Development Level

Tbio 2,061 | 10,625
Tchem 426 | 1,890
Tdark 373 | 7,003
Tclin 78 | 602

Collection

Eligible Kinase Proteins 25 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 192 | 633
preweaning lethality, incomple... 59 | 260
embryonic lethality prior to o... 55 | 148
embryonic lethality prior to t... 55 | 187
abnormal behavior 41 | 226
decreased body weight 41 | 174
decreased total body fat amoun... 39 | 186
abnormal embryo size 33 | 112
decreased lean body mass 33 | 195
abnormal bone structure 29 | 131
increased or absent threshold ... 26 | 128
decreased body length 25 | 108
decreased bone mineral content 24 | 157
increased grip strength 22 | 83
abnormal retina morphology 21 | 100
decreased circulating glucose ... 21 | 121
hyperactivity 21 | 108
increased circulating alkaline... 21 | 119
increased mean corpuscular hem... 21 | 93
prenatal lethality prior to he... 21 | 64
abnormal lens morphology 19 | 73
increased mean corpuscular vol... 19 | 91
decreased bone mineral density 18 | 126
decreased grip strength 18 | 123
enlarged heart 18 | 111
increased bone mineral content 18 | 92
increased lean body mass 18 | 107
decreased rib number 17 | 59
increased sacral vertebrae num... 17 | 62
abnormal bone mineralization 16 | 55
decreased circulating choleste... 15 | 85
decreased leukocyte cell numbe... 15 | 54
abnormal gait 14 | 51
decreased circulating HDL chol... 14 | 77
decreased lumbar vertebrae num... 14 | 62
short tibia 14 | 82
decreased caudal vertebrae num... 13 | 49
decreased circulating triglyce... 13 | 83
decreased hemoglobin content 13 | 53
increased circulating HDL chol... 13 | 63
abnormal eye morphology 12 | 38
abnormal retinal pigmentation 12 | 61
decreased circulating serum al... 12 | 79
hypoactivity 12 | 89
increased circulating sodium l... 12 | 71
male infertility 12 | 62
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating LDL chol... 11 | 37
decreased erythrocyte cell num... 11 | 43
decreased prepulse inhibition 11 | 52
increased bone mineral density 11 | 52
decreased mean corpuscular vol... 10 | 50
embryonic growth retardation 10 | 28
abnormal heart morphology 9 | 51
decreased circulating insulin ... 9 | 75
decreased hematocrit 9 | 25
increased circulating choleste... 9 | 53
increased circulating creatini... 9 | 29
increased fasted circulating g... 9 | 68
thrombocytopenia 9 | 46
abnormal locomotor activation 8 | 26
abnormal neural tube closure 8 | 37
cataract 8 | 26
corneal opacity 8 | 25
decreased circulating alanine ... 8 | 53
decreased circulating alkaline... 8 | 41
decreased mean corpuscular hem... 8 | 34
increased circulating chloride... 8 | 43
increased circulating triglyce... 8 | 24
tremors 8 | 34
abnormal behavioral response t... 7 | 52
abnormal cornea morphology 7 | 24
abnormal spleen morphology 7 | 36
anophthalmia 7 | 20
decreased T cell number 7 | 31
decreased circulating chloride... 7 | 32
decreased circulating iron lev... 7 | 25
decreased circulating total pr... 7 | 41
decreased eosinophil cell numb... 7 | 41
decreased fasted circulating g... 7 | 49
decreased startle reflex 7 | 48
decreased threshold for audito... 7 | 32
female infertility 7 | 34
impaired glucose tolerance 7 | 52
increased blood urea nitrogen ... 7 | 44
increased exploration in new e... 7 | 56
increased hemoglobin content 7 | 45
increased mean corpuscular hem... 7 | 25
limb grasping 7 | 35
pale yolk sac 7 | 12
abnormal cranium morphology 6 | 32
abnormal rib morphology 6 | 28
abnormal tooth morphology 6 | 24
decreased circulating aspartat... 6 | 27
decreased circulating free fat... 6 | 39
decreased circulating fructosa... 6 | 31
improved glucose tolerance 6 | 56
increased heart weight 6 | 37
increased total body fat amoun... 6 | 57
small testis 6 | 37

