Development Level

Tbio 4,463 | 10,625
Tdark 1,482 | 7,003
Tchem 789 | 1,890
Tclin 163 | 602

Collection

Eligible Kinase Proteins 69 | 134
Eligible Ion Channel Proteins 5 | 117
Eligible non-olfactory GPCR Proteins 4 | 143

IMPC Term

preweaning lethality, complete... 342 | 633
preweaning lethality, incomple... 116 | 260
embryonic lethality prior to t... 100 | 187
abnormal behavior 97 | 226
decreased lean body mass 83 | 195
decreased body weight 82 | 174
embryonic lethality prior to o... 79 | 148
decreased total body fat amoun... 73 | 186
decreased bone mineral content 65 | 157
abnormal bone structure 60 | 131
abnormal embryo size 56 | 112
decreased grip strength 53 | 123
increased circulating alkaline... 52 | 119
decreased body length 49 | 108
increased or absent threshold ... 49 | 128
decreased bone mineral density 46 | 126
decreased circulating glucose ... 46 | 121
increased lean body mass 46 | 107
abnormal retina morphology 42 | 100
hyperactivity 42 | 108
decreased circulating choleste... 41 | 85
hypoactivity 40 | 89
enlarged heart 39 | 111
increased grip strength 39 | 83
increased mean corpuscular vol... 39 | 91
decreased circulating HDL chol... 37 | 77
increased bone mineral content 37 | 92
abnormal lens morphology 35 | 73
prenatal lethality prior to he... 33 | 64
decreased circulating triglyce... 32 | 83
increased mean corpuscular hem... 32 | 93
short tibia 30 | 82
abnormal coat/hair pigmentatio... 29 | 54
decreased circulating serum al... 29 | 79
increased circulating HDL chol... 29 | 63
increased circulating choleste... 29 | 53
increased sacral vertebrae num... 28 | 62
decreased lumbar vertebrae num... 27 | 62
abnormal bone mineralization 26 | 55
increased fasted circulating g... 26 | 68
decreased caudal vertebrae num... 25 | 49
decreased rib number 25 | 59
decreased circulating insulin ... 24 | 75
impaired glucose tolerance 24 | 52
increased total body fat amoun... 24 | 57
male infertility 24 | 62
abnormal retinal pigmentation 23 | 61
decreased leukocyte cell numbe... 23 | 54
tremors 23 | 34
abnormal behavioral response t... 22 | 52
decreased circulating alanine ... 22 | 53
decreased fasted circulating g... 22 | 49
decreased hemoglobin content 22 | 53
improved glucose tolerance 22 | 56
increased circulating sodium l... 22 | 71
abnormal gait 21 | 51
decreased heart weight 21 | 44
abnormal neural tube closure 20 | 37
decreased mean corpuscular vol... 20 | 50
decreased prepulse inhibition 20 | 52
increased exploration in new e... 20 | 56
increased heart weight 20 | 37
thrombocytopenia 20 | 46
abnormal heart morphology 19 | 51
decreased circulating LDL chol... 19 | 37
increased bone mineral density 19 | 52
abnormal eye morphology 18 | 38
decreased circulating alkaline... 18 | 41
decreased erythrocyte cell num... 18 | 43
increased hemoglobin content 18 | 45
abnormal seminal vesicle morph... 17 | 47
increased blood urea nitrogen ... 17 | 44
increased circulating chloride... 17 | 43
increased startle reflex 17 | 38
abnormal cornea morphology 16 | 24
abnormal locomotor activation 16 | 26
abnormal sleep behavior 16 | 63
abnormal spleen morphology 16 | 36
corneal opacity 16 | 25
increased body weight 16 | 42
increased circulating creatini... 16 | 29
decreased circulating total pr... 15 | 41
decreased mean corpuscular hem... 15 | 34
decreased startle reflex 15 | 48
abnormal hindbrain development 14 | 24
abnormal kidney morphology 14 | 30
decreased T cell number 14 | 31
decreased circulating aspartat... 14 | 27
decreased circulating chloride... 14 | 32
decreased circulating free fat... 14 | 39
decreased circulating iron lev... 14 | 25
decreased eosinophil cell numb... 14 | 41
decreased threshold for audito... 14 | 32
female infertility 14 | 34
increased circulating serum al... 14 | 25
increased circulating triglyce... 14 | 24
anophthalmia 13 | 20
decreased blood urea nitrogen ... 13 | 31
decreased circulating fructosa... 13 | 31
limb grasping 13 | 35

