Development Level

Tbio 3,518 | 11,651
Tdark 1,006 | 6,593
Tchem 446 | 1,388
Tclin 107 | 612

Collection

RFA-RM-18-021 51 | 328
Kinase: IDG Consortium (Target... 43 | 125
Kinase: IDG Consortium (Comple... 13 | 37
GPCR: IDG Consortium (Targets) 7 | 126
Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

preweaning lethality, complete... 441 | 979
preweaning lethality, incomple... 162 | 499
embryonic lethality prior to t... 121 | 278
embryonic lethality prior to o... 111 | 239
abnormal behavior 99 | 298
abnormal embryo size 93 | 220
decreased total body fat amoun... 69 | 207
decreased body weight 59 | 161
enlarged heart 59 | 210
increased lean body mass 54 | 172
abnormal bone structure 52 | 187
abnormal heart morphology 52 | 162
increased startle reflex 46 | 112
decreased vertical activity 45 | 208
hypoactivity 44 | 132
hyperactivity 43 | 148
decreased lean body mass 40 | 135
increased bone mineral content 40 | 108
increased or absent threshold ... 40 | 101
male infertility 40 | 123
embryonic growth retardation 39 | 106
prenatal lethality prior to he... 39 | 87
decreased circulating glucose ... 38 | 126
decreased body length 37 | 101
decreased grip strength 37 | 116
decreased bone mineral content 36 | 151
decreased bone mineral density 36 | 126
increased circulating alkaline... 35 | 122
increased mean corpuscular hem... 35 | 96
decreased circulating choleste... 34 | 93
increased bone mineral density 34 | 72
increased total body fat amoun... 34 | 134
decreased prepulse inhibition 33 | 82
increased mean corpuscular vol... 33 | 92
cataract 32 | 92
short tibia 30 | 97
abnormal lens morphology 28 | 81
decreased leukocyte cell numbe... 28 | 73
abnormal kidney morphology 27 | 65
decreased circulating triglyce... 26 | 79
abnormal seminal vesicle morph... 25 | 114
decreased circulating serum al... 25 | 82
decreased lymphocyte cell numb... 25 | 83
increased circulating HDL chol... 25 | 80
abnormal retina morphology 24 | 71
abnormal coat-hair pigmentatio... 23 | 64
decreased mean corpuscular vol... 23 | 79
abnormal behavioral response t... 22 | 66
abnormal gait 22 | 69
decreased erythrocyte cell num... 22 | 62
increased circulating choleste... 22 | 66
impaired glucose tolerance 21 | 75
abnormal eye morphology 20 | 68
decreased caudal vertebrae num... 20 | 53
decreased hemoglobin content 20 | 68
decreased startle reflex 20 | 75
abnormal neural tube closure 19 | 46
decreased circulating alkaline... 19 | 46
decreased mean corpuscular hem... 19 | 50
edema 19 | 59
small testis 19 | 58
thrombocytopenia 19 | 56
decreased circulating HDL chol... 18 | 68
female infertility 18 | 60
abnormal skin morphology 17 | 50
abnormal spleen morphology 17 | 55
corneal opacity 17 | 32
small superior vagus ganglion 17 | 74
tremors 17 | 39
decreased blood urea nitrogen ... 16 | 51
decreased circulating total pr... 16 | 49
increased grip strength 16 | 41
abnormal embryo turning 15 | 31
decreased circulating insulin ... 15 | 76
decreased fasted circulating g... 15 | 65
increased circulating chloride... 15 | 41
increased circulating sodium l... 15 | 71
increased fasted circulating g... 15 | 76
increased hemoglobin content 15 | 45
increased lymphocyte cell numb... 15 | 32
increased mean platelet volume 15 | 45
increased monocyte cell number 15 | 63
increased neutrophil cell numb... 15 | 46
abnormal sleep behavior 14 | 70
decreased circulating LDL chol... 14 | 38
decreased circulating alanine ... 14 | 47
decreased heart left ventricle... 14 | 28
decreased hematocrit 14 | 46
decreased neutrophil cell numb... 14 | 42
increased blood urea nitrogen ... 14 | 48
increased heart weight 14 | 62
long tibia 14 | 25
abnormal craniofacial morpholo... 13 | 33
hydrometra 13 | 53
improved glucose tolerance 13 | 79
increased circulating creatini... 13 | 38
increased circulating triglyce... 13 | 42
pallor 13 | 34
abnormal bone mineralization 12 | 38
anophthalmia 12 | 33

