Targets

Target Filters...

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Mitochondrial 2-oxodicarboxylate carrier	SLC25A21	Tbio	Transporter	-0.46900	2.68	102
Zinc finger and BTB domain-containing protein 1	ZBTB1	Tbio	Transcription Factor	-0.57513	5.01	57
HLA class I histocompatibility antigen, A-3 alpha chain	HLA-A	Tbio	Non-IDG	-3.60614	4042.7	585
GTPase KRas	KRAS	Tbio	Enzyme	-3.75582	5694.2	421
RNA pseudouridylate synthase domain-containing protein 3	RPUSD3	Tdark	Enzyme		0.42	34
D(2) dopamine receptor	DRD2	Tclin	GPCR	-3.24474	1775.2	248
Proto-oncogene c-Fos	FOS	Tchem	Transcription Factor	-4.11560	13094.7	961
Zinc finger protein 136	ZNF136	Tdark	Transcription Factor	0.12	0.68	102
Syntaxin-1B	STX1B	Tbio	Non-IDG	-1.74488	52.6	27
Interleukin-1 beta	IL1B	Tclin	Non-IDG	-4.34333	22444.2	1345

	Eligible Kinase Proteins	91 \| 134
	Eligible Ion Channel Proteins	32 \| 117
	Eligible non-olfactory GPCR Proteins	17 \| 143

	preweaning lethality, complete...	557 \| 633
	preweaning lethality, incomple...	197 \| 260
	embryonic lethality prior to t...	172 \| 187
	abnormal behavior	169 \| 226
	decreased lean body mass	153 \| 195
	decreased body weight	142 \| 174
	decreased total body fat amoun...	142 \| 186
	embryonic lethality prior to o...	141 \| 148
	decreased bone mineral content	125 \| 157
	abnormal bone structure	103 \| 131
	decreased grip strength	100 \| 123
	decreased bone mineral density	98 \| 126
	abnormal embryo size	97 \| 112
	increased circulating alkaline...	96 \| 119
	increased or absent threshold ...	94 \| 128
	decreased circulating glucose ...	90 \| 121
	decreased body length	89 \| 108
	abnormal retina morphology	82 \| 100
	hyperactivity	78 \| 108
	increased lean body mass	77 \| 107
	enlarged heart	73 \| 111
	hypoactivity	71 \| 89
	decreased circulating choleste...	70 \| 85
	increased bone mineral content	70 \| 92
	increased mean corpuscular vol...	70 \| 91
	increased mean corpuscular hem...	68 \| 93
	short tibia	65 \| 82
	abnormal lens morphology	64 \| 73
	increased grip strength	64 \| 83
	decreased circulating HDL chol...	63 \| 77
	decreased circulating triglyce...	62 \| 83
	decreased circulating serum al...	57 \| 79
	decreased circulating insulin ...	55 \| 75
	increased circulating sodium l...	53 \| 71
	prenatal lethality prior to he...	52 \| 64
	increased fasted circulating g...	51 \| 68
	decreased lumbar vertebrae num...	49 \| 62
	increased sacral vertebrae num...	47 \| 62
	abnormal bone mineralization	46 \| 55
	male infertility	46 \| 62
	abnormal retinal pigmentation	45 \| 61
	decreased mean corpuscular vol...	44 \| 50
	increased total body fat amoun...	44 \| 57
	decreased leukocyte cell numbe...	43 \| 54
	increased circulating HDL chol...	43 \| 63
	decreased circulating alanine ...	42 \| 53
	decreased hemoglobin content	42 \| 53
	abnormal sleep behavior	41 \| 63
	decreased rib number	41 \| 59
	impaired glucose tolerance	41 \| 52
	improved glucose tolerance	41 \| 56
	abnormal coat/hair pigmentatio...	40 \| 54
	increased circulating choleste...	40 \| 53
	abnormal behavioral response t...	39 \| 52
	increased bone mineral density	39 \| 52
	increased exploration in new e...	39 \| 56
	decreased fasted circulating g...	38 \| 49
	decreased prepulse inhibition	38 \| 52
	decreased heart weight	37 \| 44
	abnormal gait	36 \| 51
	decreased startle reflex	36 \| 48
	increased circulating chloride...	36 \| 43
	thrombocytopenia	36 \| 46
	abnormal seminal vesicle morph...	35 \| 47
	decreased caudal vertebrae num...	35 \| 49
	abnormal neural tube closure	34 \| 37
	increased blood urea nitrogen ...	34 \| 44
	decreased erythrocyte cell num...	33 \| 43
	increased body weight	33 \| 42
	decreased circulating alkaline...	32 \| 41
	increased heart weight	32 \| 37
	increased hemoglobin content	32 \| 45
	abnormal heart morphology	31 \| 51
	decreased circulating LDL chol...	31 \| 37
	decreased eosinophil cell numb...	30 \| 41
	abnormal eye morphology	29 \| 38
	decreased circulating total pr...	29 \| 41
	increased startle reflex	29 \| 38
	cardiovascular system phenotyp...	28 \| 35
	decreased mean corpuscular hem...	28 \| 34
	tremors	28 \| 34
	increased leukocyte cell numbe...	27 \| 37
	abnormal kidney morphology	26 \| 30
	decreased T cell number	25 \| 31
	decreased threshold for audito...	25 \| 32
	embryonic growth retardation	25 \| 28
	increased circulating creatini...	25 \| 29
	increased hematocrit	25 \| 36
	increased rib number	25 \| 41
	limb grasping	25 \| 35
	small testis	25 \| 37
	abnormal cranium morphology	24 \| 32
	abnormal spleen morphology	24 \| 36
	decreased blood urea nitrogen ...	24 \| 31
	decreased circulating calcium ...	24 \| 33
	decreased circulating free fat...	24 \| 39
	decreased circulating fructosa...	24 \| 31
	decreased neutrophil cell numb...	24 \| 37
	decreased circulating aspartat...	23 \| 27
	increased circulating calcium ...	23 \| 32

