Development Level

Tbio 245 | 10,625
Tdark 124 | 7,003
Tchem 39 | 1,890
Tclin 6 | 602

Collection

Kinase: IDG Consortium (Targets) 6 | 125
Kinase: IDG Consortium (Complete/Control) 4 | 37
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, complete... 25 | 633
embryonic lethality prior to t... 7 | 187
abnormal lens morphology 6 | 73
embryonic lethality prior to o... 6 | 148
preweaning lethality, incomple... 6 | 260
abnormal behavior 4 | 226
abnormal retina morphology 4 | 100
decreased CD8-positive, alpha-... 4 | 26
decreased total body fat amoun... 4 | 186
increased bone mineral content 4 | 92
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
decreased T cell number 3 | 31
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
decreased leukocyte cell numbe... 3 | 54
increased body length 3 | 20
increased bone mineral density 3 | 52
increased rib number 3 | 41
abnormal brain morphology 2 | 6
abnormal coat-hair pigmentatio... 2 | 54
abnormal embryo size 2 | 112
abnormal gait 2 | 51
abnormal neural tube morpholog... 2 | 8
abnormal retinal blood vessel ... 2 | 18
abnormal startle reflex 2 | 14
cataract 2 | 26
decreased CD4-positive, alpha ... 2 | 19
decreased Ly6C high monocyte n... 2 | 18
decreased alpha-beta T cell nu... 2 | 12
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased effector memory CD8-... 2 | 24
decreased fasted circulating g... 2 | 49
decreased gamma-delta T cell n... 2 | 18
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased mature B cell number 2 | 25
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased threshold for audito... 2 | 32
decreased total retina thickne... 2 | 20
enlarged heart 2 | 111
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased CD4-positive, CD25-p... 2 | 18
increased CD4-positive, alpha ... 2 | 15
increased body weight 2 | 42
increased fasted circulating g... 2 | 68
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
persistence of hyaloid vascula... 2 | 22
short tibia 2 | 82
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal eyelid morphology 1 | 6
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased NK cell number 1 | 16
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
enlarged spleen 1 | 26
hydroencephaly 1 | 6
impaired righting response 1 | 19
increased CD5-positive Ly6C-po... 1 | 4
increased blood urea nitrogen ... 1 | 44
increased circulating amylase ... 1 | 13
increased circulating creatini... 1 | 29
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased startle reflex 1 | 38
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
sparse hair 1 | 6
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 231 | 8,491
osteosarcoma 227 | 7,933
medulloblastoma, large-cell 149 | 6,234
glioblastoma 142 | 5,572
psoriasis 142 | 6,685
lung cancer 114 | 4,473
atypical teratoid / rhabdoid tumor 106 | 4,369
malignant mesothelioma 88 | 3,163
ependymoma 87 | 2,514
primitive neuroectodermal tumor 80 | 3,031
oligodendroglioma 79 | 2,849
pediatric high grade glioma 71 | 2,712
Breast cancer 69 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,988
invasive ductal carcinoma 66 | 2,950
group 3 medulloblastoma 65 | 2,254
non-small cell lung cancer 64 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 63 | 2,956
pilocytic astrocytoma 60 | 3,086
astrocytic glioma 59 | 2,241
Carcinoma 53 | 2,147
lung carcinoma 53 | 2,844
Pick disease 51 | 1,893
group 4 medulloblastoma 49 | 1,875
lung adenocarcinoma 49 | 2,714
adult high grade glioma 48 | 2,148
astrocytoma 48 | 1,493
Multiple myeloma 47 | 1,327
subependymal giant cell astrocytoma 47 | 2,287
Cancer 46 | 2,346
medulloblastoma 45 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
juvenile dermatomyositis 39 | 1,189
acute quadriplegic myopathy 36 | 1,157
interstitial cystitis 36 | 2,299
posterior fossa group B ependymoma 36 | 1,530
pancreatic cancer 34 | 2,300
sonic hedgehog group medulloblastoma 34 | 1,482
tuberculosis 33 | 1,563
atypical teratoid/rhabdoid tumor 32 | 1,095
ductal carcinoma in situ 32 | 1,745
progressive supranuclear palsy 32 | 674
ulcerative colitis 32 | 2,087
adrenocortical carcinoma 31 | 1,427
pituitary cancer 31 | 1,972
dermatomyositis 30 | 966
diabetes mellitus 29 | 1,663
Rheumatoid Arthritis 27 | 1,170
Waldenstrons macroglobulinemia 25 | 764
spina bifida 25 | 1,064
tuberculosis and treatment for 6 months 25 | 686
cystic fibrosis 24 | 1,670
hepatocellular carcinoma 24 | 550
breast carcinoma 23 | 1,614
non primary Sjogren syndrome sicca 23 | 840
acute myeloid leukemia 21 | 785
posterior fossa group A ependymoma 20 | 1,511
colon cancer 19 | 1,475
nasopharyngeal carcinoma 19 | 1,056
primary pancreatic ductal adenocarcinoma 19 | 1,271
Atopic dermatitis 17 | 944
primary Sjogren syndrome 17 | 788
Intellectual disability 15 | 573
chronic rhinosinusitis 15 | 512
cutaneous lupus erythematosus 15 | 1,056
Alzheimer's disease 14 | 644
Amyotrophic Lateral Sclerosis 14 | 432
Down syndrome 14 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
Gaucher disease type 1 13 | 171
gastric cancer 12 | 436
Adenoid Cystic Carcinoma 11 | 99
active Crohn's disease 11 | 918
aldosterone-producing adenoma 11 | 664
gastric carcinoma 11 | 832
pancreatic carcinoma 11 | 567
Duchenne muscular dystrophy 10 | 602
Prostatic Neoplasms 10 | 471
Schizophrenia 10 | 503
esophageal adenocarcinoma 10 | 737
hereditary spastic paraplegia 10 | 313
interstitial lung disease 10 | 292
Polycystic Ovary Syndrome 9 | 334
glioblastoma multiforme 9 | 347
tuberculosis and treatment for 3 months 9 | 327
Acquired metabolic disease 8 | 267
Crohn's disease 8 | 304
Endometriosis 8 | 535
IGA Glomerulonephritis 8 | 454
Mammary Neoplasms 8 | 410
Melanoma 8 | 261
Renal Cell Carcinoma 8 | 199
fibroadenoma 8 | 557
inflammatory breast cancer 8 | 404
sarcoidosis 8 | 368
Becker muscular dystrophy 7 | 187
Multiple Sclerosis 7 | 498
Type 2 diabetes mellitus 7 | 192
head and neck cancer 7 | 270

