Development Level

Tbio 684 | 11,178
Tdark 127 | 6,569
Tchem 90 | 1,885
Tclin 15 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125
GPCR: IDG Consortium (Targets) 3 | 126
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 88 | 979
embryonic lethality prior to o... 29 | 239
preweaning lethality, incomple... 29 | 499
embryonic lethality prior to t... 26 | 278
abnormal embryo size 18 | 220
abnormal behavior 15 | 298
decreased lean body mass 11 | 135
decreased vertical activity 11 | 208
short tibia 11 | 97
abnormal heart morphology 10 | 162
decreased body weight 10 | 161
enlarged heart 10 | 210
hyperactivity 10 | 148
abnormal bone structure 9 | 187
increased startle reflex 9 | 112
abnormal coat-hair pigmentatio... 8 | 64
decreased circulating HDL chol... 8 | 68
decreased circulating choleste... 8 | 93
decreased total body fat amoun... 8 | 207
impaired glucose tolerance 8 | 75
increased circulating alkaline... 8 | 122
increased lean body mass 8 | 172
abnormal spleen morphology 7 | 55
decreased fasted circulating g... 7 | 65
decreased grip strength 7 | 116
increased circulating chloride... 7 | 41
increased total body fat amoun... 7 | 134
male infertility 7 | 123
decreased circulating alanine ... 6 | 47
decreased circulating glucose ... 6 | 126
decreased erythrocyte cell num... 6 | 62
decreased mean corpuscular vol... 6 | 79
embryonic growth retardation 6 | 106
increased fasted circulating g... 6 | 76
increased or absent threshold ... 6 | 101
abnormal lens morphology 5 | 81
abnormal neural tube closure 5 | 46
decreased body length 5 | 101
decreased bone mineral content 5 | 151
decreased circulating iron lev... 5 | 32
decreased circulating serum al... 5 | 82
decreased circulating total pr... 5 | 49
decreased hemoglobin content 5 | 68
decreased prepulse inhibition 5 | 82
edema 5 | 59
increased bone mineral content 5 | 108
increased circulating triglyce... 5 | 42
prenatal lethality prior to he... 5 | 87
small testis 5 | 58
abnormal gait 4 | 69
abnormal locomotor behavior 4 | 24
abnormal seminal vesicle morph... 4 | 114
anophthalmia 4 | 33
cataract 4 | 92
decreased circulating insulin ... 4 | 76
decreased circulating sodium l... 4 | 22
female infertility 4 | 60
hypoactivity 4 | 132
increased bone mineral density 4 | 72
increased circulating HDL chol... 4 | 80
increased circulating sodium l... 4 | 71
pale yolk sac 4 | 25
tremors 4 | 39
abnormal body wall morphology 3 | 9
abnormal bone mineralization 3 | 38
abnormal eye morphology 3 | 68
abnormal forebrain development 3 | 20
abnormal placenta size 3 | 20
abnormal sleep behavior 3 | 70
abnormal testis morphology 3 | 43
abnormal vertebrae morphology 3 | 18
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased circulating triglyce... 3 | 79
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 50
decreased pulmonary respirator... 3 | 5
decreased startle reflex 3 | 75
enlarged spleen 3 | 41
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased heart weight 3 | 62
pallor 3 | 34
small superior vagus ganglion 3 | 74
vertebral transformation 3 | 12
abnormal epididymis morphology 2 | 42
abnormal limb bud morphology 2 | 17
abnormal liver morphology 2 | 17
corneal opacity 2 | 32
decreased circulating creatini... 2 | 39
increased circulating free fat... 2 | 20
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
microphthalmia 2 | 26

