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Target Filters...

Development Level

Tbio 8,516 | 11,651
Tdark 2,286 | 6,593
Tchem 1,041 | 1,388
Tclin 395 | 612

Collection

RFA-RM-18-021 132 | 328
Kinase: IDG Consortium (Target... 87 | 125
Kinase: IDG Consortium (Comple... 32 | 37
Ion Channel: IDG Consortium (T... 27 | 99
GPCR: IDG Consortium (Targets) 22 | 126
GPCR: IDG Consortium (Complete... 8 | 25

IMPC Phenotype

preweaning lethality, complete... 863 | 979
preweaning lethality, incomple... 371 | 499
embryonic lethality prior to t... 253 | 278
embryonic lethality prior to o... 217 | 239
abnormal behavior 209 | 298
abnormal embryo size 186 | 220
decreased total body fat amoun... 154 | 207
abnormal bone structure 139 | 187
decreased vertical activity 135 | 208
enlarged heart 133 | 210
decreased body weight 131 | 161
increased lean body mass 121 | 172
decreased bone mineral content 113 | 151
hypoactivity 109 | 132
decreased lean body mass 108 | 135
abnormal heart morphology 106 | 162
increased total body fat amoun... 106 | 134
hyperactivity 99 | 148
embryonic growth retardation 96 | 106
decreased bone mineral density 93 | 126
decreased circulating glucose ... 93 | 126
decreased grip strength 93 | 116
increased circulating alkaline... 91 | 122
increased startle reflex 91 | 112
male infertility 91 | 123
abnormal seminal vesicle morph... 81 | 114
decreased circulating choleste... 79 | 93
increased bone mineral content 75 | 108
decreased body length 73 | 101
prenatal lethality prior to he... 72 | 87
increased mean corpuscular vol... 71 | 92
cataract 70 | 92
short tibia 69 | 97
increased or absent threshold ... 68 | 101
increased mean corpuscular hem... 67 | 96
decreased circulating serum al... 65 | 82
decreased mean corpuscular vol... 64 | 79
decreased lymphocyte cell numb... 62 | 83
abnormal lens morphology 61 | 81
decreased prepulse inhibition 61 | 82
increased fasted circulating g... 60 | 76
impaired glucose tolerance 59 | 75
decreased circulating HDL chol... 58 | 68
decreased circulating triglyce... 58 | 79
decreased hemoglobin content 57 | 68
decreased leukocyte cell numbe... 55 | 73
improved glucose tolerance 55 | 79
increased bone mineral density 55 | 72
increased circulating HDL chol... 54 | 80
edema 52 | 59
increased circulating sodium l... 52 | 71
small superior vagus ganglion 52 | 74
abnormal gait 51 | 69
abnormal retina morphology 51 | 71
decreased circulating insulin ... 51 | 76
decreased startle reflex 51 | 75
increased heart weight 51 | 62
abnormal kidney morphology 50 | 65
abnormal behavioral response t... 49 | 66
abnormal coat-hair pigmentatio... 48 | 64
increased circulating choleste... 48 | 66
decreased fasted circulating g... 47 | 65
decreased erythrocyte cell num... 46 | 62
abnormal eye morphology 45 | 68
increased monocyte cell number 45 | 63
abnormal sleep behavior 44 | 70
female infertility 43 | 60
decreased mean corpuscular hem... 42 | 50
thrombocytopenia 42 | 56
abnormal neural tube closure 41 | 46
decreased circulating total pr... 41 | 49
small testis 41 | 58
decreased caudal vertebrae num... 40 | 53
decreased circulating alanine ... 39 | 47
decreased circulating alkaline... 39 | 46
abnormal spleen morphology 38 | 55
decreased blood urea nitrogen ... 37 | 51
increased circulating chloride... 36 | 41
decreased hematocrit 35 | 46
increased blood urea nitrogen ... 35 | 48
decreased circulating LDL chol... 34 | 38
hydrometra 34 | 53
increased hemoglobin content 34 | 45
increased leukocyte cell numbe... 34 | 47
increased neutrophil cell numb... 34 | 46
abnormal skin morphology 33 | 50
tremors 33 | 39
abnormal testis morphology 32 | 43
increased circulating triglyce... 32 | 42
increased mean platelet volume 31 | 45
decreased circulating creatini... 30 | 39
enlarged spleen 30 | 41
increased circulating creatini... 30 | 38
increased grip strength 30 | 41
increased hematocrit 30 | 46
decreased circulating calcium ... 29 | 36
abnormal bone mineralization 28 | 38
abnormal cornea morphology 28 | 31
abnormal craniofacial morpholo... 28 | 33
pallor 28 | 34