Tissue

Female tissues 414 | 18,646
Nervous System 414 | 18,560
Endocrine System 413 | 18,511
Liver and Pancreas 413 | 18,135
Male tissues 413 | 17,968
Blood and immune system 412 | 17,994
Cardiovascular System 412 | 17,957
Urinary Tract 412 | 18,443
Digestive Tract 411 | 18,472
Skin and soft tissues 407 | 18,114
Respiratory system 404 | 17,483

Target Family

Non-IDG 241 | 11,969
Enzyme 69 | 4,146
Transcription Factor 52 | 1,400
Kinase 26 | 634
Epigenetic 15 | 242
GPCR 3 | 408
Transporter 3 | 473
Ion Channel 2 | 341
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

Compartment GO Term

Nuclear speckles 414 | 414
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108
Zinc finger CW-type PWWP domain protein 2 ZCWPW2 Tdark Epigenetic 0.56 0.42 10
U4/U6 small nuclear ribonucleoprotein Prp4 PRPF4 Tchem Non-IDG -0.55879 7.56 79
Protein piccolo PCLO Tbio Non-IDG -2.47496 292.6 99
Erbin ERBIN Tbio Non-IDG -1.68182 53.5 111
THAP domain-containing protein 4 THAP4 Tdark Transcription Factor -0.45882 2.29 33
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.91165 83.2 324
Putative zinc finger protein 286B ZNF286B Tdark Non-IDG 0.30 0.50 55
Peptidyl-prolyl cis-trans isomerase E PPIE Tbio Enzyme -1.30532 19.4 143