Development Level

Tbio 301 | 11,651
Tdark 129 | 6,593
Tclin 64 | 612
Tchem 31 | 1,388

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 60 | 979
embryonic lethality prior to o... 20 | 239
embryonic lethality prior to t... 15 | 278
preweaning lethality, incomple... 12 | 499
abnormal behavior 11 | 298
abnormal embryo size 10 | 220
embryonic growth retardation 8 | 106
increased total body fat amoun... 8 | 134
cataract 7 | 92
abnormal heart morphology 6 | 162
decreased bone mineral content 6 | 151
decreased vertical activity 6 | 208
enlarged heart 6 | 210
pallor 6 | 34
prenatal lethality prior to he... 6 | 87
abnormal lens morphology 5 | 81
decreased body weight 5 | 161
increased lean body mass 5 | 172
abnormal bone structure 4 | 187
abnormal neural tube closure 4 | 46
decreased heart weight 4 | 27
decreased hemoglobin content 4 | 68
decreased lean body mass 4 | 135
hyperactivity 4 | 148
hypoactivity 4 | 132
increased fasted circulating g... 4 | 76
increased heart weight 4 | 62
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo turning 3 | 31
abnormal sleep behavior 3 | 70
decreased circulating LDL chol... 3 | 38
decreased circulating glucose ... 3 | 126
decreased circulating phosphat... 3 | 27
decreased erythrocyte cell num... 3 | 62
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased total body fat amoun... 3 | 207
improved glucose tolerance 3 | 79
increased circulating phosphat... 3 | 26
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 96
increased prepulse inhibition 3 | 32
pale yolk sac 3 | 25
thrombocytopenia 3 | 56
abnormal allantois morphology 2 | 8
abnormal gait 2 | 69
abnormal hindbrain development 2 | 16
abnormal limb bud morphology 2 | 17
abnormal midbrain development 2 | 20
abnormal neural tube morpholog... 2 | 12
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal tail bud morphology 2 | 8
abnormal tail morphology 2 | 25
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating chloride... 2 | 30
decreased circulating free fat... 2 | 31
decreased food intake 2 | 13
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
enlarged spleen 2 | 41
female infertility 2 | 60
hemorrhage 2 | 23
impaired righting response 2 | 26
increased anti-nuclear antigen... 2 | 19
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating glucose ... 2 | 24
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prolonged QT interval 2 | 38
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased circulating creatine... 1 | 4
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
decreased total retina thickne... 1 | 17
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
long tibia 1 | 25
thin ventricular wall 1 | 24