	ovarian cancer	6,417 \| 8,484
	osteosarcoma	5,722 \| 7,933
	psoriasis	4,632 \| 6,685
	medulloblastoma, large-cell	4,436 \| 6,234
	glioblastoma	4,050 \| 5,572
	lung cancer	3,479 \| 4,466
	atypical teratoid / rhabdoid tumor	3,090 \| 4,369
	intraductal papillary-mucinous neoplasm (IPMN)	2,491 \| 3,289
	malignant mesothelioma	2,439 \| 3,162
	Breast cancer	2,326 \| 3,094
	intraductal papillary-mucinous carcinoma (IPMC)	2,212 \| 2,988
	primitive neuroectodermal tumor	2,192 \| 3,031
	invasive ductal carcinoma	2,168 \| 2,950
	intraductal papillary-mucinous adenoma (IPMA)	2,131 \| 2,956
	pilocytic astrocytoma	2,129 \| 3,086
	oligodendroglioma	2,042 \| 2,849
	non-small cell lung cancer	2,041 \| 2,798
	Cancer	2,023 \| 2,346
	pediatric high grade glioma	1,992 \| 2,712
	lung adenocarcinoma	1,944 \| 2,713
	lung carcinoma	1,894 \| 2,844
	ependymoma	1,827 \| 2,514
	pancreatic cancer	1,723 \| 2,300
	group 3 medulloblastoma	1,699 \| 2,254
	subependymal giant cell astrocytoma	1,598 \| 2,287
	astrocytic glioma	1,558 \| 2,241
	interstitial cystitis	1,516 \| 2,299
	Carcinoma	1,508 \| 2,147
	ulcerative colitis	1,463 \| 2,087
	Pick disease	1,421 \| 1,893
	pancreatic ductal adenocarcinoma liver metastasis	1,410 \| 1,795
	adult high grade glioma	1,407 \| 2,148
	group 4 medulloblastoma	1,371 \| 1,875
	pituitary cancer	1,364 \| 1,972
	ductal carcinoma in situ	1,286 \| 1,745
	diabetes mellitus	1,220 \| 1,663
	breast carcinoma	1,212 \| 1,614
	astrocytoma	1,184 \| 1,493
	Multiple myeloma	1,179 \| 1,327
	cystic fibrosis	1,167 \| 1,665
	colon cancer	1,144 \| 1,475
	tuberculosis	1,127 \| 1,557
	medulloblastoma	1,089 \| 1,524
	adrenocortical carcinoma	1,073 \| 1,427
	posterior fossa group A ependymoma	1,051 \| 1,511
	sonic hedgehog group medulloblastoma	1,047 \| 1,482
	posterior fossa group B ependymoma	986 \| 1,530
	primary pancreatic ductal adenocarcinoma	973 \| 1,271
	juvenile dermatomyositis	935 \| 1,189
	acute quadriplegic myopathy	922 \| 1,157
	Rheumatoid Arthritis	919 \| 1,160
	atypical teratoid/rhabdoid tumor	798 \| 1,095
	dermatomyositis	793 \| 933
	spina bifida	780 \| 1,064
	nasopharyngeal carcinoma	770 \| 1,056
	cutaneous lupus erythematosus	738 \| 1,056
	Waldenstrons macroglobulinemia	678 \| 765
	active Crohn's disease	674 \| 918
	Atopic dermatitis	673 \| 944
	non primary Sjogren syndrome sicca	626 \| 840
	acute myeloid leukemia	618 \| 780
	gastric carcinoma	602 \| 832
	esophageal adenocarcinoma	572 \| 737
	primary Sjogren syndrome	558 \| 789
	tuberculosis and treatment for 6 months	523 \| 686
	aldosterone-producing adenoma	517 \| 664
	progressive supranuclear palsy	507 \| 674
	Alzheimer's disease	498 \| 644
	Obesity	486 \| 616
	Intellectual disability	475 \| 573
	Duchenne muscular dystrophy	474 \| 602
	Down syndrome	436 \| 548
	pancreatic carcinoma	422 \| 567
	Endometriosis	414 \| 535
	Prostatic Neoplasms	407 \| 471
	hepatocellular carcinoma	403 \| 532
	autosomal dominant Emery-Dreifuss muscular dystrophy	401 \| 499
	fibroadenoma	392 \| 557
	IGA Glomerulonephritis	373 \| 454
	Schizophrenia	365 \| 501
	Amyotrophic Lateral Sclerosis	357 \| 431
	Multiple Sclerosis	351 \| 498
	Kidney disease	345 \| 396
	chronic rhinosinusitis	345 \| 512
	Neurodegenerative disease	343 \| 383
	Mammary Neoplasms	342 \| 410
	active ulcerative colitis	341 \| 477
	mucosa-associated lymphoid tissue lymphoma	323 \| 480
	gastric cancer	321 \| 430
	inflammatory breast cancer	299 \| 404
	Parkinson's disease	296 \| 364
	Polycystic Ovary Syndrome	273 \| 332
	hereditary spastic paraplegia	271 \| 313
	non-small cell lung carcinoma	268 \| 413
	glioblastoma multiforme	258 \| 347
	Stomach Neoplasms	252 \| 282
	sarcoidosis	251 \| 358
	nephrosclerosis	247 \| 329
	Epilepsy	245 \| 346
	Asthma	244 \| 349

