Development Level

Tbio 3,205 | 11,651
Tdark 546 | 6,593
Tchem 432 | 1,388
Tclin 107 | 612

Collection

RFA-RM-18-021 41 | 328
Kinase: IDG Consortium (Target... 30 | 125
Kinase: IDG Consortium (Comple... 14 | 37
GPCR: IDG Consortium (Targets) 6 | 126
Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 427 | 979
preweaning lethality, incomple... 137 | 499
embryonic lethality prior to t... 114 | 278
embryonic lethality prior to o... 107 | 239
abnormal behavior 84 | 298
abnormal embryo size 81 | 220
decreased body weight 58 | 161
abnormal bone structure 55 | 187
decreased total body fat amoun... 54 | 207
enlarged heart 52 | 210
increased lean body mass 49 | 172
abnormal heart morphology 46 | 162
decreased lean body mass 45 | 135
decreased vertical activity 44 | 208
increased startle reflex 41 | 112
decreased bone mineral content 36 | 151
hypoactivity 36 | 132
increased circulating alkaline... 36 | 122
male infertility 36 | 123
decreased circulating choleste... 35 | 93
embryonic growth retardation 35 | 106
hyperactivity 35 | 148
decreased circulating glucose ... 33 | 126
increased bone mineral density 33 | 72
increased mean corpuscular vol... 33 | 92
increased total body fat amoun... 32 | 134
decreased bone mineral density 31 | 126
decreased body length 30 | 101
increased bone mineral content 30 | 108
increased or absent threshold ... 30 | 101
cataract 28 | 92
decreased grip strength 28 | 116
decreased prepulse inhibition 28 | 82
prenatal lethality prior to he... 28 | 87
increased mean corpuscular hem... 27 | 96
short tibia 27 | 97
abnormal lens morphology 25 | 81
decreased hemoglobin content 25 | 68
decreased leukocyte cell numbe... 25 | 73
decreased lymphocyte cell numb... 25 | 83
increased circulating HDL chol... 24 | 80
abnormal coat-hair pigmentatio... 23 | 64
abnormal kidney morphology 23 | 65
decreased circulating HDL chol... 23 | 68
decreased circulating triglyce... 23 | 79
impaired glucose tolerance 23 | 75
decreased mean corpuscular vol... 22 | 79
abnormal seminal vesicle morph... 21 | 114
decreased circulating serum al... 21 | 82
decreased erythrocyte cell num... 21 | 62
edema 21 | 59
increased circulating choleste... 21 | 66
abnormal gait 19 | 69
abnormal retina morphology 19 | 71
corneal opacity 19 | 32
female infertility 19 | 60
increased fasted circulating g... 19 | 76
abnormal neural tube closure 18 | 46
decreased caudal vertebrae num... 18 | 53
decreased fasted circulating g... 18 | 65
decreased hematocrit 18 | 46
increased monocyte cell number 17 | 63
small testis 17 | 58
tremors 17 | 39
abnormal eye morphology 16 | 68
decreased circulating insulin ... 16 | 76
increased grip strength 16 | 41
abnormal bone mineralization 15 | 38
abnormal craniofacial morpholo... 15 | 33
abnormal spleen morphology 15 | 55
decreased circulating alanine ... 15 | 47
decreased circulating alkaline... 15 | 46
decreased circulating total pr... 15 | 49
decreased mean corpuscular hem... 15 | 50
decreased neutrophil cell numb... 15 | 42
decreased startle reflex 15 | 75
increased circulating sodium l... 15 | 71
increased circulating triglyce... 15 | 42
increased heart weight 15 | 62
increased mean platelet volume 15 | 45
small superior vagus ganglion 15 | 74
thrombocytopenia 15 | 56
abnormal behavioral response t... 14 | 66
decreased circulating LDL chol... 14 | 38
decreased circulating iron lev... 14 | 32
hydrometra 14 | 53
increased circulating chloride... 14 | 41
increased neutrophil cell numb... 14 | 46
abnormal cornea morphology 13 | 31
anophthalmia 13 | 33
decreased blood urea nitrogen ... 13 | 51
improved glucose tolerance 13 | 79
increased body length 13 | 32
increased hemoglobin content 13 | 45
abnormal embryo turning 12 | 31
decreased heart left ventricle... 12 | 28
increased blood urea nitrogen ... 12 | 48
abnormal skin morphology 11 | 50
abnormal sleep behavior 11 | 70
decreased circulating aspartat... 11 | 34

