Development Level

Tbio 557 | 10,625
Tchem 115 | 1,890
Tdark 84 | 7,003
Tclin 24 | 602

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 64 | 633
embryonic lethality prior to o... 20 | 148
embryonic lethality prior to t... 18 | 187
preweaning lethality, incomple... 18 | 260
decreased total body fat amoun... 11 | 186
decreased body weight 9 | 174
decreased leukocyte cell numbe... 9 | 54
decreased body length 8 | 108
decreased lean body mass 8 | 195
abnormal behavior 7 | 226
abnormal embryo size 7 | 112
abnormal retina morphology 7 | 100
increased grip strength 7 | 83
abnormal lens morphology 6 | 73
decreased bone mineral content 6 | 157
decreased bone mineral density 6 | 126
decreased circulating glucose ... 6 | 121
decreased grip strength 6 | 123
decreased rib number 6 | 59
increased sacral vertebrae num... 6 | 62
prenatal lethality prior to he... 6 | 64
abnormal bone mineralization 5 | 55
abnormal bone structure 5 | 131
abnormal gait 5 | 51
decreased lumbar vertebrae num... 5 | 62
hyperactivity 5 | 108
increased bone mineral content 5 | 92
abnormal heart morphology 4 | 51
abnormal maxilla morphology 4 | 16
abnormal retinal pigmentation 4 | 61
decreased Ly6C low monocyte nu... 4 | 23
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased erythrocyte cell num... 4 | 43
increased bone mineral density 4 | 52
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased lean body mass 4 | 107
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
male infertility 4 | 62
short tibia 4 | 82
abnormal eye morphology 3 | 38
abnormal snout morphology 3 | 18
abnormal startle reflex 3 | 14
abnormal tooth morphology 3 | 24
cataract 3 | 26
decreased circulating chloride... 3 | 32
decreased circulating insulin ... 3 | 75
decreased circulating iron lev... 3 | 25
decreased hemoglobin content 3 | 53
decreased prepulse inhibition 3 | 52
decreased respiratory quotient 3 | 12
decreased total retina thickne... 3 | 20
enlarged heart 3 | 111
hypoactivity 3 | 89
increased circulating HDL chol... 3 | 63
increased circulating chloride... 3 | 43
increased circulating choleste... 3 | 53
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 25
increased mean corpuscular vol... 3 | 91
increased total body fat amoun... 3 | 57
abnormal coat/hair pigmentatio... 2 | 54
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal epididymis morphology 2 | 31
abnormal locomotor activation 2 | 26
abnormal rib morphology 2 | 28
decreased Ly6C high monocyte n... 2 | 18
decreased T cell number 2 | 31
decreased circulating calcium ... 2 | 33
decreased circulating sodium l... 2 | 18
decreased effector memory CD8-... 2 | 24
decreased eosinophil cell numb... 2 | 41
decreased hematocrit 2 | 25
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
decreased threshold for audito... 2 | 32
enlarged spleen 2 | 26
female infertility 2 | 34
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased circulating alkaline... 2 | 119
increased circulating amylase ... 2 | 13
increased circulating creatini... 2 | 29
increased circulating magnesiu... 2 | 10
increased circulating serum al... 2 | 25
increased circulating total pr... 2 | 20
increased effector memory CD4-... 2 | 15
increased granulocyte number 2 | 8
increased mean platelet volume 2 | 19
limb grasping 2 | 35
oligodactyly 2 | 14
thrombocytopenia 2 | 46
thrombocytosis 2 | 23
tremors 2 | 34