Disease

Carcinoma 3,290 | 11,493
ovarian cancer 2,863 | 8,520
osteosarcoma 2,549 | 7,950
medulloblastoma, large-cell 1,861 | 6,241
psoriasis 1,832 | 6,694
glioblastoma 1,735 | 5,792
lung cancer 1,559 | 4,740
atypical teratoid / rhabdoid tumor 1,501 | 5,112
group 3 medulloblastoma 1,421 | 4,104
ependymoma 1,259 | 4,679
malignant mesothelioma 1,131 | 3,232
Breast cancer 1,127 | 3,578
adult high grade glioma 1,008 | 3,801
primitive neuroectodermal tumor 969 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 962 | 3,291
Cancer 951 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 870 | 2,989
oligodendroglioma 853 | 2,850
non-small cell lung cancer 827 | 2,890
invasive ductal carcinoma 823 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 821 | 2,955
Kidney cancer 809 | 2,613
astrocytic glioma 747 | 2,597
lung adenocarcinoma 735 | 2,716
Astrocytoma, Pilocytic 701 | 3,081
pancreatic cancer 662 | 2,398
subependymal giant cell astrocytoma 615 | 2,287
Pick disease 596 | 1,894
lung carcinoma 596 | 2,843
tuberculosis 555 | 2,010
group 4 medulloblastoma 550 | 1,855
Multiple myeloma 526 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 523 | 1,962
pituitary cancer 511 | 1,972
interstitial cystitis 509 | 2,312
breast carcinoma 487 | 1,638
ductal carcinoma in situ 479 | 1,745
adrenocortical carcinoma 463 | 1,428
colon cancer 444 | 1,478
acute quadriplegic myopathy 438 | 1,158
diabetes mellitus 435 | 1,728
ulcerative colitis 433 | 1,819
juvenile dermatomyositis 414 | 1,187
astrocytoma 409 | 1,146
cystic fibrosis 395 | 1,696
Rheumatoid arthritis 393 | 1,191
Intellectual disability 377 | 1,016
dermatomyositis 364 | 966
pediatric high grade glioma 347 | 1,064
spina bifida 345 | 1,074
Autosomal recessive predisposition 343 | 1,442
Waldenstrons macroglobulinemia 341 | 765
primary pancreatic ductal adenocarcinoma 325 | 1,109
acute myeloid leukemia 314 | 783
nasopharyngeal carcinoma 301 | 1,058
Schizophrenia 297 | 1,160
cutaneous lupus erythematosus 250 | 1,057
non primary Sjogren syndrome sicca 249 | 891
progressive supranuclear palsy 249 | 676
Atopic dermatitis 241 | 952
Dull intelligence 236 | 645
Low intelligence 236 | 645
Mental Retardation 236 | 645
Mental deficiency 236 | 645
Poor school performance 236 | 645
Short stature 224 | 531
primary Sjogren syndrome 224 | 735
Cognitive delay 219 | 608
Global developmental delay 219 | 608
Mental and motor retardation 219 | 608
medulloblastoma 217 | 720
aldosterone-producing adenoma 215 | 665
active Crohn's disease 211 | 922
Epilepsy 198 | 792
Liver Cirrhosis, Experimental 197 | 769
Breast Neoplasms 196 | 445
gastric carcinoma 194 | 807
Mammary Neoplasms 186 | 425
hepatocellular carcinoma 186 | 547
active ulcerative colitis 185 | 764
esophageal adenocarcinoma 185 | 737
Muscle hypotonia 183 | 571
Endometriosis 181 | 540
Alzheimer's disease 175 | 658
Bipolar Disorder 175 | 666
Obesity 173 | 678
Small head 171 | 374
Prostatic Neoplasms 167 | 495
pancreatic carcinoma 167 | 562
Seizures 166 | 596
Amyotrophic lateral sclerosis 164 | 451
Liver cancer 164 | 604
Melanoma 162 | 711
tuberculosis and treatment for 6 months 160 | 409
sonic hedgehog group medulloblastoma 147 | 467
gastric cancer 146 | 459
autosomal dominant Emery-Dreifuss muscular dystrophy 140 | 510
Cryptorchidism 135 | 296
Down syndrome 134 | 499
Duchenne muscular dystrophy 128 | 601

Tissue

Endocrine System 5,010 | 18,159
Digestive Tract 4,979 | 17,369
Female tissues 4,965 | 17,400
Skin and soft tissues 4,964 | 17,230
Male tissues 4,959 | 17,142
Blood and immune system 4,919 | 16,909
Urinary Tract 4,916 | 16,678
Liver and Pancreas 4,914 | 16,750
Nervous System 4,904 | 16,725
Respiratory system 4,891 | 16,393
Cardiovascular System 4,737 | 15,192

Target Family

Non-IDG 2,731 | 12,091
Enzyme 1,072 | 4,145
Transcription Factor 689 | 1,400
Kinase 224 | 634
Epigenetic 188 | 242
Transporter 52 | 473
Nuclear Receptor 47 | 48
TF/Epigenetic 32 | 38
GPCR 23 | 408
Ion Channel 19 | 344

Compartment GO Term

Nucleoplasm 5,077 | 5,077
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18