnormal neural tube closure 19 | 46
corneal opacity 19 | 32
decreased startle reflex 19 | 75
tremors 19 | 39
abnormal spleen morphology 18 | 55
decreased caudal vertebrae num... 18 | 53
decreased circulating alkaline... 18 | 46
decreased hematocrit 18 | 46
decreased mean corpuscular hem... 18 | 50
female infertility 18 | 60
increased circulating triglyce... 18 | 42
increased grip strength 18 | 41
abnormal bone mineralization 17 | 38
decreased circulating iron lev... 17 | 32
small superior vagus ganglion 17 | 74
small testis 17 | 58
thrombocytopenia 17 | 56
abnormal behavioral response t... 16 | 66
abnormal skin morphology 16 | 50
decreased circulating LDL chol... 16 | 38
hydrometra 16 | 53
improved glucose tolerance 16 | 79
increased circulating sodium l... 16 | 71
abnormal craniofacial morpholo... 15 | 33
decreased circulating alanine ... 15 | 47
increased blood urea nitrogen ... 15 | 48
increased hemoglobin content 15 | 45
abnormal sleep behavior 14 | 70
decreased neutrophil cell numb... 14 | 42
enlarged spleen 14 | 41
increased body length 14 | 32
increased circulating chloride... 14 | 41
increased mean platelet volume 14 | 45
increased monocyte cell number 14 | 63
increased neutrophil cell numb... 14 | 46
abnormal embryo turning 13 | 31
abnormal tooth morphology 13 | 24
anophthalmia 13 | 33
increased mean corpuscular hem... 13 | 36
long tibia 13 | 25

Disease

Carcinoma 3,258 | 11,493
ovarian cancer 2,973 | 8,520
osteosarcoma 2,506 | 7,950
psoriasis 1,915 | 6,694
medulloblastoma, large-cell 1,827 | 6,241
glioblastoma 1,747 | 5,792
lung cancer 1,702 | 4,740
atypical teratoid / rhabdoid tumor 1,466 | 5,112
group 3 medulloblastoma 1,372 | 4,104
ependymoma 1,197 | 4,679
Breast cancer 1,166 | 3,578
malignant mesothelioma 1,136 | 3,232
Cancer 1,114 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 1,001 | 3,291
adult high grade glioma 995 | 3,801
primitive neuroectodermal tumor 910 | 3,035
non-small cell lung cancer 887 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 876 | 2,989
invasive ductal carcinoma 843 | 2,951
oligodendroglioma 812 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 808 | 2,955
lung adenocarcinoma 805 | 2,716
Kidney cancer 758 | 2,613
Astrocytoma, Pilocytic 724 | 3,081
pancreatic cancer 707 | 2,398
astrocytic glioma 692 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 668 | 1,962
Multiple myeloma 641 | 1,332
subependymal giant cell astrocytoma 625 | 2,287
lung carcinoma 601 | 2,843
Pick disease 581 | 1,894
diabetes mellitus 569 | 1,728
tuberculosis 568 | 2,010
Autosomal recessive predisposition 550 | 1,442
group 4 medulloblastoma 524 | 1,855
breast carcinoma 514 | 1,638
interstitial cystitis 513 | 2,312
pituitary cancer 510 | 1,972
ductal carcinoma in situ 493 | 1,745
colon cancer 485 | 1,478
ulcerative colitis 479 | 1,819
acute quadriplegic myopathy 470 | 1,158
adrenocortical carcinoma 459 | 1,428
juvenile dermatomyositis 455 | 1,187
astrocytoma 434 | 1,146
Intellectual disability 432 | 1,016
cystic fibrosis 413 | 1,696
Rheumatoid arthritis 405 | 1,191
Waldenstrons macroglobulinemia 404 | 765
dermatomyositis 401 | 966
pediatric high grade glioma 361 | 1,064
primary pancreatic ductal adenocarcinoma 356 | 1,109
Schizophrenia 337 | 1,160
acute myeloid leukemia 319 | 783
non primary Sjogren syndrome sicca 315 | 891
nasopharyngeal carcinoma 313 | 1,058
Cognitive delay 293 | 608
Global developmental delay 293 | 608
Mental and motor retardation 293 | 608
spina bifida 291 | 1,074
Dull intelligence 288 | 645
Epilepsy 288 | 792
Low intelligence 288 | 645
Mental Retardation 288 | 645
Mental deficiency 288 | 645
Poor school performance 288 | 645
cutaneous lupus erythematosus 287 | 1,057
Atopic dermatitis 273 | 952
Short stature 266 | 531
Liver Cirrhosis, Experimental 265 | 769
Muscle hypotonia 255 | 571
Seizures 251 | 596
gastric carcinoma 238 | 807
primary Sjogren syndrome 233 | 735
active Crohn's disease 231 | 922
aldosterone-producing adenoma 230 | 665
Breast Neoplasms 228 | 445
Obesity 224 | 678
esophageal adenocarcinoma 220 | 737
medulloblastoma 218 | 720
Mammary Neoplasms 216 | 425
Alzheimer's disease 215 | 658
progressive supranuclear palsy 215 | 676
Prostatic Neoplasms 206 | 495
Endometriosis 201 | 540
active ulcerative colitis 201 | 764
hepatocellular carcinoma 198 | 547
Small head 196 | 374
Bipolar Disorder 184 | 666
Melanoma 180 | 711
Duchenne muscular dystrophy 178 | 601
autosomal dominant Emery-Dreifuss muscular dystrophy 177 | 510
Liver cancer 174 | 604
Neurodegenerative disease 173 | 414
pancreatic carcinoma 173 | 562
Amyotrophic lateral sclerosis 172 | 451
Down syndrome 163 | 499
Kidney disease 162 | 430
Failure to gain weight 161 | 365
Pediatric failure to thrive 161 | 365

Tissue

Endocrine System 4,994 | 18,159
Digestive Tract 4,967 | 17,369
Female tissues 4,964 | 17,400
Skin and soft tissues 4,947 | 17,230
Male tissues 4,925 | 17,142
Blood and immune system 4,907 | 16,909
Liver and Pancreas 4,898 | 16,750
Urinary Tract 4,892 | 16,678
Nervous System 4,862 | 16,725
Respiratory system 4,853 | 16,393
Cardiovascular System 4,705 | 15,192

Target Family

Non-IDG 2,670 | 12,091
Enzyme 1,358 | 4,145
Transcription Factor 525 | 1,400
Kinase 221 | 634
Epigenetic 183 | 242
Nuclear Receptor 47 | 48
Transporter 31 | 473
TF/Epigenetic 28 | 38
GPCR 17 | 408
Ion Channel 10 | 344

Compartment GO Term

Organelle lumen 5,090 | 5,090
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225