Development Level

Tbio 598 | 10,625
Tdark 151 | 7,003
Tchem 76 | 1,890
Tclin 14 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 53 | 633
embryonic lethality prior to o... 18 | 148
embryonic lethality prior to t... 17 | 187
abnormal behavior 12 | 226
preweaning lethality, incomple... 12 | 260
decreased body weight 10 | 174
decreased lean body mass 10 | 195
decreased body length 9 | 108
abnormal embryo size 8 | 112
abnormal retina morphology 7 | 100
decreased bone mineral content 7 | 157
hyperactivity 7 | 108
increased circulating alkaline... 7 | 119
increased fasted circulating g... 7 | 68
abnormal coat/hair pigmentatio... 6 | 54
decreased bone mineral density 6 | 126
decreased fasted circulating g... 6 | 49
decreased lumbar vertebrae num... 6 | 62
increased sacral vertebrae num... 6 | 62
prenatal lethality prior to he... 6 | 64
abnormal bone mineralization 5 | 55
abnormal bone structure 5 | 131
abnormal lens morphology 5 | 73
abnormal limb bud morphology 5 | 15
decreased circulating HDL chol... 5 | 77
decreased circulating alanine ... 5 | 53
decreased circulating choleste... 5 | 85
decreased circulating glucose ... 5 | 121
enlarged heart 5 | 111
increased bone mineral content 5 | 92
increased circulating chloride... 5 | 43
increased lean body mass 5 | 107
increased or absent threshold ... 5 | 128
polydactyly 5 | 22
abnormal heart morphology 4 | 51
abnormal rib morphology 4 | 28
abnormal spleen morphology 4 | 36
decreased circulating chloride... 4 | 32
decreased circulating serum al... 4 | 79
decreased grip strength 4 | 123
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
decreased rib number 4 | 59
decreased total body fat amoun... 4 | 186
increased startle reflex 4 | 38
short tibia 4 | 82
abnormal body wall morphology 3 | 7
cataract 3 | 26
decreased NK T cell number 3 | 28
decreased caudal vertebrae num... 3 | 49
decreased circulating aspartat... 3 | 27
decreased circulating iron lev... 3 | 25
decreased erythrocyte cell num... 3 | 43
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased neutrophil cell numb... 3 | 37
decreased startle reflex 3 | 48
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
increased body weight 3 | 42
increased circulating HDL chol... 3 | 63
increased circulating LDL chol... 3 | 15
increased circulating sodium l... 3 | 71
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
male infertility 3 | 62
vertebral transformation 3 | 12
abnormal cornea morphology 2 | 24
abnormal epididymis morphology 2 | 31
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal retinal inner nuclear... 2 | 5
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal snout morphology 2 | 18
abnormal thoracic vertebrae mo... 2 | 16
abnormal tooth morphology 2 | 24
abnormal vocalization 2 | 21
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
corneal opacity 2 | 25
decreased Ly6C high monocyte n... 2 | 18
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
enlarged spleen 2 | 26
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
increased CD4-positive, CD25-p... 2 | 18
increased NK cell number 2 | 19
increased bone mineral density 2 | 52
increased circulating glucose ... 2 | 16
increased circulating triglyce... 2 | 24
increased exploration in new e... 2 | 56
increased hemoglobin content 2 | 45
increased mean platelet volume 2 | 19
small testis 2 | 37
vertebral fusion 2 | 23