Disease

ovarian cancer 465 | 8,484
osteosarcoma 403 | 7,933
psoriasis 287 | 6,685
medulloblastoma, large-cell 267 | 6,234
lung cancer 244 | 4,466
glioblastoma 236 | 5,572
Cancer 225 | 2,346
atypical teratoid / rhabdoid tumor 190 | 4,369
malignant mesothelioma 177 | 3,162
Breast cancer 149 | 3,094
group 3 medulloblastoma 147 | 2,254
primitive neuroectodermal tumor 142 | 3,031
Carcinoma 137 | 2,147
oligodendroglioma 131 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 130 | 3,289
Multiple myeloma 126 | 1,327
ependymoma 115 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 106 | 2,988
pediatric high grade glioma 106 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 101 | 2,956
non-small cell lung cancer 98 | 2,798
Pick disease 97 | 1,893
astrocytoma 94 | 1,493
astrocytic glioma 93 | 2,241
lung adenocarcinoma 93 | 2,713
diabetes mellitus 90 | 1,663
invasive ductal carcinoma 90 | 2,950
subependymal giant cell astrocytoma 88 | 2,287
Waldenstrons macroglobulinemia 82 | 765
acute quadriplegic myopathy 82 | 1,157
dermatomyositis 80 | 933
adult high grade glioma 78 | 2,148
pilocytic astrocytoma 77 | 3,086
pancreatic cancer 76 | 2,300
Rheumatoid Arthritis 74 | 1,160
group 4 medulloblastoma 73 | 1,875
juvenile dermatomyositis 70 | 1,189
pituitary cancer 69 | 1,972
acute myeloid leukemia 67 | 780
tuberculosis 66 | 1,557
ulcerative colitis 66 | 2,087
Intellectual disability 63 | 573
medulloblastoma 63 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,795
lung carcinoma 61 | 2,844
adrenocortical carcinoma 57 | 1,427
sonic hedgehog group medulloblastoma 57 | 1,482
breast carcinoma 53 | 1,614
colon cancer 53 | 1,475
ductal carcinoma in situ 53 | 1,745
Mammary Neoplasms 52 | 410
Prostatic Neoplasms 48 | 471
posterior fossa group A ependymoma 46 | 1,511
tuberculosis and treatment for 6 months 45 | 686
primary pancreatic ductal adenocarcinoma 44 | 1,271
spina bifida 43 | 1,064
progressive supranuclear palsy 42 | 674
non primary Sjogren syndrome sicca 41 | 840
Alzheimer's disease 39 | 644
Endometriosis 39 | 535
atypical teratoid/rhabdoid tumor 39 | 1,095
interstitial cystitis 39 | 2,299
posterior fossa group B ependymoma 39 | 1,530
cystic fibrosis 34 | 1,665
hepatocellular carcinoma 34 | 532
nasopharyngeal carcinoma 34 | 1,056
Lung Neoplasms 32 | 171
Stomach Neoplasms 32 | 282
primary Sjogren syndrome 32 | 789
Obesity 31 | 616
aldosterone-producing adenoma 31 | 664
Amyotrophic Lateral Sclerosis 30 | 431
Liver carcinoma 29 | 217
Melanoma 28 | 261
Neurodegenerative disease 28 | 383
Vascular disease 28 | 281
Anemia 26 | 252
Kidney disease 25 | 396
Peripheral Neuropathy 25 | 303
autosomal dominant Emery-Dreifuss muscular dystrophy 25 | 499
pancreatic carcinoma 25 | 567
Bladder Neoplasm 24 | 109
IGA Glomerulonephritis 24 | 454
Pancreatic Neoplasm 24 | 79
cutaneous lupus erythematosus 24 | 1,056
gastric carcinoma 24 | 832
Adenoid Cystic Carcinoma 23 | 99
Cockayne syndrome 23 | 54
Colonic Neoplasms 23 | 126
Parkinson's disease 23 | 364
Adenocarcinoma 21 | 115
Adenoma 21 | 165
Leukemia 21 | 88
glioblastoma multiforme 21 | 347
inflammatory breast cancer 21 | 404
ovarian neoplasm 21 | 97
Down syndrome 20 | 548
Neoplasm Metastasis 20 | 138
gastric cancer 20 | 430
non-small cell lung carcinoma 20 | 413

Tissue

Female tissues 768 | 18,647
Blood and immune system 767 | 17,995
Liver and Pancreas 767 | 18,136
Nervous System 767 | 18,561
Cardiovascular System 765 | 17,958
Digestive Tract 765 | 18,473
Male tissues 765 | 17,969
Urinary Tract 764 | 18,444
Endocrine System 763 | 18,512
Respiratory system 758 | 17,484
Skin and soft tissues 757 | 18,115

Target Family

Non-IDG 421 | 11,971
Enzyme 167 | 4,146
Epigenetic 80 | 242
Transcription Factor 64 | 1,400
Kinase 36 | 634
TF/Epigenetic 9 | 38
Nuclear Receptor 3 | 48

Compartment GO Term

Nucleoplasm part 780 | 780
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Zinc finger protein GLIS2 GLIS2 Tbio Transcription Factor -1.86726 74.7 85