	Female tissues	12,374 \| 18,647
	Nervous System	12,355 \| 18,561
	Endocrine System	12,337 \| 18,512
	Digestive Tract	12,324 \| 18,473
	Urinary Tract	12,288 \| 18,444
	Liver and Pancreas	12,238 \| 18,136
	Blood and immune system	12,213 \| 17,995
	Male tissues	12,209 \| 17,969
	Cardiovascular System	12,181 \| 17,958
	Skin and soft tissues	12,177 \| 18,115
	Respiratory system	11,986 \| 17,484

	Non-IDG	6,801 \| 11,971
	Enzyme	3,159 \| 4,146
	Transcription Factor	1,385 \| 1,400
	Kinase	476 \| 634
	Transporter	280 \| 473
	Epigenetic	220 \| 242
	Ion Channel	138 \| 341
	GPCR	104 \| 406
	Nuclear Receptor	47 \| 48
	TF/Epigenetic	37 \| 38
	oGPCR	2 \| 421

Development Level

Collection

IMPC Term

Disease

Tissue

Target Family

Compartment GO Term

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source

	Tbio	8,168 \| 10,625
	Tdark	2,644 \| 7,003
	Tchem	1,440 \| 1,890
	Tclin	397 \| 602

	Organelle	12,649 \| 12,649
	cellular_component	18,238 \| 18,238
	Cell	15,807 \| 15,807
	Cell part	15,807 \| 15,807
	Intracellular	13,611 \| 13,611
	Intracellular part	13,474 \| 13,474
	membrane-bounded organelle	11,794 \| 11,794
	Intracellular organelle	11,618 \| 11,618
	Intracellular membrane-bounded...	10,619 \| 10,619
	Cytoplasm	10,352 \| 10,352
	Membrane	8,872 \| 8,872
	Organelle part	8,170 \| 8,170
	Intracellular organelle part	8,012 \| 8,012
	Cytoplasmic part	7,830 \| 7,830
	Nucleus	6,897 \| 6,897
	Membrane part	6,469 \| 6,469
	Intrinsic component of membran...	5,445 \| 5,445
	Integral component of membrane	5,315 \| 5,315
	Macromolecular complex	5,172 \| 5,172
	Cell periphery	5,145 \| 5,145
	Plasma membrane	5,059 \| 5,059
	Extracellular region	4,606 \| 4,606
	Protein complex	4,438 \| 4,438
	Intracellular organelle lumen	4,331 \| 4,331
	Organelle lumen	4,331 \| 4,331
	membrane-enclosed lumen	4,331 \| 4,331
	Extracellular region part	3,873 \| 3,873
	Intracellular non-membrane-bou...	3,840 \| 3,840
	non-membrane-bounded organelle	3,839 \| 3,839
	Nuclear part	3,808 \| 3,808
	Endomembrane system	3,720 \| 3,720
	Vesicle	3,667 \| 3,667
	membrane-bounded vesicle	3,495 \| 3,495
	Nuclear lumen	3,465 \| 3,465
	Cytosol	3,352 \| 3,352
	Nucleoplasm	2,938 \| 2,938
