Development Level

Tbio 2,947 | 11,445
Tdark 485 | 6,588
Tchem 438 | 1,598
Tclin 98 | 613

Collection

Kinase: IDG Consortium (Target... 30 | 125
Kinase: IDG Consortium (Comple... 14 | 37
GPCR: IDG Consortium (Targets) 6 | 126
Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

preweaning lethality, complete... 407 | 979
preweaning lethality, incomple... 129 | 499
embryonic lethality prior to t... 111 | 278
embryonic lethality prior to o... 104 | 239
abnormal behavior 81 | 298
abnormal embryo size 77 | 220
decreased body weight 56 | 161
decreased total body fat amoun... 52 | 207
abnormal bone structure 49 | 187
enlarged heart 47 | 210
increased lean body mass 45 | 172
decreased lean body mass 43 | 135
abnormal heart morphology 41 | 162
increased startle reflex 40 | 112
decreased vertical activity 39 | 208
embryonic growth retardation 35 | 106
decreased circulating choleste... 34 | 93
hyperactivity 34 | 148
increased circulating alkaline... 34 | 122
decreased bone mineral content 33 | 151
decreased circulating glucose ... 33 | 126
increased bone mineral density 32 | 72
male infertility 32 | 123
hypoactivity 31 | 132
decreased body length 30 | 101
decreased bone mineral density 30 | 126
increased mean corpuscular vol... 30 | 92
increased total body fat amoun... 30 | 134
increased bone mineral content 29 | 108
increased or absent threshold ... 29 | 101
decreased prepulse inhibition 28 | 82
prenatal lethality prior to he... 28 | 87
cataract 27 | 92
decreased grip strength 27 | 116
increased mean corpuscular hem... 26 | 96
short tibia 26 | 97
abnormal lens morphology 25 | 81
decreased leukocyte cell numbe... 24 | 73
abnormal kidney morphology 23 | 65
abnormal coat-hair pigmentatio... 22 | 64
decreased circulating triglyce... 22 | 79
decreased hemoglobin content 22 | 68
decreased lymphocyte cell numb... 22 | 83
decreased circulating HDL chol... 21 | 68
decreased mean corpuscular vol... 21 | 79
abnormal seminal vesicle morph... 20 | 114
decreased circulating serum al... 20 | 82
increased circulating HDL chol... 20 | 80
corneal opacity 19 | 32
decreased erythrocyte cell num... 19 | 62
edema 19 | 59
impaired glucose tolerance 19 | 75
abnormal gait 18 | 69
abnormal retina morphology 18 | 71
female infertility 18 | 60
increased circulating choleste... 18 | 66
decreased fasted circulating g... 17 | 65
increased fasted circulating g... 17 | 76
tremors 17 | 39
abnormal eye morphology 16 | 68
abnormal neural tube closure 16 | 46
increased grip strength 16 | 41
abnormal spleen morphology 15 | 55
decreased caudal vertebrae num... 15 | 53
decreased circulating total pr... 15 | 49
decreased hematocrit 15 | 46
decreased mean corpuscular hem... 15 | 50
decreased startle reflex 15 | 75
increased heart weight 15 | 62
thrombocytopenia 15 | 56
abnormal bone mineralization 14 | 38
decreased circulating LDL chol... 14 | 38
decreased circulating alanine ... 14 | 47
decreased circulating iron lev... 14 | 32
hydrometra 14 | 53
increased circulating chloride... 14 | 41
increased circulating sodium l... 14 | 71
increased circulating triglyce... 14 | 42
increased mean platelet volume 14 | 45
small testis 14 | 58
abnormal behavioral response t... 13 | 66
abnormal craniofacial morpholo... 13 | 33
anophthalmia 13 | 33
decreased blood urea nitrogen ... 13 | 51
decreased circulating alkaline... 13 | 46
decreased circulating insulin ... 13 | 76
decreased neutrophil cell numb... 13 | 42
increased body length 13 | 32
small superior vagus ganglion 13 | 74
abnormal cornea morphology 12 | 31
abnormal embryo turning 12 | 31
decreased heart left ventricle... 12 | 28
improved glucose tolerance 12 | 79
increased hemoglobin content 12 | 45
increased monocyte cell number 12 | 63
increased neutrophil cell numb... 12 | 46
abnormal skin morphology 11 | 50
abnormal sleep behavior 10 | 70
decreased circulating aspartat... 10 | 34
pallor 10 | 34

