Development Level

Tbio 4,757 | 10,625
Tdark 1,812 | 7,003
Tchem 833 | 1,890
Tclin 175 | 602

Collection

Eligible Kinase Proteins 76 | 134
Eligible Ion Channel Proteins 9 | 117
Eligible non-olfactory GPCR Proteins 7 | 145

IMPC Term

preweaning lethality, complete... 355 | 633
preweaning lethality, incomple... 123 | 260
embryonic lethality prior to t... 106 | 187
abnormal behavior 101 | 226
decreased lean body mass 92 | 195
embryonic lethality prior to o... 85 | 148
decreased body weight 84 | 174
decreased total body fat amoun... 77 | 186
decreased bone mineral content 70 | 157
abnormal bone structure 63 | 131
abnormal embryo size 57 | 112
increased circulating alkaline... 57 | 119
decreased grip strength 56 | 123
increased or absent threshold ... 54 | 128
decreased body length 51 | 108
decreased bone mineral density 49 | 126
decreased circulating glucose ... 49 | 121
increased lean body mass 48 | 107
abnormal retina morphology 46 | 100
hyperactivity 45 | 108
hypoactivity 44 | 89
decreased circulating choleste... 42 | 85
increased grip strength 42 | 83
increased mean corpuscular vol... 41 | 91
enlarged heart 40 | 111
decreased circulating HDL chol... 39 | 77
increased bone mineral content 38 | 92
abnormal lens morphology 36 | 73
decreased circulating triglyce... 35 | 83
short tibia 35 | 82
prenatal lethality prior to he... 34 | 64
increased circulating HDL chol... 33 | 63
increased mean corpuscular hem... 33 | 93
decreased circulating serum al... 32 | 79
abnormal coat/hair pigmentatio... 31 | 54
increased circulating choleste... 31 | 53
increased sacral vertebrae num... 31 | 62
increased fasted circulating g... 30 | 68
decreased circulating insulin ... 29 | 75
decreased lumbar vertebrae num... 29 | 62
decreased rib number 28 | 59
abnormal bone mineralization 27 | 55
increased total body fat amoun... 27 | 57
male infertility 27 | 62
abnormal retinal pigmentation 26 | 61
decreased caudal vertebrae num... 26 | 49
impaired glucose tolerance 25 | 52
decreased leukocyte cell numbe... 24 | 54
abnormal behavioral response t... 23 | 52
abnormal gait 23 | 51
decreased hemoglobin content 23 | 53
improved glucose tolerance 23 | 56
increased circulating sodium l... 23 | 71
thrombocytopenia 23 | 46
tremors 23 | 34
decreased circulating alanine ... 22 | 53
decreased fasted circulating g... 22 | 49
decreased heart weight 22 | 44
decreased prepulse inhibition 22 | 52
abnormal neural tube closure 21 | 37
decreased erythrocyte cell num... 21 | 43
increased heart weight 21 | 37
decreased circulating LDL chol... 20 | 37
decreased mean corpuscular vol... 20 | 50
increased bone mineral density 20 | 52
increased exploration in new e... 20 | 56
abnormal eye morphology 19 | 38
abnormal heart morphology 19 | 51
abnormal seminal vesicle morph... 19 | 47
abnormal sleep behavior 19 | 63
decreased circulating alkaline... 19 | 41
increased blood urea nitrogen ... 19 | 44
increased startle reflex 19 | 38
increased body weight 18 | 42
increased hemoglobin content 18 | 45
abnormal spleen morphology 17 | 36
decreased startle reflex 17 | 48
abnormal cornea morphology 16 | 24
abnormal locomotor activation 16 | 26
corneal opacity 16 | 25
decreased eosinophil cell numb... 16 | 41
increased circulating chloride... 16 | 43
increased circulating creatini... 16 | 29
abnormal hindbrain development 15 | 24
abnormal kidney morphology 15 | 30
abnormal rib morphology 15 | 28
cardiovascular system phenotyp... 15 | 35
decreased circulating free fat... 15 | 39
decreased circulating total pr... 15 | 41
decreased mean corpuscular hem... 15 | 34
decreased threshold for audito... 15 | 32
female infertility 15 | 34
increased rib number 15 | 41
abnormal cranium morphology 14 | 32
abnormal tooth morphology 14 | 24
decreased T cell number 14 | 31
decreased circulating aspartat... 14 | 27
decreased circulating iron lev... 14 | 25
decreased neutrophil cell numb... 14 | 37
increased circulating serum al... 14 | 25

