Development Level

Tbio 104 | 11,651
Tdark 12 | 6,593
Tchem 6 | 1,388

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal behavior 4 | 298
abnormal retina morphology 4 | 71
decreased total body fat amoun... 4 | 207
decreased grip strength 3 | 116
improved glucose tolerance 3 | 79
increased or absent threshold ... 3 | 101
abnormal heart left ventricle ... 2 | 16
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
decreased body length 2 | 101
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating insulin ... 2 | 76
decreased startle reflex 2 | 75
enlarged heart 2 | 210
hyperactivity 2 | 148
hypoactivity 2 | 132
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cyanosis 1 | 7
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased vertical activity 1 | 24
male infertility 1 | 123
mammalian phenotype 1 | 17
shortened PR interval 1 | 6
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 87 | 11,493
ovarian cancer 76 | 8,520
osteosarcoma 58 | 7,950
psoriasis 55 | 6,694
medulloblastoma, large-cell 53 | 6,241
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
atypical teratoid / rhabdoid tumor 45 | 5,112
ependymoma 43 | 4,679
glioblastoma 42 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
invasive ductal carcinoma 41 | 2,951
non-small cell lung cancer 41 | 2,890
interstitial cystitis 38 | 2,312
Breast cancer 37 | 3,578
lung cancer 37 | 4,740
lung adenocarcinoma 35 | 2,716
group 3 medulloblastoma 34 | 4,104
ductal carcinoma in situ 32 | 1,745
pancreatic cancer 31 | 2,398
lung carcinoma 29 | 2,843
Cancer 28 | 2,499
adult high grade glioma 27 | 3,801
Kidney cancer 26 | 2,613
primitive neuroectodermal tumor 26 | 3,035
malignant mesothelioma 25 | 3,232
Astrocytoma, Pilocytic 24 | 3,081
oligodendroglioma 24 | 2,850
spina bifida 24 | 1,074
subependymal giant cell astrocytoma 23 | 2,287
astrocytic glioma 21 | 2,597
breast carcinoma 21 | 1,638
pituitary cancer 21 | 1,972
cystic fibrosis 17 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
ulcerative colitis 17 | 1,819
Pick disease 14 | 1,894
active Crohn's disease 14 | 922
group 4 medulloblastoma 14 | 1,855
primary pancreatic ductal adenocarcinoma 14 | 1,109
Schizophrenia 13 | 1,160
nasopharyngeal carcinoma 13 | 1,058
Prostatic Neoplasms 12 | 495
esophageal adenocarcinoma 12 | 737
Autosomal recessive predisposition 11 | 1,442
Intellectual disability 11 | 1,016
active ulcerative colitis 11 | 764
adrenocortical carcinoma 11 | 1,428
gastric carcinoma 11 | 807
tuberculosis 11 | 2,010
Atopic dermatitis 10 | 952
diabetes mellitus 10 | 1,728
colon cancer 9 | 1,478
juvenile dermatomyositis 9 | 1,187
Inflammatory bowel disease 8 | 151
Melanoma 8 | 711
Skin cancer 8 | 469
acute quadriplegic myopathy 8 | 1,158
astrocytoma 8 | 1,146
cutaneous lupus erythematosus 8 | 1,057
pediatric high grade glioma 8 | 1,064
urothelial carcinoma 8 | 318
Breast Neoplasms 7 | 445
Down syndrome 7 | 499
Dull intelligence 7 | 645
Kidney disease 7 | 430
Liver Cirrhosis, Experimental 7 | 769
Liver cancer 7 | 604
Low intelligence 7 | 645
Mammary Neoplasms 7 | 425
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
dermatomyositis 7 | 966
medulloblastoma 7 | 720
progressive supranuclear palsy 7 | 676
Bipolar Disorder 6 | 666
Diarrhea 6 | 253
Duchenne muscular dystrophy 6 | 601
Endometriosis 6 | 540
Epilepsy 6 | 792
Hypertensive disease 6 | 292
Multiple myeloma 6 | 1,332
Polycystic ovary syndrome 6 | 360
acute myeloid leukemia 6 | 783
aldosterone-producing adenoma 6 | 665
non primary Sjogren syndrome sicca 6 | 891
primary Sjogren syndrome 6 | 735
Alzheimer's disease 5 | 658
Cataract 5 | 297
Cerebrovascular disease 5 | 238
Muscle hypotonia 5 | 571
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 559
mucosa-associated lymphoid tissue lymphoma 5 | 484
nephrosclerosis 5 | 333
periodontitis 5 | 293

Tissue

Digestive Tract 116 | 17,369
Endocrine System 116 | 18,159
Female tissues 116 | 17,400
Urinary Tract 115 | 16,678
Skin and soft tissues 114 | 17,230
Male tissues 113 | 17,142
Nervous System 111 | 16,725
Respiratory system 111 | 16,393
Blood and immune system 110 | 16,909
Liver and Pancreas 110 | 16,750
Cardiovascular System 105 | 15,192

Target Family

Non-IDG 105 | 12,091
Enzyme 11 | 4,145
Kinase 4 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Compartment GO Term

Occluding junction 122 | 122
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Claudin-12 CLDN12 Tbio Non-IDG -1.03235 8.71 137
Claudin-8 CLDN8 Tbio Non-IDG -1.50382 29.7 184
Claudin-6 CLDN6 Tbio Non-IDG -1.76879 66.0 370
Claudin-15 CLDN15 Tbio Non-IDG -1.33932 19.3 154
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.22596 16.1 79
Lipolysis-stimulated lipoprotein receptor LSR Tbio Non-IDG -1.92670 81.8 89
Cingulin-like protein 1 CGNL1 Tbio Non-IDG -0.84049 8.54 64
Blood vessel epicardial substance BVES Tbio Non-IDG -1.50394 37.0 168
Junctional adhesion molecule-like JAML Tbio Non-IDG -1.66747 47.0 202