Disease

Carcinoma 2,596 | 11,493
ovarian cancer 2,349 | 8,520
osteosarcoma 2,004 | 7,950
medulloblastoma, large-cell 1,506 | 6,241
psoriasis 1,480 | 6,694
glioblastoma 1,395 | 5,792
lung cancer 1,314 | 4,740
atypical teratoid / rhabdoid tumor 1,180 | 5,112
group 3 medulloblastoma 1,167 | 4,104
ependymoma 936 | 4,679
Breast cancer 923 | 3,578
malignant mesothelioma 904 | 3,232
Cancer 900 | 2,499
adult high grade glioma 791 | 3,801
primitive neuroectodermal tumor 766 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 753 | 3,291
oligodendroglioma 672 | 2,850
non-small cell lung cancer 671 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 665 | 2,989
invasive ductal carcinoma 642 | 2,951
Kidney cancer 632 | 2,613
lung adenocarcinoma 594 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 591 | 2,955
astrocytic glioma 565 | 2,597
Astrocytoma, Pilocytic 518 | 3,081
Multiple myeloma 507 | 1,332
pancreatic cancer 498 | 2,398
subependymal giant cell astrocytoma 483 | 2,287
Pick disease 475 | 1,894
lung carcinoma 414 | 2,843
group 4 medulloblastoma 413 | 1,855
tuberculosis 409 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 404 | 1,962
acute quadriplegic myopathy 385 | 1,158
breast carcinoma 383 | 1,638
colon cancer 381 | 1,478
diabetes mellitus 378 | 1,728
pituitary cancer 372 | 1,972
ductal carcinoma in situ 367 | 1,745
adrenocortical carcinoma 358 | 1,428
juvenile dermatomyositis 353 | 1,187
astrocytoma 352 | 1,146
Intellectual disability 344 | 1,016
Rheumatoid arthritis 339 | 1,191
interstitial cystitis 339 | 2,312
Waldenstrons macroglobulinemia 333 | 765
dermatomyositis 328 | 966
ulcerative colitis 319 | 1,819
Autosomal recessive predisposition 305 | 1,442
pediatric high grade glioma 284 | 1,064
acute myeloid leukemia 272 | 783
cystic fibrosis 270 | 1,696
spina bifida 255 | 1,074
primary pancreatic ductal adenocarcinoma 253 | 1,109
Schizophrenia 246 | 1,160
nasopharyngeal carcinoma 237 | 1,058
non primary Sjogren syndrome sicca 223 | 891
Dull intelligence 218 | 645
Low intelligence 218 | 645
Mental Retardation 218 | 645
Mental deficiency 218 | 645
Poor school performance 218 | 645
cutaneous lupus erythematosus 208 | 1,057
Cognitive delay 206 | 608
Global developmental delay 206 | 608
Mental and motor retardation 206 | 608
Short stature 196 | 531
primary Sjogren syndrome 189 | 735
Breast Neoplasms 187 | 445
Atopic dermatitis 186 | 952
progressive supranuclear palsy 179 | 676
Mammary Neoplasms 176 | 425
aldosterone-producing adenoma 176 | 665
medulloblastoma 176 | 720
Epilepsy 174 | 792
Endometriosis 167 | 540
Small head 163 | 374
hepatocellular carcinoma 161 | 547
Muscle hypotonia 157 | 571
active Crohn's disease 155 | 922
Alzheimer's disease 153 | 658
Liver Cirrhosis, Experimental 152 | 769
Obesity 151 | 678
gastric carcinoma 151 | 807
Seizures 149 | 596
Amyotrophic lateral sclerosis 146 | 451
Prostatic Neoplasms 144 | 495
Bipolar Disorder 137 | 666
Liver cancer 137 | 604
active ulcerative colitis 136 | 764
esophageal adenocarcinoma 136 | 737
Melanoma 128 | 711
pancreatic carcinoma 128 | 562
tuberculosis and treatment for 6 months 127 | 409
Stomach Neoplasms 124 | 300
Cryptorchidism 123 | 296
gastric cancer 123 | 459
Hypoplastic mandible condyle 121 | 275
Mandibular hypoplasia 121 | 275
Micrognathism 121 | 275

Tissue

Endocrine System 3,907 | 18,159
Digestive Tract 3,878 | 17,369
Female tissues 3,874 | 17,400
Male tissues 3,863 | 17,142
Skin and soft tissues 3,862 | 17,230
Blood and immune system 3,840 | 16,909
Liver and Pancreas 3,824 | 16,750
Urinary Tract 3,824 | 16,678
Nervous System 3,815 | 16,725
Respiratory system 3,810 | 16,393
Cardiovascular System 3,711 | 15,192

Target Family

Non-IDG 2,087 | 12,091
Enzyme 854 | 4,145
Transcription Factor 524 | 1,400
Kinase 195 | 634
Epigenetic 183 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 28 | 38
Transporter 24 | 473
GPCR 17 | 408
Ion Channel 9 | 344

Compartment GO Term

Nuclear lumen 3,968 | 3,968
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN PTEN Tchem Enzyme -3.70874 5099.6 916