Development Level

Tbio 2,647 | 10,625
Tdark 569 | 7,003
Tchem 497 | 1,890
Tclin 94 | 602

Collection

Kinase: IDG Consortium (Targets) 23 | 125
Kinase: IDG Consortium (Complete/Control) 8 | 37
GPCR: IDG Consortium (Targets) 4 | 128
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, complete... 238 | 633
preweaning lethality, incomple... 70 | 260
embryonic lethality prior to t... 67 | 187
embryonic lethality prior to o... 62 | 148
abnormal behavior 56 | 226
decreased body weight 53 | 174
decreased lean body mass 46 | 195
decreased total body fat amoun... 44 | 186
abnormal embryo size 39 | 112
abnormal bone structure 37 | 131
decreased bone mineral content 35 | 157
decreased body length 34 | 108
abnormal retina morphology 30 | 100
decreased circulating glucose ... 30 | 121
increased or absent threshold ... 30 | 128
increased circulating alkaline... 29 | 119
decreased grip strength 28 | 123
hyperactivity 28 | 108
increased lean body mass 28 | 107
decreased bone mineral density 26 | 126
decreased circulating choleste... 25 | 85
enlarged heart 25 | 111
increased bone mineral content 25 | 92
increased mean corpuscular hem... 25 | 93
increased mean corpuscular vol... 25 | 91
increased grip strength 24 | 83
decreased circulating HDL chol... 23 | 77
abnormal lens morphology 21 | 73
increased sacral vertebrae num... 21 | 62
prenatal lethality prior to he... 21 | 64
decreased rib number 20 | 59
abnormal bone mineralization 19 | 55
decreased lumbar vertebrae num... 19 | 62
hypoactivity 19 | 89
short tibia 19 | 82
abnormal coat-hair pigmentatio... 17 | 54
decreased caudal vertebrae num... 17 | 49
decreased circulating serum al... 17 | 79
decreased hemoglobin content 17 | 53
decreased leukocyte cell numbe... 17 | 54
decreased circulating triglyce... 16 | 83
decreased fasted circulating g... 16 | 49
increased circulating HDL chol... 16 | 63
decreased prepulse inhibition 15 | 52
increased bone mineral density 15 | 52
increased circulating sodium l... 15 | 71
male infertility 15 | 62
abnormal retinal pigmentation 14 | 61
increased fasted circulating g... 14 | 68
abnormal eye morphology 13 | 38
decreased circulating LDL chol... 13 | 37
decreased circulating alanine ... 13 | 53
decreased erythrocyte cell num... 13 | 43
decreased mean corpuscular vol... 13 | 50
increased circulating choleste... 13 | 53
abnormal gait 12 | 51
abnormal heart morphology 12 | 51
abnormal locomotor activation 12 | 26
corneal opacity 12 | 25
impaired glucose tolerance 12 | 52
increased circulating creatini... 12 | 29
tremors 12 | 34
abnormal cornea morphology 11 | 24
decreased circulating aspartat... 11 | 27
decreased hematocrit 11 | 25
increased blood urea nitrogen ... 11 | 44
thrombocytopenia 11 | 46
abnormal neural tube closure 10 | 37
cataract 10 | 26
decreased circulating alkaline... 10 | 41
decreased circulating insulin ... 10 | 75
decreased circulating iron lev... 10 | 25
decreased heart weight 10 | 44
decreased mean corpuscular hem... 10 | 34
embryonic growth retardation 10 | 28
increased exploration in new e... 10 | 56
increased hemoglobin content 10 | 45
polydactyly 10 | 22
abnormal behavioral response t... 9 | 52
abnormal limb bud morphology 9 | 15
abnormal sleep behavior 9 | 63
anophthalmia 9 | 20
decreased T cell number 9 | 31
decreased circulating free fat... 9 | 39
decreased circulating total pr... 9 | 41
decreased startle reflex 9 | 48
decreased threshold for audito... 9 | 32
female infertility 9 | 34
increased circulating chloride... 9 | 43
increased circulating triglyce... 9 | 24
abnormal spleen morphology 8 | 36
decreased circulating chloride... 8 | 32
decreased circulating fructosa... 8 | 31
decreased eosinophil cell numb... 8 | 41
hydrops fetalis 8 | 22
improved glucose tolerance 8 | 56
increased heart weight 8 | 37
increased mean corpuscular hem... 8 | 25
increased startle reflex 8 | 38
increased total body fat amoun... 8 | 57