Disease

ovarian cancer 473 | 8,484
osteosarcoma 409 | 7,933
medulloblastoma, large-cell 323 | 6,234
lung cancer 297 | 4,466
psoriasis 293 | 6,685
glioblastoma 264 | 5,572
atypical teratoid / rhabdoid tumor 191 | 4,369
Cancer 175 | 2,346
malignant mesothelioma 162 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 161 | 3,289
group 3 medulloblastoma 156 | 2,254
Breast cancer 147 | 3,094
primitive neuroectodermal tumor 141 | 3,031
pediatric high grade glioma 136 | 2,712
Multiple myeloma 130 | 1,327
oligodendroglioma 125 | 2,849
invasive ductal carcinoma 123 | 2,950
non-small cell lung cancer 123 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 121 | 2,988
lung adenocarcinoma 121 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 120 | 2,956
ependymoma 118 | 2,514
pilocytic astrocytoma 106 | 3,086
subependymal giant cell astrocytoma 106 | 2,287
colon cancer 104 | 1,475
Carcinoma 102 | 2,147
astrocytic glioma 96 | 2,241
acute quadriplegic myopathy 93 | 1,157
pancreatic cancer 93 | 2,300
diabetes mellitus 91 | 1,663
lung carcinoma 86 | 2,844
Waldenstrons macroglobulinemia 85 | 765
sonic hedgehog group medulloblastoma 84 | 1,482
astrocytoma 80 | 1,493
Pick disease 79 | 1,893
adult high grade glioma 74 | 2,148
dermatomyositis 74 | 933
group 4 medulloblastoma 72 | 1,875
pituitary cancer 71 | 1,972
juvenile dermatomyositis 69 | 1,189
ductal carcinoma in situ 68 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 68 | 1,795
medulloblastoma 65 | 1,524
breast carcinoma 63 | 1,614
ulcerative colitis 63 | 2,087
Rheumatoid Arthritis 60 | 1,160
cystic fibrosis 60 | 1,665
adrenocortical carcinoma 59 | 1,427
atypical teratoid/rhabdoid tumor 59 | 1,095
posterior fossa group A ependymoma 59 | 1,511
cutaneous lupus erythematosus 58 | 1,056
interstitial cystitis 55 | 2,299
tuberculosis 55 | 1,557
acute myeloid leukemia 54 | 780
nasopharyngeal carcinoma 52 | 1,056
primary pancreatic ductal adenocarcinoma 52 | 1,271
non primary Sjogren syndrome sicca 51 | 840
spina bifida 48 | 1,064
Intellectual disability 47 | 573
tuberculosis and treatment for 6 months 46 | 686
posterior fossa group B ependymoma 42 | 1,530
Alzheimer's disease 35 | 644
progressive supranuclear palsy 35 | 674
Prostatic Neoplasms 34 | 471
Mammary Neoplasms 33 | 410
primary Sjogren syndrome 31 | 789
Endometriosis 30 | 535
Amyotrophic Lateral Sclerosis 29 | 431
Neurodegenerative disease 29 | 383
Stomach Neoplasms 27 | 282
active Crohn's disease 27 | 918
hepatocellular carcinoma 27 | 532
Down syndrome 26 | 548
IGA Glomerulonephritis 26 | 454
esophageal adenocarcinoma 26 | 737
gastric carcinoma 26 | 832
inflammatory breast cancer 25 | 404
pancreatic carcinoma 25 | 567
Atopic dermatitis 24 | 944
aldosterone-producing adenoma 24 | 664
Anemia 23 | 252
Duchenne muscular dystrophy 23 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 22 | 499
Microcephaly 21 | 149
Obesity 20 | 616
Disease Progression 19 | 125
gastric cancer 19 | 430
non-small cell lung carcinoma 19 | 413
Adenoma 18 | 165
chronic rhinosinusitis 18 | 512
mucosa-associated lymphoid tissue lymphoma 18 | 480
Kidney disease 17 | 396
Melanoma 17 | 261
Parkinson's disease 17 | 364
Schizophrenia 17 | 501
Vascular disease 17 | 281
Heart disease 16 | 279
Liver carcinoma 16 | 217
Multiple Sclerosis 16 | 498
Polycystic Ovary Syndrome 16 | 332

Tissue

Female tissues 829 | 18,647
Nervous System 828 | 18,561
Digestive Tract 826 | 18,473
Male tissues 826 | 17,969
Endocrine System 824 | 18,512
Blood and immune system 823 | 17,995
Liver and Pancreas 823 | 18,136
Urinary Tract 820 | 18,444
Cardiovascular System 819 | 17,958
Respiratory system 815 | 17,484
Skin and soft tissues 815 | 18,115

Target Family

Non-IDG 503 | 11,971
Enzyme 207 | 4,146
Transcription Factor 61 | 1,400
Epigenetic 27 | 242
Kinase 27 | 634
TF/Epigenetic 5 | 38
Transporter 5 | 473
GPCR 2 | 406
Nuclear Receptor 2 | 48

Compartment GO Term

Nucleolus 839 | 839
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Interleukin enhancer-binding factor 2 ILF2 Tbio Non-IDG -1.51960 36.4 249
Interleukin enhancer-binding factor 3 ILF3 Tbio Non-IDG -2.09543 135.8 239
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
A-kinase anchor protein 8 AKAP8 Tbio Enzyme -1.32097 22.6 240
U3 small nucleolar RNA-interacting protein 2 RRP9 Tbio Non-IDG -0.95790 8.59 56
Zinc finger BED domain-containing protein 6 ZBED6 Tdark Non-IDG -0.79472 9.28 0
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60