Disease

ovarian cancer 281 | 8,520
osteosarcoma 208 | 7,950
Carcinoma 200 | 11,493
psoriasis 142 | 6,694
lung cancer 138 | 4,740
medulloblastoma, large-cell 138 | 6,241
glioblastoma 119 | 5,792
pancreatic ductal adenocarcinoma liver metastasis 116 | 1,962
atypical teratoid / rhabdoid tumor 113 | 5,112
Multiple myeloma 105 | 1,332
ependymoma 97 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 88 | 3,291
Autosomal recessive predisposition 85 | 1,442
Breast cancer 80 | 3,578
adult high grade glioma 75 | 3,801
astrocytic glioma 75 | 2,597
group 3 medulloblastoma 69 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,989
malignant mesothelioma 61 | 3,232
non-small cell lung cancer 61 | 2,890
oligodendroglioma 61 | 2,850
invasive ductal carcinoma 58 | 2,951
Epilepsy 57 | 792
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
Cerebellar Ataxia 54 | 304
Cognitive delay 54 | 608
Global developmental delay 54 | 608
Mental and motor retardation 54 | 608
lung adenocarcinoma 53 | 2,716
Diabetes mellitus type 2 51 | 69
Leigh disease 51 | 100
Muscle hypotonia 50 | 571
Pick disease 50 | 1,894
Treatment Refractory Type 2 Diabetes Mellitus 50 | 53
diabetes mellitus 49 | 1,728
Astrocytoma, Pilocytic 48 | 3,081
Failure to gain weight 46 | 365
Pediatric failure to thrive 46 | 365
Acidosis, Lactic 45 | 97
Lactic acidemia 45 | 95
Seizures 45 | 596
group 4 medulloblastoma 45 | 1,855
non primary Sjogren syndrome sicca 45 | 891
primitive neuroectodermal tumor 45 | 3,035
Waldenstrons macroglobulinemia 44 | 765
tuberculosis 44 | 2,010
subependymal giant cell astrocytoma 43 | 2,287
Cancer 42 | 2,499
Mitochondrial complex I deficiency 39 | 46
Nystagmus 39 | 317
lung carcinoma 39 | 2,843
Blepharoptosis 38 | 231
Hyperreflexia 38 | 209
acute myeloid leukemia 38 | 783
breast carcinoma 38 | 1,638
pancreatic cancer 38 | 2,398
Dystonia 37 | 164
Optic Atrophy 37 | 242
Sensorineural Hearing Loss (disorder) 37 | 284
Intellectual disability 34 | 1,016
Muscle Spasticity 34 | 195
Muscle Weakness 34 | 170
Hypertrophic Cardiomyopathy 33 | 117
Increased serum lactate 33 | 60
Schizophrenia 33 | 1,160
Highly variable clinical phenotype 31 | 150
Highly variable phenotype and severity 31 | 150
Highly variable phenotype, even within families 31 | 150
Phenotypic variability 31 | 150
ulcerative colitis 31 | 1,819
Rheumatoid arthritis 30 | 1,191
Strabismus 30 | 270
Dull intelligence 29 | 645
Dystonic disease 29 | 106
Hypoglycemia 29 | 152
Low intelligence 29 | 645
Mental Retardation 29 | 645
Mental deficiency 29 | 645
Poor school performance 29 | 645
Myopathy 28 | 185
Respiratory Failure 28 | 104
astrocytoma 28 | 1,146
colon cancer 28 | 1,478
Neurodegenerative disease 27 | 414
adrenocortical carcinoma 27 | 1,428
cystic fibrosis 27 | 1,696
Babinski Reflex 26 | 100
CSF lactate increased 26 | 33
Mitochondrial Complex 1 Deficiency 26 | 28
acute quadriplegic myopathy 26 | 1,158
pituitary cancer 26 | 1,972
Leigh syndrome 25 | 28
Vomiting 25 | 116
ductal carcinoma in situ 25 | 1,745
interstitial cystitis 25 | 2,312
pediatric high grade glioma 25 | 1,064
Alzheimer's disease 24 | 658
Developmental regression 24 | 95
Loss of developmental milestones 24 | 95
Psychomotor regression, progressive 24 | 95

Tissue

Endocrine System 517 | 18,159
Digestive Tract 511 | 17,369
Liver and Pancreas 510 | 16,750
Male tissues 509 | 17,142
Female tissues 507 | 17,400
Skin and soft tissues 506 | 17,230
Nervous System 503 | 16,725
Urinary Tract 503 | 16,678
Blood and immune system 502 | 16,909
Respiratory system 497 | 16,393
Cardiovascular System 490 | 15,192

Target Family

Non-IDG 224 | 12,091
Enzyme 221 | 4,145
Transporter 55 | 473
Ion Channel 9 | 344
Kinase 8 | 634
Epigenetic 3 | 242
Transcription Factor 3 | 1,400
GPCR 2 | 408

Compartment GO Term

Organelle inner membrane 525 | 525
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
39S ribosomal protein L40, mitochondrial MRPL40 Tbio Non-IDG -0.92179 8.33 105
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Transmembrane protein 11, mitochondrial TMEM11 Tdark Non-IDG -2.44072 252.5 35
Hydroxyproline dehydrogenase PRODH2 Tbio Enzyme -0.72861 5.94 76
Cytochrome b-c1 complex subunit 6-like, mitochondrial UQCRHL Tdark Non-IDG -0.84371 11.5 0