Disease

ovarian cancer 3,582 | 8,484
osteosarcoma 3,188 | 7,933
psoriasis 2,477 | 6,685
medulloblastoma, large-cell 2,445 | 6,234
glioblastoma 2,149 | 5,572
lung cancer 1,996 | 4,466
atypical teratoid / rhabdoid tumor 1,664 | 4,369
malignant mesothelioma 1,381 | 3,162
Cancer 1,337 | 2,346
Breast cancer 1,293 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 1,271 | 3,289
primitive neuroectodermal tumor 1,240 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,127 | 2,988
oligodendroglioma 1,107 | 2,849
invasive ductal carcinoma 1,082 | 2,950
group 3 medulloblastoma 1,073 | 2,254
non-small cell lung cancer 1,057 | 2,798
pediatric high grade glioma 1,055 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 1,015 | 2,956
ependymoma 963 | 2,514
lung adenocarcinoma 958 | 2,713
pilocytic astrocytoma 949 | 3,086
pancreatic cancer 839 | 2,300
astrocytic glioma 825 | 2,241
Carcinoma 816 | 2,147
subependymal giant cell astrocytoma 814 | 2,287
lung carcinoma 788 | 2,844
group 4 medulloblastoma 764 | 1,875
Pick disease 739 | 1,893
Multiple myeloma 723 | 1,327
adult high grade glioma 707 | 2,148
ulcerative colitis 684 | 2,087
pituitary cancer 675 | 1,972
interstitial cystitis 666 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 645 | 1,795
astrocytoma 641 | 1,493
breast carcinoma 627 | 1,614
ductal carcinoma in situ 625 | 1,745
diabetes mellitus 613 | 1,663
colon cancer 608 | 1,475
medulloblastoma 596 | 1,524
adrenocortical carcinoma 592 | 1,427
sonic hedgehog group medulloblastoma 589 | 1,482
acute quadriplegic myopathy 560 | 1,157
Rheumatoid Arthritis 554 | 1,160
tuberculosis 552 | 1,557
cystic fibrosis 538 | 1,665
juvenile dermatomyositis 538 | 1,189
posterior fossa group A ependymoma 515 | 1,511
dermatomyositis 488 | 933
Waldenstrons macroglobulinemia 457 | 765
primary pancreatic ductal adenocarcinoma 457 | 1,271
posterior fossa group B ependymoma 447 | 1,530
spina bifida 440 | 1,064
atypical teratoid/rhabdoid tumor 429 | 1,095
nasopharyngeal carcinoma 401 | 1,056
acute myeloid leukemia 389 | 780
cutaneous lupus erythematosus 388 | 1,056
non primary Sjogren syndrome sicca 335 | 840
Atopic dermatitis 332 | 944
tuberculosis and treatment for 6 months 325 | 686
primary Sjogren syndrome 310 | 789
progressive supranuclear palsy 292 | 674
Alzheimer's disease 284 | 644
active Crohn's disease 280 | 918
Intellectual disability 277 | 573
gastric carcinoma 273 | 832
aldosterone-producing adenoma 272 | 664
esophageal adenocarcinoma 269 | 737
Endometriosis 260 | 535
Mammary Neoplasms 258 | 410
Obesity 252 | 616
Down syndrome 244 | 548
hepatocellular carcinoma 243 | 532
Prostatic Neoplasms 239 | 471
pancreatic carcinoma 225 | 567
Amyotrophic Lateral Sclerosis 220 | 431
autosomal dominant Emery-Dreifuss muscular dystrophy 200 | 499
IGA Glomerulonephritis 197 | 454
Schizophrenia 190 | 501
Duchenne muscular dystrophy 186 | 602
gastric cancer 183 | 430
inflammatory breast cancer 183 | 404
Multiple Sclerosis 180 | 498
Kidney disease 179 | 396
Neurodegenerative disease 174 | 383
Stomach Neoplasms 172 | 282
Parkinson's disease 163 | 364
chronic rhinosinusitis 160 | 512
fibroadenoma 156 | 557
Polycystic Ovary Syndrome 150 | 332
active ulcerative colitis 149 | 477
Peripheral Neuropathy 145 | 303
Asthma 142 | 349
Vascular disease 142 | 281
non-small cell lung carcinoma 140 | 413
sarcoidosis 138 | 358
Heart disease 137 | 279
mucosa-associated lymphoid tissue lymphoma 135 | 480
Crohn's disease 133 | 304

Tissue

Female tissues 6,781 | 18,647
Nervous System 6,765 | 18,561
Endocrine System 6,763 | 18,512
Digestive Tract 6,741 | 18,473
Urinary Tract 6,715 | 18,444
Male tissues 6,693 | 17,969
Blood and immune system 6,686 | 17,995
Liver and Pancreas 6,676 | 18,136
Skin and soft tissues 6,645 | 18,115
Cardiovascular System 6,643 | 17,958
Respiratory system 6,518 | 17,484

Target Family

Non-IDG 3,476 | 11,971
Transcription Factor 1,378 | 1,400
Enzyme 1,323 | 4,146
Kinase 327 | 634
Epigenetic 210 | 242
Nuclear Receptor 47 | 48
Transporter 47 | 473
TF/Epigenetic 37 | 38
GPCR 27 | 406
Ion Channel 25 | 341

Compartment GO Term

Nucleus 6,897 | 6,897
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345