Development Level

Tbio 301 | 11,651
Tdark 108 | 6,593
Tchem 36 | 1,388
Tclin 16 | 612

Collection

RFA-RM-18-021 5 | 328
GPCR: IDG Consortium (Complete... 3 | 25
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 26 | 979
preweaning lethality, incomple... 17 | 499
abnormal behavior 11 | 298
enlarged heart 8 | 210
hypoactivity 8 | 132
abnormal bone structure 7 | 187
abnormal heart morphology 6 | 162
decreased body weight 6 | 161
embryonic lethality prior to t... 6 | 278
increased lean body mass 6 | 172
increased total body fat amoun... 6 | 134
male infertility 6 | 123
abnormal embryo size 5 | 220
abnormal sleep behavior 5 | 70
decreased hematocrit 5 | 46
decreased hemoglobin content 5 | 68
decreased lean body mass 5 | 135
decreased vertical activity 5 | 208
embryonic lethality prior to o... 5 | 239
hyperactivity 5 | 148
tremors 5 | 39
decreased bone mineral content 4 | 151
decreased grip strength 4 | 116
decreased total body fat amoun... 4 | 207
impaired glucose tolerance 4 | 75
increased hematocrit 4 | 46
short tibia 4 | 97
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased basophil cell number 3 | 16
decreased circulating HDL chol... 3 | 68
decreased circulating alkaline... 3 | 46
decreased circulating insulin ... 3 | 76
decreased fasted circulating g... 3 | 65
decreased leukocyte cell numbe... 3 | 73
edema 3 | 59
increased blood urea nitrogen ... 3 | 48
increased circulating alkaline... 3 | 122
increased circulating amylase ... 3 | 25
increased circulating chloride... 3 | 41
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased red blood cell distr... 3 | 34
increased startle reflex 3 | 112
small thymus 3 | 16
abnormal behavioral response t... 2 | 66
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal locomotor behavior 2 | 24
abnormal optic disc morphology 2 | 10
abnormal pericardium morpholog... 2 | 26
abnormal retina morphology 2 | 71
abnormal snout morphology 2 | 23
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating glycerol... 2 | 16
decreased circulating triglyce... 2 | 79
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased pulmonary respirator... 2 | 5
decreased red blood cell distr... 2 | 41
embryonic growth retardation 2 | 106
enlarged stomach 2 | 2
female infertility 2 | 60
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
small testis 2 | 58
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal whole-body plethysmog... 1 | 4
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating creatine... 1 | 5
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
small superior vagus ganglion 1 | 74

