Development Level

Tbio 8,168 | 10,625
Tdark 2,644 | 7,003
Tchem 1,440 | 1,890
Tclin 397 | 602

Collection

Eligible Kinase Proteins 91 | 134
Eligible Ion Channel Proteins 32 | 117
Eligible non-olfactory GPCR Proteins 17 | 143

IMPC Term

preweaning lethality, complete... 557 | 633
preweaning lethality, incomple... 197 | 260
embryonic lethality prior to t... 172 | 187
abnormal behavior 169 | 226
decreased lean body mass 153 | 195
decreased body weight 142 | 174
decreased total body fat amoun... 142 | 186
embryonic lethality prior to o... 141 | 148
decreased bone mineral content 125 | 157
abnormal bone structure 103 | 131
decreased grip strength 100 | 123
decreased bone mineral density 98 | 126
abnormal embryo size 97 | 112
increased circulating alkaline... 96 | 119
increased or absent threshold ... 94 | 128
decreased circulating glucose ... 90 | 121
decreased body length 89 | 108
abnormal retina morphology 82 | 100
hyperactivity 78 | 108
increased lean body mass 77 | 107
enlarged heart 73 | 111
hypoactivity 71 | 89
decreased circulating choleste... 70 | 85
increased bone mineral content 70 | 92
increased mean corpuscular vol... 70 | 91
increased mean corpuscular hem... 68 | 93
short tibia 65 | 82
abnormal lens morphology 64 | 73
increased grip strength 64 | 83
decreased circulating HDL chol... 63 | 77
decreased circulating triglyce... 62 | 83
decreased circulating serum al... 57 | 79
decreased circulating insulin ... 55 | 75
increased circulating sodium l... 53 | 71
prenatal lethality prior to he... 52 | 64
increased fasted circulating g... 51 | 68
decreased lumbar vertebrae num... 49 | 62
increased sacral vertebrae num... 47 | 62
abnormal bone mineralization 46 | 55
male infertility 46 | 62
abnormal retinal pigmentation 45 | 61
decreased mean corpuscular vol... 44 | 50
increased total body fat amoun... 44 | 57
decreased leukocyte cell numbe... 43 | 54
increased circulating HDL chol... 43 | 63
decreased circulating alanine ... 42 | 53
decreased hemoglobin content 42 | 53
abnormal sleep behavior 41 | 63
decreased rib number 41 | 59
impaired glucose tolerance 41 | 52
improved glucose tolerance 41 | 56
abnormal coat/hair pigmentatio... 40 | 54
increased circulating choleste... 40 | 53
abnormal behavioral response t... 39 | 52
increased bone mineral density 39 | 52
increased exploration in new e... 39 | 56
decreased fasted circulating g... 38 | 49
decreased prepulse inhibition 38 | 52
decreased heart weight 37 | 44
abnormal gait 36 | 51
decreased startle reflex 36 | 48
increased circulating chloride... 36 | 43
thrombocytopenia 36 | 46
abnormal seminal vesicle morph... 35 | 47
decreased caudal vertebrae num... 35 | 49
abnormal neural tube closure 34 | 37
increased blood urea nitrogen ... 34 | 44
decreased erythrocyte cell num... 33 | 43
increased body weight 33 | 42
decreased circulating alkaline... 32 | 41
increased heart weight 32 | 37
increased hemoglobin content 32 | 45
abnormal heart morphology 31 | 51
decreased circulating LDL chol... 31 | 37
decreased eosinophil cell numb... 30 | 41
abnormal eye morphology 29 | 38
decreased circulating total pr... 29 | 41
increased startle reflex 29 | 38
cardiovascular system phenotyp... 28 | 35
decreased mean corpuscular hem... 28 | 34
tremors 28 | 34
increased leukocyte cell numbe... 27 | 37
abnormal kidney morphology 26 | 30
decreased T cell number 25 | 31
decreased threshold for audito... 25 | 32
embryonic growth retardation 25 | 28
increased circulating creatini... 25 | 29
increased hematocrit 25 | 36
increased rib number 25 | 41
limb grasping 25 | 35
small testis 25 | 37
abnormal cranium morphology 24 | 32
abnormal spleen morphology 24 | 36
decreased blood urea nitrogen ... 24 | 31
decreased circulating calcium ... 24 | 33
decreased circulating free fat... 24 | 39
decreased circulating fructosa... 24 | 31
decreased neutrophil cell numb... 24 | 37
decreased circulating aspartat... 23 | 27
increased circulating calcium ... 23 | 32