Disease

ovarian cancer 3,904 | 8,492
osteosarcoma 3,517 | 7,933
medulloblastoma, large-cell 2,687 | 6,234
psoriasis 2,672 | 6,685
glioblastoma 2,379 | 5,572
lung cancer 2,133 | 4,473
atypical teratoid / rhabdoid tumor 1,865 | 4,369
malignant mesothelioma 1,529 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 1,405 | 3,289
Breast cancer 1,396 | 3,099
Cancer 1,365 | 2,346
primitive neuroectodermal tumor 1,363 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,247 | 2,988
oligodendroglioma 1,229 | 2,849
invasive ductal carcinoma 1,221 | 2,950
non-small cell lung cancer 1,165 | 2,798
pediatric high grade glioma 1,163 | 2,712
group 3 medulloblastoma 1,159 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 1,141 | 2,956
pilocytic astrocytoma 1,077 | 3,086
ependymoma 1,073 | 2,514
lung adenocarcinoma 1,059 | 2,714
astrocytic glioma 923 | 2,241
subependymal giant cell astrocytoma 918 | 2,287
pancreatic cancer 911 | 2,300
lung carcinoma 903 | 2,844
Carcinoma 878 | 2,147
group 4 medulloblastoma 826 | 1,875
Pick disease 823 | 1,893
adult high grade glioma 796 | 2,148
ulcerative colitis 763 | 2,087
Multiple myeloma 757 | 1,328
pituitary cancer 757 | 1,972
interstitial cystitis 748 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 716 | 1,795
ductal carcinoma in situ 709 | 1,745
breast carcinoma 689 | 1,614
astrocytoma 685 | 1,493
medulloblastoma 669 | 1,524
adrenocortical carcinoma 656 | 1,427
diabetes mellitus 651 | 1,663
colon cancer 649 | 1,475
sonic hedgehog group medulloblastoma 649 | 1,482
cystic fibrosis 617 | 1,670
tuberculosis 600 | 1,563
acute quadriplegic myopathy 598 | 1,157
Rheumatoid Arthritis 584 | 1,171
juvenile dermatomyositis 578 | 1,189
posterior fossa group A ependymoma 572 | 1,511
posterior fossa group B ependymoma 521 | 1,530
dermatomyositis 509 | 967
primary pancreatic ductal adenocarcinoma 492 | 1,271
spina bifida 483 | 1,064
Waldenstrons macroglobulinemia 471 | 765
atypical teratoid/rhabdoid tumor 463 | 1,095
nasopharyngeal carcinoma 444 | 1,056
cutaneous lupus erythematosus 419 | 1,056
acute myeloid leukemia 415 | 785
Atopic dermatitis 364 | 944
non primary Sjogren syndrome sicca 362 | 840
tuberculosis and treatment for 6 months 356 | 686
primary Sjogren syndrome 332 | 789
progressive supranuclear palsy 321 | 674
active Crohn's disease 312 | 918
Alzheimer's disease 304 | 644
Intellectual disability 300 | 573
gastric carcinoma 300 | 832
aldosterone-producing adenoma 299 | 664
esophageal adenocarcinoma 292 | 737
Endometriosis 281 | 535
hepatocellular carcinoma 274 | 550
Obesity 266 | 616
Mammary Neoplasms 261 | 410
Down syndrome 258 | 548
Prostatic Neoplasms 248 | 471
pancreatic carcinoma 240 | 567
Amyotrophic Lateral Sclerosis 235 | 432
autosomal dominant Emery-Dreifuss muscular dystrophy 213 | 499
Duchenne muscular dystrophy 212 | 602
IGA Glomerulonephritis 209 | 454
gastric cancer 207 | 436
Schizophrenia 203 | 503
inflammatory breast cancer 200 | 404
Multiple Sclerosis 194 | 498
fibroadenoma 191 | 557
Kidney disease 186 | 397
Neurodegenerative disease 181 | 383
chronic rhinosinusitis 181 | 512
Stomach Neoplasms 174 | 282
Parkinson's disease 171 | 364
Polycystic Ovary Syndrome 166 | 335
active ulcerative colitis 166 | 477
mucosa-associated lymphoid tissue lymphoma 155 | 480
sarcoidosis 152 | 368
Peripheral Neuropathy 151 | 303
Asthma 149 | 349
non-small cell lung carcinoma 146 | 413
Vascular disease 145 | 281
Heart disease 142 | 279
tuberculosis and treatment for 3 months 142 | 327

Tissue

Female tissues 7,447 | 18,647
Nervous System 7,436 | 18,561
Endocrine System 7,426 | 18,512
Digestive Tract 7,408 | 18,473
Urinary Tract 7,377 | 18,444
Male tissues 7,362 | 17,969
Blood and immune system 7,348 | 17,995
Liver and Pancreas 7,341 | 18,136
Cardiovascular System 7,305 | 17,958
Skin and soft tissues 7,302 | 18,115
Respiratory system 7,172 | 17,484

Target Family

Non-IDG 3,932 | 11,969
Enzyme 1,487 | 4,146
Transcription Factor 1,380 | 1,400
Kinase 351 | 634
Epigenetic 214 | 242
Transporter 61 | 473
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
GPCR 34 | 408
Ion Channel 34 | 341

Compartment GO Term

Nucleus 7,577 | 7,577
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Transcription factor HES-4 HES4 Tbio Transcription Factor -0.93868 8.35 73
Serine/threonine-protein kinase RIO1 RIOK1 Tchem Kinase -0.72835 5.14 142
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82