Development Level

Tbio 273 | 10,625
Tdark 140 | 7,003
Tclin 63 | 602
Tchem 43 | 1,890

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 39 | 633
embryonic lethality prior to o... 19 | 148
embryonic lethality prior to t... 13 | 187
abnormal behavior 9 | 226
abnormal embryo size 7 | 112
decreased body weight 7 | 174
decreased bone mineral content 7 | 157
prenatal lethality prior to he... 6 | 64
preweaning lethality, incomple... 6 | 260
decreased circulating glucose ... 5 | 121
embryonic growth retardation 5 | 28
increased heart weight 5 | 37
abnormal bone structure 4 | 131
abnormal lens morphology 4 | 73
abnormal retina morphology 4 | 100
decreased circulating choleste... 4 | 85
decreased grip strength 4 | 123
decreased lean body mass 4 | 195
decreased rib number 4 | 59
decreased total body fat amoun... 4 | 186
hyperactivity 4 | 108
increased circulating phosphat... 4 | 24
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 68
abnormal heart morphology 3 | 51
abnormal neural tube closure 3 | 37
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased leukocyte cell numbe... 3 | 54
decreased mean platelet volume 3 | 12
enlarged heart 3 | 111
hypoactivity 3 | 89
increased grip strength 3 | 83
increased lean body mass 3 | 107
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular hem... 3 | 93
pallor 3 | 13
abnormal embryo turning 2 | 15
abnormal limb bud morphology 2 | 15
abnormal skin coloration 2 | 18
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
abnormal snout morphology 2 | 18
abnormal tail bud morphology 2 | 6
abnormal tooth morphology 2 | 24
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating LDL chol... 2 | 37
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating glycerol... 2 | 19
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 34
decreased red blood cell distr... 2 | 11
decreased startle reflex 2 | 48
decreased total retina thickne... 2 | 20
immune system phenotype 2 | 17
increased blood urea nitrogen ... 2 | 44
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating creatini... 2 | 29
increased exploration in new e... 2 | 56
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
narrow eye opening 2 | 15
persistence of hyaloid vascula... 2 | 22
prenatal lethality 2 | 16
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal kidney morphology 1 | 30
abnormal neural tube morpholog... 1 | 8
abnormal retinal blood vessel ... 1 | 18
abnormal skin appearance 1 | 8
abnormal tail movements 1 | 12
absent pinna reflex 1 | 21
decreased blood urea nitrogen ... 1 | 31
decreased circulating creatini... 1 | 31
decreased circulating magnesiu... 1 | 11
decreased circulating phosphat... 1 | 15
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased hematocrit 1 | 25
enlarged lymph nodes 1 | 27
female infertility 1 | 34
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased CD5-positive Ly6C-po... 1 | 4
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62