	Extracellular organelle	2,850 \| 2,850
	Extracellular vesicle	2,849 \| 2,849
	Extracellular exosome	2,829 \| 2,829
	Organelle membrane	2,593 \| 2,593
	Plasma membrane part	2,563 \| 2,563
	Cytoskeleton	2,045 \| 2,045
	Intrinsic component of plasma ...	1,783 \| 1,783
	Bounding membrane of organelle	1,729 \| 1,729
	Integral component of plasma m...	1,723 \| 1,723
	Endoplasmic reticulum	1,663 \| 1,663
	Cytoskeletal part	1,567 \| 1,567
	Mitochondrion	1,530 \| 1,530
	Cell projection	1,426 \| 1,426
	Golgi apparatus	1,402 \| 1,402
	Extracellular space	1,329 \| 1,329
	Whole membrane	1,320 \| 1,320
	GO:0098796	1,304 \| 1,304
	Cell junction	1,301 \| 1,301
	Vacuole	1,263 \| 1,263
	Intracellular vesicle	1,256 \| 1,256
	Cytoplasmic vesicle	1,255 \| 1,255
	Catalytic complex	1,233 \| 1,233
	Endoplasmic reticulum part	1,230 \| 1,230
	cytoplasmic, membrane-bounded ...	1,125 \| 1,125
	GO:0031975	1,093 \| 1,093
	Microtubule cytoskeleton	1,087 \| 1,087
	Organelle envelope	1,085 \| 1,085
	Nuclear outer membrane-endopla...	1,079 \| 1,079
	Endoplasmic reticulum membrane	1,062 \| 1,062
	Chromosome	999 \| 999
	Mitochondrial part	989 \| 989
	Golgi apparatus part	940 \| 940
	Neuron part	913 \| 913
	Chromosomal part	862 \| 862
	Endosome	857 \| 857
	Nucleolus	839 \| 839
	Cell surface	836 \| 836
	Transferase complex	816 \| 816
	Ribonucleoprotein complex	794 \| 794
	Intracellular ribonucleoprotei...	790 \| 790
	Nucleoplasm part	780 \| 780
	Plasma membrane region	777 \| 777
	Vacuolar part	776 \| 776
	Polymeric cytoskeletal fiber	758 \| 758
	Supramolecular fiber	758 \| 758
	Cell projection part	738 \| 738
	Plasma membrane protein comple...	720 \| 720
	Mitochondrial envelope	716 \| 716
	Golgi membrane	710 \| 710
	Anchoring junction	702 \| 702
	Adherens junction	687 \| 687
	Cytoplasmic vesicle part	682 \| 682
	Neuron projection	681 \| 681
	Vacuolar membrane	667 \| 667
	Mitochondrial membrane	663 \| 663
	Receptor complex	657 \| 657
	Extracellular matrix	633 \| 633
	Microtubule organizing center	617 \| 617
	Synapse	594 \| 594
	Lysosome	571 \| 571
	Lytic vacuole	571 \| 571
	Vesicle membrane	559 \| 559
	cell-cell junction	557 \| 557
	Cytoplasmic vesicle membrane	552 \| 552