Development Level

Tbio 41 | 11,178
Tchem 9 | 1,885
Tclin 5 | 612
Tdark 2 | 6,569

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 3 | 499
abnormal blood vessel morpholo... 2 | 5
abnormal heart morphology 2 | 162
decreased circulating glucose ... 2 | 126
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal rib morphology 1 | 10
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 35 | 11,192
ovarian cancer 35 | 8,297
group 3 medulloblastoma 34 | 4,002
malignant mesothelioma 31 | 3,135
lung cancer 30 | 4,607
Cancer 27 | 2,388
medulloblastoma, large-cell 26 | 6,086
Breast cancer 25 | 3,469
primitive neuroectodermal tumor 25 | 2,957
atypical teratoid / rhabdoid tumor 23 | 4,971
glioblastoma 23 | 5,635
psoriasis 23 | 6,514
osteosarcoma 22 | 7,766
non-small cell lung cancer 20 | 2,799
colon cancer 16 | 1,428
ependymoma 15 | 4,559
adult high grade glioma 14 | 3,701
Xeroderma pigmentosum 13 | 42
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,204
Kidney cancer 12 | 2,548
Fanconi anemia 11 | 56
adrenocortical carcinoma 11 | 1,385
Autosomal recessive predisposition 10 | 1,407
Bloom syndrome 10 | 29
Nijmegen breakage syndrome 10 | 23
Ataxia telangiectasia 9 | 33
Breast Neoplasms 9 | 423
Mammary Neoplasms 9 | 403
Short stature 9 | 514
Werner syndrome 9 | 29
diabetes mellitus 9 | 1,683
ductal carcinoma in situ 9 | 1,686
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,902
invasive ductal carcinoma 9 | 2,867
Dull intelligence 8 | 634
Intellectual disability 8 | 998
Low intelligence 8 | 634
Mental Retardation 8 | 634
Mental deficiency 8 | 634
Poor school performance 8 | 634
lung adenocarcinoma 8 | 2,627
nasopharyngeal carcinoma 8 | 1,024
oligodendroglioma 8 | 2,768
pediatric high grade glioma 8 | 1,035
Astrocytoma, Pilocytic 7 | 3,006
Colorectal Neoplasms 7 | 235
Seckel syndrome 7 | 34
Waldenstrons macroglobulinemia 7 | 742
ulcerative colitis 7 | 1,765
Cockayne syndrome 6 | 59
Epilepsy 6 | 775
Schizophrenia 6 | 1,136
Seizures 6 | 584
Small head 6 | 366
breast carcinoma 6 | 1,589
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,872
lung carcinoma 6 | 2,755
pancreatic cancer 6 | 2,322
tuberculosis 6 | 1,963
Chromosome Breakage 5 | 35
Cognitive delay 5 | 596
Convex nasal ridge 5 | 36
Cryptorchidism 5 | 287
Endometriosis 5 | 521
Global developmental delay 5 | 596
Lung Neoplasms 5 | 217
Lynch syndrome 5 | 34
Mental and motor retardation 5 | 596
Pancreatic Neoplasm 5 | 82
Prostatic Neoplasms 5 | 472
Thrombocytopenia 5 | 193
astrocytic glioma 5 | 2,530
non primary Sjogren syndrome sicca 5 | 861
Acquired scoliosis 4 | 274
Adenocarcinoma of pancreas 4 | 14
Anemia 4 | 353
Atopic dermatitis 4 | 915
Chronic Lymphocytic Leukemia 4 | 254
Curvature of spine 4 | 275
Endometrial cancer 4 | 301
Fetal Growth Retardation 4 | 186
Hereditary Breast and Ovarian Cancer Syndrome 4 | 13
Hypoplastic mandible condyle 4 | 273
Increased chromosomal breakage 4 | 27
Infant, Small for Gestational Age 4 | 174
Intrauterine retardation 4 | 174
Liver cancer 4 | 589
Malignant tumor of ovary 4 | 25
Mandibular hypoplasia 4 | 273
Micrognathism 4 | 273
Myocardial Infarction 4 | 142
Pancreatic Neoplasms 4 | 82
Stomach Neoplasms 4 | 287
Strabismus 4 | 265
Telangiectasis 4 | 35
cystic fibrosis 4 | 1,629
hepatocellular carcinoma 4 | 536
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
subependymal giant cell astrocytoma 4 | 2,230
juvenile dermatomyositis 3 | 1,147

Tissue

Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Female tissues 57 | 17,400
Liver and Pancreas 57 | 16,750
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Respiratory system 57 | 16,393
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678
Cardiovascular System 56 | 15,192

Target Family

Non-IDG 27 | 12,091
Enzyme 24 | 4,145
Kinase 4 | 634
Transcription Factor 2 | 1,400

Compartment GO Term

Nuclear replisome 57 | 57
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase RFWD3 RFWD3 Tbio Enzyme -0.67619 6.67 73
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Transcriptional activator protein Pur-alpha PURA Tbio Non-IDG -2.17708 158.7 170
Transcriptional activator protein Pur-beta PURB Tbio Non-IDG -1.49692 30.7 79
Ewing's tumor-associated antigen 1 ETAA1 Tbio Non-IDG -0.76616 7.50 40
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Exonuclease 1 EXO1 Tbio Enzyme -2.64302 437.0 263
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 SMARCAL1 Tbio Non-IDG -1.74852 65.1 133