Development Level

Tbio 3,136 | 10,625
Tdark 1,130 | 7,003
Tchem 563 | 1,890
Tclin 101 | 602

Collection

Eligible Kinase Proteins 46 | 134
Eligible non-olfactory GPCR Proteins 6 | 145

IMPC Term

preweaning lethality, complete... 266 | 633
preweaning lethality, incomple... 87 | 260
embryonic lethality prior to t... 74 | 187
abnormal behavior 69 | 226
decreased body weight 66 | 174
embryonic lethality prior to o... 65 | 148
decreased total body fat amoun... 57 | 186
decreased lean body mass 54 | 195
increased or absent threshold ... 47 | 128
abnormal embryo size 44 | 112
decreased bone mineral content 43 | 157
abnormal bone structure 42 | 131
decreased body length 41 | 108
increased circulating alkaline... 38 | 119
decreased circulating glucose ... 35 | 121
increased mean corpuscular hem... 35 | 93
abnormal retina morphology 34 | 100
increased lean body mass 34 | 107
decreased bone mineral density 33 | 126
decreased grip strength 33 | 123
hyperactivity 31 | 108
decreased circulating serum al... 29 | 79
enlarged heart 29 | 111
increased bone mineral content 29 | 92
short tibia 29 | 82
hypoactivity 28 | 89
increased grip strength 28 | 83
prenatal lethality prior to he... 28 | 64
decreased circulating choleste... 27 | 85
increased mean corpuscular vol... 27 | 91
abnormal lens morphology 23 | 73
abnormal retinal pigmentation 23 | 61
increased sacral vertebrae num... 23 | 62
decreased rib number 22 | 59
decreased circulating HDL chol... 21 | 77
decreased circulating triglyce... 21 | 83
male infertility 21 | 62
abnormal bone mineralization 20 | 55
decreased hemoglobin content 20 | 53
decreased prepulse inhibition 20 | 52
increased circulating HDL chol... 20 | 63
abnormal coat/hair pigmentatio... 19 | 54
decreased caudal vertebrae num... 19 | 49
decreased leukocyte cell numbe... 19 | 54
decreased lumbar vertebrae num... 19 | 62
abnormal eye morphology 18 | 38
decreased circulating alkaline... 18 | 41
decreased erythrocyte cell num... 18 | 43
decreased mean corpuscular vol... 18 | 50
abnormal gait 17 | 51
abnormal behavioral response t... 16 | 52
decreased circulating total pr... 16 | 41
impaired glucose tolerance 16 | 52
increased bone mineral density 16 | 52
increased circulating sodium l... 16 | 71
tremors 16 | 34
abnormal heart morphology 15 | 51
abnormal sleep behavior 15 | 63
increased circulating choleste... 15 | 53
increased exploration in new e... 15 | 56
increased hemoglobin content 15 | 45
thrombocytopenia 15 | 46
decreased circulating alanine ... 14 | 53
decreased circulating calcium ... 14 | 33
decreased mean corpuscular hem... 14 | 34
decreased startle reflex 14 | 48
decreased circulating LDL chol... 13 | 37
decreased eosinophil cell numb... 13 | 41
increased circulating chloride... 13 | 43
abnormal neural tube closure 12 | 37
decreased circulating creatini... 12 | 31
decreased circulating insulin ... 12 | 75
increased body weight 12 | 42
increased fasted circulating g... 12 | 68
increased startle reflex 12 | 38
abnormal locomotor activation 11 | 26
abnormal spleen morphology 11 | 36
cataract 11 | 26
embryonic growth retardation 11 | 28
improved glucose tolerance 11 | 56
increased circulating creatini... 11 | 29
increased circulating triglyce... 11 | 24
increased total body fat amoun... 11 | 57
long tibia 11 | 13
abnormal epididymis morphology 10 | 31
corneal opacity 10 | 25
decreased T cell number 10 | 31
decreased hematocrit 10 | 25
increased heart weight 10 | 37
increased hematocrit 10 | 36
increased rib number 10 | 41
limb grasping 10 | 35
anophthalmia 9 | 20
cardiovascular system phenotyp... 9 | 35
decreased circulating fructosa... 9 | 31
decreased fasted circulating g... 9 | 49
decreased heart weight 9 | 44
decreased neutrophil cell numb... 9 | 37
small testis 9 | 37
thrombocytosis 9 | 23