Disease

ovarian cancer 274 | 8,491
osteosarcoma 204 | 7,933
psoriasis 144 | 6,685
medulloblastoma, large-cell 134 | 6,234
lung cancer 133 | 4,473
glioblastoma 118 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 108 | 1,795
Multiple myeloma 102 | 1,327
atypical teratoid / rhabdoid tumor 93 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 87 | 3,289
Breast cancer 77 | 3,098
ependymoma 71 | 2,514
astrocytic glioma 69 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 63 | 2,988
pediatric high grade glioma 63 | 2,712
oligodendroglioma 62 | 2,849
malignant mesothelioma 59 | 3,163
non-small cell lung cancer 58 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,956
invasive ductal carcinoma 55 | 2,950
lung adenocarcinoma 53 | 2,714
Diabetes mellitus type 2 51 | 69
Pick disease 50 | 1,893
Treatment Refractory Type 2 Diabetes Mellitus 50 | 53
pilocytic astrocytoma 49 | 3,086
primitive neuroectodermal tumor 45 | 3,031
Leigh disease 44 | 81
subependymal giant cell astrocytoma 44 | 2,287
diabetes mellitus 43 | 1,663
Waldenstrons macroglobulinemia 42 | 764
group 3 medulloblastoma 42 | 2,254
non primary Sjogren syndrome sicca 41 | 840
Cancer 40 | 2,346
lung carcinoma 40 | 2,844
pancreatic cancer 40 | 2,300
medulloblastoma 39 | 1,524
acute myeloid leukemia 38 | 785
adult high grade glioma 37 | 2,148
breast carcinoma 34 | 1,614
tuberculosis 34 | 1,563
ulcerative colitis 34 | 2,087
astrocytoma 33 | 1,493
Mitochondrial complex I deficiency 32 | 37
group 4 medulloblastoma 31 | 1,875
Rheumatoid Arthritis 28 | 1,170
colon cancer 28 | 1,475
Leigh syndrome 27 | 34
Neurodegenerative disease 27 | 383
cystic fibrosis 27 | 1,670
Mitochondrial Complex 1 Deficiency 26 | 28
acute quadriplegic myopathy 26 | 1,157
adrenocortical carcinoma 26 | 1,427
interstitial cystitis 26 | 2,299
pituitary cancer 26 | 1,972
posterior fossa group A ependymoma 26 | 1,511
atypical teratoid/rhabdoid tumor 24 | 1,095
ductal carcinoma in situ 24 | 1,745
sonic hedgehog group medulloblastoma 24 | 1,482
Alzheimer's disease 22 | 644
aldosterone-producing adenoma 22 | 664
hereditary spastic paraplegia 20 | 313
nasopharyngeal carcinoma 20 | 1,056
primary pancreatic ductal adenocarcinoma 20 | 1,271
Cardiomyopathy 19 | 110
NADH:Q(1) Oxidoreductase deficiency 19 | 20
dermatomyositis 19 | 966
posterior fossa group B ependymoma 19 | 1,530
Obesity 18 | 616
juvenile dermatomyositis 18 | 1,189
tuberculosis and treatment for 6 months 18 | 686
Kidney disease 17 | 397
Mammary Neoplasms 17 | 410
Myopathy 17 | 128
Epilepsy 16 | 346
Leber hereditary optic neuropathy 15 | 17
Multiple Sclerosis 15 | 498
Neuropathy 15 | 210
Parkinson's disease 15 | 364
Schizophrenia 15 | 503
Anemia 14 | 252
Down syndrome 14 | 548
Heart disease 14 | 279
primary Sjogren syndrome 14 | 788
Cerebrovascular disease 13 | 231
Duchenne muscular dystrophy 13 | 602
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 13 | 14
Polycystic Ovary Syndrome 13 | 334
cutaneous lupus erythematosus 13 | 1,056
gastric carcinoma 13 | 832
mucosa-associated lymphoid tissue lymphoma 13 | 480
spina bifida 13 | 1,064
3-methylglutaconic aciduria 12 | 29
Amyotrophic Lateral Sclerosis 12 | 432
Dystonia 12 | 77
Lactic acidosis 12 | 43
Mitochondrial myopathy 12 | 24
Multiple acyl-CoA dehydrogenase deficiency 12 | 26
Stomach Neoplasms 12 | 282
progressive supranuclear palsy 12 | 674
Intellectual disability 11 | 573

Tissue

Blood and immune system 515 | 17,994
Digestive Tract 515 | 18,472
Endocrine System 515 | 18,511
Female tissues 515 | 18,646
Male tissues 514 | 17,968
Nervous System 514 | 18,560
Urinary Tract 514 | 18,443
Cardiovascular System 513 | 17,957
Liver and Pancreas 513 | 18,135
Respiratory system 510 | 17,483
Skin and soft tissues 509 | 18,114

Target Family

Non-IDG 220 | 11,969
Enzyme 217 | 4,146
Transporter 56 | 473
Ion Channel 9 | 341
Kinase 9 | 634
Epigenetic 3 | 242
Transcription Factor 3 | 1,400
GPCR 2 | 408

Compartment GO Term

Organelle inner membrane 519 | 519
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114
Galectin-3 LGALS3 Tchem Non-IDG -3.33005 2249.5 911
Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 Tbio Transporter -1.36706 24.8 148
28S ribosomal protein S18a, mitochondrial MRPS18A Tdark Non-IDG 0.32 0.72 46
Mitochondrial ribosome-associated GTPase 1 MTG1 Tdark Enzyme -0.54103 1.85 75
Protoheme IX farnesyltransferase, mitochondrial COX10 Tbio Enzyme -1.58383 36.7 127
Maltase-glucoamylase, intestinal MGAM Tclin Enzyme -4.50018 27956.4 30
LETM1 domain-containing protein 1 LETMD1 Tbio Non-IDG -0.19266 1.43 110
Mitochondrial inner membrane protease subunit 2 IMMP2L Tbio Enzyme -1.20948 14.7 87