Disease

ovarian cancer 1,783 | 8,484
osteosarcoma 1,506 | 7,933
medulloblastoma, large-cell 1,134 | 6,234
psoriasis 1,134 | 6,685
glioblastoma 1,007 | 5,572
lung cancer 974 | 4,466
atypical teratoid / rhabdoid tumor 777 | 4,369
Cancer 711 | 2,346
malignant mesothelioma 689 | 3,162
Breast cancer 609 | 3,094
primitive neuroectodermal tumor 598 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 577 | 3,289
group 3 medulloblastoma 545 | 2,254
oligodendroglioma 527 | 2,849
pediatric high grade glioma 512 | 2,712
non-small cell lung cancer 499 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 497 | 2,988
invasive ductal carcinoma 470 | 2,950
ependymoma 469 | 2,514
lung adenocarcinoma 428 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 427 | 2,956
Multiple myeloma 415 | 1,327
Carcinoma 400 | 2,147
astrocytic glioma 379 | 2,241
Pick disease 369 | 1,893
pilocytic astrocytoma 369 | 3,086
subependymal giant cell astrocytoma 360 | 2,287
pancreatic cancer 354 | 2,300
astrocytoma 340 | 1,493
group 4 medulloblastoma 321 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 308 | 1,795
adult high grade glioma 300 | 2,148
acute quadriplegic myopathy 294 | 1,157
colon cancer 291 | 1,475
diabetes mellitus 291 | 1,663
ulcerative colitis 290 | 2,087
breast carcinoma 283 | 1,614
adrenocortical carcinoma 281 | 1,427
lung carcinoma 281 | 2,844
ductal carcinoma in situ 279 | 1,745
pituitary cancer 278 | 1,972
sonic hedgehog group medulloblastoma 276 | 1,482
Waldenstrons macroglobulinemia 274 | 765
juvenile dermatomyositis 271 | 1,189
medulloblastoma 259 | 1,524
dermatomyositis 251 | 933
Rheumatoid Arthritis 250 | 1,160
interstitial cystitis 241 | 2,299
tuberculosis 235 | 1,557
posterior fossa group A ependymoma 222 | 1,511
acute myeloid leukemia 202 | 780
spina bifida 201 | 1,064
atypical teratoid/rhabdoid tumor 200 | 1,095
primary pancreatic ductal adenocarcinoma 196 | 1,271
nasopharyngeal carcinoma 191 | 1,056
cystic fibrosis 186 | 1,665
posterior fossa group B ependymoma 170 | 1,530
tuberculosis and treatment for 6 months 155 | 686
Intellectual disability 153 | 573
progressive supranuclear palsy 150 | 674
non primary Sjogren syndrome sicca 148 | 840
Endometriosis 147 | 535
Mammary Neoplasms 147 | 410
Atopic dermatitis 145 | 944
cutaneous lupus erythematosus 139 | 1,056
primary Sjogren syndrome 131 | 789
aldosterone-producing adenoma 128 | 664
Alzheimer's disease 121 | 644
hepatocellular carcinoma 121 | 532
active Crohn's disease 119 | 918
Amyotrophic Lateral Sclerosis 117 | 431
gastric carcinoma 112 | 832
Prostatic Neoplasms 108 | 471
esophageal adenocarcinoma 101 | 737
IGA Glomerulonephritis 98 | 454
pancreatic carcinoma 98 | 567
Obesity 97 | 616
Stomach Neoplasms 94 | 282
Down syndrome 91 | 548
gastric cancer 83 | 430
inflammatory breast cancer 81 | 404
Neurodegenerative disease 80 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 79 | 499
Peripheral Neuropathy 73 | 303
Liver carcinoma 70 | 217
Vascular disease 69 | 281
Crohn's disease 68 | 304
Polycystic Ovary Syndrome 68 | 332
chronic rhinosinusitis 67 | 512
non-small cell lung carcinoma 66 | 413
Schizophrenia 65 | 501
glioblastoma multiforme 64 | 347
Melanoma 63 | 261
Lung Neoplasms 62 | 171
Parkinson's disease 61 | 364
active ulcerative colitis 60 | 477
Multiple Sclerosis 59 | 498
hereditary spastic paraplegia 59 | 313
mucosa-associated lymphoid tissue lymphoma 58 | 480
Kidney disease 57 | 396

Tissue

Female tissues 2,909 | 18,647
Nervous System 2,908 | 18,561
Digestive Tract 2,907 | 18,473
Male tissues 2,904 | 17,969
Liver and Pancreas 2,902 | 18,136
Blood and immune system 2,901 | 17,995
Endocrine System 2,901 | 18,512
Urinary Tract 2,900 | 18,444
Cardiovascular System 2,897 | 17,958
Skin and soft tissues 2,879 | 18,115
Respiratory system 2,877 | 17,484

Target Family

Non-IDG 1,519 | 11,971
Enzyme 643 | 4,146
Transcription Factor 375 | 1,400
Epigenetic 159 | 242
Kinase 154 | 634
Nuclear Receptor 46 | 48
TF/Epigenetic 25 | 38
Transporter 10 | 473
GPCR 4 | 406
Ion Channel 3 | 341

Compartment GO Term

Nucleoplasm 2,938 | 2,938
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178