Disease

ovarian cancer 2,246 | 8,491
osteosarcoma 1,919 | 7,933
medulloblastoma, large-cell 1,449 | 6,234
psoriasis 1,421 | 6,685
glioblastoma 1,269 | 5,572
lung cancer 1,237 | 4,473
atypical teratoid / rhabdoid tumor 981 | 4,369
malignant mesothelioma 852 | 3,163
Cancer 849 | 2,346
Breast cancer 789 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 757 | 3,289
primitive neuroectodermal tumor 737 | 3,031
group 3 medulloblastoma 697 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 664 | 2,988
oligodendroglioma 654 | 2,849
pediatric high grade glioma 645 | 2,712
non-small cell lung cancer 632 | 2,798
invasive ductal carcinoma 624 | 2,950
ependymoma 581 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 573 | 2,956
lung adenocarcinoma 561 | 2,714
Multiple myeloma 518 | 1,327
pilocytic astrocytoma 500 | 3,086
Carcinoma 491 | 2,147
pancreatic cancer 476 | 2,300
subependymal giant cell astrocytoma 476 | 2,287
astrocytic glioma 472 | 2,241
Pick disease 459 | 1,893
astrocytoma 405 | 1,493
group 4 medulloblastoma 402 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 388 | 1,795
adult high grade glioma 387 | 2,148
lung carcinoma 382 | 2,844
acute quadriplegic myopathy 376 | 1,157
colon cancer 372 | 1,475
ulcerative colitis 365 | 2,087
ductal carcinoma in situ 364 | 1,745
diabetes mellitus 361 | 1,663
pituitary cancer 361 | 1,972
breast carcinoma 358 | 1,614
juvenile dermatomyositis 353 | 1,189
sonic hedgehog group medulloblastoma 347 | 1,482
adrenocortical carcinoma 344 | 1,427
medulloblastoma 332 | 1,524
Waldenstrons macroglobulinemia 325 | 764
dermatomyositis 323 | 966
Rheumatoid Arthritis 319 | 1,170
interstitial cystitis 317 | 2,299
tuberculosis 299 | 1,563
posterior fossa group A ependymoma 294 | 1,511
primary pancreatic ductal adenocarcinoma 270 | 1,271
acute myeloid leukemia 255 | 785
spina bifida 253 | 1,064
atypical teratoid/rhabdoid tumor 252 | 1,095
cystic fibrosis 249 | 1,670
nasopharyngeal carcinoma 243 | 1,056
posterior fossa group B ependymoma 215 | 1,530
tuberculosis and treatment for 6 months 203 | 686
non primary Sjogren syndrome sicca 199 | 840
cutaneous lupus erythematosus 197 | 1,056
Intellectual disability 184 | 573
Atopic dermatitis 181 | 944
progressive supranuclear palsy 179 | 674
Mammary Neoplasms 177 | 410
primary Sjogren syndrome 175 | 788
Endometriosis 172 | 535
Alzheimer's disease 165 | 644
aldosterone-producing adenoma 161 | 664
hepatocellular carcinoma 155 | 550
gastric carcinoma 152 | 832
Amyotrophic Lateral Sclerosis 151 | 432
active Crohn's disease 150 | 918
esophageal adenocarcinoma 137 | 737
Prostatic Neoplasms 133 | 471
IGA Glomerulonephritis 130 | 454
Down syndrome 129 | 548
pancreatic carcinoma 127 | 567
gastric cancer 113 | 436
Stomach Neoplasms 112 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 110 | 499
Obesity 107 | 616
Neurodegenerative disease 101 | 383
inflammatory breast cancer 100 | 404
Schizophrenia 92 | 503
Duchenne muscular dystrophy 87 | 602
Polycystic Ovary Syndrome 87 | 334
Multiple Sclerosis 84 | 498
non-small cell lung carcinoma 83 | 413
Parkinson's disease 82 | 364
Peripheral Neuropathy 82 | 303
Vascular disease 82 | 281
Crohn's disease 81 | 304
hereditary spastic paraplegia 81 | 313
active ulcerative colitis 80 | 477
Liver carcinoma 79 | 217
chronic rhinosinusitis 79 | 512
glioblastoma multiforme 79 | 347
mucosa-associated lymphoid tissue lymphoma 77 | 480
Kidney disease 76 | 397
Melanoma 74 | 261

Tissue

Female tissues 3,768 | 18,646
Nervous System 3,765 | 18,560
Digestive Tract 3,758 | 18,472
Male tissues 3,757 | 17,968
Endocrine System 3,756 | 18,511
Liver and Pancreas 3,752 | 18,135
Blood and immune system 3,751 | 17,994
Urinary Tract 3,751 | 18,443
Cardiovascular System 3,741 | 17,957
Skin and soft tissues 3,712 | 18,114
Respiratory system 3,711 | 17,483

Target Family

Non-IDG 2,074 | 11,969
Enzyme 811 | 4,146
Transcription Factor 451 | 1,400
Kinase 176 | 634
Epigenetic 171 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 26 | 38
Transporter 21 | 473
Ion Channel 19 | 341
GPCR 12 | 408

Compartment GO Term

Nuclear part 3,807 | 3,807
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
membrane-bounded organelle 11,793 | 11,793
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
WD repeat-containing protein mio MIOS Tdark Non-IDG -1.44864 27.4 14
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108
mRNA cap guanine-N7 methyltransferase RNMT Tbio Enzyme -1.91115 79.0 301
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Small cell adhesion glycoprotein SMAGP Tdark Non-IDG 0.00000 1.85 72