Development Level

Tbio 657 | 10,625
Tdark 218 | 7,003
Tchem 124 | 1,890
Tclin 85 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 62 | 633
embryonic lethality prior to o... 22 | 148
embryonic lethality prior to t... 19 | 187
abnormal behavior 17 | 226
decreased body weight 17 | 174
preweaning lethality, incomple... 16 | 260
decreased lean body mass 13 | 195
decreased bone mineral content 12 | 157
decreased grip strength 11 | 123
decreased circulating glucose ... 10 | 121
hypoactivity 10 | 89
abnormal bone structure 9 | 131
decreased circulating choleste... 9 | 85
decreased total body fat amoun... 9 | 186
increased grip strength 9 | 83
increased lean body mass 9 | 107
increased mean corpuscular hem... 9 | 93
abnormal embryo size 8 | 112
abnormal lens morphology 7 | 73
decreased circulating HDL chol... 7 | 77
decreased rib number 7 | 59
increased circulating alkaline... 7 | 119
increased circulating sodium l... 7 | 71
increased mean corpuscular vol... 7 | 91
decreased body length 6 | 108
decreased leukocyte cell numbe... 6 | 54
enlarged heart 6 | 111
increased circulating choleste... 6 | 53
increased circulating phosphat... 6 | 24
increased heart weight 6 | 37
increased or absent threshold ... 6 | 128
prenatal lethality prior to he... 6 | 64
abnormal retina morphology 5 | 100
abnormal snout morphology 5 | 18
decreased caudal vertebrae num... 5 | 49
decreased circulating alkaline... 5 | 41
decreased heart weight 5 | 44
decreased lumbar vertebrae num... 5 | 62
decreased total retina thickne... 5 | 20
embryonic growth retardation 5 | 28
hyperactivity 5 | 108
increased blood urea nitrogen ... 5 | 44
increased sacral vertebrae num... 5 | 62
short tibia 5 | 82
thrombocytopenia 5 | 46
abnormal bone mineralization 4 | 55
abnormal locomotor activation 4 | 26
abnormal skin morphology 4 | 23
decreased circulating LDL chol... 4 | 37
decreased circulating insulin ... 4 | 75
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased mean corpuscular vol... 4 | 50
increased circulating HDL chol... 4 | 63
increased circulating creatini... 4 | 29
increased exploration in new e... 4 | 56
increased fasted circulating g... 4 | 68
increased total body fat amoun... 4 | 57
abnormal clavicle morphology 3 | 5
abnormal femur morphology 3 | 14
abnormal heart left ventricle ... 3 | 20
abnormal heart morphology 3 | 51
abnormal limb bud morphology 3 | 15
abnormal neural tube closure 3 | 37
abnormal rib morphology 3 | 28
abnormal sleep behavior 3 | 63
abnormal tibia morphology 3 | 14
abnormal tooth morphology 3 | 24
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating aspartat... 3 | 27
decreased circulating creatini... 3 | 31
decreased circulating glycerol... 3 | 19
decreased circulating iron lev... 3 | 25
decreased circulating total pr... 3 | 41
decreased fasted circulating g... 3 | 49
decreased hematocrit 3 | 25
decreased mean corpuscular hem... 3 | 34
decreased mean platelet volume 3 | 12
decreased startle reflex 3 | 48
female infertility 3 | 34
impaired glucose tolerance 3 | 52
increased bone mineral content 3 | 92
increased circulating aspartat... 3 | 17
increased startle reflex 3 | 38
male infertility 3 | 62
pallor 3 | 13
persistence of hyaloid vascula... 3 | 22
small thymus 3 | 11
tremors 3 | 34
abnormal gait 2 | 51
decreased circulating calcium ... 2 | 33
decreased circulating potassiu... 2 | 17
decreased hemoglobin content 2 | 53
increased body weight 2 | 42
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased respiratory quotient 2 | 12