Disease

Carcinoma 308 | 11,493
ovarian cancer 252 | 8,520
osteosarcoma 236 | 7,950
medulloblastoma, large-cell 182 | 6,241
psoriasis 174 | 6,694
glioblastoma 156 | 5,792
lung cancer 151 | 4,740
atypical teratoid / rhabdoid tumor 146 | 5,112
group 3 medulloblastoma 137 | 4,104
ependymoma 114 | 4,679
malignant mesothelioma 107 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 99 | 3,291
adult high grade glioma 95 | 3,801
Breast cancer 94 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 93 | 2,989
invasive ductal carcinoma 84 | 2,951
non-small cell lung cancer 83 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 81 | 2,955
oligodendroglioma 80 | 2,850
primitive neuroectodermal tumor 76 | 3,035
Astrocytoma, Pilocytic 71 | 3,081
Kidney cancer 70 | 2,613
lung adenocarcinoma 68 | 2,716
pancreatic cancer 68 | 2,398
lung carcinoma 63 | 2,843
interstitial cystitis 62 | 2,312
subependymal giant cell astrocytoma 62 | 2,287
Cancer 61 | 2,499
astrocytic glioma 61 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 59 | 1,962
tuberculosis 59 | 2,010
Multiple myeloma 56 | 1,332
Pick disease 56 | 1,894
breast carcinoma 52 | 1,638
ulcerative colitis 51 | 1,819
acute quadriplegic myopathy 49 | 1,158
cystic fibrosis 49 | 1,696
ductal carcinoma in situ 48 | 1,745
group 4 medulloblastoma 47 | 1,855
dermatomyositis 45 | 966
adrenocortical carcinoma 43 | 1,428
Rheumatoid arthritis 42 | 1,191
colon cancer 41 | 1,478
juvenile dermatomyositis 41 | 1,187
pituitary cancer 41 | 1,972
primary pancreatic ductal adenocarcinoma 39 | 1,109
Autosomal recessive predisposition 37 | 1,442
nasopharyngeal carcinoma 33 | 1,058
pediatric high grade glioma 32 | 1,064
diabetes mellitus 31 | 1,728
astrocytoma 30 | 1,146
cutaneous lupus erythematosus 29 | 1,057
Amyotrophic lateral sclerosis 27 | 451
Waldenstrons macroglobulinemia 27 | 765
primary Sjogren syndrome 27 | 735
Atopic dermatitis 26 | 952
Schizophrenia 26 | 1,160
progressive supranuclear palsy 26 | 676
Alzheimer's disease 24 | 658
active ulcerative colitis 24 | 764
non primary Sjogren syndrome sicca 24 | 891
Epilepsy 23 | 792
Down syndrome 21 | 499
Duchenne muscular dystrophy 21 | 601
aldosterone-producing adenoma 21 | 665
Bipolar Disorder 20 | 666
Neurodegenerative disease 20 | 414
esophageal adenocarcinoma 20 | 737
spina bifida 20 | 1,074
Intellectual disability 19 | 1,016
Liver Cirrhosis, Experimental 19 | 769
active Crohn's disease 19 | 922
acute myeloid leukemia 19 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
gastric carcinoma 19 | 807
pancreatic carcinoma 18 | 562
Seizures 17 | 596
sonic hedgehog group medulloblastoma 17 | 467
Asthma 16 | 385
Cognitive delay 16 | 608
Endometriosis 16 | 540
Global developmental delay 16 | 608
Mammary Neoplasms 16 | 425
Mental and motor retardation 16 | 608
sarcoidosis 16 | 370
Breast Neoplasms 15 | 445
Emery-Dreifuss muscular dystrophy 15 | 23
Liver cancer 15 | 604
Parkinson's disease 15 | 392
Prostatic Neoplasms 15 | 495
Depressive disorder 14 | 409
Melanoma 14 | 711
medulloblastoma 14 | 720
Endometrial cancer 13 | 311
Heart disease 13 | 306
Orbital separation excessive 13 | 244
Short stature 13 | 531
Vascular disease 13 | 319
hereditary spastic paraplegia 13 | 318
mucosa-associated lymphoid tissue lymphoma 13 | 484

Tissue

Endocrine System 451 | 18,159
Female tissues 447 | 17,400
Digestive Tract 445 | 17,369
Liver and Pancreas 445 | 16,750
Male tissues 444 | 17,142
Skin and soft tissues 444 | 17,230
Blood and immune system 438 | 16,909
Nervous System 436 | 16,725
Urinary Tract 435 | 16,678
Respiratory system 430 | 16,393
Cardiovascular System 413 | 15,192

Target Family

Non-IDG 270 | 12,091
Enzyme 94 | 4,145
Transcription Factor 40 | 1,400
Ion Channel 19 | 344
Kinase 14 | 634
GPCR 9 | 408
Epigenetic 7 | 242
Transporter 7 | 473
Nuclear Receptor 1 | 48

Compartment GO Term

Nuclear membrane 461 | 461
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
RanBP2-like and GRIP domain-containing protein 3 RGPD3 Tdark Non-IDG 0.00000 0
Butyrophilin-like protein 9 BTNL9 Tdark Non-IDG -0.69979 4.69 67
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
Protein KASH5 CCDC155 Tdark Non-IDG -0.58600 3.79 39
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366