Disease

Carcinoma 598 | 11,192
ovarian cancer 513 | 8,297
osteosarcoma 446 | 7,766
medulloblastoma, large-cell 355 | 6,086
lung cancer 327 | 4,607
psoriasis 327 | 6,514
glioblastoma 295 | 5,635
group 3 medulloblastoma 285 | 4,002
atypical teratoid / rhabdoid tumor 259 | 4,971
ependymoma 198 | 4,559
malignant mesothelioma 196 | 3,135
Breast cancer 193 | 3,469
Cancer 193 | 2,388
intraductal papillary-mucinous neoplasm (IPMN) 180 | 3,204
adult high grade glioma 176 | 3,701
primitive neuroectodermal tumor 158 | 2,957
non-small cell lung cancer 146 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 144 | 2,902
invasive ductal carcinoma 143 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 138 | 2,872
oligodendroglioma 136 | 2,768
Multiple myeloma 134 | 1,296
lung adenocarcinoma 133 | 2,627
Kidney cancer 127 | 2,548
astrocytic glioma 123 | 2,530
Astrocytoma, Pilocytic 120 | 3,006
subependymal giant cell astrocytoma 117 | 2,230
colon cancer 116 | 1,428
pancreatic cancer 108 | 2,322
acute quadriplegic myopathy 100 | 1,133
Pick disease 99 | 1,856
lung carcinoma 99 | 2,755
diabetes mellitus 96 | 1,683
Waldenstrons macroglobulinemia 91 | 742
Intellectual disability 87 | 998
tuberculosis 84 | 1,963
group 4 medulloblastoma 82 | 1,806
juvenile dermatomyositis 80 | 1,147
ductal carcinoma in situ 78 | 1,686
breast carcinoma 76 | 1,589
pancreatic ductal adenocarcinoma liver metastasis 75 | 1,911
dermatomyositis 73 | 941
cystic fibrosis 72 | 1,629
Autosomal recessive predisposition 71 | 1,407
astrocytoma 70 | 1,113
pituitary cancer 70 | 1,915
adrenocortical carcinoma 68 | 1,385
non primary Sjogren syndrome sicca 68 | 861
Rheumatoid arthritis 66 | 1,156
pediatric high grade glioma 63 | 1,035
acute myeloid leukemia 59 | 760
interstitial cystitis 58 | 2,237
ulcerative colitis 58 | 1,765
cutaneous lupus erythematosus 57 | 1,016
nasopharyngeal carcinoma 54 | 1,024
Cognitive delay 53 | 596
Dull intelligence 53 | 634
Global developmental delay 53 | 596
Low intelligence 53 | 634
Mental Retardation 53 | 634
Mental and motor retardation 53 | 596
Mental deficiency 53 | 634
Poor school performance 53 | 634
Schizophrenia 51 | 1,136
spina bifida 51 | 1,053
primary pancreatic ductal adenocarcinoma 50 | 1,071
Small head 46 | 366
Short stature 44 | 514
Breast Neoplasms 40 | 423
progressive supranuclear palsy 39 | 656
Amyotrophic lateral sclerosis 38 | 437
Epilepsy 38 | 775
Neurodegenerative disease 37 | 402
Mammary Neoplasms 36 | 403
Prostatic Neoplasms 36 | 472
Stomach Neoplasms 36 | 287
Liver Cirrhosis, Experimental 35 | 733
Melanoma 34 | 689
Muscle hypotonia 34 | 562
medulloblastoma 34 | 702
primary Sjogren syndrome 34 | 710
Anemia 32 | 353
Liver cancer 32 | 589
aldosterone-producing adenoma 32 | 646
hepatocellular carcinoma 32 | 536
Cryptorchidism 31 | 287
Microcephaly 29 | 166
Seizures 29 | 584
esophageal adenocarcinoma 29 | 696
Alzheimer's disease 28 | 640
Atopic dermatitis 28 | 915
Down syndrome 28 | 480
Duchenne muscular dystrophy 28 | 587
Endometriosis 28 | 521
Obesity 28 | 655
active Crohn's disease 28 | 882
Failure to gain weight 27 | 359
Pediatric failure to thrive 27 | 359
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 492
sonic hedgehog group medulloblastoma 27 | 459

Tissue

Endocrine System 905 | 18,159
Female tissues 898 | 17,400
Digestive Tract 897 | 17,369
Male tissues 895 | 17,142
Skin and soft tissues 892 | 17,230
Blood and immune system 891 | 16,909
Urinary Tract 889 | 16,678
Liver and Pancreas 888 | 16,750
Nervous System 887 | 16,725
Respiratory system 886 | 16,393
Cardiovascular System 867 | 15,192

Target Family

Non-IDG 520 | 12,091
Enzyme 239 | 4,145
Transcription Factor 77 | 1,400
Kinase 36 | 634
Epigenetic 30 | 242
TF/Epigenetic 6 | 38
Transporter 4 | 473
GPCR 3 | 408
Nuclear Receptor 1 | 48

Compartment GO Term

Nucleolus 916 | 916
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MyoD family inhibitor domain-containing protein MDFIC Tbio Non-IDG -2.90969 749.0 122
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Wilms tumor protein WT1 Tbio Transcription Factor -3.48344 3138.9 571
DNA-directed RNA polymerase I subunit RPA2 POLR1B Tbio Enzyme -0.78946 5.77 86
Ankycorbin RAI14 Tdark Non-IDG -1.33275 19.5 49
Forkhead box protein J2 FOXJ2 Tbio Transcription Factor -1.74969 54.7 138
Homeobox protein NANOG NANOG Tchem Transcription Factor -2.94914 1130.5 958
Non-homologous end-joining factor 1 NHEJ1 Tbio Non-IDG -1.93558 91.5 270
tRNA methyltransferase 10 homolog A TRMT10A Tbio Enzyme -1.10123 12.2 75