Disease

ovarian cancer 590 | 8,492
osteosarcoma 486 | 7,933
medulloblastoma, large-cell 367 | 6,234
psoriasis 351 | 6,685
lung cancer 346 | 4,473
glioblastoma 313 | 5,572
atypical teratoid / rhabdoid tumor 240 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 199 | 3,289
Breast cancer 195 | 3,099
pancreatic ductal adenocarcinoma liver metastasis 187 | 1,795
malignant mesothelioma 181 | 3,163
Cancer 174 | 2,346
Multiple myeloma 174 | 1,328
invasive ductal carcinoma 168 | 2,950
non-small cell lung cancer 167 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 164 | 2,988
pediatric high grade glioma 162 | 2,712
oligodendroglioma 157 | 2,849
ependymoma 155 | 2,514
primitive neuroectodermal tumor 153 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 149 | 2,956
lung adenocarcinoma 147 | 2,714
astrocytic glioma 143 | 2,241
group 3 medulloblastoma 142 | 2,254
pilocytic astrocytoma 136 | 3,086
Pick disease 124 | 1,893
pancreatic cancer 124 | 2,300
lung carcinoma 121 | 2,844
subependymal giant cell astrocytoma 111 | 2,287
ulcerative colitis 111 | 2,087
diabetes mellitus 109 | 1,663
group 4 medulloblastoma 102 | 1,875
adult high grade glioma 101 | 2,148
breast carcinoma 100 | 1,614
ductal carcinoma in situ 91 | 1,745
astrocytoma 89 | 1,493
interstitial cystitis 87 | 2,299
medulloblastoma 87 | 1,524
colon cancer 86 | 1,475
tuberculosis 85 | 1,563
Rheumatoid Arthritis 82 | 1,171
pituitary cancer 82 | 1,972
Waldenstrons macroglobulinemia 79 | 765
dermatomyositis 79 | 967
acute quadriplegic myopathy 78 | 1,157
non primary Sjogren syndrome sicca 78 | 840
Alzheimer's disease 77 | 644
adrenocortical carcinoma 77 | 1,427
Neurodegenerative disease 75 | 383
Carcinoma 73 | 2,147
acute myeloid leukemia 72 | 785
cystic fibrosis 72 | 1,670
posterior fossa group A ependymoma 71 | 1,511
primary pancreatic ductal adenocarcinoma 69 | 1,271
sonic hedgehog group medulloblastoma 69 | 1,482
atypical teratoid/rhabdoid tumor 64 | 1,095
nasopharyngeal carcinoma 64 | 1,056
Obesity 63 | 616
posterior fossa group B ependymoma 63 | 1,530
juvenile dermatomyositis 62 | 1,189
Parkinson's disease 58 | 364
aldosterone-producing adenoma 58 | 664
Mammary Neoplasms 53 | 410
Diabetes mellitus type 2 52 | 69
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
cutaneous lupus erythematosus 51 | 1,056
Leigh disease 46 | 81
Vascular disease 46 | 281
tuberculosis and treatment for 6 months 46 | 686
Toxic encephalopathy 44 | 131
Kidney disease 43 | 397
hereditary spastic paraplegia 43 | 313
primary Sjogren syndrome 43 | 789
Amyotrophic Lateral Sclerosis 42 | 432
Atopic dermatitis 42 | 944
Schizophrenia 41 | 503
gastric carcinoma 40 | 832
progressive supranuclear palsy 40 | 674
Down syndrome 39 | 548
Stomach Neoplasms 37 | 282
Prostatic Neoplasms 36 | 471
active Crohn's disease 36 | 918
esophageal adenocarcinoma 36 | 737
pancreatic carcinoma 35 | 567
spina bifida 35 | 1,064
Heart disease 33 | 279
hepatocellular carcinoma 33 | 550
IGA Glomerulonephritis 32 | 454
Mitochondrial complex I deficiency 32 | 37
Neuropathy 32 | 210
Diabetes Mellitus, Experimental 31 | 106
Multiple Sclerosis 31 | 498
Atherosclerosis 29 | 275
Brain disease 29 | 84
Duchenne muscular dystrophy 29 | 602
Endometriosis 29 | 535
Polycystic Ovary Syndrome 29 | 335
Asthma 28 | 349
Cerebrovascular disease 28 | 231
Liver carcinoma 28 | 217

Tissue

Nervous System 1,070 | 18,561
Blood and immune system 1,069 | 17,995
Female tissues 1,069 | 18,647
Male tissues 1,069 | 17,969
Urinary Tract 1,068 | 18,444
Liver and Pancreas 1,067 | 18,136
Digestive Tract 1,066 | 18,473
Endocrine System 1,066 | 18,512
Cardiovascular System 1,064 | 17,958
Skin and soft tissues 1,056 | 18,115
Respiratory system 1,055 | 17,484

Target Family

Non-IDG 547 | 11,969
Enzyme 362 | 4,146
Transporter 71 | 473
Kinase 40 | 634
Transcription Factor 28 | 1,400
Ion Channel 16 | 341
Epigenetic 9 | 242
GPCR 7 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

Organelle envelope 1,084 | 1,084
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.72649 574.1 155
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tchem Enzyme -1.86960 75.6 147
Apoptosis-inducing factor 2 AIFM2 Tbio Non-IDG -1.15514 16.2 195
MICOS complex subunit MIC25 CHCHD6 Tbio Non-IDG -1.52785 31.8 140
Cardiolipin synthase (CMP-forming) CRLS1 Tbio Enzyme -0.80844 6.24 93
Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 Tbio Enzyme -1.42607 27.2 143