Disease

Carcinoma 7,703 | 11,493
ovarian cancer 6,210 | 8,520
osteosarcoma 5,611 | 7,950
psoriasis 4,457 | 6,694
medulloblastoma, large-cell 4,296 | 6,241
glioblastoma 4,066 | 5,792
atypical teratoid / rhabdoid tumor 3,529 | 5,112
lung cancer 3,504 | 4,740
ependymoma 3,142 | 4,679
group 3 medulloblastoma 2,926 | 4,104
Breast cancer 2,555 | 3,578
adult high grade glioma 2,496 | 3,801
malignant mesothelioma 2,384 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,343 | 3,291
primitive neuroectodermal tumor 2,119 | 3,035
Cancer 2,086 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 2,085 | 2,989
invasive ductal carcinoma 2,042 | 2,951
Astrocytoma, Pilocytic 2,029 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,001 | 2,955
non-small cell lung cancer 1,996 | 2,890
oligodendroglioma 1,959 | 2,850
lung adenocarcinoma 1,840 | 2,716
Kidney cancer 1,797 | 2,613
lung carcinoma 1,779 | 2,843
astrocytic glioma 1,759 | 2,597
pancreatic cancer 1,673 | 2,398
subependymal giant cell astrocytoma 1,542 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,455 | 1,962
interstitial cystitis 1,428 | 2,312
tuberculosis 1,427 | 2,010
Pick disease 1,374 | 1,894
group 4 medulloblastoma 1,309 | 1,855
pituitary cancer 1,295 | 1,972
diabetes mellitus 1,228 | 1,728
ulcerative colitis 1,209 | 1,819
ductal carcinoma in situ 1,195 | 1,745
breast carcinoma 1,161 | 1,638
Autosomal recessive predisposition 1,150 | 1,442
Multiple myeloma 1,142 | 1,332
cystic fibrosis 1,101 | 1,696
colon cancer 1,061 | 1,478
adrenocortical carcinoma 1,032 | 1,428
juvenile dermatomyositis 909 | 1,187
Rheumatoid arthritis 908 | 1,191
acute quadriplegic myopathy 900 | 1,158
astrocytoma 890 | 1,146
Intellectual disability 858 | 1,016
Schizophrenia 830 | 1,160
dermatomyositis 814 | 966
pediatric high grade glioma 788 | 1,064
primary pancreatic ductal adenocarcinoma 781 | 1,109
spina bifida 741 | 1,074
nasopharyngeal carcinoma 726 | 1,058
cutaneous lupus erythematosus 725 | 1,057
Waldenstrons macroglobulinemia 665 | 765
non primary Sjogren syndrome sicca 655 | 891
active Crohn's disease 635 | 922
Atopic dermatitis 631 | 952
Epilepsy 631 | 792
acute myeloid leukemia 610 | 783
Liver Cirrhosis, Experimental 571 | 769
Dull intelligence 556 | 645
Low intelligence 556 | 645
Mental Retardation 556 | 645
Mental deficiency 556 | 645
Poor school performance 556 | 645
gastric carcinoma 551 | 807
Cognitive delay 545 | 608
Global developmental delay 545 | 608
Mental and motor retardation 545 | 608
esophageal adenocarcinoma 538 | 737
Obesity 532 | 678
primary Sjogren syndrome 515 | 735
active ulcerative colitis 509 | 764
Alzheimer's disease 508 | 658
Seizures 507 | 596
aldosterone-producing adenoma 493 | 665
progressive supranuclear palsy 487 | 676
Muscle hypotonia 486 | 571
Bipolar Disorder 482 | 666
medulloblastoma 477 | 720
Short stature 464 | 531
Melanoma 463 | 711
Duchenne muscular dystrophy 440 | 601
hepatocellular carcinoma 416 | 547
pancreatic carcinoma 409 | 562
Liver cancer 403 | 604
Prostatic Neoplasms 393 | 495
Endometriosis 385 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 380 | 510
Down syndrome 378 | 499
Multiple Sclerosis 368 | 540
Amyotrophic lateral sclerosis 366 | 451
Breast Neoplasms 366 | 445
Neurodegenerative disease 363 | 414
fibroadenoma 358 | 559
Kidney disease 354 | 430
Mammary Neoplasms 351 | 425
gastric cancer 339 | 459

Tissue

Endocrine System 11,827 | 18,159
Digestive Tract 11,557 | 17,369
Female tissues 11,533 | 17,400
Skin and soft tissues 11,521 | 17,230
Male tissues 11,426 | 17,142
Blood and immune system 11,334 | 16,909
Liver and Pancreas 11,294 | 16,750
Nervous System 11,275 | 16,725
Urinary Tract 11,266 | 16,678
Respiratory system 11,112 | 16,393
Cardiovascular System 10,572 | 15,192

Target Family

Non-IDG 6,585 | 12,091
Enzyme 2,978 | 4,145
Transcription Factor 1,382 | 1,400
Kinase 465 | 634
Transporter 253 | 473
Epigenetic 223 | 242
GPCR 132 | 408
Ion Channel 131 | 344
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 5 | 421

Compartment GO Term

Organelle 12,238 | 12,238
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50