Disease

ovarian cancer 2,765 | 8,492
osteosarcoma 2,460 | 7,933
medulloblastoma, large-cell 1,813 | 6,234
psoriasis 1,775 | 6,685
glioblastoma 1,613 | 5,572
lung cancer 1,458 | 4,473
atypical teratoid / rhabdoid tumor 1,272 | 4,369
malignant mesothelioma 1,064 | 3,163
Breast cancer 969 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 950 | 3,289
primitive neuroectodermal tumor 944 | 3,031
Cancer 872 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 848 | 2,988
oligodendroglioma 837 | 2,849
group 3 medulloblastoma 809 | 2,254
invasive ductal carcinoma 801 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 792 | 2,956
non-small cell lung cancer 778 | 2,798
pediatric high grade glioma 775 | 2,712
ependymoma 758 | 2,514
lung adenocarcinoma 700 | 2,714
pilocytic astrocytoma 681 | 3,086
astrocytic glioma 639 | 2,241
Carcinoma 622 | 2,147
pancreatic cancer 608 | 2,300
subependymal giant cell astrocytoma 600 | 2,287
Pick disease 589 | 1,893
group 4 medulloblastoma 573 | 1,875
lung carcinoma 568 | 2,844
adult high grade glioma 541 | 2,148
Multiple myeloma 521 | 1,328
pituitary cancer 495 | 1,972
astrocytoma 488 | 1,493
interstitial cystitis 479 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 479 | 1,795
ulcerative colitis 476 | 2,087
breast carcinoma 470 | 1,614
ductal carcinoma in situ 469 | 1,745
adrenocortical carcinoma 454 | 1,427
sonic hedgehog group medulloblastoma 452 | 1,482
colon cancer 428 | 1,475
acute quadriplegic myopathy 423 | 1,157
medulloblastoma 418 | 1,524
diabetes mellitus 417 | 1,663
tuberculosis 416 | 1,563
juvenile dermatomyositis 401 | 1,189
cystic fibrosis 382 | 1,670
Rheumatoid Arthritis 366 | 1,171
posterior fossa group A ependymoma 359 | 1,511
dermatomyositis 352 | 967
posterior fossa group B ependymoma 352 | 1,530
primary pancreatic ductal adenocarcinoma 342 | 1,271
Waldenstrons macroglobulinemia 340 | 765
spina bifida 333 | 1,064
acute myeloid leukemia 308 | 785
atypical teratoid/rhabdoid tumor 307 | 1,095
nasopharyngeal carcinoma 294 | 1,056
progressive supranuclear palsy 244 | 674
cutaneous lupus erythematosus 236 | 1,056
tuberculosis and treatment for 6 months 236 | 686
Atopic dermatitis 232 | 944
non primary Sjogren syndrome sicca 231 | 840
Intellectual disability 214 | 573
primary Sjogren syndrome 210 | 789
aldosterone-producing adenoma 209 | 664
active Crohn's disease 204 | 918
gastric carcinoma 195 | 832
Endometriosis 182 | 535
hepatocellular carcinoma 182 | 550
esophageal adenocarcinoma 180 | 737
Mammary Neoplasms 174 | 410
Alzheimer's disease 171 | 644
pancreatic carcinoma 165 | 567
Amyotrophic Lateral Sclerosis 160 | 432
Prostatic Neoplasms 153 | 471
Down syndrome 148 | 548
Obesity 145 | 616
IGA Glomerulonephritis 138 | 454
gastric cancer 137 | 436
autosomal dominant Emery-Dreifuss muscular dystrophy 132 | 499
inflammatory breast cancer 124 | 404
active ulcerative colitis 119 | 477
chronic rhinosinusitis 118 | 512
fibroadenoma 117 | 557
Duchenne muscular dystrophy 116 | 602
Stomach Neoplasms 111 | 282
Neurodegenerative disease 109 | 383
Schizophrenia 109 | 503
non-small cell lung carcinoma 106 | 413
glioblastoma multiforme 104 | 347
tuberculosis and treatment for 3 months 102 | 327
Polycystic Ovary Syndrome 100 | 335
mucosa-associated lymphoid tissue lymphoma 99 | 480
Peripheral Neuropathy 96 | 303
hereditary spastic paraplegia 96 | 313
Multiple Sclerosis 93 | 498
Crohn's disease 90 | 304
Parkinson's disease 90 | 364
sarcoidosis 90 | 368
Vascular disease 87 | 281

Tissue

Female tissues 4,886 | 18,647
Nervous System 4,886 | 18,561
Digestive Tract 4,877 | 18,473
Endocrine System 4,872 | 18,512
Male tissues 4,870 | 17,969
Liver and Pancreas 4,867 | 18,136
Urinary Tract 4,867 | 18,444
Cardiovascular System 4,862 | 17,958
Blood and immune system 4,861 | 17,995
Skin and soft tissues 4,837 | 18,115
Respiratory system 4,818 | 17,484

Target Family

Non-IDG 2,671 | 11,969
Enzyme 1,038 | 4,146
Transcription Factor 661 | 1,400
Kinase 218 | 634
Epigenetic 177 | 242
Transporter 52 | 473
Nuclear Receptor 46 | 48
TF/Epigenetic 31 | 38
GPCR 19 | 408
Ion Channel 17 | 341

Compartment GO Term

Nucleoplasm 4,930 | 4,930
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Transcription factor HES-4 HES4 Tbio Transcription Factor -0.93868 8.35 73
Serine/threonine-protein kinase RIO1 RIOK1 Tchem Kinase -0.72835 5.14 142
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG 0.08 0.71 6
NACHT, LRR and PYD domains-containing protein 10 NLRP10 Tbio Non-IDG -1.30183 21.3 121
Thioredoxin reductase 3 TXNRD3 Tchem Enzyme -1.69637 55.1 0