Disease

Carcinoma 2,804 | 11,493
ovarian cancer 2,512 | 8,520
osteosarcoma 2,173 | 7,950
medulloblastoma, large-cell 1,628 | 6,241
psoriasis 1,601 | 6,694
glioblastoma 1,500 | 5,792
lung cancer 1,411 | 4,740
atypical teratoid / rhabdoid tumor 1,274 | 5,112
group 3 medulloblastoma 1,249 | 4,104
ependymoma 1,017 | 4,679
Breast cancer 1,000 | 3,578
malignant mesothelioma 969 | 3,232
Cancer 955 | 2,499
adult high grade glioma 860 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 830 | 3,291
primitive neuroectodermal tumor 813 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 742 | 2,989
oligodendroglioma 724 | 2,850
non-small cell lung cancer 720 | 2,890
invasive ductal carcinoma 706 | 2,951
Kidney cancer 680 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 661 | 2,955
lung adenocarcinoma 637 | 2,716
astrocytic glioma 609 | 2,597
Astrocytoma, Pilocytic 575 | 3,081
pancreatic cancer 544 | 2,398
Multiple myeloma 539 | 1,332
subependymal giant cell astrocytoma 532 | 2,287
Pick disease 514 | 1,894
lung carcinoma 457 | 2,843
tuberculosis 451 | 2,010
group 4 medulloblastoma 449 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 446 | 1,962
breast carcinoma 422 | 1,638
acute quadriplegic myopathy 420 | 1,158
colon cancer 414 | 1,478
pituitary cancer 409 | 1,972
diabetes mellitus 403 | 1,728
ductal carcinoma in situ 400 | 1,745
adrenocortical carcinoma 388 | 1,428
juvenile dermatomyositis 388 | 1,187
interstitial cystitis 378 | 2,312
astrocytoma 373 | 1,146
Rheumatoid arthritis 371 | 1,191
Intellectual disability 361 | 1,016
dermatomyositis 357 | 966
ulcerative colitis 352 | 1,819
Waldenstrons macroglobulinemia 348 | 765
Autosomal recessive predisposition 329 | 1,442
pediatric high grade glioma 303 | 1,064
cystic fibrosis 299 | 1,696
acute myeloid leukemia 282 | 783
primary pancreatic ductal adenocarcinoma 281 | 1,109
Schizophrenia 271 | 1,160
spina bifida 266 | 1,074
nasopharyngeal carcinoma 258 | 1,058
non primary Sjogren syndrome sicca 242 | 891
cutaneous lupus erythematosus 236 | 1,057
Dull intelligence 233 | 645
Low intelligence 233 | 645
Mental Retardation 233 | 645
Mental deficiency 233 | 645
Poor school performance 233 | 645
Cognitive delay 221 | 608
Global developmental delay 221 | 608
Mental and motor retardation 221 | 608
Short stature 206 | 531
primary Sjogren syndrome 205 | 735
Atopic dermatitis 204 | 952
Breast Neoplasms 203 | 445
Epilepsy 195 | 792
Mammary Neoplasms 192 | 425
progressive supranuclear palsy 192 | 676
aldosterone-producing adenoma 191 | 665
medulloblastoma 185 | 720
Alzheimer's disease 174 | 658
Endometriosis 173 | 540
Muscle hypotonia 171 | 571
Liver Cirrhosis, Experimental 170 | 769
Small head 170 | 374
active Crohn's disease 168 | 922
hepatocellular carcinoma 168 | 547
Seizures 166 | 596
gastric carcinoma 165 | 807
Amyotrophic lateral sclerosis 163 | 451
Obesity 160 | 678
Bipolar Disorder 157 | 666
Prostatic Neoplasms 156 | 495
active ulcerative colitis 150 | 764
esophageal adenocarcinoma 149 | 737
Liver cancer 147 | 604
Melanoma 142 | 711
tuberculosis and treatment for 6 months 135 | 409
Down syndrome 134 | 499
pancreatic carcinoma 134 | 562
Stomach Neoplasms 133 | 300
autosomal dominant Emery-Dreifuss muscular dystrophy 132 | 510
Cryptorchidism 130 | 296
Neurodegenerative disease 130 | 414
gastric cancer 129 | 459

Tissue

Endocrine System 4,219 | 18,159
Digestive Tract 4,185 | 17,369
Female tissues 4,182 | 17,400
Male tissues 4,166 | 17,142
Skin and soft tissues 4,165 | 17,230
Blood and immune system 4,142 | 16,909
Liver and Pancreas 4,127 | 16,750
Urinary Tract 4,123 | 16,678
Nervous System 4,110 | 16,725
Respiratory system 4,103 | 16,393
Cardiovascular System 3,995 | 15,192

Target Family

Non-IDG 2,280 | 12,091
Enzyme 926 | 4,145
Transcription Factor 542 | 1,400
Kinase 203 | 634
Epigenetic 187 | 242
Nuclear Receptor 47 | 48
Transporter 30 | 473
TF/Epigenetic 28 | 38
Ion Channel 25 | 344
GPCR 22 | 408

Compartment GO Term

Nuclear part 4,290 | 4,290
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225