Disease

ovarian cancer 6,417 | 8,484
osteosarcoma 5,722 | 7,933
psoriasis 4,632 | 6,685
medulloblastoma, large-cell 4,436 | 6,234
glioblastoma 4,050 | 5,572
lung cancer 3,479 | 4,466
atypical teratoid / rhabdoid tumor 3,090 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,491 | 3,289
malignant mesothelioma 2,439 | 3,162
Breast cancer 2,326 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,212 | 2,988
primitive neuroectodermal tumor 2,192 | 3,031
invasive ductal carcinoma 2,168 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,131 | 2,956
pilocytic astrocytoma 2,129 | 3,086
oligodendroglioma 2,042 | 2,849
non-small cell lung cancer 2,041 | 2,798
Cancer 2,023 | 2,346
pediatric high grade glioma 1,992 | 2,712
lung adenocarcinoma 1,944 | 2,713
lung carcinoma 1,894 | 2,844
ependymoma 1,827 | 2,514
pancreatic cancer 1,723 | 2,300
group 3 medulloblastoma 1,699 | 2,254
subependymal giant cell astrocytoma 1,598 | 2,287
astrocytic glioma 1,558 | 2,241
interstitial cystitis 1,516 | 2,299
Carcinoma 1,508 | 2,147
ulcerative colitis 1,463 | 2,087
Pick disease 1,421 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,410 | 1,795
adult high grade glioma 1,407 | 2,148
group 4 medulloblastoma 1,371 | 1,875
pituitary cancer 1,364 | 1,972
ductal carcinoma in situ 1,286 | 1,745
diabetes mellitus 1,220 | 1,663
breast carcinoma 1,212 | 1,614
astrocytoma 1,184 | 1,493
Multiple myeloma 1,179 | 1,327
cystic fibrosis 1,167 | 1,665
colon cancer 1,144 | 1,475
tuberculosis 1,127 | 1,557
medulloblastoma 1,089 | 1,524
adrenocortical carcinoma 1,073 | 1,427
posterior fossa group A ependymoma 1,051 | 1,511
sonic hedgehog group medulloblastoma 1,047 | 1,482
posterior fossa group B ependymoma 986 | 1,530
primary pancreatic ductal adenocarcinoma 973 | 1,271
juvenile dermatomyositis 935 | 1,189
acute quadriplegic myopathy 922 | 1,157
Rheumatoid Arthritis 919 | 1,160
atypical teratoid/rhabdoid tumor 798 | 1,095
dermatomyositis 793 | 933
spina bifida 780 | 1,064
nasopharyngeal carcinoma 770 | 1,056
cutaneous lupus erythematosus 738 | 1,056
Waldenstrons macroglobulinemia 678 | 765
active Crohn's disease 674 | 918
Atopic dermatitis 673 | 944
non primary Sjogren syndrome sicca 626 | 840
acute myeloid leukemia 618 | 780
gastric carcinoma 602 | 832
esophageal adenocarcinoma 572 | 737
primary Sjogren syndrome 558 | 789
tuberculosis and treatment for 6 months 523 | 686
aldosterone-producing adenoma 517 | 664
progressive supranuclear palsy 507 | 674
Alzheimer's disease 498 | 644
Obesity 486 | 616
Intellectual disability 475 | 573
Duchenne muscular dystrophy 474 | 602
Down syndrome 436 | 548
pancreatic carcinoma 422 | 567
Endometriosis 414 | 535
Prostatic Neoplasms 407 | 471
hepatocellular carcinoma 403 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 401 | 499
fibroadenoma 392 | 557
IGA Glomerulonephritis 373 | 454
Schizophrenia 365 | 501
Amyotrophic Lateral Sclerosis 357 | 431
Multiple Sclerosis 351 | 498
Kidney disease 345 | 396
chronic rhinosinusitis 345 | 512
Neurodegenerative disease 343 | 383
Mammary Neoplasms 342 | 410
active ulcerative colitis 341 | 477
mucosa-associated lymphoid tissue lymphoma 323 | 480
gastric cancer 321 | 430
inflammatory breast cancer 299 | 404
Parkinson's disease 296 | 364
Polycystic Ovary Syndrome 273 | 332
hereditary spastic paraplegia 271 | 313
non-small cell lung carcinoma 268 | 413
glioblastoma multiforme 258 | 347
Stomach Neoplasms 252 | 282
sarcoidosis 251 | 358
nephrosclerosis 247 | 329
Epilepsy 245 | 346
Asthma 244 | 349

Tissue

Female tissues 12,374 | 18,647
Nervous System 12,355 | 18,561
Endocrine System 12,337 | 18,512
Digestive Tract 12,324 | 18,473
Urinary Tract 12,288 | 18,444
Liver and Pancreas 12,238 | 18,136
Blood and immune system 12,213 | 17,995
Male tissues 12,209 | 17,969
Cardiovascular System 12,181 | 17,958
Skin and soft tissues 12,177 | 18,115
Respiratory system 11,986 | 17,484

Target Family

Non-IDG 6,801 | 11,971
Enzyme 3,159 | 4,146
Transcription Factor 1,385 | 1,400
Kinase 476 | 634
Transporter 280 | 473
Epigenetic 220 | 242
Ion Channel 138 | 341
GPCR 104 | 406
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 2 | 421

Compartment GO Term

Organelle 12,649 | 12,649
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345